9130768

N-(oxolan-2-ylmethyl)-5-phenyl-2-propylfuran-3-carboxamide

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_3227
Screen concentration 49.5 μM
Source Chembridge (Drug-like library)
PubChem CID 17720899
SMILES CCCC1=C(C=C(O1)C2=CC=CC=C2)C(=O)NCC3CCCO3
Standardized SMILES CCCc1oc(cc1C(=O)NCC2CCCO2)c3ccccc3
Molecular weight 313.3908
ALogP 3.58
H-bond donor count 1
H-bond acceptor count 3
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 9.56
% growth inhibition (Hom. pool) 9.81


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 17720899
Download HIP data (tab-delimited text)  (excel)
Gene:SED5(YLR026C)|FD-Score:3.23|P-value:6.13E-4|Clearance:0.15||SGD DESC:cis-Golgi t-SNARE syntaxin required for vesicular transport between the ER and the Golgi complex, binds at least 9 SNARE proteins Gene:TEM1(YML064C)|FD-Score:3.16|P-value:8.01E-4|Clearance:0.15||SGD DESC:GTP-binding protein of the ras superfamily involved in termination of M-phase; controls actomyosin and septin dynamics during cytokinesis Gene:SED5(YLR026C)|FD-Score:3.23|P-value:6.13E-4|Clearance:0.15||SGD DESC:cis-Golgi t-SNARE syntaxin required for vesicular transport between the ER and the Golgi complex, binds at least 9 SNARE proteins Gene:TEM1(YML064C)|FD-Score:3.16|P-value:8.01E-4|Clearance:0.15||SGD DESC:GTP-binding protein of the ras superfamily involved in termination of M-phase; controls actomyosin and septin dynamics during cytokinesis

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 17720899
Download HOP data (tab-delimited text)  (excel)
Gene:AIM18(YHR198C)|FD-Score:4.61|P-value:2.06E-6||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss Gene:APM3(YBR288C)|FD-Score:4.61|P-value:2.03E-6||SGD DESC:Mu3-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway Gene:DAP1(YPL170W)|FD-Score:5.81|P-value:3.19E-9||SGD DESC:Heme-binding protein involved in regulation of cytochrome P450 protein Erg11p; damage response protein, related to mammalian membrane progesterone receptors; mutations lead to defects in telomeres, mitochondria, and sterol synthesis Gene:GCN2(YDR283C)|FD-Score:-3.09|P-value:0.00100||SGD DESC:Protein kinase, phosphorylates the alpha-subunit of translation initiation factor eIF2 (Sui2p) in response to starvation; activated by uncharged tRNAs and the Gcn1p-Gcn20p complex; contributes to DNA damage checkpoint control Gene:GPT2(YKR067W)|FD-Score:3.12|P-value:9.15E-4||SGD DESC:Glycerol-3-phosphate/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase located in lipid particles and the ER; involved in the stepwise acylation of glycerol-3-phosphate and dihydroxyacetone in lipid biosynthesis; the most conserved motifs and functionally relevant residues are oriented towards the ER lumen Gene:HEL2(YDR266C)|FD-Score:3.61|P-value:1.53E-4||SGD DESC:RING finger ubiquitin ligase (E3); involved in ubiquitylation and degradation of excess histones; interacts with Ubc4p and Rad53p; null mutant sensitive to hydroxyurea (HU); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; computational analysis suggests a role as a transcription factor Gene:IRC4(YDR540C)|FD-Score:3.39|P-value:3.49E-4||SGD DESC:Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus Gene:IRS4(YKR019C)|FD-Score:3.73|P-value:9.42E-5||SGD DESC:EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; IRS4 has a paralog, TAX4, that arose from the whole genome duplication Gene:IZH1(YDR492W)|FD-Score:-3.61|P-value:1.52E-4||SGD DESC:Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family; transcription is regulated directly by Zap1p, expression induced by zinc deficiency and fatty acids; deletion increases sensitivity to elevated zinc Gene:MCK1(YNL307C)|FD-Score:3.12|P-value:9.05E-4||SGD DESC:Protein serine/threonine/tyrosine (dual-specificity) kinase; involved in control of chromosome segregation and in regulating entry into meiosis; interacts with Clb2p and Mih1p; inhibits Clb2p-Cdk1 activity; related to mammalian glycogen synthase kinases of the GSK-3 family