9132204

N-[2-(cyclohexen-1-yl)ethyl]-4-methyl-2-pyridin-3-yl-1,3-thiazole-5-carboxamide

[PubChem] [DrugBank] [Wikipedia] [WikiGenes] [ChEMBL] [ChemSpider] 



Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_3229
Screen concentration 49.5 μM
Source Chembridge (Drug-like library)
PubChem CID 17682924
SMILES CC1=C(SC(=N1)C2=CN=CC=C2)C(=O)NCCC3=CCCCC3
Standardized SMILES Cc1nc(sc1C(=O)NCCC2=CCCCC2)c3cccnc3
Molecular weight 327.4438
ALogP 3.17
H-bond donor count 1
H-bond acceptor count 4
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 8.72
% growth inhibition (Hom. pool) 7.79


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 17682924
Download HIP data (tab-delimited text)  (excel)
Gene:MIM1(YOL026C)|FD-Score:-3.13|P-value:8.67E-4|Clearance:0||SGD DESC:Mitochondrial protein required for outer membrane protein import; cooperates with Tom70p to import the subset of proteins with multiple alpha-helical transmembrane segments, including Ugo1p, Tom20p, and others; present in a complex with Mim2p in the outer membrane that may create a local environment to facilitate membrane insertion of substrate proteins; also has a role in assembly of Tom20p into the TOM complex Gene:PRP43(YGL120C)|FD-Score:3.58|P-value:1.70E-4|Clearance:0.61||SGD DESC:RNA helicase in the DEAH-box family, functions in both RNA polymerase I and polymerase II transcript metabolism, involved in release of the lariat-intron from the spliceosome Gene:SRB6(YBR253W)|FD-Score:3.58|P-value:1.75E-4|Clearance:0.61||SGD DESC:Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation Gene:MIM1(YOL026C)|FD-Score:-3.13|P-value:8.67E-4|Clearance:0||SGD DESC:Mitochondrial protein required for outer membrane protein import; cooperates with Tom70p to import the subset of proteins with multiple alpha-helical transmembrane segments, including Ugo1p, Tom20p, and others; present in a complex with Mim2p in the outer membrane that may create a local environment to facilitate membrane insertion of substrate proteins; also has a role in assembly of Tom20p into the TOM complex Gene:PRP43(YGL120C)|FD-Score:3.58|P-value:1.70E-4|Clearance:0.61||SGD DESC:RNA helicase in the DEAH-box family, functions in both RNA polymerase I and polymerase II transcript metabolism, involved in release of the lariat-intron from the spliceosome Gene:SRB6(YBR253W)|FD-Score:3.58|P-value:1.75E-4|Clearance:0.61||SGD DESC:Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 17682924
Download HOP data (tab-delimited text)  (excel)
Gene:DOM34(YNL001W)|FD-Score:3.54|P-value:1.97E-4||SGD DESC:Protein that facilitates ribosomal subunit dissociation; acts when translation is stalled, with binding partner Hbs1p; required for RNA cleavage in no-go decay, but reports conflict on endonuclease activity; Pelota ortholog; protein abundance increases in response to DNA replication stress; DOM34 has a paralog, YCL001W-B, that arose from the whole genome duplication Gene:FRE8(YLR047C)|FD-Score:3.68|P-value:1.17E-4||SGD DESC:Protein with sequence similarity to iron/copper reductases, involved in iron homeostasis; deletion mutant has iron deficiency/accumulation growth defects; expression increased in the absence of copper-responsive transcription factor Mac1p Gene:HAC1(YFL031W)|FD-Score:3.57|P-value:1.76E-4||SGD DESC:Basic leucine zipper (bZIP) transcription factor (ATF/CREB1 homolog); regulates the unfolded protein response, via UPRE binding, and membrane biogenesis; ER stress-induced splicing pathway facilitates efficient Hac1p synthesis; protein abundance increases in response to DNA replication stress Gene:SEC72(YLR292C)|FD-Score:3.28|P-value:5.17E-4||SGD DESC:Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER Gene:SMI1(YGR229C)|FD-Score:4.05|P-value:2.55E-5||SGD DESC:Protein involved in the regulation of cell wall synthesis; proposed to be involved in coordinating cell cycle progression with cell wall integrity Gene:SPT7(YBR081C)|FD-Score:3.21|P-value:6.61E-4||SGD