9110352

N-[3-(2-methylprop-2-enoxy)phenyl]benzamide

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_3191
Screen concentration 49.5 μM
Source Chembridge (Drug-like library)
PubChem CID 17122424
SMILES CC(=C)COC1=CC=CC(=C1)NC(=O)C2=CC=CC=C2
Standardized SMILES CC(=C)COc1cccc(NC(=O)c2ccccc2)c1
Molecular weight 267.3224
ALogP 3.66
H-bond donor count 1
H-bond acceptor count 2
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 17.16
% growth inhibition (Hom. pool) 12.91


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 17122424
Download HIP data (tab-delimited text)  (excel)
Gene:ARP7(YPR034W)|FD-Score:-3.21|P-value:6.58E-4|Clearance:0||SGD DESC:Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation Gene:BET2(YPR176C)|FD-Score:-3.57|P-value:1.78E-4|Clearance:0||SGD DESC:Beta subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p Gene:GRS1(YBR121C)|FD-Score:5.4|P-value:3.37E-8|Clearance:1.14||SGD DESC:Cytoplasmic and mitochondrial glycyl-tRNA synthase; ligates glycine to the cognate anticodon-bearing tRNA; transcription termination factor that may interact with the 3'-end of pre-mRNA to promote 3'-end formation; GRS1 has a paralog, GRS2, that arose from the whole genome duplication Gene:NDC1(YML031W)|FD-Score:-5.04|P-value:2.38E-7|Clearance:0||SGD DESC:Subunit of the transmembrane ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis and spindle pole body duplication; homologous to human NDC1 Gene:NUS1(YDL193W)|FD-Score:-3.22|P-value:6.31E-4|Clearance:0||SGD DESC:Putative prenyltransferase, required for cell viability; proposed to be involved in protein trafficking because tet-repressible mutant shows accumulation of hypoglycosylated forms of CPY Gene:RSC4(YKR008W)|FD-Score:-4.26|P-value:1.03E-5|Clearance:0||SGD DESC:Component of the RSC chromatin remodeling complex; found in close proximity to nucleosomal DNA; displaced from the surface of nucleosomal DNA after chromatin remodeling; acetylated (K25) by Gcn5p, altering replication stress tolerance; contains tandem bromodomains that recognize histone H3 acetylated on K14 (H3K14ac) by Gcn5p Gene:SEC20(YDR498C)|FD-Score:-5.16|P-value:1.22E-7|Clearance:0||SGD DESC:Membrane glycoprotein v-SNARE involved in retrograde transport from the Golgi to the ER; required for N- and O-glycosylation in the Golgi but not in the ER; interacts with the Dsl1p complex through Tip20p Gene:SOF1(YLL011W)|FD-Score:-3.37|P-value:3.77E-4|Clearance:0||SGD DESC:Essential protein required for biogenesis of 40S (small) ribosomal subunit; has similarity to the beta subunit of trimeric G-proteins and the splicing factor Prp4p Gene:SPC97(YHR172W)|FD-Score:3.1|P-value:9.61E-4|Clearance:0.07||SGD DESC:Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque Gene:SQT1(YIR012W)|FD-Score:-3.59|P-value:1.68E-4|Clearance:0||SGD DESC:Protein involved in 60S ribosomal subunit assembly or modification; contains multiple WD repeats; interacts with Qsr1p in a two-hybrid assay; protein abundance increases in response to DNA replication stress Gene:SWP1(YMR149W)|FD-Score:-3.22|P-value:6.32E-4|Clearance:0||SGD DESC:Delta subunit of the oligosaccharyl transferase glycoprotein complex, which is required for N-linked glycosylation of proteins in the endoplasmic reticulum Gene:TTI1(YKL033W)|FD-Score:4.26|P-value:1.02E-5|Clearance:1.09||SGD DESC:Subunit of the ASTRA complex, involved in chromatin remodeling; telomere length regulator involved in the stability or biogenesis of PIKKs such as TORC1; similar to S. pombe Tti1p; detected in highly purified mitochondria in high-throughput studies Gene:YDR526C(YDR526C_d)|FD-Score:3.17|P-value:7.66E-4|Clearance:0.07||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:ARP7(YPR034W)|FD-Score:-3.21|P-value:6.58E-4|Clearance:0||SGD DESC:Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation Gene:BET2(YPR176C)|FD-Score:-3.57|P-value:1.78E-4|Clearance:0||SGD DESC:Beta subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p Gene:GRS1(YBR121C)|FD-Score:5.4|P-value:3.37E-8|Clearance:1.14||SGD DESC:Cytoplasmic and mitochondrial glycyl-tRNA synthase; ligates glycine to the cognate anticodon-bearing tRNA; transcription termination factor that may interact with the 3'-end of pre-mRNA to promote 3'-end formation; GRS1 has a paralog, GRS2, that arose from the whole genome duplication Gene:NDC1(YML031W)|FD-Score:-5.04|P-value:2.38E-7|Clearance:0||SGD DESC:Subunit of the transmembrane ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis and spindle pole body duplication; homologous to human NDC1 Gene:NUS1(YDL193W)|FD-Score:-3.22|P-value:6.31E-4|Clearance:0||SGD DESC:Putative prenyltransferase, required for cell viability; proposed to be involved in protein trafficking because tet-repressible mutant shows accumulation of hypoglycosylated forms of CPY Gene:RSC4(YKR008W)|FD-Score:-4.26|P-value:1.03E-5|Clearance:0||SGD DESC:Component of the RSC chromatin remodeling complex; found in close proximity to nucleosomal DNA; displaced from the surface of nucleosomal DNA after chromatin remodeling; acetylated (K25) by Gcn5p, altering replication stress tolerance; contains tandem bromodomains that recognize histone H3 acetylated on K14 (H3K14ac) by Gcn5p Gene:SEC20(YDR498C)|FD-Score:-5.16|P-value:1.22E-7|Clearance:0||SGD DESC:Membrane glycoprotein v-SNARE involved in retrograde transport from the Golgi to the ER; required for N- and O-glycosylation in the Golgi but not in