Deletion Strain | FD score | P-value | Gene | Gene Description |
---|
YDL240W | 5.03 | 2.45E-7 | LRG1 | Putative GTPase-activating protein (GAP) involved in the Pkc1p-mediated signaling pathway that controls cell wall integrity; appears to specifically regulate 1,3-beta-glucan synthesis |
YCR095W-A_p | 4.74 | 1.07E-6 | YCR095W-A_p | Putative protein of unknown function |
YNL047C | 4.51 | 3.30E-6 | SLM2 | Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm1p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; phosphorylated by the TORC2 complex; SLM2 has a paralog, SLM1, that arose from the whole genome duplication |
YKR096W | 4.34 | 7.06E-6 | ESL2 | Protein of unknown function that interacts with Pex14p; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; predicted to contain a PINc domain |
YDL006W | 4.30 | 8.36E-6 | PTC1 | Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p, inactivating osmosensing MAPK cascade; involved in Fus3p activation during pheromone response; deletion affects precursor tRNA splicing, mitochondrial inheritance, and sporulation |
YNL180C | 4.22 | 1.22E-5 | RHO5 | Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely involved in protein kinase C (Pkc1p)-dependent signal transduction pathway that controls cell integrity |
YGL078C | 4.15 | 1.66E-5 | DBP3 | RNA-Dependent ATPase, member of DExD/H-box family; involved in cleavage of site A3 within the ITS1 spacer during rRNA processing; not essential for growth, but deletion causes severe slow-growth phenotype |
YPR007C | 3.98 | 3.43E-5 | REC8 | Meiosis-specific component of sister chromatid cohesion complex; maintains cohesion between sister chromatids during meiosis I; maintains cohesion between centromeres of sister chromatids until meiosis II; homolog of S. pombe Rec8p |
YBL063W | 3.97 | 3.63E-5 | KIP1 | Kinesin-related motor protein required for mitotic spindle assembly, chromosome segregation, and 2 micron plasmid partitioning; functionally redundant with Cin8p for chromosomal but not plasmid functions |
YKR099W | 3.92 | 4.34E-5 | BAS1 | Myb-related transcription factor involved in regulating basal and induced expression of genes of the purine and histidine biosynthesis pathways; also involved in regulation of meiotic recombination at specific genes |
YGL242C_p | 3.89 | 4.91E-5 | YGL242C_p | Putative protein of unknown function; deletion mutant is viable |
YNL043C_d | 3.84 | 6.06E-5 | YNL043C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YIP3/YNL044W |
YGR034W | 3.77 | 8.17E-5 | RPL26B | Ribosomal 60S subunit protein L26B; binds to 5.8S rRNA; homologous to mammalian ribosomal protein L26 and bacterial L24; RPL26B has a paralog, RPL26A, that arose from the whole genome duplication |
YLR415C_p | 3.70 | 1.08E-4 | YLR415C_p | Putative protein of unknown function; YLR415C is not an essential gene |
YGL180W | 3.70 | 1.08E-4 | ATG1 | Protein ser/thr kinase required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; structurally required for phagophore assembly site formation; during autophagy forms a complex with Atg13p and Atg17p |