Deletion Strain | FD score | P-value | Gene | Gene Description |
---|
YLR014C | 4.97 | 3.41E-7 | PPR1 | Zinc finger transcription factor containing a Zn(2)-Cys(6) binuclear cluster domain, positively regulates transcription of URA1, URA3, URA4, and URA10, which are involved in de novo pyrimidine biosynthesis, in response to pyrimidine starvation; activity may be modulated by interaction with Tup1p |
YBR239C_p | 4.04 | 2.63E-5 | ERT1_p | Transcriptional regulator of nonfermentable carbon utilization; GFP-fusion protein localizes to cytoplasm, nucleus; null mutation affects periodicity of transcriptional and metabolic oscillation; plays role in restricting Ty1 transposition |
YCR066W | 4.00 | 3.23E-5 | RAD18 | E3 ubiquitin ligase; forms heterodimer with Rad6p to monoubiquitinate PCNA-K164; heterodimer binds single-stranded DNA and has single-stranded DNA dependent ATPase activity; required for postreplication repair; SUMO-targeted ubiquitin ligase (STUbl) that contains a SUMO-interacting motif (SIM) which stimulates its ubiquitin ligase activity towards the sumoylated form of PCNA |
YGL226W | 3.92 | 4.36E-5 | MTC3 | Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; mtc3 is synthetically sick with cdc13-1 |
YGL256W | 3.78 | 7.83E-5 | ADH4 | Alcohol dehydrogenase isoenzyme type IV, dimeric enzyme demonstrated to be zinc-dependent despite sequence similarity to iron-activated alcohol dehydrogenases; transcription is induced in response to zinc deficiency |
YKR023W_p | 3.74 | 9.28E-5 | YKR023W_p | Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies |
YJL068C | 3.69 | 1.14E-4 | YJL068C | Non-essential intracellular esterase that can function as an S-formylglutathione hydrolase; may be involved in the detoxification of formaldehyde, which can be metabolized to S-formylglutathione; similar to human esterase D |
YJL136W-A_p | 3.65 | 1.30E-4 | YJL136W-A_p | Putative protein of unknown function; identified by SAGE |
YLR344W | 3.51 | 2.24E-4 | RPL26A | Ribosomal 60S subunit protein L26A; binds to 5.8S rRNA; homologous to mammalian ribosomal protein L26 and bacterial L24; RPL26A has a paralog, RPL26B, that arose from the whole genome duplication |
YOL126C | 3.49 | 2.44E-4 | MDH2 | Cytoplasmic malate dehydrogenase, one of three isozymes that catalyze interconversion of malate and oxaloacetate; involved in the glyoxylate cycle and gluconeogenesis during growth on two-carbon compounds; interacts with Pck1p and Fbp1 |
YIL018W | 3.36 | 3.85E-4 | RPL2B | Ribosomal 60S subunit protein L2B; homologous to mammalian ribosomal protein L2 and bacterial L2; RPL2B has a paralog, RPL2A, that arose from the whole genome duplication; expression is upregulated at low temperatures |
YNL301C | 3.35 | 4.04E-4 | RPL18B | Ribosomal 60S subunit protein L18B; homologous to mammalian ribosomal protein L18, no bacterial homolog; RPL18B has a paralog, RPL18A, that arose from the whole genome duplication |
YEL014C_d | 3.35 | 4.10E-4 | YEL014C_d | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
YKL127W | 3.31 | 4.59E-4 | PGM1 | Phosphoglucomutase, minor isoform; catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism |
YCR015C_p | 3.31 | 4.61E-4 | YCR015C_p | Putative protein of unknown function; YCR015C is not an essential gene |