the ER; interacts with the Dsl1p complex through Tip20p Gene:SOF1(YLL011W)|FD-Score:-3.37|P-value:3.77E-4|Clearance:0||SGD DESC:Essential protein required for biogenesis of 40S (small) ribosomal subunit; has similarity to the beta subunit of trimeric G-proteins and the splicing factor Prp4p Gene:SPC97(YHR172W)|FD-Score:3.1|P-value:9.61E-4|Clearance:0.07||SGD DESC:Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque Gene:SQT1(YIR012W)|FD-Score:-3.59|P-value:1.68E-4|Clearance:0||SGD DESC:Protein involved in 60S ribosomal subunit assembly or modification; contains multiple WD repeats; interacts with Qsr1p in a two-hybrid assay; protein abundance increases in response to DNA replication stress Gene:SWP1(YMR149W)|FD-Score:-3.22|P-value:6.32E-4|Clearance:0||SGD DESC:Delta subunit of the oligosaccharyl transferase glycoprotein complex, which is required for N-linked glycosylation of proteins in the endoplasmic reticulum Gene:TTI1(YKL033W)|FD-Score:4.26|P-value:1.02E-5|Clearance:1.09||SGD DESC:Subunit of the ASTRA complex, involved in chromatin remodeling; telomere length regulator involved in the stability or biogenesis of PIKKs such as TORC1; similar to S. pombe Tti1p; detected in highly purified mitochondria in high-throughput studies Gene:YDR526C(YDR526C_d)|FD-Score:3.17|P-value:7.66E-4|Clearance:0.07||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 17122424
Download HOP data (tab-delimited text)  (excel)
Gene:AMS1(YGL156W)|FD-Score:3.7|P-value:1.09E-4||SGD DESC:Vacuolar alpha mannosidase, involved in free oligosaccharide (fOS) degradation; delivered to the vacuole in a novel pathway separate from the secretory pathway Gene:ART10(YLR392C)|FD-Score:-3.09|P-value:9.98E-4||SGD DESC:Protein of unknown function that contains 2 PY motifs and is ubiquinated by Rsp5p; overexpression confers resistance to arsenite; green fluorescent protein (GFP)-fusion protein localizes it to the cytoplasm; non-essential gene Gene:ATG1(YGL180W)|FD-Score:3.7|P-value:1.08E-4||SGD DESC:Protein ser/thr kinase required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; structurally required for phagophore assembly site formation; during autophagy forms a complex with Atg13p and Atg17p Gene:ATG15(YCR068W)|FD-Score:3.33|P-value:4.30E-4||SGD DESC:Lipase required for intravacuolar lysis of autophagic bodies and Cvt bodies; targeted to intravacuolar vesicles during autophagy via the multivesicular body (MVB) pathway Gene:BAS1(YKR099W)|FD-Score:3.92|P-value:4.34E-5||SGD DESC:Myb-related transcription factor involved in regulating basal and induced expression of genes of the purine and histidine biosynthesis pathways; also involved in regulation of meiotic recombination at specific genes Gene:BCK1(YJL095W)|FD-Score:-3.19|P-value:7.18E-4||SGD DESC:Mitogen-activated protein (MAP) kinase kinase kinase acting in the protein kinase C signaling pathway, which controls cell integrity; upon activation by Pkc1p phosphorylates downstream kinases Mkk1p and Mkk2p Gene:COA2(YPL189C-A)|FD-Score:-4.85|P-value:6.25E-7||SGD DESC:Cytochrome oxidase assembly factor; null mutation results in respiratory deficiency with specific loss of cytochrome oxidase activity; functions downstream of assembly factors Mss51p and Coa1p and interacts with assembly factor Shy1p Gene:COX17(YLL009C)|FD-Score:-6.39|P-value:8.15E-11||SGD DESC:Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs Gene:CSG2(YBR036C)|FD-Score:3.52|P-value:2.19E-4||SGD DESC:Endoplasmic reticulum membrane protein, required for mannosylation of inositolphosphorylceramide and for growth at high calcium concentrations; protein abundance increases in response to DNA replication stress Gene:CTH1(YDR151C)|FD-Score:-4.19|P-value:1.37E-5||SGD DESC:Member of the CCCH zinc finger family; has similarity to mammalian Tis11 protein, which activates transcription and also has a role in mRNA degradation; may function with Tis11p in iron homeostasis Gene:CUE4(YML101C)|FD-Score:-3.43|P-value:3.02E-4||SGD DESC:Protein of unknown function; has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination; CUE4 has a paralog, CUE1, that arose from the whole genome duplication Gene:DBP3(YGL078C)|FD-Score:4.15|P-value:1.66E-5||SGD DESC:RNA-Dependent ATPase, member of DExD/H-box family; involved in cleavage of site A3 within the ITS1 spacer during rRNA processing; not essential for growth, but deletion causes severe slow-growth phenotype Gene:ELO1(YJL196C)|FD-Score:3.41|P-value:3.24E-4||SGD DESC:Elongase I, medium-chain acyl elongase; catalyzes carboxy-terminal elongation of unsaturated C12-C16 fatty acyl-CoAs to C16-C18 fatty acids; ELO1 has a paralog, FEN1, that arose from the whole genome duplication Gene:ESL2(YKR096W)|FD-Score:4.34|P-value:7.06E-6||SGD DESC:Protein of unknown function that interacts with Pex14p; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; predicted to contain a PINc domain Gene:FMP21(YBR269C_p)|FD-Score:3.54|P-value:1.97E-4||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:GAT2(YMR136W)|FD-Score:-5.68|P-value:6.87E-9||SGD DESC:Protein containing GATA family zinc finger motifs; similar to Gln3p and Dal80p; expression repressed by leucine Gene:GPH1(YPR160W)|FD-Score:-3.37|P-value:3.81E-4||SGD DESC:Non-essential glycogen phosphorylase required for the mobilization of glycogen, activity is regulated by cyclic AMP-mediated phosphorylation, expression is regulated by stress-response elements