9108758

N-(3-ethoxyphenyl)benzamide

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_3184
Screen concentration 49.5 μM
Source Chembridge (Drug-like library)
PubChem CID 902885
SMILES CCOC1=CC=CC(=C1)NC(=O)C2=CC=CC=C2
Standardized SMILES CCOc1cccc(NC(=O)c2ccccc2)c1
Molecular weight 241.2851
ALogP 2.95
H-bond donor count 1
H-bond acceptor count 2
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 6.55
% growth inhibition (Hom. pool) 5.31


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 902885
Download HIP data (tab-delimited text)  (excel)
Gene:BOS1(YLR078C)|FD-Score:3.12|P-value:9.15E-4|Clearance:0.36||SGD DESC:v-SNARE (vesicle specific SNAP receptor), localized to the endoplasmic reticulum membrane and necessary for vesicular transport from the ER to the Golgi Gene:RIO2(YNL207W)|FD-Score:3.44|P-value:2.86E-4|Clearance:0.36||SGD DESC:Essential serine kinase involved in the processing of the 20S pre-rRNA into mature 18S rRNA; has similarity to Rio1p Gene:TFA2(YKR062W)|FD-Score:3.52|P-value:2.14E-4|Clearance:0.36||SGD DESC:TFIIE small subunit, involved in RNA polymerase II transcription initiation Gene:BOS1(YLR078C)|FD-Score:3.12|P-value:9.15E-4|Clearance:0.36||SGD DESC:v-SNARE (vesicle specific SNAP receptor), localized to the endoplasmic reticulum membrane and necessary for vesicular transport from the ER to the Golgi Gene:RIO2(YNL207W)|FD-Score:3.44|P-value:2.86E-4|Clearance:0.36||SGD DESC:Essential serine kinase involved in the processing of the 20S pre-rRNA into mature 18S rRNA; has similarity to Rio1p Gene:TFA2(YKR062W)|FD-Score:3.52|P-value:2.14E-4|Clearance:0.36||SGD DESC:TFIIE small subunit, involved in RNA polymerase II transcription initiation

