9131665

N,N,3-trimethyl-4-propoxybenzenesulfonamide

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_3230
Screen concentration 49.5 μM
Source Chembridge (Drug-like library)
PubChem CID 15943720
SMILES CCCOC1=C(C=C(C=C1)S(=O)(=O)N(C)C)C
Standardized SMILES CCCOc1ccc(cc1C)S(=O)(=O)N(C)C
Molecular weight 257.3492
ALogP 2.29
H-bond donor count 0
H-bond acceptor count 4
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 6.51
% growth inhibition (Hom. pool) 5.6


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 15943720
Download HIP data (tab-delimited text)  (excel)
Gene:CDC13(YDL220C)|FD-Score:-3.51|P-value:2.25E-4|Clearance:0||SGD DESC:Single stranded DNA-binding protein found at TG1-3 telomere G-tails; regulates telomere replication through recruitment of specific sub-complexes, but the essential function is telomere capping; autophagy and proteasome are involved in Cdc13p degradation Gene:DRE2(YKR071C)|FD-Score:-3.81|P-value:6.96E-5|Clearance:0||SGD DESC:Component of the cytosolic Fe-S protein assembly (CIA) machinery; contains an Fe-S cluster that receives electrons from NADPH via the action of Tah18pin an early step in the CIA pathway; ortholog of human Ciapin1; protein abundance increases in response to DNA replication stress Gene:GPI8(YDR331W)|FD-Score:3.29|P-value:4.94E-4|Clearance:0.33||SGD DESC:ER membrane glycoprotein subunit of the glycosylphosphatidylinositol transamidase complex that adds glycosylphosphatidylinositol (GPI) anchors to newly synthesized proteins; human PIG-K protein is a functional homolog Gene:RPC37(YKR025W)|FD-Score:3.3|P-value:4.79E-4|Clearance:0.33||SGD DESC:RNA polymerase III subunit C37 Gene:YLR379W(YLR379W_d)|FD-Score:-3.31|P-value:4.61E-4|Clearance:0||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential ORF SEC61/YLR378C Gene:YML6(YML025C)|FD-Score:-3.9|P-value:4.85E-5|Clearance:0||SGD DESC:Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L4 ribosomal protein and human mitoribosomal MRP-L4 protein; essential for viability, unlike most other mitoribosomal proteins Gene:YPD1(YDL235C)|FD-Score:-3.11|P-value:9.34E-4|Clearance:0||SGD DESC:Phosphorelay intermediate protein, phosphorylated by the plasma membrane sensor Sln1p in response to osmotic stress and then in turn phosphorylates the response regulators Ssk1p in the cytosol and Skn7p in the nucleus Gene:CDC13(YDL220C)|FD-Score:-3.51|P-value:2.25E-4|Clearance:0||SGD DESC:Single stranded DNA-binding protein found at TG1-3 telomere G-tails; regulates telomere replication through recruitment of specific sub-complexes, but the essential function is telomere capping; autophagy and proteasome are involved in Cdc13p degradation Gene:DRE2(YKR071C)|FD-Score:-3.81|P-value:6.96E-5|Clearance:0||SGD DESC:Component of the cytosolic Fe-S protein assembly (CIA) machinery; contains an Fe-S cluster that receives electrons from NADPH via the action of Tah18pin an early step in the CIA pathway; ortholog of human Ciapin1; protein abundance increases in response to DNA replication stress Gene:GPI8(YDR331W)|FD-Score:3.29|P-value:4.94E-4|Clearance:0.33||SGD DESC:ER membrane glycoprotein subunit of the glycosylphosphatidylinositol transamidase complex that adds glycosylphosphatidylinositol (GPI) anchors to newly synthesized proteins; human PIG-K protein is a functional homolog Gene:RPC37(YKR025W)|FD-Score:3.3|P-value:4.79E-4|Clearance:0.33||SGD DESC:RNA polymerase III subunit C37 Gene:YLR379W(YLR379W_d)|FD-Score:-3.31|P-value:4.61E-4|Clearance:0||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential ORF SEC61/YLR378C Gene:YML6(YML025C)|FD-Score:-3.9|P-value:4.85E-5|Clearance:0||SGD DESC:Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L4 ribosomal protein and human mitoribosomal MRP-L4 protein; essential for viability, unlike most other mitoribosomal proteins Gene:YPD1(YDL235C)|FD-Score:-3.11|P-value:9.34E-4|Clearance:0||SGD DESC:Phosphorelay intermediate protein, phosphorylated by the plasma membrane sensor Sln1p in response to osmotic stress and then in turn phosphorylates the response regulators Ssk1p in the cytosol and Skn7p in the nucleus