and by the HOG MAP kinase pathway Gene:GTT1(YIR038C)|FD-Score:3.63|P-value:1.44E-4||SGD DESC:ER associated glutathione S-transferase capable of homodimerization; expression induced during the diauxic shift and throughout stationary phase; functional overlap with Gtt2p, Grx1p, and Grx2p Gene:HAM1(YJR069C)|FD-Score:-3.44|P-value:2.92E-4||SGD DESC:Nucleoside triphosphate pyrophosphohydrolase; active against a wide range of substrates including ITP, dITP and XTP; mediates exclusion of noncanonical purines and pyrimadines from deoxyribonucleoside triphosphate pools; mutant is sensitive to the base analog 6-N-hydroxylaminopurine; protein abundance increases in response to DNA replication stress Gene:HSP104(YLL026W)|FD-Score:-3.22|P-value:6.33E-4||SGD DESC:Disaggregase; heat shock protein that cooperates with Ydj1p (Hsp40) and Ssa1p (Hsp70) to refold and reactivate previously denatured, aggregated proteins; responsive to stresses including: heat, ethanol, and sodium arsenite; involved in [PSI+] propagation; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress Gene:KIP1(YBL063W)|FD-Score:3.97|P-value:3.63E-5||SGD DESC:Kinesin-related motor protein required for mitotic spindle assembly, chromosome segregation, and 2 micron plasmid partitioning; functionally redundant with Cin8p for chromosomal but not plasmid functions Gene:LRG1(YDL240W)|FD-Score:5.03|P-value:2.45E-7||SGD DESC:Putative GTPase-activating protein (GAP) involved in the Pkc1p-mediated signaling pathway that controls cell wall integrity; appears to specifically regulate 1,3-beta-glucan synthesis Gene:LSB3(YFR024C-A)|FD-Score:-3.38|P-value:3.60E-4||SGD DESC:Protein containing a C-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; protein abundance increases in response to DNA replication stress; LSB3 has a paralog, YSC84, that arose from the whole genome duplication Gene:MRP13(YGR084C)|FD-Score:-4.64|P-value:1.76E-6||SGD DESC:Mitochondrial ribosomal protein of the small subunit Gene:MSD1(YPL104W)|FD-Score:3.26|P-value:5.55E-4||SGD DESC:Mitochondrial aspartyl-tRNA synthetase, required for acylation of aspartyl-tRNA; yeast and bacterial aspartyl-, asparaginyl-, and lysyl-tRNA synthetases contain regions with high sequence similarity, suggesting a common ancestral gene Gene:NTG1(YAL015C)|FD-Score:-3.55|P-value:1.91E-4||SGD DESC:DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress; NTG1 has a paralog, NTG2, that arose from the whole genome duplication Gene:OMS1(YDR316W)|FD-Score:3.66|P-value:1.24E-4||SGD DESC:Protein integral to the mitochondrial membrane; has a conserved methyltransferase motif; multicopy suppressor of respiratory defects caused by OXA1 mutations Gene:PET112(YBL080C)|FD-Score:-3.12|P-value:9.16E-4||SGD DESC:Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; mutation is functionally complemented by the bacterial GatB ortholog Gene:PHM6(YDR281C)|FD-Score:3.14|P-value:8.32E-4||SGD DESC:Protein of unknown function, expression is regulated by phosphate levels Gene:PTC1(YDL006W)|FD-Score:4.3|P-value:8.36E-6||SGD DESC:Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p, inactivating osmosensing MAPK cascade; involved in Fus3p activation during pheromone response; deletion affects precursor tRNA splicing, mitochondrial inheritance, and sporulation Gene:PUF6(YDR496C)|FD-Score:-3.16|P-value:7.88E-4||SGD DESC:Pumilio-homology domain protein that binds the 3' UTR of ASH1 mRNA and represses its translation, resulting in proper asymmetric localization of ASH1 mRNA; also co-sediments with the 60S ribosomal subunit and is required for its biogenesis Gene:REC8(YPR007C)|FD-Score:3.98|P-value:3.43E-5||SGD DESC:Meiosis-specific component of sister chromatid cohesion complex; maintains cohesion between sister chromatids during meiosis I; maintains cohesion between centromeres of sister chromatids until meiosis II; homolog of S. pombe Rec8p Gene:RHO5(YNL180C)|FD-Score:4.22|P-value:1.22E-5||SGD DESC:Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely involved in protein kinase C (Pkc1p)-dependent signal transduction pathway that controls cell integrity Gene:RIM11(YMR139W)|FD-Score:-3.43|P-value:3.06E-4||SGD DESC:Protein kinase; required for signal transduction during entry into meiosis; promotes the formation of the Ime1p-Ume6p complex by phosphorylating Ime1p and Ume6p; shares similarity with mammalian glycogen synthase kinase 3-beta; protein abundance increases in response to DNA replication stress Gene:RPL26B(YGR034W)|FD-Score:3.77|P-value:8.17E-5||SGD DESC:Ribosomal 60S subunit protein L26B; binds to 5.8S rRNA; homologous to mammalian ribosomal protein L26 and bacterial L24; RPL26B has a paralog, RPL26A, that arose from the whole genome duplication Gene:SAC6(YDR129C)|FD-Score:3.18|P-value:7.31E-4||SGD DESC:Fimbrin, actin-bundling protein; cooperates with Scp1p (calponin/transgelin) in the organization and maintenance of the actin cytoskeleton; relocalizes from plasma membrane to cytoplasm upon DNA replication stress Gene:SAN1(YDR143C)|FD-Score:3.17|P-value:7.63E-4||SGD DESC:Ubiquitin-protein ligase; involved in the proteasome-dependent degradation of aberrant nuclear proteins; targets substrates with regions of exposed hydrophobicity containing 5 or more contiguous hydrophobic residues; contains intrinsically disordered regions that contribute to substrate recognition Gene:SAP1(YER047C)|FD-Score:3.15|P-value:8.23E-4||SGD DESC:Putative