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 902885
Download HOP data (tab-delimited text)  (excel)
Gene:ARF2(YDL137W)|FD-Score:3.51|P-value:2.23E-4||SGD DESC:ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated formation vesicles in intracellular trafficking within the Golgi; ARF2 has a paralog, ARF1, that arose from the whole genome duplication Gene:CMR1(YDL156W)|FD-Score:3.61|P-value:1.51E-4||SGD DESC:DNA-binding protein with preference for UV-damaged DNA; protein sequence contains three WD domains (WD-40 repeat); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; potential regulatory target of Mbp1p, which binds to the promoter region; co-localizes with Hos2p in nuclear foci in response to DNA damage by MMS Gene:COX17(YLL009C)|FD-Score:3.59|P-value:1.66E-4||SGD DESC:Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs Gene:DBR1(YKL149C)|FD-Score:5.04|P-value:2.31E-7||SGD DESC:RNA lariat debranching enzyme, involved in intron turnover; required for efficient Ty1 transposition Gene:ECM33(YBR078W)|FD-Score:3.52|P-value:2.18E-4||SGD DESC:GPI-anchored protein of unknown function, has a possible role in apical bud growth; GPI-anchoring on the plasma membrane crucial to function; phosphorylated in mitochondria; similar to Sps2p and Pst1p Gene:FUS2(YMR232W)|FD-Score:4.09|P-value:2.17E-5||SGD DESC:Cytoplasmic protein localized to the shmoo tip; required for the alignment of parental nuclei before nuclear fusion during mating Gene:GEP5(YLR091W)|FD-Score:3.63|P-value:1.43E-4||SGD DESC:Protein of unknown function, required for mitochondrial genome maintenance; detected in highly purified mitochondria in high-throughput studies; null mutant has decreased levels of cardiolipin and phosphatidylethanolamine Gene:MGM101(YJR144W)|FD-Score:4.01|P-value:3.01E-5||SGD DESC:Protein with a role in mitochondrial DNA recombinational repair;also involved in interstrand cross-link repair; binds to and catalyzes the annealing of single-stranded mtDNA; oligomerizes to form rings and filaments; related to Rad52-type recombination proteins, with limited overall similarity but sharing conserved functionally important residues; component of the mitochondrial nucleoid, required for the repair of oxidative mtDNA damage Gene:MSC7(YHR039C)|FD-Score:4.75|P-value:1.02E-6||SGD DESC:Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; msc7 mutants are defective in directing meiotic recombination events to homologous chromatids Gene:MTC1(YJL123C)|FD-Score:-3.1|P-value:9.60E-4||SGD DESC:Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to COPI-coated vesicles (early Golgi); mtc1 is synthetically lethal with cdc13-1 Gene:OCH1(YGL038C)|FD-Score:3.12|P-value:8.95E-4||SGD DESC:Mannosyltransferase of the cis-Golgi apparatus, initiates the polymannose outer chain elongation of N-linked oligosaccharides of glycoproteins Gene:RGT1(YKL038W)|FD-Score:3.3|P-value:4.88E-4||SGD DESC:Glucose-responsive transcription factor; regulates expression of several glucose transporter (HXT) genes in response to glucose; binds to promoters and acts both as a transcriptional activator and repressor; RGT1 has a paralog, EDS1, that arose from the whole genome duplication Gene:STE23(YLR389C)|FD-Score:-3.19|P-value:7.14E-4||SGD DESC:Metalloprotease involved, with homolog Axl1p, in N-terminal processing of pro-a-factor to the mature form; expressed in both haploids and diploids; member of the insulin-degrading enzyme family Gene:TMA46(YOR091W)|FD-Score:-3.11|P-value:9.25E-4||SGD DESC:Protein of unknown function that associates with translating ribosomes; interacts with GTPase Rbg1p Gene:TRP2(YER090W)|FD-Score:4.59|P-value:2.21E-6||SGD DESC:Anthranilate synthase, catalyzes the initial step of tryptophan biosynthesis, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp3p Gene:TRP3(YKL211C)|FD-Score:3.65|P-value:1.32E-4||SGD DESC:Indole-3-glycerol-phosphate synthase; forms bifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p Gene:VMA11(YPL234C)|FD-Score:-3.56|P-value:1.87E-4||SGD DESC:Vacuolar ATPase V0 domain subunit c', involved in proton transport activity; hydrophobic integral membrane protein (proteolipid) containing four transmembrane segments; N and C termini are in the vacuolar lumen Gene:VPS61(YDR136C_d)|FD-Score:3.79|P-value:7.54E-5||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 4% of ORF overlaps the verified gene RGP1; deletion causes a vacuolar protein sorting defect Gene:YFR054C(YFR054C_d)|FD-Score:-3.13|P-value:8.89E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YMR315W(YMR315W)|FD-Score:3.49|P-value:2.45E-4||SGD DESC:Protein with NADP(H) oxidoreductase activity; transcription is regulated by Stb5p in response to NADPH depletion induced by diamide; promoter contains a putative Stb5p binding site; protein abundance increases in response to DNA replication stress Gene:YNL162W-A(YNL162W-A_p)|FD-Score:3.09|P-value:9.99E-4||SGD DESC:Putative protein of unknown function; identified by homology Gene:YPR114W(YPR114W_p)|FD-Score:4.03|P-value:2.81E-5||SGD DESC:Putative protein of unknown function Gene:ARF2(YDL137W)|FD-Score:3.51|P-value:2.23E-4||SGD DESC:ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated formation vesicles in intracellular trafficking within the Golgi; ARF2 has a paralog, ARF1, that arose from the whole genome duplication Gene:CMR1(YDL156W)|FD-Score:3.61|P-value:1.51E-4||SGD DESC:DNA-binding protein with preference for UV-damaged DNA; protein sequence contains three WD domains (WD-40 repeat); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; potential regulatory target of Mbp1p, which binds to the promoter region; co-localizes with Hos2p in nuclear foci in response to DNA damage by MMS Gene:COX17(YLL009C)|FD-Score:3.59|P-value:1.66E-4||SGD DESC:Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs Gene:DBR1(YKL149C)|FD-Score:5.04|P-value:2.31E-7||SGD DESC:RNA lariat debranching enzyme, involved in intron turnover; required for efficient Ty1 transposition Gene:ECM33(YBR078W)|FD-Score:3.52|P-value:2.18E-4||SGD DESC:GPI-anchored protein of unknown function, has a possible role in apical bud growth; GPI-anchoring on the plasma membrane crucial to function; phosphorylated in mitochondria; similar to Sps2p and Pst1p Gene:FUS2(YMR232W)|FD-Score:4.09|P-value:2.17E-5||SGD DESC:Cytoplasmic protein localized to the shmoo tip; required for the alignment of parental nuclei before nuclear fusion during mating Gene:GEP5(YLR091W)|FD-Score:3.63|P-value:1.43E-4||SGD DESC:Protein of unknown function, required for mitochondrial genome maintenance; detected in highly purified mitochondria in high-throughput studies; null mutant has decreased levels of cardiolipin and phosphatidylethanolamine Gene:MGM101(YJR144W)|FD-Score:4.01|P-value:3.01E-5||SGD DESC:Protein with a role in mitochondrial DNA recombinational repair;also involved in interstrand cross-link repair; binds to and catalyzes the annealing of single-stranded mtDNA; oligomerizes to form rings and filaments; related to Rad52-type recombination proteins, with limited overall similarity but sharing conserved functionally important residues; component of the mitochondrial nucleoid, required for the repair of oxidative mtDNA damage Gene:MSC7(YHR039C)|FD-Score:4.75|P-value:1.02E-6||SGD DESC:Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; msc7 mutants are defective in directing meiotic recombination events to homologous chromatids Gene:MTC1(YJL123C)|FD-Score:-3.1|P-value:9.60E-4||SGD DESC:Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to COPI-coated vesicles (early Golgi); mtc1 is synthetically lethal with cdc13-1 Gene:OCH1(YGL038C)|FD-Score:3.12|P-value:8.95E-4||SGD DESC:Mannosyltransferase of the cis-Golgi apparatus, initiates the polymannose outer chain elongation of N-linked oligosaccharides of glycoproteins Gene:RGT1(YKL038W)|FD-Score:3.3|P-value:4.88E-4||SGD DESC:Glucose-responsive transcription factor; regulates expression of several glucose transporter (HXT) genes in response to glucose; binds to promoters and acts both as a transcriptional activator and repressor; RGT1 has a paralog, EDS1, that arose from the whole genome duplication Gene:STE23(YLR389C)|FD-Score:-3.19|P-value:7.14E-4||SGD DESC:Metalloprotease involved, with homolog Axl1p, in N-terminal processing of pro-a-factor to the mature form; expressed in both haploids and diploids; member of the insulin-degrading enzyme family Gene:TMA46(YOR091W)|FD-Score:-3.11|P-value:9.25E-4||SGD DESC:Protein of unknown function that associates with translating ribosomes; interacts with GTPase Rbg1p Gene:TRP2(YER090W)|FD-Score:4.59|P-value:2.21E-6||SGD DESC:Anthranilate synthase, catalyzes the initial step of tryptophan biosynthesis, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp3p Gene:TRP3(YKL211C)|FD-Score:3.65|P-value:1.32E-4||SGD DESC:Indole-3-glycerol-phosphate synthase; forms bifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p Gene:VMA11(YPL234C)|FD-Score:-3.56|P-value:1.87E-4||SGD DESC:Vacuolar ATPase V0 domain subunit c', involved in proton transport activity; hydrophobic integral membrane protein (proteolipid) containing four transmembrane segments; N and C termini are in the vacuolar lumen Gene:VPS61(YDR136C_d)|FD-Score:3.79|P-value:7.54E-5||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 4% of ORF overlaps the verified gene RGP1; deletion causes a vacuolar protein sorting defect Gene:YFR054C(YFR054C_d)|FD-Score:-3.13|P-value:8.89E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YMR315W(YMR315W)|FD-Score:3.49|P-value:2.45E-4||SGD DESC:Protein with NADP(H) oxidoreductase activity; transcription is regulated by Stb5p in response to NADPH depletion induced by diamide; promoter contains a putative Stb5p binding site; protein abundance increases in response to DNA replication stress Gene:YNL162W-A(YNL162W-A_p)|FD-Score:3.09|P-value:9.99E-4||SGD DESC:Putative protein of unknown function; identified by homology Gene:YPR114W(YPR114W_p)|FD-Score:4.03|P-value:2.81E-5||SGD DESC:Putative protein of unknown function

