9111903

[4-(propanoylamino)phenyl] 2-chlorobenzoate

[PubChem] [DrugBank] [Wikipedia] [WikiGenes] [ChEMBL] [ChemSpider] 



Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_3194
Screen concentration 49.5 μM
Source Chembridge (Drug-like library)
PubChem CID 17087251
SMILES CCC(=O)NC1=CC=C(C=C1)OC(=O)C2=CC=CC=C2Cl
Standardized SMILES CCC(=O)Nc1ccc(OC(=O)c2ccccc2Cl)cc1
Molecular weight 303.7403
ALogP 3.71
H-bond donor count 1
H-bond acceptor count 3
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 14.38
% growth inhibition (Hom. pool) 11.04


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 17087251
Download HIP data (tab-delimited text)  (excel)
Gene:CIA1(YDR267C)|FD-Score:-3.6|P-value:1.61E-4|Clearance:0||SGD DESC:Component of cytosolic iron-sulfur protein assembly (CIA) machinery; acts at a late step of Fe-S cluster assembly; forms the CIA targeting complex with Cia2p and Met18p that directs Fe-S cluster incorporation into a subset of proteins involved in methionine biosynthesis, DNA replication and repair, transcription, and telomere maintenance; contains WD40 repeats; ortholog of human Ciao1 protein Gene:CRM1(YGR218W)|FD-Score:3.14|P-value:8.42E-4|Clearance:0.08||SGD DESC:Major karyopherin, involved in export of proteins, RNAs, and ribosomal subunits from the nucleus; exportin Gene:MCM5(YLR274W)|FD-Score:3.83|P-value:6.36E-5|Clearance:0.5||SGD DESC:Component of the hexameric MCM complex, which is important for priming origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation when activated by Cdc7p-Dbf4p in S-phase Gene:MSL5(YLR116W)|FD-Score:4.26|P-value:1.02E-5|Clearance:0.5||SGD DESC:Component of the commitment complex, which defines the first step in the splicing pathway; essential protein that interacts with Mud2p and Prp40p, forming a bridge between the intron ends; also involved in nuclear retention of pre-mRNA Gene:NOG1(YPL093W)|FD-Score:4.79|P-value:8.38E-7|Clearance:0.5||SGD DESC:Putative GTPase that associates with free 60S ribosomal subunits in the nucleolus and is required for 60S ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; member of the ODN family of nucleolar G-proteins Gene:REB1(YBR049C)|FD-Score:4.54|P-value:2.85E-6|Clearance:0.5||SGD DESC:RNA polymerase I enhancer binding protein; DNA binding protein that binds to genes transcribed by both RNA polymerase I and RNA polymerase II; required for termination of RNA polymerase I transcription; REB1 has a paralog, NSI1, that arose from the whole genome duplication Gene:RER2(YBR002C)|FD-Score:3.33|P-value:4.28E-4|Clearance:0.18||SGD DESC:Cis-prenyltransferase involved in dolichol synthesis; participates in endoplasmic reticulum (ER) protein sorting Gene:RIO1(YOR119C)|FD-Score:-3.41|P-value:3.27E-4|Clearance:0||SGD DESC:Essential serine kinase involved in cell cycle progression and processing of the 20S pre-rRNA into mature 18S rRNA Gene:RNA1(YMR235C)|FD-Score:3.99|P-value:3.28E-5|Clearance:0.5||SGD DESC:GTPase activating protein (GAP) for Gsp1p, involved in nuclear transport Gene:SEC1(YDR164C)|FD-Score:-3.63|P-value:1.42E-4|Clearance:0||SGD DESC:Sm-like protein involved in docking and fusion of exocytic vesicles; binds to assembled SNARE complexes at the membrane and stimulates membrane fusion; localization to sites of secretion (bud neck and bud tip) is dependent on SNARE function Gene:SLD5(YDR489W)|FD-Score:3.94|P-value:4.09E-5|Clearance:0.5||SGD DESC:Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery Gene:YDL163W(YDL163W_d)|FD-Score:-3.8|P-value:7.11E-5|Clearance:0||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene CDC9/YDL164C encoding DNA ligase Gene:YPL044C(YPL044C_d)|FD-Score:3.15|P-value:8.17E-4|Clearance:0.01||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NOP4/YPL043W Gene:CIA1(YDR267C)|FD-Score:-3.6|P-value:1.61E-4|Clearance:0||SGD DESC:Component of cytosolic iron-sulfur protein assembly (CIA) machinery; acts at a late step of Fe-S cluster assembly; forms the CIA targeting complex with Cia2p and Met18p that directs Fe-S cluster incorporation into a subset of proteins involved in methionine biosynthesis, DNA replication and repair, transcription, and telomere maintenance; contains WD40 repeats; ortholog of human Ciao1 protein Gene:CRM1(YGR218W)|FD-Score:3.14|P-value:8.42E-4|Clearance:0.08||SGD DESC:Major karyopherin, involved in export of proteins, RNAs, and ribosomal subunits from the nucleus; exportin Gene:MCM5(YLR274W)|FD-Score:3.83|P-value:6.36E-5|Clearance:0.5||SGD DESC:Component of the hexameric MCM complex, which is important for priming origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation when activated by Cdc7p-Dbf4p in S-phase Gene:MSL5(YLR116W)|FD-Score:4.26|P-value:1.02E-5|Clearance:0.5||SGD DESC:Component of the commitment complex, which defines the first step in the splicing pathway; essential protein that interacts with Mud2p and Prp40p, forming a bridge between the intron ends; also involved in nuclear retention of pre-mRNA Gene:NOG1(YPL093W)|FD-Score:4.79|P-value:8.38E-7|Clearance:0.5||SGD DESC:Putative GTPase that associates with free 60S ribosomal subunits in the nucleolus and is required for 60S ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; member of the ODN family of nucleolar G-proteins Gene:REB1(YBR049C)|FD-Score:4.54|P-value:2.85E-6|Clearance:0.5||SGD DESC:RNA polymerase I enhancer binding protein; DNA binding protein that binds to genes transcribed by both RNA polymerase I and RNA polymerase II; required for termination of RNA polymerase I transcription; REB1 has a paralog, NSI1, that arose from the whole genome duplication Gene:RER2(YBR002C)|FD-Score:3.33|P-value:4.28E-4|Clearance:0.18||SGD DESC:Cis-prenyltransferase involved in dolichol synthesis; participates in endoplasmic reticulum (ER) protein sorting Gene:RIO1(YOR119C)|FD-Score:-3.41|P-value:3.27E-4|Clearance:0||SGD DESC:Essential serine kinase involved in cell cycle progression and processing of the 20S pre-rRNA into mature 18S rRNA Gene:RNA1(YMR235C)|FD-Score:3.99|P-value:3.28E-5|Clearance:0.5||SGD DESC:GTPase activating protein (GAP) for Gsp1p, involved in nuclear transport Gene:SEC1(YDR164C)|FD-Score:-3.63|P-value:1.42E-4|Clearance:0||SGD DESC:Sm-like protein involved in docking and fusion of exocytic vesicles; binds to assembled SNARE complexes at the membrane and stimulates membrane fusion; localization to sites of secretion (bud neck and bud tip) is dependent on SNARE function Gene:SLD5(YDR489W)|FD-Score:3.94|P-value:4.09E-5|Clearance:0.5||SGD DESC:Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery Gene:YDL163W(YDL163W_d)|FD-Score:-3.8|P-value:7.11E-5|Clearance:0||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene CDC9/YDL164C encoding DNA ligase Gene:YPL044C(YPL044C_d)|FD-Score:3.15|P-value:8.17E-4|Clearance:0.01||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NOP4/YPL043W