ATPase of the AAA family, interacts with the Sin1p transcriptional repressor in the two-hybrid system Gene:SLI1(YGR212W)|FD-Score:3.45|P-value:2.77E-4||SGD DESC:N-acetyltransferase, confers resistance to the sphingolipid biosynthesis inhibitor myriocin (ISP-1) by converting it into N-acetyl-myriocin, co-operates with Ypk1p in mediating resistance to myriocin Gene:SLM2(YNL047C)|FD-Score:4.51|P-value:3.30E-6||SGD DESC:Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm1p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; phosphorylated by the TORC2 complex; SLM2 has a paralog, SLM1, that arose from the whole genome duplication Gene:SLM5(YCR024C)|FD-Score:-4.38|P-value:5.95E-6||SGD DESC:Mitochondrial asparaginyl-tRNA synthetase Gene:SOV1(YMR066W)|FD-Score:-3.64|P-value:1.34E-4||SGD DESC:Mitochondrial protein of unknown function Gene:SPO16(YHR153C)|FD-Score:3.21|P-value:6.60E-4||SGD DESC:Meiosis-specific protein involved in synaptonemal complex assembly; implicated in regulation of crossover formation; required for sporulation Gene:TRM7(YBR061C)|FD-Score:-3.26|P-value:5.58E-4||SGD DESC:2'-O-ribose methyltransferase; methylates the 2'-O-ribose of tRNA-Phe, tRNA-Trp, and tRNA-Leu at positions C32 and N34 of the tRNA anticodon loop; crucial biological role likely modification of tRNA-Phe; interacts with Trm732p and Rtt10p in 2'-O-methylation of C32 and N34 substrate tRNAs, respectively Gene:VAM3(YOR106W)|FD-Score:3.57|P-value:1.78E-4||SGD DESC:Syntaxin-like vacuolar t-SNARE that functions with Vam7p in vacuolar protein trafficking; mediates docking/fusion of late transport intermediates with the vacuole; has an acidic di-leucine sorting signal and C-terminal transmembrane region Gene:VBA1(YMR088C)|FD-Score:3.12|P-value:9.04E-4||SGD DESC:Permease of basic amino acids in the vacuolar membrane Gene:YBP1(YBR216C)|FD-Score:-3.48|P-value:2.55E-4||SGD DESC:Protein involved in cellular response to oxidative stress; required for oxidation of specific cysteine residues of transcription factor Yap1p, resulting in nuclear localization of Yap1p in response to stress; YBP1 has a paralog, YBP2, that arose from the whole genome duplication Gene:YBR182C-A(YBR182C-A_p)|FD-Score:3.12|P-value:8.94E-4||SGD DESC:Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching Gene:YCR095W-A(YCR095W-A_p)|FD-Score:4.74|P-value:1.07E-6||SGD DESC:Putative protein of unknown function Gene:YDR094W(YDR094W_d)|FD-Score:-3.51|P-value:2.22E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF DNF2 Gene:YDR149C(YDR149C_d)|FD-Score:3.6|P-value:1.59E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene NUM1; null mutation blocks anaerobic growth Gene:YGL242C(YGL242C_p)|FD-Score:3.89|P-value:4.91E-5||SGD DESC:Putative protein of unknown function; deletion mutant is viable Gene:YGR242W(YGR242W_d)|FD-Score:3.15|P-value:8.30E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YAP1802/YGR241C Gene:YIG1(YPL201C)|FD-Score:3.62|P-value:1.46E-4||SGD DESC:Protein that interacts with glycerol 3-phosphatase and plays a role in anaerobic glycerol production; localizes to the nucleus and cytosol Gene:YIL089W(YIL089W)|FD-Score:-3.15|P-value:8.17E-4||SGD DESC:Protein of unknown function found in the ER and vacuole lumen; overexpression of YIL089W affects endocytic protein trafficking Gene:YKL077W(YKL077W_p)|FD-Score:-4.68|P-value:1.45E-6||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole Gene:YKL151C(YKL151C)|FD-Score:-3.99|P-value:3.31E-5||SGD DESC:NADHX dehydratase; converts (S)-NADHX to NADH in an ATP-dependent manner; homologous to Carkd in mammals, and the C-terminal domain of YjeF in E.coli; enzyme is widespread in eukaryotes, prokaryotes and archaea; YKL151C promoter contains STREs (stress response elements) and expression is induced by heat shock or methyl methanesulfonate; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress Gene:YLL006W-A(YLL006W-A_p)|FD-Score:-3.2|P-value:6.83E-4||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR Gene:YLR118C(YLR118C)|FD-Score:-3.76|P-value:8.62E-5||SGD DESC:Acyl-protein thioesterase responsible for depalmitoylation of Gpa1p; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus and is induced in response to the DNA-damaging agent MMS Gene:YLR264C-A(YLR264C-A_p)|FD-Score:-3.38|P-value:3.67E-4||SGD DESC:Putative protein of unknown function Gene:YLR415C(YLR415C_p)|FD-Score:3.7|P-value:1.08E-4||SGD DESC:Putative protein of unknown function; YLR415C is not an essential gene Gene:YML116W-A(YML116W-A_d)|FD-Score:-4.92|P-value:4.42E-7||SGD DESC:Putative protein of unknown function Gene:YNL043C(YNL043C_d)|FD-Score:3.84|P-value:6.06E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YIP3/YNL044W Gene:AMS1(YGL156W)|FD-Score:3.7|P-value:1.09E-4||SGD DESC:Vacuolar alpha mannosidase, involved in free oligosaccharide (fOS) degradation; delivered to the vacuole in a novel pathway separate from the secretory pathway Gene:ART10(YLR392C)|FD-Score:-3.09|P-value:9.98E-4||SGD DESC:Protein of unknown function that contains 2 PY motifs and is ubiquinated by Rsp5p; overexpression confers resistance to arsenite; green fluorescent protein (GFP)-fusion protein localizes it to the cytoplasm; non-essential gene Gene:ATG1(YGL180W)|FD-Score:3.7|P-value:1.08E-4||SGD DESC:Protein ser/thr kinase required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; structurally required for phagophore assembly site formation; during autophagy