9112019

N-(furan-2-ylmethyl)-2-methyl-[1]benzofuro[3,2-d]pyrimidin-4-amine hydrochloride

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_3198
Screen concentration 49.5 μM
Source Chembridge (Drug-like library)
PubChem CID 45595555
SMILES CC1=NC2=C(C(=N1)NCC3=CC=CO3)OC4=CC=CC=C42.Cl
Standardized SMILES Cc1nc(NCc2occc2)c3oc4ccccc4c3n1
Molecular weight 315.7543
ALogP 3.43
H-bond donor count 2
H-bond acceptor count 5
Response signature mitochondrial processes

Pool Growth Kinetics
% growth inhibition (Het. pool) 21.34
% growth inhibition (Hom. pool) 8.14


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 45595555
Download HIP data (tab-delimited text)  (excel)
Gene:CDC14(YFR028C)|FD-Score:3.8|P-value:7.20E-5|Clearance:0.25||SGD DESC:Protein phosphatase required for mitotic exit; located in the nucleolus until liberated by the FEAR and Mitotic Exit Network in anaphase, enabling it to act on key substrates to effect a decrease in CDK/B-cyclin activity and mitotic exit; required for meiosis I spindle disassembly; released from nucleolus upon entry into anaphase I of meiosis, resequestered in metaphase II, then released again upon entry into anaphase II; maintained in nucleolus by Cdc55p in early meiosis Gene:CDC20(YGL116W)|FD-Score:-5.17|P-value:1.18E-7|Clearance:0||SGD DESC:Activator of anaphase-promoting complex/cyclosome (APC/C); APC/C is required for metaphase/anaphase transition; directs ubiquitination of mitotic cyclins, Pds1p, and other anaphase inhibitors; cell-cycle regulated; potential Cdc28p substrate; relative distribution to the nucleus increases upon DNA replication stress Gene:IPP1(YBR011C)|FD-Score:4.92|P-value:4.26E-7|Clearance:0.1||SGD DESC:Cytoplasmic inorganic pyrophosphatase (PPase), homodimer that catalyzes the rapid exchange of oxygens from Pi with water, highly expressed and essential for viability, active-site residues show identity to those from E. coli PPase Gene:NOP8(YOL144W)|FD-Score:4.55|P-value:2.63E-6|Clearance:0.38||SGD DESC:Nucleolar protein required for 60S ribosomal subunit biogenesis Gene:PRP4(YPR178W)|FD-Score:-3.35|P-value:4.11E-4|Clearance:0||SGD DESC:Splicing factor, component of the U4/U6-U5 snRNP complex Gene:RER2(YBR002C)|FD-Score:3.38|P-value:3.59E-4|Clearance:0.2||SGD DESC:Cis-prenyltransferase involved in dolichol synthesis; participates in endoplasmic reticulum (ER) protein sorting Gene:RSC58(YLR033W)|FD-Score:4.82|P-value:7.02E-7|Clearance:0.27||SGD DESC:Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance Gene:RSC6(YCR052W)|FD-Score:4.18|P-value:1.47E-5|Clearance:0.38||SGD DESC:Component of the RSC chromatin remodeling complex; essential for mitotic growth; homolog of SWI/SNF subunit Swp73p Gene:SEC26(YDR238C)|FD-Score:3.55|P-value:1.92E-4|Clearance:0.17||SGD DESC:Essential beta-coat protein of the COPI coatomer, involved in ER-to-Golgi protein trafficking and maintenance of normal ER morphology; shares 43% sequence identity with mammalian beta-coat protein (beta-COP) Gene:SPN1(YPR133C)|FD-Score:3.18|P-value:7.31E-4|Clearance:0.18||SGD DESC:Protein involved in RNA polymerase II transcription; interacts genetically or physically with RNAP II, TBP, TFIIS, and chromatin remodelling factors; central domain highly conserved throughout eukaryotes; mutations confer an Spt- phenotype Gene:TOM40(YMR203W)|FD-Score:6.29|P-value:1.63E-10|Clearance:1.36||SGD DESC:Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; constitutes the core element of the protein conducting pore Gene:UTP9(YHR196W)|FD-Score:-3.12|P-value:8.96E-4|Clearance:0||SGD DESC:Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA Gene:CDC14(YFR028C)|FD-Score:3.8|P-value:7.20E-5|Clearance:0.25||SGD DESC:Protein phosphatase required for mitotic exit; located in the nucleolus until liberated by the FEAR and Mitotic Exit Network in anaphase, enabling it to act on key substrates to effect a decrease in CDK/B-cyclin activity and mitotic exit; required for meiosis I spindle disassembly; released from nucleolus upon entry into anaphase I of meiosis, resequestered in metaphase II, then released again upon entry into anaphase II; maintained in nucleolus by Cdc55p in early meiosis Gene:CDC20(YGL116W)|FD-Score:-5.17|P-value:1.18E-7|Clearance:0||SGD DESC:Activator of anaphase-promoting complex/cyclosome (APC/C); APC/C is required for metaphase/anaphase transition; directs ubiquitination of mitotic cyclins, Pds1p, and other anaphase inhibitors; cell-cycle regulated; potential Cdc28p substrate; relative distribution to the nucleus increases upon DNA replication stress Gene:IPP1(YBR011C)|FD-Score:4.92|P-value:4.26E-7|Clearance:0.1||SGD DESC:Cytoplasmic inorganic pyrophosphatase (PPase), homodimer that catalyzes the rapid exchange of oxygens from Pi with water, highly expressed and essential for viability, active-site residues show identity to those from E. coli PPase Gene:NOP8(YOL144W)|FD-Score:4.55|P-value:2.63E-6|Clearance:0.38||SGD DESC:Nucleolar protein required for 60S ribosomal subunit biogenesis Gene:PRP4(YPR178W)|FD-Score:-3.35|P-value:4.11E-4|Clearance:0||SGD DESC:Splicing factor, component of the U4/U6-U5 snRNP complex Gene:RER2(YBR002C)|FD-Score:3.38|P-value:3.59E-4|Clearance:0.2||SGD DESC:Cis-prenyltransferase involved in dolichol synthesis; participates in endoplasmic reticulum (ER) protein sorting Gene:RSC58(YLR033W)|FD-Score:4.82|P-value:7.02E-7|Clearance:0.27||SGD DESC:Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance Gene:RSC6(YCR052W)|FD-Score:4.18|P-value:1.47E-5|Clearance:0.38||SGD DESC:Component of