Gene:MCM22(YJR135C)|FD-Score:3.21|P-value:6.60E-4||SGD DESC:Outer kinetochore protein and component of the Ctf3 subcomplex; binds to centromeric DNA in a Ctf19p-dependent manner; involved in chromosome segregation and minichromosome maintenance; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-K and fission yeast sim4 Gene:MNT3(YIL014W)|FD-Score:3.52|P-value:2.18E-4||SGD DESC:Alpha-1,3-mannosyltransferase, adds the fourth and fifth alpha-1,3-linked mannose residues to O-linked glycans during protein O-glycosylation Gene:MXR1(YER042W)|FD-Score:3.11|P-value:9.50E-4||SGD DESC:Methionine-S-sulfoxide reductase, involved in the response to oxidative stress; protects iron-sulfur clusters from oxidative inactivation along with MXR2; involved in the regulation of lifespan Gene:OPI11(YPR044C_d)|FD-Score:4.29|P-value:9.11E-6||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene RPL43A/YPR043W; deletion confers sensitivity to GSAO Gene:PFA3(YNL326C)|FD-Score:3.83|P-value:6.35E-5||SGD DESC:Palmitoyltransferase for Vac8p, required for vacuolar membrane fusion; contains an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; autoacylates; required for vacuolar integrity under stress conditions Gene:PUS7(YOR243C)|FD-Score:3.17|P-value:7.49E-4||SGD DESC:Pseudouridine synthase, catalyzes pseudouridylation at positions 35 and 56 in U2 snRNA, position 50 in 5S rRNA, position 13 in cytoplasmic tRNAs, and position 35 in pre-tRNA(Tyr); conserved in archaea, vertebrates, and some bacteria Gene:RNR4(YGR180C)|FD-Score:3.1|P-value:9.78E-4||SGD DESC:Ribonucleotide-diphosphate reductase (RNR) small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits; relocalizes from nucleus to cytoplasm upon DNA replication stress Gene:SBE2(YDR351W)|FD-Score:-3.14|P-value:8.42E-4||SGD DESC:Protein involved in the transport of cell wall components from the Golgi to the cell surface; required for bud growth Gene:SNT1(YCR033W)|FD-Score:3.99|P-value:3.29E-5||SGD DESC:Subunit of the Set3C deacetylase complex that interacts directly with the Set3C subunit, Sif2p; putative DNA-binding protein; mutant has increased aneuploidy tolerance Gene:SPS22(YCL048W)|FD-Score:-3.23|P-value:6.16E-4||SGD DESC:Protein of unknown function; SPS22 has a paralog, SPS2, that arose from the whole genome duplication; redundant with Sps2p for the organization of the beta-glucan layer of the spore wall Gene:SSN3(YPL042C)|FD-Score:3.34|P-value:4.20E-4||SGD DESC:Cyclin-dependent protein kinase, component of RNA polymerase II holoenzyme; involved in phosphorylation of the RNA polymerase II C-terminal domain; involved in glucose repression Gene:TCB1(YOR086C)|FD-Score:-3.67|P-value:1.20E-4||SGD DESC:Lipid-binding ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; contains three calcium and lipid binding domains; non-tagged protein also localizes to mitochondria; C-termini of Tcb1p, Tcb2p and Tcb3p interact Gene:THR1(YHR025W)|FD-Score:3.89|P-value:4.93E-5||SGD DESC:Homoserine kinase, conserved protein required for threonine biosynthesis; expression is regulated by the GCN4-mediated general amino acid control pathway Gene:TMA16(YOR252W)|FD-Score:3.16|P-value:7.86E-4||SGD DESC:Protein of unknown function that associates with ribosomes Gene:TRP4(YDR354W)|FD-Score:-4.55|P-value:2.65E-6||SGD DESC:Anthranilate phosphoribosyl transferase of the tryptophan biosynthetic pathway, catalyzes the phosphoribosylation of anthranilate, subject to the general control system of amino acid biosynthesis Gene:TRS85(YDR108W)|FD-Score:3.75|P-value:9.00E-5||SGD DESC:Subunit of TRAPPIII (transport protein particle), a multimeric guanine nucleotide-exchange factor for Ypt1p, required for membrane expansion during autophagy and the CVT pathway; directs Ypt1p to the PAS; late post-replication meiotic role Gene:TSC3(YBR058C-A)|FD-Score:3.18|P-value:7.29E-4||SGD DESC:Protein that stimulates the activity of serine palmitoyltransferase (Lcb1p, Lcb2p) several-fold; involved in sphingolipid biosynthesis Gene:YHP1(YDR451C)|FD-Score:4.04|P-value:2.65E-5||SGD