Deletion Strain | FD score | P-value | Gene | Gene Description |
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YER183C | 12.20 | 1.01E-34 | FAU1 | 5,10-methenyltetrahydrofolate synthetase, involved in folic acid biosynthesis |
YER001W | 8.94 | 2.04E-19 | MNN1 | Alpha-1,3-mannosyltransferase, integral membrane glycoprotein of the Golgi complex, required for addition of alpha1,3-mannose linkages to N-linked and O-linked oligosaccharides, one of five S. cerevisiae proteins of the MNN1 family |
YGR160W_d | 6.29 | 1.55E-10 | YGR160W_d | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
YPR087W_d | 5.85 | 2.47E-9 | VPS69_d | Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 85% of ORF overlaps the verified gene SRP54; deletion causes a vacuolar protein sorting defect |
YFR056C_d | 5.73 | 4.97E-9 | YFR056C_d | Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W |
YKL023W_p | 5.54 | 1.48E-8 | YKL023W_p | Putative protein of unknown function, predicted by computational methods to be involved in mRNA degradation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm |
YCL024W | 5.07 | 1.99E-7 | KCC4 | Protein kinase of the bud neck involved in the septin checkpoint; associates with septin proteins, negatively regulates Swe1p by phosphorylation, shows structural homology to bud neck kinases Gin4p and Hsl1p; KCC4 has a paralog, GIN4, that arose from the whole genome duplication |
YNL100W | 4.98 | 3.15E-7 | AIM37 | Mitochondrial inner membrane protein; component of the mitochondrial inner membrane organizing system (MitOS, MICOS, or MINOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture |
YMR001C-A_p | 4.87 | 5.72E-7 | YMR001C-A_p | Putative protein of unknown function |
YBL009W | 4.77 | 9.34E-7 | ALK2 | Protein kinase; accumulation and phosphorylation are periodic during the cell cycle; phosphorylated in response to DNA damage; contains characteristic motifs for degradation via the APC pathway; ALK2 has a paralog, ALK1, that arose from the whole genome duplication; similar to mammalian haspins |
YOR343C_d | 4.57 | 2.39E-6 | YOR343C_d | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
YJL047C-A_p | 4.55 | 2.65E-6 | YJL047C-A_p | Putative protein of unknown function |
YOR246C | 4.54 | 2.87E-6 | ENV9 | Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing and defects in vacuolar morphology; has similarity to oxidoreductases, found in lipid particles; required for replication of Brome mosaic virus in S. cerevisiae, a model system for studying replication of positive-strand RNA viruses in their natural hosts |
YBR130C | 4.51 | 3.24E-6 | SHE3 | Protein that acts as an adaptor between Myo4p and the She2p-mRNA complex; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud; also required for cortical ER inheritance |
YFR035C_p | 4.50 | 3.45E-6 | YFR035C_p | Putative protein of unknown function, deletion mutant exhibits synthetic phenotype with alpha-synuclein |