the RSC chromatin remodeling complex; essential for mitotic growth; homolog of SWI/SNF subunit Swp73p Gene:SEC26(YDR238C)|FD-Score:3.55|P-value:1.92E-4|Clearance:0.17||SGD DESC:Essential beta-coat protein of the COPI coatomer, involved in ER-to-Golgi protein trafficking and maintenance of normal ER morphology; shares 43% sequence identity with mammalian beta-coat protein (beta-COP) Gene:SPN1(YPR133C)|FD-Score:3.18|P-value:7.31E-4|Clearance:0.18||SGD DESC:Protein involved in RNA polymerase II transcription; interacts genetically or physically with RNAP II, TBP, TFIIS, and chromatin remodelling factors; central domain highly conserved throughout eukaryotes; mutations confer an Spt- phenotype Gene:TOM40(YMR203W)|FD-Score:6.29|P-value:1.63E-10|Clearance:1.36||SGD DESC:Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; constitutes the core element of the protein conducting pore Gene:UTP9(YHR196W)|FD-Score:-3.12|P-value:8.96E-4|Clearance:0||SGD DESC:Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 45595555
Download HOP data (tab-delimited text)  (excel)
Gene:ACH1(YBL015W)|FD-Score:-3.86|P-value:5.68E-5||SGD DESC:Protein with CoA transferase activity, particularly for CoASH transfer from succinyl-CoA to acetate; has minor acetyl-CoA-hydrolase activity; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth Gene:ADE16(YLR028C)|FD-Score:4.16|P-value:1.59E-5||SGD DESC:Enzyme of 'de novo' purine biosynthesis; contains both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities; ADE16 has a paralog, ADE17, that arose from the whole genome duplication; ade16 ade17 mutants require adenine and histidine Gene:AIM18(YHR198C)|FD-Score:3.11|P-value:9.45E-4||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss Gene:AMS1(YGL156W)|FD-Score:3.27|P-value:5.44E-4||SGD DESC:Vacuolar alpha mannosidase, involved in free oligosaccharide (fOS) degradation; delivered to the vacuole in a novel pathway separate from the secretory pathway Gene:APM3(YBR288C)|FD-Score:3.12|P-value:9.19E-4||SGD DESC:Mu3-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway Gene:ATG12(YBR217W)|FD-Score:4.24|P-value:1.10E-5||SGD DESC:Conserved ubiquitin-like modifier involved in autophagy and the Cvt pathway; conjugated to Atg5p to form a complex involved in Atg8p lipidation; Atg12p-Atg5p also forms a complex with Atg16p that is required for autophagosome formation Gene:ATG7(YHR171W)|FD-Score:4.61|P-value:2.03E-6||SGD DESC:Autophagy-related protein and dual specificity member of the E1 family of ubiquitin-activating enzymes; mediates the conjugation of Atg12p with Atg5p and Atg8p with phosphatidylethanolamine, required steps in autophagosome formation Gene:BAT2(YJR148W)|FD-Score:-3.27|P-value:5.35E-4||SGD DESC:Cytosolic branched-chain amino acid (BCAA) aminotransferase, preferentially involved in BCAA catabolism; homolog of murine ECA39; highly expressed during stationary phase and repressed during logarithmic phase Gene:CAF40(YNL288W)|FD-Score:-3.3|P-value:4.77E-4||SGD DESC:Evolutionarily conserved subunit of the CCR4-NOT complex involved in controlling mRNA initiation, elongation and degradation; binds Cdc39p Gene:CCP1(YKR066C)|FD-Score:3.64|P-value:1.37E-4||SGD DESC:Mitochondrial cytochrome-c peroxidase; degrades reactive oxygen species in mitochondria, involved in the response to oxidative stress Gene:CCR4(YAL021C)|FD-Score:3.72|P-value:9.77E-5||SGD DESC:Component of the CCR4-NOT transcriptional complex, which is involved in regulation of gene expression; component of the major cytoplasmic deadenylase, which is involved in mRNA poly(A) tail shortening Gene:CDH1(YGL003C)|FD-Score:3.25|P-value:5.71E-4||SGD DESC:Cell-cycle regulated activator of the anaphase-promoting complex/cyclosome (APC/C), which directs ubiquitination of cyclins resulting in mitotic exit; targets the APC/C to specific substrates including Cdc20p, Ase1p, Cin8p and Fin1p Gene:CEX1(YOR112W)|FD-Score:3.3|P-value:4.90E-4||SGD DESC:Cytoplasmic component of the nuclear aminoacylation-dependent tRNA export pathway; interacts with nuclear pore component Nup116p; copurifies with tRNA export receptors Los1p and Msn5p, as well as eIF-1a and the RAN GTPase Gsp1p Gene:CHZ1(YER030W)|FD-Score:3.44|P-value:2.91E-4||SGD DESC:Histone chaperone for Htz1p/H2A-H2B dimer; required for the stabilization of the Chz1p-Htz1-H2B complex; has overlapping function with Nap1p; null mutant displays weak sensitivity to MMS and benomyl; contains a highly conserved CHZ motif; protein abundance increases in response to DNA replication stress Gene:CLB4(YLR210W)|FD-Score:5.52|P-value:1.65E-8||SGD DESC:B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation Gene:CTR1(YPR124W)|FD-Score:3.18|P-value:7.34E-4||SGD DESC:High-affinity copper transporter of the plasma membrane; mediates nearly all copper uptake under low copper conditions; transcriptionally induced at low copper levels and degraded at high copper levels; protein increases in abundance and relocalizes from nucleus to plasma membrane upon DNA replication stress Gene:CWC15(YDR163W)|FD-Score:3.84|P-value:6.12E-5||SGD DESC:Non-essential protein involved in pre-mRNA splicing, component of a complex containing Cef1p; has similarity to S. pombe Cwf15p Gene:DSE1(YER124C)|FD-Score:4.87|P-value:5.62E-7||SGD DESC:Daughter cell-specific protein, may regulate cross-talk between the mating and filamentation pathways; deletion affects cell separation after division and sensitivity to alpha-factor and drugs affecting the cell wall; relocalizes from bud neck to cytoplasm upon DNA