DESC:Homeobox transcriptional repressor; binds Mcm1p and early cell cycle box (ECB) elements of cell cycle regulated genes, thereby restricting ECB-mediated transcription to the M/G1 interval; YHP1 has a paralog, YOX1, that arose from the whole genome duplication Gene:YIP5(YGL161C)|FD-Score:-3.15|P-value:8.15E-4||SGD DESC:Protein that interacts with Rab GTPases, localized to late Golgi vesicles; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport Gene:YOR214C(YOR214C_p)|FD-Score:3.31|P-value:4.64E-4||SGD DESC:Putative protein of unknown function; YOR214C is not an essential gene Gene:AIM18(YHR198C)|FD-Score:4.61|P-value:2.06E-6||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss Gene:APM3(YBR288C)|FD-Score:4.61|P-value:2.03E-6||SGD DESC:Mu3-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway Gene:DAP1(YPL170W)|FD-Score:5.81|P-value:3.19E-9||SGD DESC:Heme-binding protein involved in regulation of cytochrome P450 protein Erg11p; damage response protein, related to mammalian membrane progesterone receptors; mutations lead to defects in telomeres, mitochondria, and sterol synthesis Gene:GCN2(YDR283C)|FD-Score:-3.09|P-value:0.00100||SGD DESC:Protein kinase, phosphorylates the alpha-subunit of translation initiation factor eIF2 (Sui2p) in response to starvation; activated by uncharged tRNAs and the Gcn1p-Gcn20p complex; contributes to DNA damage checkpoint control Gene:GPT2(YKR067W)|FD-Score:3.12|P-value:9.15E-4||SGD DESC:Glycerol-3-phosphate/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase located in lipid particles and the ER; involved in the stepwise acylation of glycerol-3-phosphate and dihydroxyacetone in lipid biosynthesis; the most conserved motifs and functionally relevant residues are oriented towards the ER lumen Gene:HEL2(YDR266C)|FD-Score:3.61|P-value:1.53E-4||SGD DESC:RING finger ubiquitin ligase (E3); involved in ubiquitylation and degradation of excess histones; interacts with Ubc4p and Rad53p; null mutant sensitive to hydroxyurea (HU); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; computational analysis suggests a role as a transcription factor Gene:IRC4(YDR540C)|FD-Score:3.39|P-value:3.49E-4||SGD DESC:Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus Gene:IRS4(YKR019C)|FD-Score:3.73|P-value:9.42E-5||SGD DESC:EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; IRS4 has a paralog, TAX4, that arose from the whole genome duplication Gene:IZH1(YDR492W)|FD-Score:-3.61|P-value:1.52E-4||SGD DESC:Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family; transcription is regulated directly by Zap1p, expression induced by zinc deficiency and fatty acids; deletion increases sensitivity to elevated zinc Gene:MCK1(YNL307C)|FD-Score:3.12|P-value:9.05E-4||SGD DESC:Protein serine/threonine/tyrosine (dual-specificity) kinase; involved in control of chromosome segregation and in regulating entry into meiosis; interacts with Clb2p and Mih1p; inhibits Clb2p-Cdk1 activity; related to mammalian glycogen synthase kinases of the GSK-3 family Gene:MCM22(YJR135C)|FD-Score:3.21|P-value:6.60E-4||SGD DESC:Outer kinetochore protein and component of the Ctf3 subcomplex; binds to centromeric DNA in a Ctf19p-dependent manner; involved in chromosome segregation and minichromosome maintenance; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-K and fission yeast sim4 Gene:MNT3(YIL014W)|FD-Score:3.52|P-value:2.18E-4||SGD DESC:Alpha-1,3-mannosyltransferase, adds the fourth and fifth alpha-1,3-linked mannose residues to O-linked glycans during protein O-glycosylation Gene:MXR1(YER042W)|FD-Score:3.11|P-value:9.50E-4||SGD DESC:Methionine-S-sulfoxide reductase, involved in the response to oxidative stress; protects iron-sulfur clusters from oxidative inactivation along with MXR2; involved in the regulation of lifespan Gene:OPI11(YPR044C_d)|FD-Score:4.29|P-value:9.11E-6||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene RPL43A/YPR043W; deletion confers sensitivity to GSAO