forms a complex with Atg13p and Atg17p Gene:ATG15(YCR068W)|FD-Score:3.33|P-value:4.30E-4||SGD DESC:Lipase required for intravacuolar lysis of autophagic bodies and Cvt bodies; targeted to intravacuolar vesicles during autophagy via the multivesicular body (MVB) pathway Gene:BAS1(YKR099W)|FD-Score:3.92|P-value:4.34E-5||SGD DESC:Myb-related transcription factor involved in regulating basal and induced expression of genes of the purine and histidine biosynthesis pathways; also involved in regulation of meiotic recombination at specific genes Gene:BCK1(YJL095W)|FD-Score:-3.19|P-value:7.18E-4||SGD DESC:Mitogen-activated protein (MAP) kinase kinase kinase acting in the protein kinase C signaling pathway, which controls cell integrity; upon activation by Pkc1p phosphorylates downstream kinases Mkk1p and Mkk2p Gene:COA2(YPL189C-A)|FD-Score:-4.85|P-value:6.25E-7||SGD DESC:Cytochrome oxidase assembly factor; null mutation results in respiratory deficiency with specific loss of cytochrome oxidase activity; functions downstream of assembly factors Mss51p and Coa1p and interacts with assembly factor Shy1p Gene:COX17(YLL009C)|FD-Score:-6.39|P-value:8.15E-11||SGD DESC:Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs Gene:CSG2(YBR036C)|FD-Score:3.52|P-value:2.19E-4||SGD DESC:Endoplasmic reticulum membrane protein, required for mannosylation of inositolphosphorylceramide and for growth at high calcium concentrations; protein abundance increases in response to DNA replication stress Gene:CTH1(YDR151C)|FD-Score:-4.19|P-value:1.37E-5||SGD DESC:Member of the CCCH zinc finger family; has similarity to mammalian Tis11 protein, which activates transcription and also has a role in mRNA degradation; may function with Tis11p in iron homeostasis Gene:CUE4(YML101C)|FD-Score:-3.43|P-value:3.02E-4||SGD DESC:Protein of unknown function; has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination; CUE4 has a paralog, CUE1, that arose from the whole genome duplication Gene:DBP3(YGL078C)|FD-Score:4.15|P-value:1.66E-5||SGD DESC:RNA-Dependent ATPase, member of DExD/H-box family; involved in cleavage of site A3 within the ITS1 spacer during rRNA processing; not essential for growth, but deletion causes severe slow-growth phenotype Gene:ELO1(YJL196C)|FD-Score:3.41|P-value:3.24E-4||SGD DESC:Elongase I, medium-chain acyl elongase; catalyzes carboxy-terminal elongation of unsaturated C12-C16 fatty acyl-CoAs to C16-C18 fatty acids; ELO1 has a paralog, FEN1, that arose from the whole genome duplication Gene:ESL2(YKR096W)|FD-Score:4.34|P-value:7.06E-6||SGD DESC:Protein of unknown function that interacts with Pex14p; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; predicted to contain a PINc domain Gene:FMP21(YBR269C_p)|FD-Score:3.54|P-value:1.97E-4||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:GAT2(YMR136W)|FD-Score:-5.68|P-value:6.87E-9||SGD DESC:Protein containing GATA family zinc finger motifs; similar to Gln3p and Dal80p; expression repressed by leucine Gene:GPH1(YPR160W)|FD-Score:-3.37|P-value:3.81E-4||SGD DESC:Non-essential glycogen phosphorylase required for the mobilization of glycogen, activity is regulated by cyclic AMP-mediated phosphorylation, expression is regulated by stress-response elements and by the HOG MAP kinase pathway Gene:GTT1(YIR038C)|FD-Score:3.63|P-value:1.44E-4||SGD DESC:ER associated glutathione S-transferase capable of homodimerization; expression induced during the diauxic shift and throughout stationary phase; functional overlap with Gtt2p, Grx1p, and Grx2p Gene:HAM1(YJR069C)|FD-Score:-3.44|P-value:2.92E-4||SGD DESC:Nucleoside triphosphate pyrophosphohydrolase; active against a wide range of substrates including ITP, dITP and XTP; mediates exclusion of noncanonical purines and pyrimadines from deoxyribonucleoside triphosphate pools; mutant is sensitive to the base analog 6-N-hydroxylaminopurine; protein abundance increases in response to DNA replication stress Gene:HSP104(YLL026W)|FD-Score:-3.22|P-value:6.33E-4||SGD DESC:Disaggregase; heat shock protein that cooperates with Ydj1p (Hsp40) and Ssa1p (Hsp70) to refold and reactivate previously denatured, aggregated proteins; responsive to stresses including: heat, ethanol, and sodium arsenite; involved in [PSI+] propagation; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress Gene:KIP1(YBL063W)|FD-Score:3.97|P-value:3.63E-5||SGD DESC:Kinesin-related motor protein required for mitotic spindle assembly, chromosome segregation, and 2 micron plasmid partitioning; functionally redundant with Cin8p for chromosomal but not plasmid functions Gene:LRG1(YDL240W)|FD-Score:5.03|P-value:2.45E-7||SGD DESC:Putative GTPase-activating protein (GAP) involved in the Pkc1p-mediated signaling pathway that controls cell wall integrity; appears to specifically regulate 1,3-beta-glucan synthesis Gene:LSB3(YFR024C-A)|FD-Score:-3.38|P-value:3.60E-4||SGD DESC:Protein containing a C-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; protein abundance increases in response to DNA replication stress; LSB3 has a paralog, YSC84, that arose from the whole genome duplication Gene:MRP13(YGR084C)|FD-Score:-4.64|P-value:1.76E-6||SGD DESC:Mitochondrial ribosomal protein of the small subunit Gene:MSD1(YPL104W)|FD-Score:3.26|P-value:5.55E-4||SGD DESC:Mitochondrial aspartyl-tRNA synthetase, required for acylation of aspartyl-tRNA; yeast and bacterial aspartyl-, asparaginyl-, and