replication stress Gene:EAF7(YNL136W)|FD-Score:3.13|P-value:8.70E-4||SGD DESC:Subunit of the NuA4 histone acetyltransferase complex, which acetylates the N-terminal tails of histones H4 and H2A Gene:ECT1(YGR007W)|FD-Score:3.46|P-value:2.67E-4||SGD DESC:Ethanolamine-phosphate cytidylyltransferase, catalyzes the second step of phosphatidylethanolamine biosynthesis; involved in the maintenance of plasma membrane; similar to mammalian CTP: phosphocholine cytidylyl-transferases Gene:EMC6(YLL014W)|FD-Score:3.72|P-value:1.01E-4||SGD DESC:Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm F33D4.7/EMC-6, fly CG11781, human TMEM93 Gene:ENB1(YOL158C)|FD-Score:-3.68|P-value:1.16E-4||SGD DESC:Endosomal ferric enterobactin transporter, expressed under conditions of iron deprivation; member of the major facilitator superfamily; expression is regulated by Rcs1p and affected by chloroquine treatment Gene:ERP1(YAR002C-A)|FD-Score:7.78|P-value:3.67E-15||SGD DESC:Member of the p24 family involved in ER to Golgi transport; forms heterotrimeric complex with Erp2p, Emp24p, and Erv25p; localized to COPII-coated vesicles; ERP1 has a paralog, ERP6, that arose from the whole genome duplication Gene:FMP27(YLR454W_p)|FD-Score:-3.26|P-value:5.56E-4||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:FRA2(YGL220W)|FD-Score:4.32|P-value:7.81E-6||SGD DESC:Protein involved in negative regulation of transcription of iron regulon; forms an iron independent complex with Fra2p, Grx3p, and Grx4p; null mutant fails to repress iron regulon and is sensitive to nickel Gene:FYV12(YOR183W_p)|FD-Score:-3.97|P-value:3.66E-5||SGD DESC:Protein of unknown function, required for survival upon exposure to K1 killer toxin Gene:GAT2(YMR136W)|FD-Score:-3.66|P-value:1.27E-4||SGD DESC:Protein containing GATA family zinc finger motifs; similar to Gln3p and Dal80p; expression repressed by leucine Gene:GPR1(YDL035C)|FD-Score:-3.54|P-value:2.02E-4||SGD DESC:Plasma membrane G protein coupled receptor (GPCR) that interacts with the heterotrimeric G protein alpha subunit, Gpa2p, and with Plc1p; sensor that integrates nutritional signals with the modulation of cell fate via PKA and cAMP synthesis Gene:LDB16(YCL005W)|FD-Score:3.37|P-value:3.75E-4||SGD DESC:Protein of unknown function; null mutants have decreased net negative cell surface charge; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; native protein is detected in purified mitochondria Gene:MAC1(YMR021C)|FD-Score:3.98|P-value:3.49E-5||SGD DESC:Copper-sensing transcription factor involved in regulation of genes required for high affinity copper transport Gene:MNN5(YJL186W)|FD-Score:3.57|P-value:1.77E-4||SGD DESC:Alpha-1,2-mannosyltransferase, responsible for addition of the second alpha-1,2-linked mannose of the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment Gene:MRP13(YGR084C)|FD-Score:-5.08|P-value:1.90E-7||SGD DESC:Mitochondrial ribosomal protein of the small subunit Gene:MRP49(YKL167C)|FD-Score:-4.59|P-value:2.17E-6||SGD DESC:Mitochondrial ribosomal protein of the large subunit, not essential for mitochondrial translation Gene:MRPL11(YDL202W)|FD-Score:3.92|P-value:4.42E-5||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:MRPS9(YBR146W)|FD-Score:4.22|P-value:1.22E-5||SGD DESC:Mitochondrial ribosomal protein of the small subunit Gene:MSN5(YDR335W)|FD-Score:3.81|P-value:6.89E-5||SGD DESC:Karyopherin involved in nuclear import and export of proteins, including import of replication protein A and export of Swi6p, Far1p, and Pho4p; required for re-export of mature tRNAs after their retrograde import from the cytoplasm Gene:NAP1(YKR048C)|FD-Score:3.5|P-value:2.29E-4||SGD DESC:Protein that interacts with mitotic cyclin Clb2p; required for the regulation of microtubule dynamics during mitosis; controls bud morphogenesis; involved in the transport of H2A and H2B histones to the nucleus; phosphorylated by CK2; protein abundance increases in response to DNA replication stress Gene:PNS1(YOR161C)|FD-Score:5.04|P-value:2.32E-7||SGD DESC:Protein of unknown function; has similarity to Torpedo californica tCTL1p, which is postulated to be a choline transporter, neither null mutation nor overexpression affects choline transport Gene:PRY3(YJL078C)|FD-Score:-3.19|P-value:7.06E-4||SGD DESC:Cell wall-associated protein involved in export of acetylated sterols; member of the CAP protein superfamily (cysteine-rich secretory proteins (CRISP), antigen 5, and pathogenesis related 1 proteins); role in mating efficiency; expression of full-length transcript is daughter cell-specific; in response to alpha factor, a short transcript starting at +452 is expressed and the long form is repressed by Ste12p Gene:PTK2(YJR059W)|FD-Score:-3.55|P-value:1.93E-4||SGD DESC:Putative serine/threonine protein kinase involved in regulation of ion transport across plasma membrane; enhances spermine uptake Gene:PUG1(YER185W)|FD-Score:3.28|P-value:5.27E-4||SGD DESC:Plasma membrane protein with roles in the uptake of protoprophyrin IX and the efflux of heme; expression is induced under both low-heme and low-oxygen conditions; member of the fungal lipid-translocating exporter (LTE) family of proteins Gene:RKR1(YMR247C)|FD-Score:-3.53|P-value:2.04E-4||SGD DESC:RING domain E3 ubiquitin ligase; involved in the ubiquitin-mediated degradation of non-stop proteins; functional connections to chromatin modification; nuclear protein that also co-localizes with ribosomes; homolog of mouse Listerin, whose mutation has been reported to cause neurodegeneration in mice