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 17087251
Download HOP data (tab-delimited text)  (excel)
Gene:ADA2(YDR448W)|FD-Score:3.44|P-value:2.93E-4||SGD DESC:Transcription coactivator, component of the ADA and SAGA transcriptional adaptor/HAT (histone acetyltransferase) complexes Gene:AKR2(YOR034C)|FD-Score:3.97|P-value:3.52E-5||SGD DESC:Ankyrin repeat-containing protein; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; possibly involved in constitutive endocytosis of Ste3p; AKR2 has a paralog, AKR1, that arose from the whole genome duplication Gene:API2(YDR525W_d)|FD-Score:3.12|P-value:9.11E-4||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 26% of ORF overlaps the dubious ORF YDR524C-A; insertion mutation in a cdc34-2 mutant background causes altered bud morphology Gene:APL1(YJR005W)|FD-Score:-3.31|P-value:4.67E-4||SGD DESC:Beta-adaptin, large subunit of the clathrin associated protein complex (AP-2); involved in vesicle mediated transport; similar to mammalian beta-chain of the clathrin associated protein complex Gene:ARP1(YHR129C)|FD-Score:3.63|P-value:1.41E-4||SGD DESC:Actin-related protein of the dynactin complex; required for spindle orientation and nuclear migration; putative ortholog of mammalian centractin Gene:ATP15(YPL271W)|FD-Score:3.18|P-value:7.40E-4||SGD DESC:Epsilon subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated Gene:BEM2(YER155C)|FD-Score:-3.48|P-value:2.49E-4||SGD DESC:Rho GTPase activating protein (RhoGAP) involved in the control of cytoskeleton organization and cellular morphogenesis; required for bud emergence Gene:CAM1(YPL048W)|FD-Score:4.96|P-value:3.59E-7||SGD DESC:Nuclear protein required for transcription of MXR1; binds the MXR1 promoter in the presence of other nuclear factors; binds calcium and phospholipids; has similarity to translational cofactor EF-1 gamma Gene:CCP1(YKR066C)|FD-Score:3.44|P-value:2.96E-4||SGD DESC:Mitochondrial cytochrome-c peroxidase; degrades reactive oxygen species in mitochondria, involved in the response to oxidative stress Gene:COX17(YLL009C)|FD-Score:3.3|P-value:4.88E-4||SGD DESC:Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs Gene:CRC1(YOR100C)|FD-Score:3.54|P-value:2.02E-4||SGD DESC:Mitochondrial inner membrane carnitine transporter, required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation Gene:DAS2(YDR020C_p)|FD-Score:3.43|P-value:2.96E-4||SGD DESC:Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; weak similarity with uridine kinases and with phosphoribokinases Gene:DOM34(YNL001W)|FD-Score:4.23|P-value:1.15E-5||SGD DESC:Protein that facilitates ribosomal subunit dissociation; acts when translation is stalled, with binding partner Hbs1p; required for RNA cleavage in no-go decay, but reports conflict on endonuclease activity; Pelota ortholog; protein abundance increases in response to DNA replication stress; DOM34 has a paralog, YCL001W-B, that arose from the whole genome duplication Gene:DYN2(YDR424C)|FD-Score:4.28|P-value:9.38E-6||SGD DESC:Cytoplasmic light chain dynein, microtubule motor protein; proposed to be involved in the assembly of the nuclear pore complex Gene:ERV14(YGL054C)|FD-Score:-3.5|P-value:2.28E-4||SGD DESC:COPII-coated vesicle protein; involved in vesicle formation and incorporation of specific secretory cargo; required for the delivery of bud-site selection protein Axl2p to cell surface; related to Drosophila cornichon; ERV14 has a paralog, ERV15, that arose from the whole genome duplication Gene:EXO5(YBR163W)|FD-Score:4.08|P-value:2.25E-5||SGD DESC:Mitochondrial 5'-3' exonuclease and sliding exonuclease, required for mitochondrial genome maintenance; distantly related to the RecB nuclease domain of bacterial RecBCD recombinases; may be regulated by the transcription factor Ace2 Gene:FAA2(YER015W)|FD-Score:-3.77|P-value:8.27E-5||SGD DESC:Medium chain fatty acyl-CoA synthetase, activates imported fatty acids; accepts a wide range of fatty acid chain lengths with a preference for medium chains, C9:0-C13:0; localized to the peroxisome Gene:FLO1(YAR050W)|FD-Score:3.42|P-value:3.11E-4||SGD DESC:Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin sensitive and heat resistant; similar to Flo5p Gene:FMP16(YDR070C_p)|FD-Score:4.26|P-value:1.02E-5||SGD DESC:Protein of unknown function; may be involved in responding to conditions of stress; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress Gene:FMP21(YBR269C_p)|FD-Score:-3.7|P-value:1.08E-4||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:FOX2(YKR009C)|FD-Score:-3.33|P-value:4.28E-4||SGD DESC:Multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway; has 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities Gene:GLE2(YER107C)|FD-Score:4.17|P-value:1.49E-5||SGD DESC:RNA export factor associated with the nuclear pore complex (NPC); associates with NUP116p; required for polyadenylated RNA export but not for protein import; homologous to S. pombe Rae1p and human RAE1 Gene:GUT2(YIL155C)|FD-Score:3.42|P-value:3.17E-4||SGD DESC:Mitochondrial glycerol-3-phosphate dehydrogenase; expression is repressed by both glucose and cAMP and derepressed by non-fermentable carbon sources in a Snf1p, Rsf1p, Hap2/3/4/5 complex dependent manner Gene:HGH1(YGR187C)|FD-Score:4.76|P-value:9.83E-7||SGD DESC:Nonessential protein of unknown function; predicted to be involved in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; similar to mammalian BRP16 (Brain protein 16); relative distribution to the nucleus increases upon DNA replication stress Gene:JIP4(YDR475C)|FD-Score:3.23|P-value:6.17E-4||SGD DESC:Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence Gene:KAP123(YER110C)|FD-Score:3.33|P-value:4.33E-4||SGD DESC:Karyopherin beta, mediates nuclear import of ribosomal proteins prior to assembly into ribosomes and import of histones H3 and H4; localizes to the nuclear pore, nucleus, and cytoplasm; exhibits genetic interactions with RAI1 Gene:LDB16(YCL005W)|FD-Score:-3.96|P-value:3.75E-5||SGD DESC:Protein of unknown function; null mutants have decreased net negative cell surface charge; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; native protein is detected in purified mitochondria Gene:MDM12(YOL009C)|FD-Score:4.23|P-value:1.16E-5||SGD DESC:Mitochondrial outer membrane protein, required for transmission of mitochondria to daughter cells; component of the ERMES complex that links the ER to mitochondria; may influence import and assembly of outer membrane beta-barrel proteins Gene:MDM32(YOR147W)|FD-Score:6.32|P-value:1.32E-10||SGD DESC:Mitochondrial inner membrane protein with similarity to