Gene:PFA3(YNL326C)|FD-Score:3.83|P-value:6.35E-5||SGD DESC:Palmitoyltransferase for Vac8p, required for vacuolar membrane fusion; contains an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; autoacylates; required for vacuolar integrity under stress conditions Gene:PUS7(YOR243C)|FD-Score:3.17|P-value:7.49E-4||SGD DESC:Pseudouridine synthase, catalyzes pseudouridylation at positions 35 and 56 in U2 snRNA, position 50 in 5S rRNA, position 13 in cytoplasmic tRNAs, and position 35 in pre-tRNA(Tyr); conserved in archaea, vertebrates, and some bacteria Gene:RNR4(YGR180C)|FD-Score:3.1|P-value:9.78E-4||SGD DESC:Ribonucleotide-diphosphate reductase (RNR) small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits; relocalizes from nucleus to cytoplasm upon DNA replication stress Gene:SBE2(YDR351W)|FD-Score:-3.14|P-value:8.42E-4||SGD DESC:Protein involved in the transport of cell wall components from the Golgi to the cell surface; required for bud growth Gene:SNT1(YCR033W)|FD-Score:3.99|P-value:3.29E-5||SGD DESC:Subunit of the Set3C deacetylase complex that interacts directly with the Set3C subunit, Sif2p; putative DNA-binding protein; mutant has increased aneuploidy tolerance Gene:SPS22(YCL048W)|FD-Score:-3.23|P-value:6.16E-4||SGD DESC:Protein of unknown function; SPS22 has a paralog, SPS2, that arose from the whole genome duplication; redundant with Sps2p for the organization of the beta-glucan layer of the spore wall Gene:SSN3(YPL042C)|FD-Score:3.34|P-value:4.20E-4||SGD DESC:Cyclin-dependent protein kinase, component of RNA polymerase II holoenzyme; involved in phosphorylation of the RNA polymerase II C-terminal domain; involved in glucose repression Gene:TCB1(YOR086C)|FD-Score:-3.67|P-value:1.20E-4||SGD DESC:Lipid-binding ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; contains three calcium and lipid binding domains; non-tagged protein also localizes to mitochondria; C-termini of Tcb1p, Tcb2p and Tcb3p interact Gene:THR1(YHR025W)|FD-Score:3.89|P-value:4.93E-5||SGD DESC:Homoserine kinase, conserved protein required for threonine biosynthesis; expression is regulated by the GCN4-mediated general amino acid control pathway Gene:TMA16(YOR252W)|FD-Score:3.16|P-value:7.86E-4||SGD DESC:Protein of unknown function that associates with ribosomes Gene:TRP4(YDR354W)|FD-Score:-4.55|P-value:2.65E-6||SGD DESC:Anthranilate phosphoribosyl transferase of the tryptophan biosynthetic pathway, catalyzes the phosphoribosylation of anthranilate, subject to the general control system of amino acid biosynthesis Gene:TRS85(YDR108W)|FD-Score:3.75|P-value:9.00E-5||SGD DESC:Subunit of TRAPPIII (transport protein particle), a multimeric guanine nucleotide-exchange factor for Ypt1p, required for membrane expansion during autophagy and the CVT pathway; directs Ypt1p to the PAS; late post-replication meiotic role Gene:TSC3(YBR058C-A)|FD-Score:3.18|P-value:7.29E-4||SGD DESC:Protein that stimulates the activity of serine palmitoyltransferase (Lcb1p, Lcb2p) several-fold; involved in sphingolipid biosynthesis Gene:YHP1(YDR451C)|FD-Score:4.04|P-value:2.65E-5||SGD DESC:Homeobox transcriptional repressor; binds Mcm1p and early cell cycle box (ECB) elements of cell cycle regulated genes, thereby restricting ECB-mediated transcription to the M/G1 interval; YHP1 has a paralog, YOX1, that arose from the whole genome duplication Gene:YIP5(YGL161C)|FD-Score:-3.15|P-value:8.15E-4||SGD DESC:Protein that interacts with Rab GTPases, localized to late Golgi vesicles; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport Gene:YOR214C(YOR214C_p)|FD-Score:3.31|P-value:4.64E-4||SGD DESC:Putative protein of unknown function; YOR214C is not an essential gene

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YLR026C3.236.13E-40.15SED5cis-Golgi t-SNARE syntaxin required for vesicular transport between the ER and the Golgi complex, binds at least 9 SNARE proteins
YML064C3.168.01E-40.15TEM1GTP-binding protein of the ras superfamily involved in termination of M-phase; controls actomyosin and septin dynamics during cytokinesis