Gene:ROG1(YGL144C)|FD-Score:4.44|P-value:4.56E-6||SGD DESC:Protein with putative serine active lipase domain; ROG1 has a paralog, YDL109C, that arose from the whole genome duplication Gene:RPL8A(YHL033C)|FD-Score:-3.68|P-value:1.17E-4||SGD DESC:Ribosomal 60S subunit protein L8A; mutation results in decreased amounts of free 60S subunits; homologous to mammalian ribosomal protein L7A, no bacterial homolog; RPL8A has a paralog, RPL8B, that arose from the whole genome duplication Gene:RPS6B(YBR181C)|FD-Score:-3.92|P-value:4.42E-5||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S6, no bacterial homolog; RPS6B has a paralog, RPS6A, that arose from the whole genome duplication Gene:RTS3(YGR161C_p)|FD-Score:4.1|P-value:2.07E-5||SGD DESC:Putative component of the protein phosphatase type 2A complex Gene:SEC22(YLR268W)|FD-Score:3.2|P-value:6.94E-4||SGD DESC:R-SNARE protein; assembles into SNARE complex with Bet1p, Bos1p and Sed5p; cycles between the ER and Golgi complex; involved in anterograde and retrograde transport between the ER and Golgi; synaptobrevin homolog Gene:SKN1(YGR143W)|FD-Score:3.17|P-value:7.69E-4||SGD DESC:Protein involved in sphingolipid biosynthesis; type II membrane protein with similarity to Kre6p Gene:SLM5(YCR024C)|FD-Score:-3.97|P-value:3.63E-5||SGD DESC:Mitochondrial asparaginyl-tRNA synthetase Gene:SPC2(YML055W)|FD-Score:3.77|P-value:8.08E-5||SGD DESC:Subunit of signal peptidase complex (Spc1p, Spc2p, Spc3p, Sec11p), which catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; homologous to mammalian SPC25 Gene:STL1(YDR536W)|FD-Score:3.29|P-value:5.05E-4||SGD DESC:Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock Gene:TRP2(YER090W)|FD-Score:3.18|P-value:7.43E-4||SGD DESC:Anthranilate synthase, catalyzes the initial step of tryptophan biosynthesis, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp3p Gene:TUP1(YCR084C)|FD-Score:-4.42|P-value:4.99E-6||SGD DESC:General repressor of transcription, forms complex with Cyc8p, involved in the establishment of repressive chromatin structure through interactions with histones H3 and H4, appears to enhance expression of some genes Gene:UBR1(YGR184C)|FD-Score:-3.46|P-value:2.73E-4||SGD DESC:E3 ubiquitin ligase (N-recognin); forms heterodimer with Rad6p to ubiquitinate substrates in the N-end rule pathway; regulates peptide transport via Cup9p ubiquitination; plays a major role in targeting cytosolic misfolded proteins for degradation; mutation in human UBR1 causes Johansson-Blizzard Syndrome (JBS) Gene:VPS71(YML041C)|FD-Score:3.76|P-value:8.50E-5||SGD DESC:Nucleosome-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting Gene:YBR284W(YBR284W_p)|FD-Score:3.33|P-value:4.31E-4||SGD DESC:Putative metallo-dependent hydrolase superfamily protein; similar to AMP deaminases but lacks key catalytic residues and does not rescue purine nucleotide metabolic defect of quadruple aah1 ade8 amd1 his1 mutant; null mutant exhibits longer telomeres, altered Ty mobility, decreased resistance to rapamycin and wortmannin; induced in response to hydrostatic pressure; not an essential gene; YBR284W has a paralog, YJL070C, that arose from the whole genome duplication Gene:YBR296C-A(YBR296C-A_p)|FD-Score:3.94|P-value:4.00E-5||SGD DESC:Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching Gene:YDR003W-A(YDR003W-A_p)|FD-Score:-3.31|P-value:4.67E-4||SGD DESC:Putative protein of unknown function; identified by expression profiling and mass spectrometry Gene:YGR126W(YGR126W_p)|FD-Score:3.71|P-value:1.02E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS Gene:YIG1(YPL201C)|FD-Score:4.68|P-value:1.44E-6||SGD DESC:Protein that interacts with glycerol 3-phosphatase and plays a role in anaerobic glycerol production; localizes to the nucleus and cytosol Gene:YIL163C(YIL163C_p)|FD-Score:3.51|P-value:2.25E-4||SGD DESC:Protein of unknown function; mRNA identified as translated by ribosome profiling data Gene:YKE4(YIL023C)|FD-Score:-3.11|P-value:9.29E-4||SGD DESC:Zinc transporter; localizes to the ER; null mutant is sensitive to calcofluor white, leads to zinc accumulation in cytosol; ortholog of the mouse KE4 and member of the ZIP (ZRT, IRT-like Protein) family Gene:YLR171W(YLR171W_d)|FD-Score:3.18|P-value:7.43E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YLR211C(YLR211C_p)|FD-Score:3.51|P-value:2.28E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR211C is not an essential gene; ORF contains an intron Gene:YPL088W(YPL088W_p)|FD-Score:4.77|P-value:9.03E-7||SGD DESC:Putative aryl alcohol dehydrogenase; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance Gene:ACH1(YBL015W)|FD-Score:-3.86|P-value:5.68E-5||SGD DESC:Protein with CoA transferase activity, particularly for CoASH transfer from succinyl-CoA to acetate; has minor acetyl-CoA-hydrolase activity; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth Gene:ADE16(YLR028C)|FD-Score:4.16|P-value:1.59E-5||SGD DESC:Enzyme of 'de novo' purine biosynthesis; contains both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities; ADE16 has a paralog, ADE17, that arose from the whole genome duplication; ade16 ade17 mutants require adenine and histidine Gene:AIM18(YHR198C)|FD-Score:3.11|P-value:9.45E-4||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss Gene:AMS1(YGL156W)|FD-Score:3.27|P-value:5.44E-4||SGD DESC:Vacuolar alpha mannosidase, involved in free oligosaccharide (fOS) degradation; delivered to the vacuole in a novel pathway separate from the secretory pathway Gene:APM3(YBR288C)|FD-Score:3.12|P-value:9.19E-4||SGD