Mdm31p, required for normal mitochondrial morphology and inheritance; interacts genetically with MMM1, MDM10, MDM12, and MDM34 Gene:MEF1(YLR069C)|FD-Score:4.19|P-value:1.37E-5||SGD DESC:Mitochondrial elongation factor involved in translational elongation Gene:MRH4(YGL064C)|FD-Score:6.06|P-value:6.99E-10||SGD DESC:Mitochondrial ATP-dependent RNA helicase of the DEAD-box family, plays an essential role in mitochondrial function Gene:MRP20(YDR405W)|FD-Score:4.85|P-value:6.28E-7||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:MRPL11(YDL202W)|FD-Score:-3.84|P-value:6.12E-5||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:MRPL7(YDR237W)|FD-Score:3.51|P-value:2.26E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit; MRPL7 produces both YmL5 and YmL7, which are two different modified forms of the same protein Gene:MRPS12(YNR036C)|FD-Score:5.96|P-value:1.27E-9||SGD DESC:Mitochondrial protein; may interact with ribosomes based on co-purification experiments; similar to E. coli and human mitochondrial S12 ribosomal proteins Gene:MRPS8(YMR158W)|FD-Score:3.1|P-value:9.80E-4||SGD DESC:Mitochondrial ribosomal protein of the small subunit Gene:MSB1(YOR188W)|FD-Score:-3.1|P-value:9.56E-4||SGD DESC:Protein of unknown function; may be involved in positive regulation of 1,3-beta-glucan synthesis and the Pkc1p-MAPK pathway; multicopy suppressor of temperature-sensitive mutations in CDC24 and CDC42, and of mutations in BEM4; potential Cdc28p substrate; relocalizes from bud neck to cytoplasm upon DNA replication stress Gene:MSH6(YDR097C)|FD-Score:3.45|P-value:2.83E-4||SGD DESC:Protein required for mismatch repair in mitosis and meiosis, forms a complex with Msh2p to repair both single-base & insertion-deletion mispairs; also involved in interstrand cross-link repair; potentially phosphorylated by Cdc28p Gene:MTD1(YKR080W)|FD-Score:-3.56|P-value:1.87E-4||SGD DESC:NAD-dependent 5,10-methylenetetrahydrafolate dehydrogenase, plays a catalytic role in oxidation of cytoplasmic one-carbon units; expression is regulated by Bas1p and Bas2p, repressed by adenine, and may be induced by inositol and choline Gene:MXR1(YER042W)|FD-Score:-3.28|P-value:5.19E-4||SGD DESC:Methionine-S-sulfoxide reductase, involved in the response to oxidative stress; protects iron-sulfur clusters from oxidative inactivation along with MXR2; involved in the regulation of lifespan Gene:NEW1(YPL226W)|FD-Score:3.13|P-value:8.75E-4||SGD DESC:ATP binding cassette protein that cosediments with polysomes and is required for biogenesis of the small ribosomal subunit; Asn/Gln-rich rich region supports [NU+] prion formation and susceptibility to [PSI+] prion induction Gene:NSR1(YGR159C)|FD-Score:4.31|P-value:8.00E-6||SGD DESC:Nucleolar protein that binds nuclear localization sequences, required for pre-rRNA processing and ribosome biogenesis Gene:PCD1(YLR151C)|FD-Score:-3.12|P-value:9.15E-4||SGD DESC:Peroxisomal pyrophosphatase with specificity for coenzyme A and CoA derivatives, may function to remove potentially toxic oxidized CoA disulfide from peroxisomes to maintain the capacity for beta-oxidation of fatty acids; nudix hydrolase family member Gene:PCI8(YIL071C)|FD-Score:-3.34|P-value:4.13E-4||SGD DESC:Possible shared subunit of Cop9 signalosome (CSN) and eIF3, binds eIF3b subunit Prt1p, has possible dual functions in transcriptional and translational control, contains a PCI (Proteasome-COP9 signalosome (CSN)-eIF3) domain Gene:POS5(YPL188W)|FD-Score:3.41|P-value:3.22E-4||SGD DESC:Mitochondrial NADH kinase, phosphorylates NADH; also phosphorylates NAD(+) with lower specificity; required for the response to oxidative stress Gene:PPA2(YMR267W)|FD-Score:3.43|P-value:3.06E-4||SGD DESC:Mitochondrial inorganic pyrophosphatase, required for mitochondrial function and possibly involved in energy generation from inorganic pyrophosphate Gene:PPH21(YDL134C)|FD-Score:3.36|P-value:3.88E-4||SGD DESC:Catalytic subunit of protein phosphatase 2A (PP2A); functionally redundant with Pph22p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis; forms nuclear foci upon DNA replication stress; PPH21 has a paralog, PPH22, that arose from the whole genome duplication Gene:PUF4(YGL014W)|FD-Score:3.17|P-value:7.57E-4||SGD DESC:Member of the PUF protein family, which is defined by the presence of Pumilio homology domains that confer RNA binding activity; preferentially binds mRNAs encoding nucleolar ribosomal RNA-processing factors Gene:RPA34(YJL148W)|FD-Score:3.71|P-value:1.02E-4||SGD DESC:RNA polymerase I subunit A34.5 Gene:RPL24A(YGL031C)|FD-Score:3.45|P-value:2.84E-4||SGD DESC:Ribosomal 60S subunit protein L24A; not essential for translation but may be required for normal translation rate; homologous to mammalian ribosomal protein L24, no bacterial homolog; RPL24A has a paralog, RPL24B, that arose from the whole genome duplication Gene:RPS8A(YBL072C)|FD-Score:-3.3|P-value:4.89E-4||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S8, no bacterial homolog; RPS8A has a paralog, RPS8B, that arose from the whole genome duplication Gene:RTC1(YOL138C)|FD-Score:3.18|P-value:7.40E-4||SGD DESC:Subunit of the SEA (Seh1-associated) complex, a coatomer-related complex that associates dynamically with the vacuole; null mutation suppresses cdc13-1 temperature sensitivity; has N-terminal WD-40 repeats and a C-terminal RING motif Gene:SAT4(YCR008W)|FD-Score:6.8|P-value:5.07E-12||SGD DESC:Ser/Thr protein kinase involved in salt tolerance; funtions in regulation of Trk1p-Trk2p potassium transporter; partially redundant with Hal5p; has similarity to Npr1p Gene:SCH9(YHR205W)|FD-Score:4.69|P-value:1.37E-6||SGD DESC:AGC family protein kinase; functional ortholog of mammalian S6 kinase; phosphorylated by Tor1p and required for TORC1-mediated regulation of ribosome biogenesis, translation initiation, and entry into G0 phase; involved in transactivation of osmostress-responsive genes; regulates G1 progression, cAPK activity and nitrogen activation of the FGM pathway; integrates nutrient signals and stress signals from sphingolipids to regulate lifespan Gene:SEC22(YLR268W)|FD-Score:-6.71|P-value:9.85E-12||SGD DESC:R-SNARE protein; assembles into SNARE complex with Bet1p, Bos1p and Sed5p; cycles between the ER and Golgi complex; involved in anterograde and retrograde transport between the ER and Golgi; synaptobrevin homolog Gene:SOD1(YJR104C)|FD-Score:3.85|P-value:5.80E-5||SGD DESC:Cytosolic copper-zinc superoxide dismutase; some mutations are analogous to those that cause ALS (amyotrophic lateral sclerosis) in humans; protein abundance increases in response to DNA replication stress and in response to prolonged exposure to boric acid Gene:SOV1(YMR066W)|FD-Score:9.48|P-value:1.33E-21||SGD