YOL022C3.080.001030.15TSR4Cytoplasmic protein required for correct processing of the 20S pre-rRNA at site D to generate mature 18S rRNA; essential gene in S288C background but not in CEN.PK2
YKL145W3.000.001330.15RPT1One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for optimal CDC20 transcription; interacts with Rpn12p and Ubr1p; mutant has aneuploidy tolerance
YGL120C2.850.002160.04PRP43RNA helicase in the DEAH-box family, functions in both RNA polymerase I and polymerase II transcript metabolism, involved in release of the lariat-intron from the spliceosome
YKL172W2.820.002410.07EBP2Required for 25S rRNA maturation and 60S ribosomal subunit assembly; localizes to the nucleolus and in foci along nuclear periphery; constituent of 66S pre-ribosomal particles; cooperates with Rrs1p and Mps3p to mediate telomere clustering by binding Sir4p, but is not involved in telomere tethering
YOR232W2.750.002960.06MGE1Mitochondrial matrix cochaperone, acts as a nucleotide release factor for Ssc1p in protein translocation and folding; also acts as cochaperone for Ssq1p in folding of Fe-S cluster proteins; homolog of E. coli GrpE
YNL061W2.690.003540.10NOP2Probable RNA m(5)C methyltransferase, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; localized to the nucleolus; constituent of 66S pre-ribosomal particles
YOR319W2.590.004780.01HSH49U2-snRNP associated splicing factor with similarity to the mammalian splicing factor SAP49; proposed to function as a U2-snRNP assembly factor along with Hsh155p and binding partner Cus1p; contains two RNA recognition motifs (RRM)
YDR394W2.580.004960.03RPT3One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; substrate of N-acetyltransferase B
YDR052C2.550.005430.06DBF4Regulatory subunit of Cdc7p-Dbf4p kinase complex; required for Cdc7p kinase activity and initiation of DNA replication; phosphorylates the Mcm2-7 family of proteins; cell cycle regulated; relative distribution to the nucleus increases upon DNA replication stress
YFL039C2.490.006430.01ACT1Actin, structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions
YDR113C2.480.006653.38E-4PDS1Securin, inhibits anaphase by binding separin Esp1p; blocks cyclin destruction and mitotic exit, essential for meiotic progression and mitotic cell cycle arrest; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation
YDL058W2.480.006650.01USO1Essential protein involved in the vesicle-mediated ER to Golgi transport step of secretion; binds membranes and functions during vesicle docking to the Golgi; required for assembly of the ER-to-Golgi SNARE complex
YKL042W2.470.006760.03SPC42Central plaque component of spindle pole body (SPB); involved in SPB duplication, may facilitate attachment of the SPB to the nuclear membrane

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YPL170W5.813.19E-9DAP1Heme-binding protein involved in regulation of cytochrome P450 protein Erg11p; damage response protein, related to mammalian membrane progesterone receptors; mutations lead to defects in telomeres, mitochondria, and sterol synthesis
YBR288C4.612.03E-6APM3Mu3-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway
YHR198C4.612.06E-6AIM18Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss
YPR044C_d4.299.11E-6OPI11_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene RPL43A/YPR043W; deletion confers sensitivity to GSAO
YDR451C4.042.65E-5YHP1Homeobox transcriptional repressor; binds Mcm1p and early cell cycle box (ECB) elements of cell cycle regulated genes, thereby restricting ECB-mediated transcription to the M/G1 interval; YHP1 has a paralog, YOX1, that arose from the whole genome duplication
YCR033W3.993.29E-5SNT1Subunit of the Set3C deacetylase complex that interacts directly with the Set3C subunit, Sif2p; putative DNA-binding protein; mutant has increased aneuploidy tolerance
YHR025W3.894.93E-5THR1Homoserine kinase, conserved protein required for threonine biosynthesis; expression is regulated by the GCN4-mediated general amino acid control pathway