DESC:Mu3-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway Gene:ATG12(YBR217W)|FD-Score:4.24|P-value:1.10E-5||SGD DESC:Conserved ubiquitin-like modifier involved in autophagy and the Cvt pathway; conjugated to Atg5p to form a complex involved in Atg8p lipidation; Atg12p-Atg5p also forms a complex with Atg16p that is required for autophagosome formation Gene:ATG7(YHR171W)|FD-Score:4.61|P-value:2.03E-6||SGD DESC:Autophagy-related protein and dual specificity member of the E1 family of ubiquitin-activating enzymes; mediates the conjugation of Atg12p with Atg5p and Atg8p with phosphatidylethanolamine, required steps in autophagosome formation Gene:BAT2(YJR148W)|FD-Score:-3.27|P-value:5.35E-4||SGD DESC:Cytosolic branched-chain amino acid (BCAA) aminotransferase, preferentially involved in BCAA catabolism; homolog of murine ECA39; highly expressed during stationary phase and repressed during logarithmic phase Gene:CAF40(YNL288W)|FD-Score:-3.3|P-value:4.77E-4||SGD DESC:Evolutionarily conserved subunit of the CCR4-NOT complex involved in controlling mRNA initiation, elongation and degradation; binds Cdc39p Gene:CCP1(YKR066C)|FD-Score:3.64|P-value:1.37E-4||SGD DESC:Mitochondrial cytochrome-c peroxidase; degrades reactive oxygen species in mitochondria, involved in the response to oxidative stress Gene:CCR4(YAL021C)|FD-Score:3.72|P-value:9.77E-5||SGD DESC:Component of the CCR4-NOT transcriptional complex, which is involved in regulation of gene expression; component of the major cytoplasmic deadenylase, which is involved in mRNA poly(A) tail shortening Gene:CDH1(YGL003C)|FD-Score:3.25|P-value:5.71E-4||SGD DESC:Cell-cycle regulated activator of the anaphase-promoting complex/cyclosome (APC/C), which directs ubiquitination of cyclins resulting in mitotic exit; targets the APC/C to specific substrates including Cdc20p, Ase1p, Cin8p and Fin1p Gene:CEX1(YOR112W)|FD-Score:3.3|P-value:4.90E-4||SGD DESC:Cytoplasmic component of the nuclear aminoacylation-dependent tRNA export pathway; interacts with nuclear pore component Nup116p; copurifies with tRNA export receptors Los1p and Msn5p, as well as eIF-1a and the RAN GTPase Gsp1p Gene:CHZ1(YER030W)|FD-Score:3.44|P-value:2.91E-4||SGD DESC:Histone chaperone for Htz1p/H2A-H2B dimer; required for the stabilization of the Chz1p-Htz1-H2B complex; has overlapping function with Nap1p; null mutant displays weak sensitivity to MMS and benomyl; contains a highly conserved CHZ motif; protein abundance increases in response to DNA replication stress Gene:CLB4(YLR210W)|FD-Score:5.52|P-value:1.65E-8||SGD DESC:B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation Gene:CTR1(YPR124W)|FD-Score:3.18|P-value:7.34E-4||SGD DESC:High-affinity copper transporter of the plasma membrane; mediates nearly all copper uptake under low copper conditions; transcriptionally induced at low copper levels and degraded at high copper levels; protein increases in abundance and relocalizes from nucleus to plasma membrane upon DNA replication stress Gene:CWC15(YDR163W)|FD-Score:3.84|P-value:6.12E-5||SGD DESC:Non-essential protein involved in pre-mRNA splicing, component of a complex containing Cef1p; has similarity to S. pombe Cwf15p Gene:DSE1(YER124C)|FD-Score:4.87|P-value:5.62E-7||SGD DESC:Daughter cell-specific protein, may regulate cross-talk between the mating and filamentation pathways; deletion affects cell separation after division and sensitivity to alpha-factor and drugs affecting the cell wall; relocalizes from bud neck to cytoplasm upon DNA replication stress Gene:EAF7(YNL136W)|FD-Score:3.13|P-value:8.70E-4||SGD DESC:Subunit of the NuA4 histone acetyltransferase complex, which acetylates the N-terminal tails of histones H4 and H2A Gene:ECT1(YGR007W)|FD-Score:3.46|P-value:2.67E-4||SGD DESC:Ethanolamine-phosphate cytidylyltransferase, catalyzes the second step of phosphatidylethanolamine biosynthesis; involved in the maintenance of plasma membrane; similar to mammalian CTP: phosphocholine cytidylyl-transferases Gene:EMC6(YLL014W)|FD-Score:3.72|P-value:1.01E-4||SGD DESC:Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm F33D4.7/EMC-6, fly CG11781, human TMEM93 Gene:ENB1(YOL158C)|FD-Score:-3.68|P-value:1.16E-4||SGD DESC:Endosomal ferric enterobactin transporter, expressed under conditions of iron deprivation; member of the major facilitator superfamily; expression is regulated by Rcs1p and affected by chloroquine treatment Gene:ERP1(YAR002C-A)|FD-Score:7.78|P-value:3.67E-15||SGD DESC:Member of the p24 family involved in ER to Golgi transport; forms heterotrimeric complex with Erp2p, Emp24p, and Erv25p; localized to COPII-coated vesicles; ERP1 has a paralog, ERP6, that arose from the whole genome duplication Gene:FMP27(YLR454W_p)|FD-Score:-3.26|P-value:5.56E-4||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:FRA2(YGL220W)|FD-Score:4.32|P-value:7.81E-6||SGD DESC:Protein involved in negative regulation of transcription of iron regulon; forms an iron independent complex with Fra2p, Grx3p, and Grx4p; null mutant fails to repress iron regulon and is sensitive to nickel Gene:FYV12(YOR183W_p)|FD-Score:-3.97|P-value:3.66E-5||SGD DESC:Protein of unknown function, required for survival upon exposure to K1 killer toxin Gene:GAT2(YMR136W)|FD-Score:-3.66|P-value:1.27E-4||SGD DESC:Protein containing GATA family zinc finger motifs; similar to Gln3p and Dal80p; expression repressed by leucine Gene:GPR1(YDL035C)|FD-Score:-3.54|P-value:2.02E-4||SGD DESC:Plasma membrane G protein coupled receptor (GPCR) that interacts with the