DESC:Mitochondrial protein of unknown function Gene:STI1(YOR027W)|FD-Score:3.61|P-value:1.51E-4||SGD DESC:Hsp90 cochaperone, interacts with the Ssa group of the cytosolic Hsp70 chaperones and activates Ssa1p ATPase activity; interacts with Hsp90 chaperones and inhibits their ATPase activity; homolog of mammalian Hop Gene:STP22(YCL008C)|FD-Score:3.69|P-value:1.14E-4||SGD DESC:Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; homologous to the mouse and human Tsg101 tumor susceptibility gene; mutants exhibit a Class E Vps phenotype Gene:TAT1(YBR069C)|FD-Score:4.28|P-value:9.14E-6||SGD DESC:Amino acid transporter for valine, leucine, isoleucine, and tyrosine; low-affinity tryptophan and histidine transporter; overexpression confers FK506 and FTY720 resistance; protein abundance increases in response to DNA replication stress Gene:TIF1(YKR059W)|FD-Score:-3.09|P-value:0.00100||SGD DESC:Translation initiation factor eIF4A; DEA(D/H)-box RNA helicase that couples ATPase activity to RNA binding and unwinding; forms a dumbbell structure of two compact domains connected by a linker; interacts with eIF4G; protein abundance increases in response to DNA replication stress; TIF1 has a paralog, TIF2, that arose from the whole genome duplication Gene:TRE1(YPL176C)|FD-Score:4.41|P-value:5.20E-6||SGD DESC:Transferrin receptor-like protein; plasma membrane protein that binds Bsd2p and regulates ubiquitylation and vacuolar degradation of the metal transporter Smf1p; functionally redundant with Tre2p; TRE1 has a paralog, TRE2, that arose from the whole genome duplication Gene:TRP1(YDR007W)|FD-Score:-5.18|P-value:1.12E-7||SGD DESC:Phosphoribosylanthranilate isomerase that catalyzes the third step in tryptophan biosynthesis; in 2004, the sequence of TRP1 from strain S228C was updated by changing the previously annotated internal STOP (TAA) to serine (TCA) Gene:TRP4(YDR354W)|FD-Score:3.16|P-value:8.02E-4||SGD DESC:Anthranilate phosphoribosyl transferase of the tryptophan biosynthetic pathway, catalyzes the phosphoribosylation of anthranilate, subject to the general control system of amino acid biosynthesis Gene:TRS33(YOR115C)|FD-Score:-4.4|P-value:5.30E-6||SGD DESC:One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic Gene:UBP9(YER098W)|FD-Score:-3.31|P-value:4.63E-4||SGD DESC:Ubiquitin-specific protease that cleaves ubiquitin-protein fusions; UBP9 has a paralog, UBP13, that arose from the whole genome duplication Gene:VAC8(YEL013W)|FD-Score:-3.85|P-value:6.01E-5||SGD DESC:Phosphorylated and palmitoylated vacuolar membrane protein that interacts with Atg13p, required for the cytoplasm-to-vacuole targeting (Cvt) pathway; interacts with Nvj1p to form nucleus-vacuole junctions Gene:VMA5(YKL080W)|FD-Score:4.72|P-value:1.19E-6||SGD DESC:Subunit C of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane Gene:YAR1(YPL239W)|FD-Score:3.12|P-value:8.90E-4||SGD DESC:Ankyrin-repeat containing, nucleocytoplasmic shuttling chaperone; prevents aggregation of Rps3p in the cytoplasm, associates with free Rps3p in the cytoplasm and delivers it to the 90S in the nucleus; required for 40S ribosomal subunit export, biogenesis and adaptation to osmotic and oxidative stress; expression repressed by heat shock Gene:YDR379C-A(YDR379C-A)|FD-Score:-3.34|P-value:4.15E-4||SGD DESC:Protein involved in the assembly of the mitochondrial succinate dehydrogenase complex; mutations in human ortholog SDHAF1 are associated with infantile leukoencephalopathy Gene:YER186C(YER186C_p)|FD-Score:-3.38|P-value:3.68E-4||SGD DESC:Putative protein of unknown function Gene:YJL144W(YJL144W)|FD-Score:3.15|P-value:8.12E-4||SGD DESC:Cytoplasmic hydrophilin essential in dessication-rehydration process; expression induced by osmotic stress, starvation and during stationary phase; protein abundance increases in response to DNA replication stress Gene:YJR020W(YJR020W_d)|FD-Score:3.82|P-value:6.80E-5||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YLL056C(YLL056C_p)|FD-Score:3.83|P-value:6.43E-5||SGD DESC:Putative protein of unknown function, transcription is activated by paralogous transcription factors Yrm1p and Yrr1p and genes involved in pleiotropic drug resistance (PDR); expression is induced in cells treated with the mycotoxin patulin Gene:YLR278C(YLR278C_p)|FD-Score:-3.38|P-value:3.58E-4||SGD DESC:Zinc-cluster protein; GFP-fusion protein localizes to the nucleus; mutant shows moderate growth defect on caffeine; has a prion-domain like fragment that increases frequency of [URE3]; YLR278C is not an essential gene Gene:YLR412C-A(YLR412C-A_p)|FD-Score:-3.46|P-value:2.66E-4||SGD DESC:Putative protein of unknown function Gene:YMR075C-A(YMR075C-A_d)|FD-Score:8.55|P-value:5.97E-18||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF RCO1/YMR075W Gene:YNL120C(YNL120C_d)|FD-Score:3.12|P-value:9.07E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; deletion enhances replication of Brome mosaic virus in S. cerevisiae, but likely due to effects on the overlapping gene Gene:YNR064C(YNR064C)|FD-Score:6.99|P-value:1.37E-12||SGD DESC:Epoxide hydrolase, member of the alpha/beta hydrolase fold family; may have a role in detoxification of epoxides Gene:YNR068C(YNR068C_p)|FD-Score:3.89|P-value:5.07E-5||SGD DESC:Putative protein of unknown function; exhibits homology to C-terminal end of Bul1p; expressed as a readthrough product of BSC5, the readthrough locus being termed BUL3; the BUL3 readthrough product is involved in ubiquitin-mediated sorting of plasma membrane proteins and interacts with WW domains of Rsp5p in vitro, but in a functionally different way than the non-readthrough form Gene:YOR170W(YOR170W_d)|FD-Score:-4.78|P-value:8.88E-7||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene LCB4 Gene:YOR228C(YOR228C)|FD-Score:3.22|P-value:6.39E-4||SGD DESC:Protein of unknown function, localized to the mitochondrial outer membrane Gene:YPL034W(YPL034W_p)|FD-Score:3.35|P-value:4.02E-4||SGD DESC:Putative protein of unknown function; YPL034W is not essential gene Gene:YPR063C(YPR063C_p)|FD-Score:-3.9|P-value:4.73E-5||SGD DESC:ER-localized protein of unknown function Gene:ADA2(YDR448W)|FD-Score:3.44|P-value:2.93E-4||SGD DESC:Transcription coactivator, component of the ADA and SAGA transcriptional adaptor/HAT (histone acetyltransferase) complexes Gene:AKR2(YOR034C)|FD-Score:3.97|P-value:3.52E-5||SGD DESC:Ankyrin repeat-containing protein; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; possibly involved in constitutive endocytosis of Ste3p; AKR2 has a paralog, AKR1, that arose from the whole genome duplication Gene:API2(YDR525W_d)|FD-Score:3.12|P-value:9.11E-4||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 26% of ORF overlaps the dubious ORF YDR524C-A; insertion