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YKR062W3.522.14E-40.36TFA2TFIIE small subunit, involved in RNA polymerase II transcription initiation
YNL207W3.442.86E-40.36RIO2Essential serine kinase involved in the processing of the 20S pre-rRNA into mature 18S rRNA; has similarity to Rio1p
YLR078C3.129.15E-40.36BOS1v-SNARE (vesicle specific SNAP receptor), localized to the endoplasmic reticulum membrane and necessary for vesicular transport from the ER to the Golgi
YPL210C2.760.002920.01SRP72Core component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane
YJR093C2.740.003040.11FIP1Subunit of cleavage polyadenylation factor (CPF), interacts directly with poly(A) polymerase (Pap1p) to regulate its activity; bridging factor that links Pap1p and the CPF complex via Yth1p
YIL048W2.640.004180.05NEO1Putative aminophospholipid translocase (flippase) involved in endocytosis and vacuolar biogenesis; localizes to endosomes and the Golgi aparatus
YOL005C2.580.004880.04RPB11RNA polymerase II subunit B12.5; part of central core; similar to Rpc19p and bacterial alpha subunit
YDR189W2.540.005540.02SLY1Hydrophilic protein involved in vesicle trafficking between the ER and Golgi; SM (Sec1/Munc-18) family protein that binds the tSNARE Sed5p and stimulates its assembly into a trans-SNARE membrane-protein complex
YLR458W_d2.520.005800.02YLR458W_dDubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential NBP1 gene required for mitosis
YGL172W2.510.006080.02NUP49FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; found in stable complex with Nic96p and two other FG-nucleoproteins (Nsp1p and Nup57p)
YNL062C2.490.006440.04GCD10Subunit of tRNA (1-methyladenosine) methyltransferase with Gcd14p, required for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression
YOL130W2.450.007130.02ALR1Plasma membrane Mg(2+) transporter, expression and turnover are regulated by Mg(2+) concentration; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions
YDR113C2.430.007570.02PDS1Securin, inhibits anaphase by binding separin Esp1p; blocks cyclin destruction and mitotic exit, essential for meiotic progression and mitotic cell cycle arrest; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation
YBL041W2.410.007940.07PRE7Beta 6 subunit of the 20S proteasome
YLR378C2.350.009500.02SEC61Essential subunit of Sec61 complex (Sec61p, Sbh1p, and Sss1p); forms a channel for SRP-dependent protein import and retrograde transport of misfolded proteins out of the ER; with Sec63 complex allows SRP-independent protein import into ER