heterotrimeric G protein alpha subunit, Gpa2p, and with Plc1p; sensor that integrates nutritional signals with the modulation of cell fate via PKA and cAMP synthesis Gene:LDB16(YCL005W)|FD-Score:3.37|P-value:3.75E-4||SGD DESC:Protein of unknown function; null mutants have decreased net negative cell surface charge; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; native protein is detected in purified mitochondria Gene:MAC1(YMR021C)|FD-Score:3.98|P-value:3.49E-5||SGD DESC:Copper-sensing transcription factor involved in regulation of genes required for high affinity copper transport Gene:MNN5(YJL186W)|FD-Score:3.57|P-value:1.77E-4||SGD DESC:Alpha-1,2-mannosyltransferase, responsible for addition of the second alpha-1,2-linked mannose of the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment Gene:MRP13(YGR084C)|FD-Score:-5.08|P-value:1.90E-7||SGD DESC:Mitochondrial ribosomal protein of the small subunit Gene:MRP49(YKL167C)|FD-Score:-4.59|P-value:2.17E-6||SGD DESC:Mitochondrial ribosomal protein of the large subunit, not essential for mitochondrial translation Gene:MRPL11(YDL202W)|FD-Score:3.92|P-value:4.42E-5||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:MRPS9(YBR146W)|FD-Score:4.22|P-value:1.22E-5||SGD DESC:Mitochondrial ribosomal protein of the small subunit Gene:MSN5(YDR335W)|FD-Score:3.81|P-value:6.89E-5||SGD DESC:Karyopherin involved in nuclear import and export of proteins, including import of replication protein A and export of Swi6p, Far1p, and Pho4p; required for re-export of mature tRNAs after their retrograde import from the cytoplasm Gene:NAP1(YKR048C)|FD-Score:3.5|P-value:2.29E-4||SGD DESC:Protein that interacts with mitotic cyclin Clb2p; required for the regulation of microtubule dynamics during mitosis; controls bud morphogenesis; involved in the transport of H2A and H2B histones to the nucleus; phosphorylated by CK2; protein abundance increases in response to DNA replication stress Gene:PNS1(YOR161C)|FD-Score:5.04|P-value:2.32E-7||SGD DESC:Protein of unknown function; has similarity to Torpedo californica tCTL1p, which is postulated to be a choline transporter, neither null mutation nor overexpression affects choline transport Gene:PRY3(YJL078C)|FD-Score:-3.19|P-value:7.06E-4||SGD DESC:Cell wall-associated protein involved in export of acetylated sterols; member of the CAP protein superfamily (cysteine-rich secretory proteins (CRISP), antigen 5, and pathogenesis related 1 proteins); role in mating efficiency; expression of full-length transcript is daughter cell-specific; in response to alpha factor, a short transcript starting at +452 is expressed and the long form is repressed by Ste12p Gene:PTK2(YJR059W)|FD-Score:-3.55|P-value:1.93E-4||SGD DESC:Putative serine/threonine protein kinase involved in regulation of ion transport across plasma membrane; enhances spermine uptake Gene:PUG1(YER185W)|FD-Score:3.28|P-value:5.27E-4||SGD DESC:Plasma membrane protein with roles in the uptake of protoprophyrin IX and the efflux of heme; expression is induced under both low-heme and low-oxygen conditions; member of the fungal lipid-translocating exporter (LTE) family of proteins Gene:RKR1(YMR247C)|FD-Score:-3.53|P-value:2.04E-4||SGD DESC:RING domain E3 ubiquitin ligase; involved in the ubiquitin-mediated degradation of non-stop proteins; functional connections to chromatin modification; nuclear protein that also co-localizes with ribosomes; homolog of mouse Listerin, whose mutation has been reported to cause neurodegeneration in mice Gene:ROG1(YGL144C)|FD-Score:4.44|P-value:4.56E-6||SGD DESC:Protein with putative serine active lipase domain; ROG1 has a paralog, YDL109C, that arose from the whole genome duplication Gene:RPL8A(YHL033C)|FD-Score:-3.68|P-value:1.17E-4||SGD DESC:Ribosomal 60S subunit protein L8A; mutation results in decreased amounts of free 60S subunits; homologous to mammalian ribosomal protein L7A, no bacterial homolog; RPL8A has a paralog, RPL8B, that arose from the whole genome duplication Gene:RPS6B(YBR181C)|FD-Score:-3.92|P-value:4.42E-5||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S6, no bacterial homolog; RPS6B has a paralog, RPS6A, that arose from the whole genome duplication Gene:RTS3(YGR161C_p)|FD-Score:4.1|P-value:2.07E-5||SGD DESC:Putative component of the protein phosphatase type 2A complex Gene:SEC22(YLR268W)|FD-Score:3.2|P-value:6.94E-4||SGD DESC:R-SNARE protein; assembles into SNARE complex with Bet1p, Bos1p and Sed5p; cycles between the ER and Golgi complex; involved in anterograde and retrograde transport between the ER and Golgi; synaptobrevin homolog Gene:SKN1(YGR143W)|FD-Score:3.17|P-value:7.69E-4||SGD DESC:Protein involved in sphingolipid biosynthesis; type II membrane protein with similarity to Kre6p Gene:SLM5(YCR024C)|FD-Score:-3.97|P-value:3.63E-5||SGD DESC:Mitochondrial asparaginyl-tRNA synthetase Gene:SPC2(YML055W)|FD-Score:3.77|P-value:8.08E-5||SGD DESC:Subunit of signal peptidase complex (Spc1p, Spc2p, Spc3p, Sec11p), which catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; homologous to mammalian SPC25 Gene:STL1(YDR536W)|FD-Score:3.29|P-value:5.05E-4||SGD DESC:Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock Gene:TRP2(YER090W)|FD-Score:3.18|P-value:7.43E-4||SGD DESC:Anthranilate synthase, catalyzes the initial step of tryptophan biosynthesis, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp3p Gene:TUP1(YCR084C)|FD-Score:-4.42|P-value:4.99E-6||SGD DESC:General repressor of transcription, forms complex with Cyc8p, involved in the establishment