mutation in a cdc34-2 mutant background causes altered bud morphology Gene:APL1(YJR005W)|FD-Score:-3.31|P-value:4.67E-4||SGD DESC:Beta-adaptin, large subunit of the clathrin associated protein complex (AP-2); involved in vesicle mediated transport; similar to mammalian beta-chain of the clathrin associated protein complex Gene:ARP1(YHR129C)|FD-Score:3.63|P-value:1.41E-4||SGD DESC:Actin-related protein of the dynactin complex; required for spindle orientation and nuclear migration; putative ortholog of mammalian centractin Gene:ATP15(YPL271W)|FD-Score:3.18|P-value:7.40E-4||SGD DESC:Epsilon subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated Gene:BEM2(YER155C)|FD-Score:-3.48|P-value:2.49E-4||SGD DESC:Rho GTPase activating protein (RhoGAP) involved in the control of cytoskeleton organization and cellular morphogenesis; required for bud emergence Gene:CAM1(YPL048W)|FD-Score:4.96|P-value:3.59E-7||SGD DESC:Nuclear protein required for transcription of MXR1; binds the MXR1 promoter in the presence of other nuclear factors; binds calcium and phospholipids; has similarity to translational cofactor EF-1 gamma Gene:CCP1(YKR066C)|FD-Score:3.44|P-value:2.96E-4||SGD DESC:Mitochondrial cytochrome-c peroxidase; degrades reactive oxygen species in mitochondria, involved in the response to oxidative stress Gene:COX17(YLL009C)|FD-Score:3.3|P-value:4.88E-4||SGD DESC:Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs Gene:CRC1(YOR100C)|FD-Score:3.54|P-value:2.02E-4||SGD DESC:Mitochondrial inner membrane carnitine transporter, required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation Gene:DAS2(YDR020C_p)|FD-Score:3.43|P-value:2.96E-4||SGD DESC:Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; weak similarity with uridine kinases and with phosphoribokinases Gene:DOM34(YNL001W)|FD-Score:4.23|P-value:1.15E-5||SGD DESC:Protein that facilitates ribosomal subunit dissociation; acts when translation is stalled, with binding partner Hbs1p; required for RNA cleavage in no-go decay, but reports conflict on endonuclease activity; Pelota ortholog; protein abundance increases in response to DNA replication stress; DOM34 has a paralog, YCL001W-B, that arose from the whole genome duplication Gene:DYN2(YDR424C)|FD-Score:4.28|P-value:9.38E-6||SGD DESC:Cytoplasmic light chain dynein, microtubule motor protein; proposed to be involved in the assembly of the nuclear pore complex Gene:ERV14(YGL054C)|FD-Score:-3.5|P-value:2.28E-4||SGD DESC:COPII-coated vesicle protein; involved in vesicle formation and incorporation of specific secretory cargo; required for the delivery of bud-site selection protein Axl2p to cell surface; related to Drosophila cornichon; ERV14 has a paralog, ERV15, that arose from the whole genome duplication Gene:EXO5(YBR163W)|FD-Score:4.08|P-value:2.25E-5||SGD DESC:Mitochondrial 5'-3' exonuclease and sliding exonuclease, required for mitochondrial genome maintenance; distantly related to the RecB nuclease domain of bacterial RecBCD recombinases; may be regulated by the transcription factor Ace2 Gene:FAA2(YER015W)|FD-Score:-3.77|P-value:8.27E-5||SGD DESC:Medium chain fatty acyl-CoA synthetase, activates imported fatty acids; accepts a wide range of fatty acid chain lengths with a preference for medium chains, C9:0-C13:0; localized to the peroxisome Gene:FLO1(YAR050W)|FD-Score:3.42|P-value:3.11E-4||SGD DESC:Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin sensitive and heat resistant; similar to Flo5p Gene:FMP16(YDR070C_p)|FD-Score:4.26|P-value:1.02E-5||SGD DESC:Protein of unknown function; may be involved in responding to conditions of stress; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress Gene:FMP21(YBR269C_p)|FD-Score:-3.7|P-value:1.08E-4||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:FOX2(YKR009C)|FD-Score:-3.33|P-value:4.28E-4||SGD DESC:Multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway; has 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities Gene:GLE2(YER107C)|FD-Score:4.17|P-value:1.49E-5||SGD DESC:RNA export factor associated with the nuclear pore complex (NPC); associates with NUP116p; required for polyadenylated RNA export but not for protein import; homologous to S. pombe Rae1p and human RAE1 Gene:GUT2(YIL155C)|FD-Score:3.42|P-value:3.17E-4||SGD DESC:Mitochondrial glycerol-3-phosphate dehydrogenase; expression is repressed by both glucose and cAMP and derepressed by non-fermentable carbon sources in a Snf1p, Rsf1p, Hap2/3/4/5 complex dependent manner Gene:HGH1(YGR187C)|FD-Score:4.76|P-value:9.83E-7||SGD DESC:Nonessential protein of unknown function; predicted to be involved in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; similar to mammalian BRP16 (Brain protein 16); relative distribution to the nucleus increases upon DNA replication stress Gene:JIP4(YDR475C)|FD-Score:3.23|P-value:6.17E-4||SGD DESC:Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence Gene:KAP123(YER110C)|FD-Score:3.33|P-value:4.33E-4||SGD DESC:Karyopherin beta, mediates nuclear import of ribosomal proteins prior to assembly into ribosomes and import of histones H3 and H4; localizes to the nuclear pore, nucleus, and cytoplasm; exhibits genetic interactions with RAI1 Gene:LDB16(YCL005W)|FD-Score:-3.96|P-value:3.75E-5||SGD DESC:Protein of unknown function; null mutants have decreased net negative cell surface charge; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; native protein is detected in purified mitochondria Gene:MDM12(YOL009C)|FD-Score:4.23|P-value:1.16E-5||SGD DESC:Mitochondrial outer membrane protein, required for transmission of mitochondria to daughter cells; component of the ERMES complex that links the ER to mitochondria; may influence import and assembly of outer membrane beta-barrel proteins Gene:MDM32(YOR147W)|FD-Score:6.32|P-value:1.32E-10||SGD DESC:Mitochondrial inner membrane protein with similarity to Mdm31p, required for normal mitochondrial morphology and inheritance; interacts genetically with MMM1, MDM10, MDM12, and MDM34 Gene:MEF1(YLR069C)|FD-Score:4.19|P-value:1.37E-5||SGD DESC:Mitochondrial elongation factor involved in translational elongation Gene:MRH4(YGL064C)|FD-Score:6.06|P-value:6.99E-10||SGD DESC:Mitochondrial ATP-dependent RNA helicase of the DEAD-box family, plays an essential role in mitochondrial function Gene:MRP20(YDR405W)|FD-Score:4.85|P-value:6.28E-7||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:MRPL11(YDL202W)|FD-Score:-3.84|P-value:6.12E-5||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:MRPL7(YDR237W)|FD-Score:3.51|P-value:2.26E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit; MRPL7 produces both YmL5 and YmL7, which are two different modified forms of the same protein Gene:MRPS12(YNR036C)|FD-Score:5.96|P-value:1.27E-9||SGD