Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YPL093W | 4.79 | 8.38E-7 | 0.50 | NOG1 | Putative GTPase that associates with free 60S ribosomal subunits in the nucleolus and is required for 60S ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; member of the ODN family of nucleolar G-proteins |
YBR049C | 4.54 | 2.85E-6 | 0.50 | REB1 | RNA polymerase I enhancer binding protein; DNA binding protein that binds to genes transcribed by both RNA polymerase I and RNA polymerase II; required for termination of RNA polymerase I transcription; REB1 has a paralog, NSI1, that arose from the whole genome duplication |
YLR116W | 4.26 | 1.02E-5 | 0.50 | MSL5 | Component of the commitment complex, which defines the first step in the splicing pathway; essential protein that interacts with Mud2p and Prp40p, forming a bridge between the intron ends; also involved in nuclear retention of pre-mRNA |
YMR235C | 3.99 | 3.28E-5 | 0.50 | RNA1 | GTPase activating protein (GAP) for Gsp1p, involved in nuclear transport |
YDR489W | 3.94 | 4.09E-5 | 0.50 | SLD5 | Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery |
YLR274W | 3.83 | 6.36E-5 | 0.50 | MCM5 | Component of the hexameric MCM complex, which is important for priming origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation when activated by Cdc7p-Dbf4p in S-phase |
YBR002C | 3.33 | 4.28E-4 | 0.18 | RER2 | Cis-prenyltransferase involved in dolichol synthesis; participates in endoplasmic reticulum (ER) protein sorting |
YPL044C_d | 3.15 | 8.17E-4 | 0.01 | YPL044C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NOP4/YPL043W |
YGR218W | 3.14 | 8.42E-4 | 0.08 | CRM1 | Major karyopherin, involved in export of proteins, RNAs, and ribosomal subunits from the nucleus; exportin |
YNR035C | 3.06 | 0.00112 | 0.15 | ARC35 | Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches; required for cortical localization of calmodulin |
YDR331W | 2.90 | 0.00185 | 0.06 | GPI8 | ER membrane glycoprotein subunit of the glycosylphosphatidylinositol transamidase complex that adds glycosylphosphatidylinositol (GPI) anchors to newly synthesized proteins; human PIG-K protein is a functional homolog |
YNL240C | 2.85 | 0.00221 | 0.02 | NAR1 | Component of the cytosolic iron-sulfur (FeS) protein assembly machinery, required for maturation of cytosolic and nuclear FeS proteins and for normal resistance to oxidative stress; homologous to human Narf |
YER018C | 2.82 | 0.00237 | 0.05 | SPC25 | Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering |
YBR121C | 2.78 | 0.00274 | 0.07 | GRS1 | Cytoplasmic and mitochondrial glycyl-tRNA synthase; ligates glycine to the cognate anticodon-bearing tRNA; transcription termination factor that may interact with the 3'-end of pre-mRNA to promote 3'-end formation; GRS1 has a paralog, GRS2, that arose from the whole genome duplication |
YNL216W | 2.71 | 0.00340 | 0.05 | RAP1 | Essential DNA-binding transcription regulator that binds at many loci; involved in either transcription activation or repression, chromatin silencing, and telomere length maintenance; conserved protein with an N-terminal BRCT domain, a central region with homology to the Myb DNA binding domain, and a C-terminal Rap1-specific protein-interaction domain (RCT domain) |