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YKL149C5.042.31E-7DBR1RNA lariat debranching enzyme, involved in intron turnover; required for efficient Ty1 transposition
YHR039C4.751.02E-6MSC7Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; msc7 mutants are defective in directing meiotic recombination events to homologous chromatids
YER090W4.592.21E-6TRP2Anthranilate synthase, catalyzes the initial step of tryptophan biosynthesis, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp3p
YMR232W4.092.17E-5FUS2Cytoplasmic protein localized to the shmoo tip; required for the alignment of parental nuclei before nuclear fusion during mating
YPR114W_p4.032.81E-5YPR114W_pPutative protein of unknown function
YJR144W4.013.01E-5MGM101Protein with a role in mitochondrial DNA recombinational repair;also involved in interstrand cross-link repair; binds to and catalyzes the annealing of single-stranded mtDNA; oligomerizes to form rings and filaments; related to Rad52-type recombination proteins, with limited overall similarity but sharing conserved functionally important residues; component of the mitochondrial nucleoid, required for the repair of oxidative mtDNA damage
YDR136C_d3.797.54E-5VPS61_dDubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 4% of ORF overlaps the verified gene RGP1; deletion causes a vacuolar protein sorting defect
YKL211C3.651.32E-4TRP3Indole-3-glycerol-phosphate synthase; forms bifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p
YLR091W3.631.43E-4GEP5Protein of unknown function, required for mitochondrial genome maintenance; detected in highly purified mitochondria in high-throughput studies; null mutant has decreased levels of cardiolipin and phosphatidylethanolamine
YDL156W3.611.51E-4CMR1DNA-binding protein with preference for UV-damaged DNA; protein sequence contains three WD domains (WD-40 repeat); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; potential regulatory target of Mbp1p, which binds to the promoter region; co-localizes with Hos2p in nuclear foci in response to DNA damage by MMS
YLL009C3.591.66E-4COX17Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs
YBR078W3.522.18E-4ECM33GPI-anchored protein of unknown function, has a possible role in apical bud growth; GPI-anchoring on the plasma membrane crucial to function; phosphorylated in mitochondria; similar to Sps2p and Pst1p
YDL137W3.512.23E-4ARF2ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated formation vesicles in intracellular trafficking within the Golgi; ARF2 has a paralog, ARF1, that arose from the whole genome duplication
YMR315W3.492.45E-4YMR315WProtein with NADP(H) oxidoreductase activity; transcription is regulated by Stb5p in response to NADPH depletion induced by diamide; promoter contains a putative Stb5p binding site; protein abundance increases in response to DNA replication stress
YKL038W3.304.88E-4RGT1Glucose-responsive transcription factor; regulates expression of several glucose transporter (HXT) genes in response to glucose; binds to promoters and acts both as a transcriptional activator and repressor; RGT1 has a paralog, EDS1, that arose from the whole genome duplication