lysyl-tRNA synthetases contain regions with high sequence similarity, suggesting a common ancestral gene Gene:NTG1(YAL015C)|FD-Score:-3.55|P-value:1.91E-4||SGD DESC:DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress; NTG1 has a paralog, NTG2, that arose from the whole genome duplication Gene:OMS1(YDR316W)|FD-Score:3.66|P-value:1.24E-4||SGD DESC:Protein integral to the mitochondrial membrane; has a conserved methyltransferase motif; multicopy suppressor of respiratory defects caused by OXA1 mutations Gene:PET112(YBL080C)|FD-Score:-3.12|P-value:9.16E-4||SGD DESC:Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; mutation is functionally complemented by the bacterial GatB ortholog Gene:PHM6(YDR281C)|FD-Score:3.14|P-value:8.32E-4||SGD DESC:Protein of unknown function, expression is regulated by phosphate levels Gene:PTC1(YDL006W)|FD-Score:4.3|P-value:8.36E-6||SGD DESC:Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p, inactivating osmosensing MAPK cascade; involved in Fus3p activation during pheromone response; deletion affects precursor tRNA splicing, mitochondrial inheritance, and sporulation Gene:PUF6(YDR496C)|FD-Score:-3.16|P-value:7.88E-4||SGD DESC:Pumilio-homology domain protein that binds the 3' UTR of ASH1 mRNA and represses its translation, resulting in proper asymmetric localization of ASH1 mRNA; also co-sediments with the 60S ribosomal subunit and is required for its biogenesis Gene:REC8(YPR007C)|FD-Score:3.98|P-value:3.43E-5||SGD DESC:Meiosis-specific component of sister chromatid cohesion complex; maintains cohesion between sister chromatids during meiosis I; maintains cohesion between centromeres of sister chromatids until meiosis II; homolog of S. pombe Rec8p Gene:RHO5(YNL180C)|FD-Score:4.22|P-value:1.22E-5||SGD DESC:Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely involved in protein kinase C (Pkc1p)-dependent signal transduction pathway that controls cell integrity Gene:RIM11(YMR139W)|FD-Score:-3.43|P-value:3.06E-4||SGD DESC:Protein kinase; required for signal transduction during entry into meiosis; promotes the formation of the Ime1p-Ume6p complex by phosphorylating Ime1p and Ume6p; shares similarity with mammalian glycogen synthase kinase 3-beta; protein abundance increases in response to DNA replication stress Gene:RPL26B(YGR034W)|FD-Score:3.77|P-value:8.17E-5||SGD DESC:Ribosomal 60S subunit protein L26B; binds to 5.8S rRNA; homologous to mammalian ribosomal protein L26 and bacterial L24; RPL26B has a paralog, RPL26A, that arose from the whole genome duplication Gene:SAC6(YDR129C)|FD-Score:3.18|P-value:7.31E-4||SGD DESC:Fimbrin, actin-bundling protein; cooperates with Scp1p (calponin/transgelin) in the organization and maintenance of the actin cytoskeleton; relocalizes from plasma membrane to cytoplasm upon DNA replication stress Gene:SAN1(YDR143C)|FD-Score:3.17|P-value:7.63E-4||SGD DESC:Ubiquitin-protein ligase; involved in the proteasome-dependent degradation of aberrant nuclear proteins; targets substrates with regions of exposed hydrophobicity containing 5 or more contiguous hydrophobic residues; contains intrinsically disordered regions that contribute to substrate recognition Gene:SAP1(YER047C)|FD-Score:3.15|P-value:8.23E-4||SGD DESC:Putative ATPase of the AAA family, interacts with the Sin1p transcriptional repressor in the two-hybrid system Gene:SLI1(YGR212W)|FD-Score:3.45|P-value:2.77E-4||SGD DESC:N-acetyltransferase, confers resistance to the sphingolipid biosynthesis inhibitor myriocin (ISP-1) by converting it into N-acetyl-myriocin, co-operates with Ypk1p in mediating resistance to myriocin Gene:SLM2(YNL047C)|FD-Score:4.51|P-value:3.30E-6||SGD DESC:Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm1p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; phosphorylated by the TORC2 complex; SLM2 has a paralog, SLM1, that arose from the whole genome duplication Gene:SLM5(YCR024C)|FD-Score:-4.38|P-value:5.95E-6||SGD DESC:Mitochondrial asparaginyl-tRNA synthetase Gene:SOV1(YMR066W)|FD-Score:-3.64|P-value:1.34E-4||SGD DESC:Mitochondrial protein of unknown function Gene:SPO16(YHR153C)|FD-Score:3.21|P-value:6.60E-4||SGD DESC:Meiosis-specific protein involved in synaptonemal complex assembly; implicated in regulation of crossover formation; required for sporulation Gene:TRM7(YBR061C)|FD-Score:-3.26|P-value:5.58E-4||SGD DESC:2'-O-ribose methyltransferase; methylates the 2'-O-ribose of tRNA-Phe, tRNA-Trp, and tRNA-Leu at positions C32 and N34 of the tRNA anticodon loop; crucial biological role likely modification of tRNA-Phe; interacts with Trm732p and Rtt10p in 2'-O-methylation of C32 and N34 substrate tRNAs, respectively Gene:VAM3(YOR106W)|FD-Score:3.57|P-value:1.78E-4||SGD DESC:Syntaxin-like vacuolar t-SNARE that functions with Vam7p in vacuolar protein trafficking; mediates docking/fusion of late transport intermediates with the vacuole; has an acidic di-leucine sorting signal and C-terminal transmembrane region Gene:VBA1(YMR088C)|FD-Score:3.12|P-value:9.04E-4||SGD DESC:Permease of basic amino acids in the vacuolar membrane Gene:YBP1(YBR216C)|FD-Score:-3.48|P-value:2.55E-4||SGD DESC:Protein involved in cellular response to oxidative stress; required for oxidation of specific cysteine residues of transcription factor Yap1p, resulting in nuclear localization of Yap1p in response to stress; YBP1 has a paralog, YBP2, that arose from the whole genome duplication