DESC:Mitochondrial protein; may interact with ribosomes based on co-purification experiments; similar to E. coli and human mitochondrial S12 ribosomal proteins Gene:MRPS8(YMR158W)|FD-Score:3.1|P-value:9.80E-4||SGD DESC:Mitochondrial ribosomal protein of the small subunit Gene:MSB1(YOR188W)|FD-Score:-3.1|P-value:9.56E-4||SGD DESC:Protein of unknown function; may be involved in positive regulation of 1,3-beta-glucan synthesis and the Pkc1p-MAPK pathway; multicopy suppressor of temperature-sensitive mutations in CDC24 and CDC42, and of mutations in BEM4; potential Cdc28p substrate; relocalizes from bud neck to cytoplasm upon DNA replication stress Gene:MSH6(YDR097C)|FD-Score:3.45|P-value:2.83E-4||SGD DESC:Protein required for mismatch repair in mitosis and meiosis, forms a complex with Msh2p to repair both single-base & insertion-deletion mispairs; also involved in interstrand cross-link repair; potentially phosphorylated by Cdc28p Gene:MTD1(YKR080W)|FD-Score:-3.56|P-value:1.87E-4||SGD DESC:NAD-dependent 5,10-methylenetetrahydrafolate dehydrogenase, plays a catalytic role in oxidation of cytoplasmic one-carbon units; expression is regulated by Bas1p and Bas2p, repressed by adenine, and may be induced by inositol and choline Gene:MXR1(YER042W)|FD-Score:-3.28|P-value:5.19E-4||SGD DESC:Methionine-S-sulfoxide reductase, involved in the response to oxidative stress; protects iron-sulfur clusters from oxidative inactivation along with MXR2; involved in the regulation of lifespan Gene:NEW1(YPL226W)|FD-Score:3.13|P-value:8.75E-4||SGD DESC:ATP binding cassette protein that cosediments with polysomes and is required for biogenesis of the small ribosomal subunit; Asn/Gln-rich rich region supports [NU+] prion formation and susceptibility to [PSI+] prion induction Gene:NSR1(YGR159C)|FD-Score:4.31|P-value:8.00E-6||SGD DESC:Nucleolar protein that binds nuclear localization sequences, required for pre-rRNA processing and ribosome biogenesis Gene:PCD1(YLR151C)|FD-Score:-3.12|P-value:9.15E-4||SGD DESC:Peroxisomal pyrophosphatase with specificity for coenzyme A and CoA derivatives, may function to remove potentially toxic oxidized CoA disulfide from peroxisomes to maintain the capacity for beta-oxidation of fatty acids; nudix hydrolase family member Gene:PCI8(YIL071C)|FD-Score:-3.34|P-value:4.13E-4||SGD DESC:Possible shared subunit of Cop9 signalosome (CSN) and eIF3, binds eIF3b subunit Prt1p, has possible dual functions in transcriptional and translational control, contains a PCI (Proteasome-COP9 signalosome (CSN)-eIF3) domain Gene:POS5(YPL188W)|FD-Score:3.41|P-value:3.22E-4||SGD DESC:Mitochondrial NADH kinase, phosphorylates NADH; also phosphorylates NAD(+) with lower specificity; required for the response to oxidative stress Gene:PPA2(YMR267W)|FD-Score:3.43|P-value:3.06E-4||SGD DESC:Mitochondrial inorganic pyrophosphatase, required for mitochondrial function and possibly involved in energy generation from inorganic pyrophosphate Gene:PPH21(YDL134C)|FD-Score:3.36|P-value:3.88E-4||SGD DESC:Catalytic subunit of protein phosphatase 2A (PP2A); functionally redundant with Pph22p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis; forms nuclear foci upon DNA replication stress; PPH21 has a paralog, PPH22, that arose from the whole genome duplication Gene:PUF4(YGL014W)|FD-Score:3.17|P-value:7.57E-4||SGD DESC:Member of the PUF protein family, which is defined by the presence of Pumilio homology domains that confer RNA binding activity; preferentially binds mRNAs encoding nucleolar ribosomal RNA-processing factors Gene:RPA34(YJL148W)|FD-Score:3.71|P-value:1.02E-4||SGD DESC:RNA polymerase I subunit A34.5 Gene:RPL24A(YGL031C)|FD-Score:3.45|P-value:2.84E-4||SGD DESC:Ribosomal 60S subunit protein L24A; not essential for translation but may be required for normal translation rate; homologous to mammalian ribosomal protein L24, no bacterial homolog; RPL24A has a paralog, RPL24B, that arose from the whole genome duplication Gene:RPS8A(YBL072C)|FD-Score:-3.3|P-value:4.89E-4||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S8, no bacterial homolog; RPS8A has a paralog, RPS8B, that arose from the whole genome duplication Gene:RTC1(YOL138C)|FD-Score:3.18|P-value:7.40E-4||SGD DESC:Subunit of the SEA (Seh1-associated) complex, a coatomer-related complex that associates dynamically with the vacuole; null mutation suppresses cdc13-1 temperature sensitivity; has N-terminal WD-40 repeats and a C-terminal RING motif Gene:SAT4(YCR008W)|FD-Score:6.8|P-value:5.07E-12||SGD DESC:Ser/Thr protein kinase involved in salt tolerance; funtions in regulation of Trk1p-Trk2p potassium transporter; partially redundant with Hal5p; has similarity to Npr1p Gene:SCH9(YHR205W)|FD-Score:4.69|P-value:1.37E-6||SGD DESC:AGC family protein kinase; functional ortholog of mammalian S6 kinase; phosphorylated by Tor1p and required for TORC1-mediated regulation of ribosome biogenesis, translation initiation, and entry into G0 phase; involved in transactivation of osmostress-responsive genes; regulates G1 progression, cAPK activity and nitrogen activation of the FGM pathway; integrates nutrient signals and stress signals from sphingolipids to regulate lifespan Gene:SEC22(YLR268W)|FD-Score:-6.71|P-value:9.85E-12||SGD DESC:R-SNARE protein; assembles into SNARE complex with Bet1p, Bos1p and Sed5p; cycles between the ER and Golgi complex; involved in anterograde and retrograde transport between the ER and Golgi; synaptobrevin homolog Gene:SOD1(YJR104C)|FD-Score:3.85|P-value:5.80E-5||SGD DESC:Cytosolic copper-zinc superoxide dismutase; some mutations are analogous to those that cause ALS (amyotrophic lateral sclerosis) in humans; protein abundance increases in response to DNA replication stress and in response to prolonged exposure to boric acid Gene:SOV1(YMR066W)|FD-Score:9.48|P-value:1.33E-21||SGD DESC:Mitochondrial protein of unknown function Gene:STI1(YOR027W)|FD-Score:3.61|P-value:1.51E-4||SGD DESC:Hsp90 cochaperone, interacts with the Ssa group of the cytosolic Hsp70 chaperones and activates Ssa1p ATPase activity; interacts with Hsp90 chaperones and inhibits their ATPase activity; homolog of mammalian Hop Gene:STP22(YCL008C)|FD-Score:3.69|P-value:1.14E-4||SGD DESC:Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; homologous to the mouse and human Tsg101 tumor susceptibility gene; mutants exhibit a Class E Vps phenotype Gene:TAT1(YBR069C)|FD-Score:4.28|P-value:9.14E-6||SGD DESC:Amino acid transporter for valine, leucine, isoleucine, and tyrosine; low-affinity tryptophan and histidine transporter; overexpression confers FK506 and FTY720 resistance; protein abundance increases in response to DNA replication stress