DESC:Subunit of the SAGA transcriptional regulatory complex, involved in proper assembly of the complex; also present as a C-terminally truncated form in the SLIK/SALSA transcriptional regulatory complex Gene:VOA1(YGR106C)|FD-Score:4.16|P-value:1.57E-5||SGD DESC:Endoplasmic reticulum protein that functions, together with other assembly factors, in assembly of the V0 sector of the vacuolar ATPase (V-ATPase); null mutation enhances the V-ATPase deficiency of a vma21 mutant impaired in ER retrieval Gene:VPS63(YLR261C_d)|FD-Score:5.53|P-value:1.60E-8||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene YPT6; deletion causes a vacuolar protein sorting defect Gene:YDR008C(YDR008C_d)|FD-Score:-3.45|P-value:2.80E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YHR050W-A(YHR050W-A_p)|FD-Score:3.21|P-value:6.72E-4||SGD DESC:Protein of unknown function; identified by expression profiling and mass spectrometry Gene:YJR128W(YJR128W_d)|FD-Score:3.61|P-value:1.53E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RSF2 Gene:YLR053C(YLR053C_p)|FD-Score:3.81|P-value:6.89E-5||SGD DESC:Putative protein of unknown function Gene:YPR063C(YPR063C_p)|FD-Score:-3.42|P-value:3.13E-4||SGD DESC:ER-localized protein of unknown function Gene:DOM34(YNL001W)|FD-Score:3.54|P-value:1.97E-4||SGD DESC:Protein that facilitates ribosomal subunit dissociation; acts when translation is stalled, with binding partner Hbs1p; required for RNA cleavage in no-go decay, but reports conflict on endonuclease activity; Pelota ortholog; protein abundance increases in response to DNA replication stress; DOM34 has a paralog, YCL001W-B, that arose from the whole genome duplication Gene:FRE8(YLR047C)|FD-Score:3.68|P-value:1.17E-4||SGD DESC:Protein with sequence similarity to iron/copper reductases, involved in iron homeostasis; deletion mutant has iron deficiency/accumulation growth defects; expression increased in the absence of copper-responsive transcription factor Mac1p Gene:HAC1(YFL031W)|FD-Score:3.57|P-value:1.76E-4||SGD DESC:Basic leucine zipper (bZIP) transcription factor (ATF/CREB1 homolog); regulates the unfolded protein response, via UPRE binding, and membrane biogenesis; ER stress-induced splicing pathway facilitates efficient Hac1p synthesis; protein abundance increases in response to DNA replication stress Gene:SEC72(YLR292C)|FD-Score:3.28|P-value:5.17E-4||SGD DESC:Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER Gene:SMI1(YGR229C)|FD-Score:4.05|P-value:2.55E-5||SGD DESC:Protein involved in the regulation of cell wall synthesis; proposed to be involved in coordinating cell cycle progression with cell wall integrity Gene:SPT7(YBR081C)|FD-Score:3.21|P-value:6.61E-4||SGD DESC:Subunit of the SAGA transcriptional regulatory complex, involved in proper assembly of the complex; also present as a C-terminally truncated form in the SLIK/SALSA transcriptional regulatory complex Gene:VOA1(YGR106C)|FD-Score:4.16|P-value:1.57E-5||SGD DESC:Endoplasmic reticulum protein that functions, together with other assembly factors, in assembly of the V0 sector of the vacuolar ATPase (V-ATPase); null mutation enhances the V-ATPase deficiency of a vma21 mutant impaired in ER retrieval Gene:VPS63(YLR261C_d)|FD-Score:5.53|P-value:1.60E-8||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene YPT6; deletion causes a vacuolar protein sorting defect Gene:YDR008C(YDR008C_d)|FD-Score:-3.45|P-value:2.80E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YHR050W-A(YHR050W-A_p)|FD-Score:3.21|P-value:6.72E-4||SGD DESC:Protein of unknown function; identified by expression profiling and mass spectrometry Gene:YJR128W(YJR128W_d)|FD-Score:3.61|P-value:1.53E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RSF2 Gene:YLR053C(YLR053C_p)|FD-Score:3.81|P-value:6.89E-5||SGD DESC:Putative protein of unknown function Gene:YPR063C(YPR063C_p)|FD-Score:-3.42|P-value:3.13E-4||SGD DESC:ER-localized protein of unknown function