of repressive chromatin structure through interactions with histones H3 and H4, appears to enhance expression of some genes Gene:UBR1(YGR184C)|FD-Score:-3.46|P-value:2.73E-4||SGD DESC:E3 ubiquitin ligase (N-recognin); forms heterodimer with Rad6p to ubiquitinate substrates in the N-end rule pathway; regulates peptide transport via Cup9p ubiquitination; plays a major role in targeting cytosolic misfolded proteins for degradation; mutation in human UBR1 causes Johansson-Blizzard Syndrome (JBS) Gene:VPS71(YML041C)|FD-Score:3.76|P-value:8.50E-5||SGD DESC:Nucleosome-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting Gene:YBR284W(YBR284W_p)|FD-Score:3.33|P-value:4.31E-4||SGD DESC:Putative metallo-dependent hydrolase superfamily protein; similar to AMP deaminases but lacks key catalytic residues and does not rescue purine nucleotide metabolic defect of quadruple aah1 ade8 amd1 his1 mutant; null mutant exhibits longer telomeres, altered Ty mobility, decreased resistance to rapamycin and wortmannin; induced in response to hydrostatic pressure; not an essential gene; YBR284W has a paralog, YJL070C, that arose from the whole genome duplication Gene:YBR296C-A(YBR296C-A_p)|FD-Score:3.94|P-value:4.00E-5||SGD DESC:Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching Gene:YDR003W-A(YDR003W-A_p)|FD-Score:-3.31|P-value:4.67E-4||SGD DESC:Putative protein of unknown function; identified by expression profiling and mass spectrometry Gene:YGR126W(YGR126W_p)|FD-Score:3.71|P-value:1.02E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS Gene:YIG1(YPL201C)|FD-Score:4.68|P-value:1.44E-6||SGD DESC:Protein that interacts with glycerol 3-phosphatase and plays a role in anaerobic glycerol production; localizes to the nucleus and cytosol Gene:YIL163C(YIL163C_p)|FD-Score:3.51|P-value:2.25E-4||SGD DESC:Protein of unknown function; mRNA identified as translated by ribosome profiling data Gene:YKE4(YIL023C)|FD-Score:-3.11|P-value:9.29E-4||SGD DESC:Zinc transporter; localizes to the ER; null mutant is sensitive to calcofluor white, leads to zinc accumulation in cytosol; ortholog of the mouse KE4 and member of the ZIP (ZRT, IRT-like Protein) family Gene:YLR171W(YLR171W_d)|FD-Score:3.18|P-value:7.43E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YLR211C(YLR211C_p)|FD-Score:3.51|P-value:2.28E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR211C is not an essential gene; ORF contains an intron Gene:YPL088W(YPL088W_p)|FD-Score:4.77|P-value:9.03E-7||SGD DESC:Putative aryl alcohol dehydrogenase; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YMR203W6.291.63E-101.36TOM40Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; constitutes the core element of the protein conducting pore
YBR011C4.924.26E-70.10IPP1Cytoplasmic inorganic pyrophosphatase (PPase), homodimer that catalyzes the rapid exchange of oxygens from Pi with water, highly expressed and essential for viability, active-site residues show identity to those from E. coli PPase
YLR033W4.827.02E-70.27RSC58Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance
YOL144W4.552.63E-60.38NOP8Nucleolar protein required for 60S ribosomal subunit biogenesis
YCR052W4.181.47E-50.38RSC6Component of the RSC chromatin remodeling complex; essential for mitotic growth; homolog of SWI/SNF subunit Swp73p
YFR028C3.807.20E-50.25CDC14Protein phosphatase required for mitotic exit; located in the nucleolus until liberated by the FEAR and Mitotic Exit Network in anaphase, enabling it to act on key substrates to effect a decrease in CDK/B-cyclin activity and mitotic exit; required for meiosis I spindle disassembly; released from nucleolus upon entry into anaphase I of meiosis, resequestered in metaphase II, then released again upon entry into anaphase II; maintained in nucleolus by Cdc55p in early meiosis
YDR238C3.551.92E-40.17SEC26Essential beta-coat protein of the COPI coatomer, involved in ER-to-Golgi protein trafficking and maintenance of normal ER morphology; shares 43% sequence identity with mammalian beta-coat protein (beta-COP)
YBR002C3.383.59E-40.20RER2Cis-prenyltransferase involved in dolichol synthesis; participates in endoplasmic reticulum (ER) protein sorting
YPR133C3.187.31E-40.18SPN1Protein involved in RNA polymerase II transcription; interacts genetically or physically with RNAP II, TBP, TFIIS, and chromatin remodelling factors; central domain highly conserved throughout eukaryotes; mutations confer an Spt- phenotype
YGL238W3.000.001340.01CSE1Nuclear envelope protein that mediates the nuclear export of importin alpha (Srp1p), homolog of metazoan CAS protein, required for accurate chromosome segregation
YJL086C_d2.990.001400.02YJL086C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL085W/EXO70 and YJL087C/TRL1
YLR321C2.970.001490.02SFH1Component of the RSC chromatin remodeling complex; essential gene required for cell cycle progression and maintenance of proper ploidy; phosphorylated in the G1 phase of the cell cycle; Snf5p paralog
YBR154C2.950.001600.00RPB5RNA polymerase subunit ABC27, common to RNA polymerases I, II, and III; contacts DNA and affects transactivation
YDL014W2.940.001620.01NOP1Nucleolar protein, component of the small subunit processome complex, which is required for processing of pre-18S rRNA; has similarity to mammalian fibrillarin
YBL105C2.940.001650.05PKC1Protein serine/threonine kinase essential for cell wall remodeling during growth; localized to sites of polarized growth and the mother-daughter bud neck; homolog of the alpha, beta, and gamma isoforms of mammalian protein kinase C (PKC)