Gene:YBR182C-A(YBR182C-A_p)|FD-Score:3.12|P-value:8.94E-4||SGD DESC:Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching Gene:YCR095W-A(YCR095W-A_p)|FD-Score:4.74|P-value:1.07E-6||SGD DESC:Putative protein of unknown function Gene:YDR094W(YDR094W_d)|FD-Score:-3.51|P-value:2.22E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF DNF2 Gene:YDR149C(YDR149C_d)|FD-Score:3.6|P-value:1.59E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene NUM1; null mutation blocks anaerobic growth Gene:YGL242C(YGL242C_p)|FD-Score:3.89|P-value:4.91E-5||SGD DESC:Putative protein of unknown function; deletion mutant is viable Gene:YGR242W(YGR242W_d)|FD-Score:3.15|P-value:8.30E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YAP1802/YGR241C Gene:YIG1(YPL201C)|FD-Score:3.62|P-value:1.46E-4||SGD DESC:Protein that interacts with glycerol 3-phosphatase and plays a role in anaerobic glycerol production; localizes to the nucleus and cytosol Gene:YIL089W(YIL089W)|FD-Score:-3.15|P-value:8.17E-4||SGD DESC:Protein of unknown function found in the ER and vacuole lumen; overexpression of YIL089W affects endocytic protein trafficking Gene:YKL077W(YKL077W_p)|FD-Score:-4.68|P-value:1.45E-6||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole Gene:YKL151C(YKL151C)|FD-Score:-3.99|P-value:3.31E-5||SGD DESC:NADHX dehydratase; converts (S)-NADHX to NADH in an ATP-dependent manner; homologous to Carkd in mammals, and the C-terminal domain of YjeF in E.coli; enzyme is widespread in eukaryotes, prokaryotes and archaea; YKL151C promoter contains STREs (stress response elements) and expression is induced by heat shock or methyl methanesulfonate; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress Gene:YLL006W-A(YLL006W-A_p)|FD-Score:-3.2|P-value:6.83E-4||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR Gene:YLR118C(YLR118C)|FD-Score:-3.76|P-value:8.62E-5||SGD DESC:Acyl-protein thioesterase responsible for depalmitoylation of Gpa1p; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus and is induced in response to the DNA-damaging agent MMS Gene:YLR264C-A(YLR264C-A_p)|FD-Score:-3.38|P-value:3.67E-4||SGD DESC:Putative protein of unknown function Gene:YLR415C(YLR415C_p)|FD-Score:3.7|P-value:1.08E-4||SGD DESC:Putative protein of unknown function; YLR415C is not an essential gene Gene:YML116W-A(YML116W-A_d)|FD-Score:-4.92|P-value:4.42E-7||SGD DESC:Putative protein of unknown function Gene:YNL043C(YNL043C_d)|FD-Score:3.84|P-value:6.06E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YIP3/YNL044W

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YBR121C5.403.37E-81.14GRS1Cytoplasmic and mitochondrial glycyl-tRNA synthase; ligates glycine to the cognate anticodon-bearing tRNA; transcription termination factor that may interact with the 3'-end of pre-mRNA to promote 3'-end formation; GRS1 has a paralog, GRS2, that arose from the whole genome duplication
YKL033W4.261.02E-51.09TTI1Subunit of the ASTRA complex, involved in chromatin remodeling; telomere length regulator involved in the stability or biogenesis of PIKKs such as TORC1; similar to S. pombe Tti1p; detected in highly purified mitochondria in high-throughput studies
YDR526C_d3.177.66E-40.07YDR526C_dDubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YHR172W3.109.61E-40.07SPC97Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque
YPR180W3.030.001230.06AOS1Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
YIR010W2.970.001500.25DSN1Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; important for chromosome segregation
YDR081C2.720.003280.01PDC2Transcription factor for thiamine-regulated genes; required for expression of the two isoforms of pyruvate decarboxylase (PDC1 and PDC5) along with thiamine biosynthetic genes; binds a DNA sequence in the PDC5 promoter; mutant fails to grow on 2% glucose and thus is scored as inviable under standard conditions
YKL021C2.710.003360.02MAK11Protein involved in an early, nucleolar step of 60S ribosomal subunit biogenesis; essential for cell growth and replication of killer M1 dsRNA virus; contains four beta-transducin repeats
YGL145W2.690.003610.03TIP20Peripheral membrane protein required for fusion of COPI vesicles with the ER; prohibits back-fusion of COPII vesicles with the ER; forms a tethering complex with Sec39p and Dsl1p that interacts with ER SNAREs Sec20p and Use1p
YGL238W2.660.003900.01CSE1Nuclear envelope protein that mediates the nuclear export of importin alpha (Srp1p), homolog of metazoan CAS protein, required for accurate chromosome segregation
YAR019C2.650.003970.04CDC15Protein kinase of the Mitotic Exit Network; localized to the spindle pole bodies at late anaphase; promotes mitotic exit by directly switching on the kinase activity of Dbf2p; required for spindle disassembly after meiosis II; relocalizes to the cytoplasm upon DNA replication stress
YOR373W2.610.004490.11NUD1Component of the spindle pole body outer plaque; acts through the mitotic exit network to specify asymmetric spindle pole body inheritance
YPL044C_d2.500.006200.05YPL044C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NOP4/YPL043W
YGR191W2.450.007060.02HIP1High-affinity histidine permease, also involved in the transport of manganese ions
YBR011C2.430.007560.01IPP1Cytoplasmic inorganic pyrophosphatase (PPase), homodimer that catalyzes the rapid exchange of oxygens from Pi with water, highly expressed and essential for viability, active-site residues show identity to those from E. coli PPase