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YGL120C3.581.70E-40.61PRP43RNA helicase in the DEAH-box family, functions in both RNA polymerase I and polymerase II transcript metabolism, involved in release of the lariat-intron from the spliceosome
YBR253W3.581.75E-40.61SRB6Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
YKL196C2.970.001500.07YKT6Vesicle membrane protein (v-SNARE) with acyltransferase activity; involved in trafficking to and within the Golgi, endocytic trafficking to the vacuole, and vacuolar fusion; membrane localization due to prenylation at the carboxy-terminus
YPR137W2.900.001870.05RRP9Protein involved in pre-rRNA processing, associated with U3 snRNP; component of small ribosomal subunit (SSU) processosome; ortholog of the human U3-55k protein
YPL153C2.850.002180.26RAD53Protein kinase, required for cell-cycle arrest in response to DNA damage; activated by trans autophosphorylation when interacting with hyperphosphorylated Rad9p; also interacts with ARS1 and plays a role in initiation of DNA replication
YLR298C2.600.004710.05YHC1Component of the U1 snRNP complex required for pre-mRNA splicing; putative ortholog of human U1C protein, which is involved in formation of a complex between U1 snRNP and the pre-mRNA 5' splice site
YOR148C2.550.005430.04SPP2Essential protein that promotes the first step of splicing and is required for the final stages of spliceosome maturation; interacts with Prp2p, which may release Spp2p from the spliceosome following the first cleavage reaction
YGL103W2.510.006010.01RPL28Ribosomal 60S subunit protein L28; homologous to mammalian ribosomal protein L27A and bacterial L15; may have peptidyl transferase activity; can mutate to cycloheximide resistance
YKL182W2.500.006190.11FAS1Beta subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains acetyltransacylase, dehydratase, enoyl reductase, malonyl transacylase, and palmitoyl transacylase activities
YNR017W2.390.008320.07TIM23Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); involved in protein import into mitochondrial matrix and inner membrane; with Tim17p, contributes to architecture and function of the import channel
YNL132W2.320.010200.09KRE33Essential protein, required for biogenesis of the small ribosomal subunit; heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance
YCL041C_d2.230.012800.02YCL041C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps both the verified gene PDI1/YCL043C and the uncharacterized gene YCL042W
YBL097W2.210.013600.01BRN1Subunit of the condensin complex; required for chromosome condensation and for clustering of tRNA genes at the nucleolus; may influence multiple aspects of chromosome transmission
YAL038W2.200.013900.07CDC19Pyruvate kinase; functions as a homotetramer in glycolysis to convert phosphoenolpyruvate to pyruvate, the input for aerobic (TCA cycle) or anaerobic (glucose fermentation) respiration; regulated via allosteric activation by fructose bisphosphate; CDC19 has a paralog, PYK2, that arose from the whole genome duplication
YNL287W2.130.016600.01SEC21Gamma subunit of coatomer, a heptameric protein complex that together with Arf1p forms the COPI coat; involved in ER to Golgi transport of selective cargo

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YLR261C_d5.531.60E-8VPS63_dDubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene YPT6; deletion causes a vacuolar protein sorting defect
YGR106C4.161.57E-5VOA1Endoplasmic reticulum protein that functions, together with other assembly factors, in assembly of the V0 sector of the vacuolar ATPase (V-ATPase); null mutation enhances the V-ATPase deficiency of a vma21 mutant impaired in ER retrieval
YGR229C4.052.55E-5SMI1Protein involved in the regulation of cell wall synthesis; proposed to be involved in coordinating cell cycle progression with cell wall integrity
YLR053C_p3.816.89E-5YLR053C_pPutative protein of unknown function
YLR047C3.681.17E-4FRE8Protein with sequence similarity to iron/copper reductases, involved in iron homeostasis; deletion mutant has iron deficiency/accumulation growth defects; expression increased in the absence of copper-responsive transcription factor Mac1p
YJR128W_d3.611.53E-4YJR128W_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RSF2
YFL031W3.571.76E-4HAC1Basic leucine zipper (bZIP) transcription factor (ATF/CREB1 homolog); regulates the unfolded protein response, via UPRE binding, and membrane biogenesis; ER stress-induced splicing pathway facilitates efficient Hac1p synthesis; protein abundance increases in response to DNA replication stress
YNL001W3.541.97E-4DOM34Protein that facilitates ribosomal subunit dissociation; acts when translation is stalled, with binding partner Hbs1p; required for RNA cleavage in no-go decay, but reports conflict on endonuclease activity; Pelota ortholog; protein abundance increases in response to DNA replication stress; DOM34 has a paralog, YCL001W-B, that arose from the whole genome duplication
YLR292C3.285.17E-4SEC72Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
YBR081C3.216.61E-4SPT7Subunit of the SAGA transcriptional regulatory complex, involved in proper assembly of the complex; also present as a C-terminally truncated form in the SLIK/SALSA transcriptional regulatory complex
YHR050W-A_p3.216.72E-4YHR050W-A_pProtein of unknown function; identified by expression profiling and mass spectrometry
YGR011W_d3.050.00113YGR011W_dDubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YEL033W_p3.030.00122MTC7_pPredicted metabolic role based on network analysis derived from ChIP experiments, a large-scale deletion study and localization of transcription factor binding sites; null mutant is sensitive to temperature oscillation in a cdc13-1 mutant
YMR242C3.030.00122RPL20ARibosomal 60S subunit protein L20A; homologous to mammalian ribosomal protein L18A, no bacterial homolog; RPL20A has a paralog, RPL20B, that arose from the whole genome duplication
YLR062C_d3.010.00132BUD28_dDubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene RPL22A; diploid mutant displays a weak budding pattern phenotype in a systematic assay