Gene:TIF1(YKR059W)|FD-Score:-3.09|P-value:0.00100||SGD DESC:Translation initiation factor eIF4A; DEA(D/H)-box RNA helicase that couples ATPase activity to RNA binding and unwinding; forms a dumbbell structure of two compact domains connected by a linker; interacts with eIF4G; protein abundance increases in response to DNA replication stress; TIF1 has a paralog, TIF2, that arose from the whole genome duplication Gene:TRE1(YPL176C)|FD-Score:4.41|P-value:5.20E-6||SGD DESC:Transferrin receptor-like protein; plasma membrane protein that binds Bsd2p and regulates ubiquitylation and vacuolar degradation of the metal transporter Smf1p; functionally redundant with Tre2p; TRE1 has a paralog, TRE2, that arose from the whole genome duplication Gene:TRP1(YDR007W)|FD-Score:-5.18|P-value:1.12E-7||SGD DESC:Phosphoribosylanthranilate isomerase that catalyzes the third step in tryptophan biosynthesis; in 2004, the sequence of TRP1 from strain S228C was updated by changing the previously annotated internal STOP (TAA) to serine (TCA) Gene:TRP4(YDR354W)|FD-Score:3.16|P-value:8.02E-4||SGD DESC:Anthranilate phosphoribosyl transferase of the tryptophan biosynthetic pathway, catalyzes the phosphoribosylation of anthranilate, subject to the general control system of amino acid biosynthesis Gene:TRS33(YOR115C)|FD-Score:-4.4|P-value:5.30E-6||SGD DESC:One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic Gene:UBP9(YER098W)|FD-Score:-3.31|P-value:4.63E-4||SGD DESC:Ubiquitin-specific protease that cleaves ubiquitin-protein fusions; UBP9 has a paralog, UBP13, that arose from the whole genome duplication Gene:VAC8(YEL013W)|FD-Score:-3.85|P-value:6.01E-5||SGD DESC:Phosphorylated and palmitoylated vacuolar membrane protein that interacts with Atg13p, required for the cytoplasm-to-vacuole targeting (Cvt) pathway; interacts with Nvj1p to form nucleus-vacuole junctions Gene:VMA5(YKL080W)|FD-Score:4.72|P-value:1.19E-6||SGD DESC:Subunit C of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane Gene:YAR1(YPL239W)|FD-Score:3.12|P-value:8.90E-4||SGD DESC:Ankyrin-repeat containing, nucleocytoplasmic shuttling chaperone; prevents aggregation of Rps3p in the cytoplasm, associates with free Rps3p in the cytoplasm and delivers it to the 90S in the nucleus; required for 40S ribosomal subunit export, biogenesis and adaptation to osmotic and oxidative stress; expression repressed by heat shock Gene:YDR379C-A(YDR379C-A)|FD-Score:-3.34|P-value:4.15E-4||SGD DESC:Protein involved in the assembly of the mitochondrial succinate dehydrogenase complex; mutations in human ortholog SDHAF1 are associated with infantile leukoencephalopathy Gene:YER186C(YER186C_p)|FD-Score:-3.38|P-value:3.68E-4||SGD DESC:Putative protein of unknown function Gene:YJL144W(YJL144W)|FD-Score:3.15|P-value:8.12E-4||SGD DESC:Cytoplasmic hydrophilin essential in dessication-rehydration process; expression induced by osmotic stress, starvation and during stationary phase; protein abundance increases in response to DNA replication stress Gene:YJR020W(YJR020W_d)|FD-Score:3.82|P-value:6.80E-5||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YLL056C(YLL056C_p)|FD-Score:3.83|P-value:6.43E-5||SGD DESC:Putative protein of unknown function, transcription is activated by paralogous transcription factors Yrm1p and Yrr1p and genes involved in pleiotropic drug resistance (PDR); expression is induced in cells treated with the mycotoxin patulin Gene:YLR278C(YLR278C_p)|FD-Score:-3.38|P-value:3.58E-4||SGD DESC:Zinc-cluster protein; GFP-fusion protein localizes to the nucleus; mutant shows moderate growth defect on caffeine; has a prion-domain like fragment that increases frequency of [URE3]; YLR278C is not an essential gene Gene:YLR412C-A(YLR412C-A_p)|FD-Score:-3.46|P-value:2.66E-4||SGD DESC:Putative protein of unknown function Gene:YMR075C-A(YMR075C-A_d)|FD-Score:8.55|P-value:5.97E-18||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF RCO1/YMR075W Gene:YNL120C(YNL120C_d)|FD-Score:3.12|P-value:9.07E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; deletion enhances replication of Brome mosaic virus in S. cerevisiae, but likely due to effects on the overlapping gene Gene:YNR064C(YNR064C)|FD-Score:6.99|P-value:1.37E-12||SGD DESC:Epoxide hydrolase, member of the alpha/beta hydrolase fold family; may have a role in detoxification of epoxides Gene:YNR068C(YNR068C_p)|FD-Score:3.89|P-value:5.07E-5||SGD DESC:Putative protein of unknown function; exhibits homology to C-terminal end of Bul1p; expressed as a readthrough product of BSC5, the readthrough locus being termed BUL3; the BUL3 readthrough product is involved in ubiquitin-mediated sorting of plasma membrane proteins and interacts with WW domains of Rsp5p in vitro, but in a functionally different way than the non-readthrough form Gene:YOR170W(YOR170W_d)|FD-Score:-4.78|P-value:8.88E-7||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene LCB4 Gene:YOR228C(YOR228C)|FD-Score:3.22|P-value:6.39E-4||SGD DESC:Protein of unknown function, localized to the mitochondrial outer membrane Gene:YPL034W(YPL034W_p)|FD-Score:3.35|P-value:4.02E-4||SGD DESC:Putative protein of unknown function; YPL034W is not essential gene Gene:YPR063C(YPR063C_p)|FD-Score:-3.9|P-value:4.73E-5||SGD DESC:ER-localized protein of unknown function

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YPL093W4.798.38E-70.50NOG1Putative GTPase that associates with free 60S ribosomal subunits in the nucleolus and is required for 60S ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; member of the ODN family of nucleolar G-proteins
YBR049C4.542.85E-60.50REB1RNA polymerase I enhancer binding protein; DNA binding protein that binds to genes transcribed by both RNA polymerase I and RNA polymerase II; required for termination of RNA polymerase I transcription; REB1 has a paralog, NSI1, that arose from the whole genome duplication
YLR116W4.261.02E-50.50MSL5Component of the commitment complex, which defines the first step in the splicing pathway; essential protein that interacts with Mud2p and Prp40p, forming a bridge between the intron ends; also involved in nuclear retention of pre-mRNA
YMR235C3.993.28E-50.50RNA1GTPase activating protein (GAP) for Gsp1p, involved in nuclear transport
YDR489W3.944.09E-50.50SLD5Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery
YLR274W3.836.36E-50.50MCM5Component of the hexameric MCM complex, which is important for priming origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation when activated by Cdc7p-Dbf4p in S-phase
YBR002C3.334.28E-40.18RER2Cis-prenyltransferase involved in dolichol synthesis; participates in endoplasmic reticulum (ER) protein sorting
YPL044C_d3.158.17E-40.01YPL044C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NOP4/YPL043W