YNL326C3.836.35E-5PFA3Palmitoyltransferase for Vac8p, required for vacuolar membrane fusion; contains an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; autoacylates; required for vacuolar integrity under stress conditions
YDR108W3.759.00E-5TRS85Subunit of TRAPPIII (transport protein particle), a multimeric guanine nucleotide-exchange factor for Ypt1p, required for membrane expansion during autophagy and the CVT pathway; directs Ypt1p to the PAS; late post-replication meiotic role
YKR019C3.739.42E-5IRS4EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; IRS4 has a paralog, TAX4, that arose from the whole genome duplication
YDR266C3.611.53E-4HEL2RING finger ubiquitin ligase (E3); involved in ubiquitylation and degradation of excess histones; interacts with Ubc4p and Rad53p; null mutant sensitive to hydroxyurea (HU); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; computational analysis suggests a role as a transcription factor
YIL014W3.522.18E-4MNT3Alpha-1,3-mannosyltransferase, adds the fourth and fifth alpha-1,3-linked mannose residues to O-linked glycans during protein O-glycosylation
YDR540C3.393.49E-4IRC4Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
YPL042C3.344.20E-4SSN3Cyclin-dependent protein kinase, component of RNA polymerase II holoenzyme; involved in phosphorylation of the RNA polymerase II C-terminal domain; involved in glucose repression
YOR214C_p3.314.64E-4YOR214C_pPutative protein of unknown function; YOR214C is not an essential gene

GO enrichment analysis for SGTC_3227
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.1533.84E-32SGTC_460329-0187a 2.2 μMChemDiv (Drug-like library)464948170.108108
0.1241.08E-21SGTC_900870-0863 4.6 μMChemDiv (Drug-like library)17381640.126582
0.1241.37E-21SGTC_32369132701 49.5 μMChembridge (Drug-like library)242825240.168675TSC3-RPN4
0.1232.22E-21SGTC_11951502-0147 41.1 μMChemDiv (Drug-like library)8179400.136986
0.1232.66E-21SGTC_14033909-7815 62.9 μMChemDiv (Drug-like library)66154830.116279
0.1218.14E-21SGTC_320928-0142 34.1 μMChemDiv (Drug-like library)22442420.1TSC3-RPN4
0.1211.34E-20SGTC_18584-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 μMTimTec (Natural product derivative library)7563770.111111TSC3-RPN4
0.1171.94E-19SGTC_9851493-0307 8.7 μMChemDiv (Drug-like library)32782740.0526316TSC3-RPN4
0.1132.58E-18SGTC_12991079-1439 3.7 μMChemDiv (Drug-like library)3231610.0731707TSC3-RPN4
0.1128.62E-18SGTC_8850865-0106 16.8 μMChemDiv (Drug-like library)27933800.0985916TSC3-RPN4
0.1071.16E-16SGTC_370566-0070 1.6 μMChemDiv (Drug-like library)16266860.134328
0.1062.35E-16SGTC_16014'-hydroxyflavanone 55.5 μMTimTec (Pure natural product library)1655060.125RPP1 & pyrimidine depletion
0.1054.37E-16SGTC_1604st002052 72.4 μMTimTec (Natural product derivative library)62548340.123288TSC3-RPN4
0.1057.29E-16SGTC_1679SEC14.276 6.7 μMMiscellaneous10050530.0952381Golgi
0.1049.56E-16SGTC_32399133757 49.5 μMChembridge (Drug-like library)170369230.134146

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_2899905388958.44 μM0.43756470052Chembridge (Drug-like library)276.373963.15922
SGTC_13742889-5571141 μM0.3692312853281ChemDiv (Drug-like library)269.724041.89613RSC complex & mRNA processing
SGTC_21945927483104.55 μM0.344828760979Chembridge (Fragment library)201.221241.89112
SGTC_2837900847645.46 μM0.3380282992805Chembridge (Drug-like library)328.3841.21226
SGTC_3103912082249.47 μM0.32432417141819Chembridge (Drug-like library)327.374342.9414
SGTC_14073909-790912.3 μM0.3194444411780ChemDiv (Drug-like library)319.400244.2011460S ribosome export
SGTC_3072911641949.47 μM0.31944417170162Chembridge (Drug-like library)331.793423.62113ERG2
SGTC_3226913125649.47 μM0.31578917178073Chembridge (Drug-like library)333.3292863.36815
SGTC_1918oxolan-2-ylmethyl 3-bromobenzoate70.1 μM0.313433551469TimTec (Natural product derivative library)285.133822.79203
SGTC_10593448-6867171 μM0.3132533934407ChemDiv (Drug-like library)428.90862.914