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YDL240W5.032.45E-7LRG1Putative GTPase-activating protein (GAP) involved in the Pkc1p-mediated signaling pathway that controls cell wall integrity; appears to specifically regulate 1,3-beta-glucan synthesis
YCR095W-A_p4.741.07E-6YCR095W-A_pPutative protein of unknown function
YNL047C4.513.30E-6SLM2Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm1p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; phosphorylated by the TORC2 complex; SLM2 has a paralog, SLM1, that arose from the whole genome duplication
YKR096W4.347.06E-6ESL2Protein of unknown function that interacts with Pex14p; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; predicted to contain a PINc domain
YDL006W4.308.36E-6PTC1Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p, inactivating osmosensing MAPK cascade; involved in Fus3p activation during pheromone response; deletion affects precursor tRNA splicing, mitochondrial inheritance, and sporulation
YNL180C4.221.22E-5RHO5Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely involved in protein kinase C (Pkc1p)-dependent signal transduction pathway that controls cell integrity
YGL078C4.151.66E-5DBP3RNA-Dependent ATPase, member of DExD/H-box family; involved in cleavage of site A3 within the ITS1 spacer during rRNA processing; not essential for growth, but deletion causes severe slow-growth phenotype
YPR007C3.983.43E-5REC8Meiosis-specific component of sister chromatid cohesion complex; maintains cohesion between sister chromatids during meiosis I; maintains cohesion between centromeres of sister chromatids until meiosis II; homolog of S. pombe Rec8p
YBL063W3.973.63E-5KIP1Kinesin-related motor protein required for mitotic spindle assembly, chromosome segregation, and 2 micron plasmid partitioning; functionally redundant with Cin8p for chromosomal but not plasmid functions
YKR099W3.924.34E-5BAS1Myb-related transcription factor involved in regulating basal and induced expression of genes of the purine and histidine biosynthesis pathways; also involved in regulation of meiotic recombination at specific genes
YGL242C_p3.894.91E-5YGL242C_pPutative protein of unknown function; deletion mutant is viable
YNL043C_d3.846.06E-5YNL043C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YIP3/YNL044W
YGR034W3.778.17E-5RPL26BRibosomal 60S subunit protein L26B; binds to 5.8S rRNA; homologous to mammalian ribosomal protein L26 and bacterial L24; RPL26B has a paralog, RPL26A, that arose from the whole genome duplication
YLR415C_p3.701.08E-4YLR415C_pPutative protein of unknown function; YLR415C is not an essential gene
YGL180W3.701.08E-4ATG1Protein ser/thr kinase required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; structurally required for phagophore assembly site formation; during autophagy forms a complex with Atg13p and Atg17p

GO enrichment analysis for SGTC_3191
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID		 Tanimoto
Score		 Response
Signature
0.0782.01E-9SGTC_31989112019 49.5 μMChembridge (Drug-like library)455955550.111111mitochondrial processes
0.0691.03E-7SGTC_31929110362 49.5 μMChembridge (Drug-like library)166494800.242857mitochondrial processes
0.0664.72E-7SGTC_32439134147 49.5 μMChembridge (Drug-like library)242821800.196721
0.0647.16E-7SGTC_31889110789 49.5 μMChembridge (Drug-like library)8492170.55102iron homeostasis
0.0631.27E-6SGTC_23579067248 200.0 μMChembridge (Fragment library)91502350.0952381
0.0621.97E-6SGTC_7504073-0104 132.0 μMChemDiv (Drug-like library)223309570.146667
0.0571.05E-5SGTC_2719novobiocin 32.6 μMMiscellaneous54675769NA
0.0571.06E-5SGTC_27827736369 71.4 μMChembridge (Drug-like library)29508360.25
0.0534.61E-5SGTC_12410364-0022 50.8 μMChemDiv (Drug-like library)45638950.104478ERG2
0.0518.34E-5SGTC_31969111891 49.5 μMChembridge (Drug-like library)188915100.192308mitochondrial processes
0.0519.60E-5SGTC_1926methyl fluorone black 53.6 μMTimTec (Natural product derivative library)727210.0757576DNA intercalators
0.0491.71E-4SGTC_13001094-0077 113.0 μMChemDiv (Drug-like library)55326360.162162
0.0491.77E-4SGTC_28247998404 52.0 μMChembridge (Drug-like library)8378510.384615
0.0482.48E-4SGTC_32519135047 49.5 μMChembridge (Drug-like library)176829630.18055660S ribosome export
0.0482.49E-4SGTC_31559099265 49.5 μMChembridge (Drug-like library)252364990.138889

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count		 H-bond
acceptor
count		 Response
Signature
SGTC_3182910884949.47 μM0.85365917133045Chembridge (Drug-like library)267.322383.66112RPP1 & pyrimidine depletion
SGTC_3184910875849.47 μM0.714286902885Chembridge (Drug-like library)241.28512.94712
SGTC_3189911068249.47 μM0.66666717122418Chembridge (Drug-like library)273.35013.61413
SGTC_2926901072665.15 μM0.56252994293Chembridge (Drug-like library)253.29583.21512
SGTC_3188911078949.47 μM0.55102849217Chembridge (Drug-like library)275.730163.61112iron homeostasis
SGTC_2827799384771.43 μM0.549022985692Chembridge (Drug-like library)283.321783.19813
SGTC_3091911637249.47 μM0.5417169793Chembridge (Drug-like library)285.337662.95313
SGTC_3190911036649.47 μM0.5417123768Chembridge (Drug-like library)283.321783.41923
SGTC_2867903909871.43 μM0.5192316463460Chembridge (Drug-like library)287.740863.87912iron homeostasis
SGTC_2871903851012.99 μM0.5192314945164Chembridge (Drug-like library)283.321783.19813