Deletion Strain | FD score | P-value | Gene | Gene Description |
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YGR248W | 5.06 | 2.13E-7 | SOL4 | 6-phosphogluconolactonase; protein abundance increases in response to DNA replication stress; SOL4 has a paralog, SOL3, that arose from the whole genome duplication |
YBR021W | 5.01 | 2.76E-7 | FUR4 | Plasma membrane localized uracil permease; expression is tightly regulated by uracil levels and environmental cues; conformational alterations induced by unfolding or substrate binding result in Rsp5p-mediated ubiquitination and degradation |
YHR071W | 4.96 | 3.58E-7 | PCL5 | Cyclin, interacts with and phosphorylated by Pho85p cyclin-dependent kinase (Cdk), induced by Gcn4p at level of transcription, specifically required for Gcn4p degradation, may be sensor of cellular protein biosynthetic capacity |
YPL145C | 4.92 | 4.29E-7 | KES1 | One of seven members of the yeast oxysterol binding protein family; involved in negative regulation of Sec14p-dependent Golgi complex secretory functions, peripheral membrane protein that localizes to the Golgi complex; KES1 has a paralog, HES1, that arose from the whole genome duplication |
YLR152C_p | 4.55 | 2.64E-6 | YLR152C_p | Putative protein of unknown function; YLR152C is not an essential gene |
YOR318C_d | 4.38 | 5.94E-6 | YOR318C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcript is predicted to be spliced but there is no evidence that it is spliced in vivo |
YOR385W_p | 4.34 | 7.21E-6 | YOR385W_p | Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YOR385W is not an essential gene |
YGL109W_d | 4.27 | 9.81E-6 | YGL109W_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the uncharacterized gene YGL108C |
YGL219C | 4.15 | 1.68E-5 | MDM34 | Mitochondrial component of the ERMES complex that links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth |
YDR318W | 4.12 | 1.86E-5 | MCM21 | Component of the kinetochore sub-complex COMA; COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) bridges kinetochore subunits in contact with centromeric DNA with subunits bound to microtubules during kinetochore assembly; involved in minichromosome maintenance; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-O and fission yeast mal2 |
YER063W | 3.81 | 6.84E-5 | THO1 | Conserved nuclear RNA-binding protein; specifically binds to transcribed chromatin in a THO- and RNA-dependent manner, genetically interacts with shuttling hnRNP NAB2; overproduction suppresses transcriptional defect caused by hpr1 mutation |
YMR292W | 3.68 | 1.15E-4 | GOT1 | Homodimeric protein that is packaged into COPII vesicles and cycles between the ER and Golgi; involved in secretory transport but not directly required for aspects of transport assayed in vitro; may influence membrane composition |
YOL077W-A | 3.63 | 1.42E-4 | ATP19 | Subunit k of the mitochondrial F1F0 ATP synthase, which is a large enzyme complex required for ATP synthesis; associated only with the dimeric form of ATP synthase |
YKL034W | 3.63 | 1.43E-4 | TUL1 | Subunit of the DSC ubiquitin ligase complex; golgi-localized RING-finger ubiquitin ligase (E3) involved in sorting polar transmembrane domain containing membrane proteins to multivesicular bodies for delivery to the vacuole; proposed involvement in the quality control of misfolded TMD containing proteins; ortholog of fission yeast dsc1 |
YLR407W_p | 3.58 | 1.75E-4 | YLR407W_p | Putative protein of unknown function; null mutant displays elongated buds and a large fraction of budded cells have only one nucleus |