YGR218W3.148.42E-40.08CRM1Major karyopherin, involved in export of proteins, RNAs, and ribosomal subunits from the nucleus; exportin
YNR035C3.060.001120.15ARC35Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches; required for cortical localization of calmodulin
YDR331W2.900.001850.06GPI8ER membrane glycoprotein subunit of the glycosylphosphatidylinositol transamidase complex that adds glycosylphosphatidylinositol (GPI) anchors to newly synthesized proteins; human PIG-K protein is a functional homolog
YNL240C2.850.002210.02NAR1Component of the cytosolic iron-sulfur (FeS) protein assembly machinery, required for maturation of cytosolic and nuclear FeS proteins and for normal resistance to oxidative stress; homologous to human Narf
YER018C2.820.002370.05SPC25Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering
YBR121C2.780.002740.07GRS1Cytoplasmic and mitochondrial glycyl-tRNA synthase; ligates glycine to the cognate anticodon-bearing tRNA; transcription termination factor that may interact with the 3'-end of pre-mRNA to promote 3'-end formation; GRS1 has a paralog, GRS2, that arose from the whole genome duplication
YNL216W2.710.003400.05RAP1Essential DNA-binding transcription regulator that binds at many loci; involved in either transcription activation or repression, chromatin silencing, and telomere length maintenance; conserved protein with an N-terminal BRCT domain, a central region with homology to the Myb DNA binding domain, and a C-terminal Rap1-specific protein-interaction domain (RCT domain)

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YMR066W9.481.33E-21SOV1Mitochondrial protein of unknown function
YMR075C-A_d8.555.97E-18YMR075C-A_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF RCO1/YMR075W
YNR064C6.991.37E-12YNR064CEpoxide hydrolase, member of the alpha/beta hydrolase fold family; may have a role in detoxification of epoxides
YCR008W6.805.07E-12SAT4Ser/Thr protein kinase involved in salt tolerance; funtions in regulation of Trk1p-Trk2p potassium transporter; partially redundant with Hal5p; has similarity to Npr1p
YOR147W6.321.32E-10MDM32Mitochondrial inner membrane protein with similarity to Mdm31p, required for normal mitochondrial morphology and inheritance; interacts genetically with MMM1, MDM10, MDM12, and MDM34
YGL064C6.066.99E-10MRH4Mitochondrial ATP-dependent RNA helicase of the DEAD-box family, plays an essential role in mitochondrial function
YNR036C5.961.27E-9MRPS12Mitochondrial protein; may interact with ribosomes based on co-purification experiments; similar to E. coli and human mitochondrial S12 ribosomal proteins
YPL048W4.963.59E-7CAM1Nuclear protein required for transcription of MXR1; binds the MXR1 promoter in the presence of other nuclear factors; binds calcium and phospholipids; has similarity to translational cofactor EF-1 gamma
YDR405W4.856.28E-7MRP20Mitochondrial ribosomal protein of the large subunit
YGR187C4.769.83E-7HGH1Nonessential protein of unknown function; predicted to be involved in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; similar to mammalian BRP16 (Brain protein 16); relative distribution to the nucleus increases upon DNA replication stress
YKL080W4.721.19E-6VMA5Subunit C of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane
YHR205W4.691.37E-6SCH9AGC family protein kinase; functional ortholog of mammalian S6 kinase; phosphorylated by Tor1p and required for TORC1-mediated regulation of ribosome biogenesis, translation initiation, and entry into G0 phase; involved in transactivation of osmostress-responsive genes; regulates G1 progression, cAPK activity and nitrogen activation of the FGM pathway; integrates nutrient signals and stress signals from sphingolipids to regulate lifespan
YPL176C4.415.20E-6TRE1Transferrin receptor-like protein; plasma membrane protein that binds Bsd2p and regulates ubiquitylation and vacuolar degradation of the metal transporter Smf1p; functionally redundant with Tre2p; TRE1 has a paralog, TRE2, that arose from the whole genome duplication
YGR159C4.318.00E-6NSR1Nucleolar protein that binds nuclear localization sequences, required for pre-rRNA processing and ribosome biogenesis
YBR069C4.289.14E-6TAT1Amino acid transporter for valine, leucine, isoleucine, and tyrosine; low-affinity tryptophan and histidine transporter; overexpression confers FK506 and FTY720 resistance; protein abundance increases in response to DNA replication stress

GO enrichment analysis for SGTC_3194
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.1453.76E-29SGTC_31909110366 49.5 μMChembridge (Drug-like library)171237680.245902
0.1101.88E-17SGTC_1742st038235 28.9 μMTimTec (Natural product derivative library)5641030.133333mitochondrial stress
0.1015.56E-15SGTC_3141671-0008 2.7 μMChemDiv (Drug-like library)39130600.114286
0.0773.88E-9SGTC_9861493-0483 84.0 μMChemDiv (Drug-like library)400790.267857
0.0764.83E-9SGTC_1034k072-0165 12.7 μMChemDiv (Drug-like library)58354610.0909091Golgi
0.0714.10E-8SGTC_1863455-3465 67.3 μMChemDiv (Drug-like library)7552780.0806452
0.0714.32E-8SGTC_22436634756 200.0 μMChembridge (Fragment library)8856760.283019
0.0663.35E-7SGTC_1731273-0061 2.7 μMChemDiv (Drug-like library)28474140.126984mitochondrial stress
0.0663.36E-7SGTC_100279-0212 42.6 μMChemDiv (Drug-like library)398510.107143TRP & mitochondrial translation
0.0641.03E-6SGTC_1039k821-0043 94.0 μMChemDiv (Drug-like library)159927680.205479Golgi
0.0641.02E-6SGTC_120rhodamine 6G 52.3 μMChemDiv (Drug-like library)652110.195122mitochondrial processes
0.0641.02E-6SGTC_24025553605 200.0 μMMiscellaneous67585460.0823529
0.0641.03E-6SGTC_6293448-6466 76.7 μMChemDiv (Drug-like library)5737440.174603
0.0595.56E-6SGTC_7171532-0246 73.2 μMChemDiv (Drug-like library)95619920.127273Golgi
0.0571.06E-5SGTC_30049076122 71.4 μMChembridge (Drug-like library)447825510.161765

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_3206911435049.47 μM0.73809517087243Chembridge (Drug-like library)283.321783.53513
SGTC_3193911193149.47 μM0.7209317087244Chembridge (Drug-like library)348.191263.79713
SGTC_2879904181571.43 μM0.5416674942971Chembridge (Drug-like library)289.756744.13512
SGTC_3173910569349.47 μM0.42592617096658Chembridge (Drug-like library)289.756744.13512
SGTC_1040074-0074590.99 μM0.4150943943124ChemDiv (Drug-like library)290.74155.08313
SGTC_22456637752200 μM0.391304681890Chembridge (Fragment library)199.63421.35112
SGTC_3171910319249.47 μM0.38888913018434Chembridge (Drug-like library)269.338263.50512
SGTC_13621611-0397101 μM0.38297927816ChemDiv (Drug-like library)227.258523.65612
SGTC_12961068-010211.9 μM0.377358767053ChemDiv (Drug-like library)310.175224.02712
SGTC_2980901434225.29 μM0.3773582996599Chembridge (Drug-like library)347.363983.94214