GO enrichment analysis for SGTC_3229
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.1648.59E-37SGTC_220964-0034 14.5 μMChemDiv (Drug-like library)1384020.0422535unfolded protein response
0.1111.91E-17SGTC_3531988-1175 58.3 μMChemDiv (Drug-like library)27883570.142857unfolded protein response
0.1024.06E-15SGTC_13231348-1351 11.2 μMChemDiv (Drug-like library)69896540.0978261
0.1001.34E-14SGTC_160428-0027 22.8 μMChemDiv (Drug-like library)39673390.0533333unfolded protein response
0.0991.97E-14SGTC_28659030313 52.0 μMChembridge (Drug-like library)425627540.117647
0.0864.64E-11SGTC_30789116413 49.5 μMChembridge (Drug-like library)171773220.126316unfolded protein response
0.0813.81E-10SGTC_1470k295-0292 231.0 μMChemDiv (Drug-like library)50456120.162791
0.0814.35E-10SGTC_11841269-1718 139.0 μMChemDiv (Drug-like library)54038210.1375
0.0814.51E-10SGTC_31859108267 49.5 μMChembridge (Drug-like library)49104860.090909160S ribosome export
0.0806.14E-10SGTC_28519015922 71.4 μMChembridge (Drug-like library)29968930.148148
0.0791.02E-9SGTC_21465545642 200.0 μMChembridge (Fragment library)8253260.0759494
0.0714.49E-8SGTC_5313788-1495 174.0 μMChemDiv (Drug-like library)28966550.144578unfolded protein response
0.0714.52E-8SGTC_1080509-0257 621.1 μMChemDiv (Drug-like library)5366240.121622
0.0715.60E-8SGTC_32679137951 49.5 μMChembridge (Drug-like library)166439860.0930233
0.0708.12E-8SGTC_12390337-0584 35.4 μMChemDiv (Drug-like library)9143010.0779221unfolded protein response

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_3337914434233.55 μM0.51562517682949Chembridge (Drug-like library)313.3493832.62415
SGTC_3215912994249.47 μM0.51515217682944Chembridge (Drug-like library)323.412083.36114
SGTC_3233913234049.47 μM0.50769217682950Chembridge (Drug-like library)329.803983.08314
SGTC_3269913782349.47 μM0.50769217682936Chembridge (Drug-like library)309.38552.9041460S ribosome export
SGTC_3251913504749.47 μM0.49253717682963Chembridge (Drug-like library)325.38492.4021560S ribosome export
SGTC_1444161-2749112.38 μM0.444444797501ChemDiv (Drug-like library)245.316863.12322DNA intercalators
SGTC_2972909361959.92 μM0.28395125236256Chembridge (Drug-like library)300.41853.51513
SGTC_2968909066333.37 μM0.2825236811Chembridge (Drug-like library)325.224123.43413
SGTC_3151909982149.47 μM0.27517174189Chembridge (Drug-like library)329.416662.03624
SGTC_3082911700849.47 μM0.27142941448529Chembridge (Drug-like library)240.300342.44112