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YAR002C-A7.783.67E-15ERP1Member of the p24 family involved in ER to Golgi transport; forms heterotrimeric complex with Erp2p, Emp24p, and Erv25p; localized to COPII-coated vesicles; ERP1 has a paralog, ERP6, that arose from the whole genome duplication
YLR210W5.521.65E-8CLB4B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation
YOR161C5.042.32E-7PNS1Protein of unknown function; has similarity to Torpedo californica tCTL1p, which is postulated to be a choline transporter, neither null mutation nor overexpression affects choline transport
YER124C4.875.62E-7DSE1Daughter cell-specific protein, may regulate cross-talk between the mating and filamentation pathways; deletion affects cell separation after division and sensitivity to alpha-factor and drugs affecting the cell wall; relocalizes from bud neck to cytoplasm upon DNA replication stress
YPL088W_p4.779.03E-7YPL088W_pPutative aryl alcohol dehydrogenase; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance
YPL201C4.681.44E-6YIG1Protein that interacts with glycerol 3-phosphatase and plays a role in anaerobic glycerol production; localizes to the nucleus and cytosol
YHR171W4.612.03E-6ATG7Autophagy-related protein and dual specificity member of the E1 family of ubiquitin-activating enzymes; mediates the conjugation of Atg12p with Atg5p and Atg8p with phosphatidylethanolamine, required steps in autophagosome formation
YGL144C4.444.56E-6ROG1Protein with putative serine active lipase domain; ROG1 has a paralog, YDL109C, that arose from the whole genome duplication
YGL220W4.327.81E-6FRA2Protein involved in negative regulation of transcription of iron regulon; forms an iron independent complex with Fra2p, Grx3p, and Grx4p; null mutant fails to repress iron regulon and is sensitive to nickel
YBR217W4.241.10E-5ATG12Conserved ubiquitin-like modifier involved in autophagy and the Cvt pathway; conjugated to Atg5p to form a complex involved in Atg8p lipidation; Atg12p-Atg5p also forms a complex with Atg16p that is required for autophagosome formation
YBR146W4.221.22E-5MRPS9Mitochondrial ribosomal protein of the small subunit
YLR028C4.161.59E-5ADE16Enzyme of 'de novo' purine biosynthesis; contains both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities; ADE16 has a paralog, ADE17, that arose from the whole genome duplication; ade16 ade17 mutants require adenine and histidine
YGR161C_p4.102.07E-5RTS3_pPutative component of the protein phosphatase type 2A complex
YMR021C3.983.49E-5MAC1Copper-sensing transcription factor involved in regulation of genes required for high affinity copper transport
YBR296C-A_p3.944.00E-5YBR296C-A_pPutative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching

GO enrichment analysis for SGTC_3198
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID		 Tanimoto
Score		 Response
Signature
0.1674.11E-38SGTC_31969111891 49.5 μMChembridge (Drug-like library)188915100.0777778mitochondrial processes
0.1132.29E-18SGTC_20665222451 176.0 μMChembridge (Fragment library)22811470.084507heme biosynthesis & mitochondrial translocase
0.1125.61E-18SGTC_23369001819 198.7 μMChembridge (Fragment library)29896020.0757576heme biosynthesis & mitochondrial translocase
0.1126.84E-18SGTC_9691313-0238 134.0 μMChemDiv (Drug-like library)52128740.0759494mitochondrial processes
0.1071.23E-16SGTC_2519cryptotanshinone 88.0 μMMicrosource (Natural product library)1602540.0625heme biosynthesis & mitochondrial translocase
0.1071.69E-16SGTC_31619100388 49.5 μMChembridge (Drug-like library)252363680.103896iron homeostasis
0.1001.12E-14SGTC_1771327-0068 8.4 μMChemDiv (Drug-like library)153899000.084507
0.1001.34E-14SGTC_1831st055328 12.0 μMTimTec (Natural product derivative library)11030680.117647heme biosynthesis & mitochondrial translocase
0.0983.64E-14SGTC_2617dihydrotanshinone i 20.8 μMMicrosource (Natural product library)53167430.125copper-dependent oxidative stress
0.0938.01E-13SGTC_2676harmalol 100.0 μMMicrosource (Natural product library)54591870.101449mitochondrial processes
0.0938.89E-13SGTC_643k048-0106 28.4 μMChemDiv (Drug-like library)67639200.0512821RSC & ERG11
0.0881.20E-11SGTC_2534helenine 20.1 μMMicrosource (Natural product library)727240.0519481RSC complex & mRNA processing
0.0871.77E-11SGTC_14780453-0656 35.7 μMChemDiv (Drug-like library)52584960.0675676
0.0872.08E-11SGTC_7950685-0265 78.0 μMChemDiv (Drug-like library)3027540.0714286excess fatty acid
0.0872.61E-11SGTC_22256654152 15.4 μMChembridge (Fragment library)975820.0847458

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count		 H-bond
acceptor
count		 Response
Signature
SGTC_14093909-800461.9 μM0.4909092119279ChemDiv (Drug-like library)273.35342.81215
SGTC_5264469-0568170 μM0.3333332901964ChemDiv (Drug-like library)257.310942.19715azole & statin
SGTC_23327982454138.89 μM0.3278692981748Chembridge (Fragment library)247.316123.15223
SGTC_3247913514949.47 μM0.3137268934436Chembridge (Drug-like library)220.226123.42503DNA damage response
SGTC_2944906734625.62 μM0.3050856473075Chembridge (Drug-like library)324.20184.1723
SGTC_22717849410118.62 μM0.3972430Chembridge (Fragment library)233.289542.66623
SGTC_2804795424019.48 μM0.285714828705Chembridge (Drug-like library)319.357183.68514
SGTC_2849901932112.99 μM0.2812516489627Chembridge (Drug-like library)275.365983.21713
SGTC_9322857-0803154 μM0.275862674898ChemDiv (Drug-like library)280.11732.55112
SGTC_22737815444169.05 μM0.2741942824616Chembridge (Fragment library)228.268182.00424