GO enrichment analysis for SGTC_3184
biological processes

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.1971.66E-52SGTC_1617st002906 78.0 μMTimTec (Natural product derivative library)51508590.12
0.1763.67E-42SGTC_22246650123 117.6 μMChembridge (Fragment library)29083700.136364
0.1553.00E-33SGTC_15412',3',6-trimethoxyflavone 64.0 μMTimTec (Pure natural product library)6888010.15625
0.1541.71E-32SGTC_20935331342 194.4 μMChembridge (Fragment library)338390.0983607
0.1533.47E-32SGTC_15465-methoxyflavanone 78.7 μMTimTec (Pure natural product library)1477950.166667
0.1525.24E-32SGTC_22547938975 95.2 μMChembridge (Fragment library)29692770.112903
0.1497.33E-31SGTC_11931488-0126 41.5 μMChemDiv (Drug-like library)13847100.0735294
0.1482.18E-30SGTC_1975st070967 30.8 μMTimTec (Natural product derivative library)2613910.103448
0.1474.49E-30SGTC_22037227154 166.4 μMChembridge (Fragment library)8963040.235294
0.1476.67E-30SGTC_1603st002045 67.8 μMTimTec (Natural product derivative library)58879850.135593TSC3-RPN4
0.1461.90E-29SGTC_11941488-0194 225.0 μMChemDiv (Drug-like library)13914520.0746269
0.1455.99E-29SGTC_1572epiandrosterone 68.9 μMTimTec (Pure natural product library)4413020.0434783
0.1448.49E-29SGTC_21976588183 93.1 μMChembridge (Fragment library)8841360.190476
0.1432.55E-28SGTC_2409alverine citrate 64.0 μMMiscellaneous217180.1875
0.1424.46E-28SGTC_2231micatex 6.9 μMMiscellaneous207370.0816327

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_3188911078949.47 μM0.756098849217Chembridge (Drug-like library)275.730163.61112iron homeostasis
SGTC_3191911035249.47 μM0.71428617122424Chembridge (Drug-like library)267.322383.66112
SGTC_3187910939449.47 μM0.63636417098090Chembridge (Drug-like library)247.312822.913Golgi
SGTC_3207911416349.47 μM0.636364849233Chembridge (Drug-like library)269.338263.43812
SGTC_2931901467455.67 μM0.6086962996810Chembridge (Drug-like library)326.174624.03323
SGTC_3182910884949.47 μM0.617133045Chembridge (Drug-like library)267.322383.66112RPP1 & pyrimidine depletion
SGTC_3091911637249.47 μM0.58695717169793Chembridge (Drug-like library)285.337662.95313
SGTC_2926901072665.15 μM0.5777782994293Chembridge (Drug-like library)253.29583.21512
SGTC_2827799384771.43 μM0.56252985692Chembridge (Drug-like library)283.321783.19813
SGTC_3181910827749.47 μM0.5510217097298Chembridge (Drug-like library)284.35293.02813iron homeostasis