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 15943720
Download HOP data (tab-delimited text)  (excel)
Gene:CGI121(YML036W)|FD-Score:-3.35|P-value:4.05E-4||SGD DESC:Component of the EKC/KEOPS complex with Bud32p, Kae1p, Pcc1p, and Gon7p; EKC/KEOPS complex is required for t6A tRNA modification and may have roles in telomere maintenance and transcription; Cgi121p is dispensable for tRNA modification Gene:NMA1(YLR328W)|FD-Score:-4.7|P-value:1.31E-6||SGD DESC:Nicotinic acid mononucleotide adenylyltransferase; catalyzes the transfer of the adenylyl moiety of ATP to nicotinamide mononucleotide to form NAD; involved in pathways of NAD biosynthesis, including the de novo, NAD(+) salvage, and nicotinamide riboside salvage pathways; NMA1 has a paralog, NMA2, that arose from the whole genome duplication Gene:PEX12(YMR026C)|FD-Score:-3.34|P-value:4.21E-4||SGD DESC:C3HC4-type RING-finger peroxin and E3 ubiquitin ligase, required for peroxisome biogenesis and peroxisomal matrix protein import; forms translocation subcomplex with Pex2p and Pex10p; mutations in human homolog cause peroxisomal disorder Gene:PPG1(YNR032W)|FD-Score:-3.76|P-value:8.62E-5||SGD DESC:Putative serine/threonine protein phosphatase of the type 2A-like phosphatase family, required for glycogen accumulation; interacts with Tap42p, which binds to and regulates other protein phosphatases Gene:PPN1(YDR452W)|FD-Score:-3.11|P-value:9.31E-4||SGD DESC:Vacuolar endopolyphosphatase with a role in phosphate metabolism; functions as a homodimer; relocalizes from vacuole to cytoplasm upon DNA replication stress Gene:PPR1(YLR014C)|FD-Score:-3.19|P-value:7.17E-4||SGD DESC:Zinc finger transcription factor containing a Zn(2)-Cys(6) binuclear cluster domain, positively regulates transcription of URA1, URA3, URA4, and URA10, which are involved in de novo pyrimidine biosynthesis, in response to pyrimidine starvation; activity may be modulated by interaction with Tup1p Gene:RTA1(YGR213C)|FD-Score:3.49|P-value:2.43E-4||SGD DESC:Protein involved in 7-aminocholesterol resistance; has seven potential membrane-spanning regions; expression is induced under both low-heme and low-oxygen conditions; member of the fungal lipid-translocating exporter (LTE) family of protein Gene:SUR7(YML052W)|FD-Score:3.18|P-value:7.47E-4||SGD DESC:Plasma membrane protein that localizes to furrow-like invaginations (MCC patches); component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants Gene:TRP2(YER090W)|FD-Score:-3.34|P-value:4.12E-4||SGD DESC:Anthranilate synthase, catalyzes the initial step of tryptophan biosynthesis, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp3p Gene:VPS1(YKR001C)|FD-Score:-3.35|P-value:4.04E-4||SGD DESC:Dynamin-like GTPase required for vacuolar sorting; also involved in actin cytoskeleton organization, endocytosis, late Golgi-retention of some proteins, regulation of peroxisome biogenesis Gene:VPS52(YDR484W)|FD-Score:-4.21|P-value:1.27E-5||SGD DESC:Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; involved in localization of actin and chitin Gene:YCR087W(YCR087W_d)|FD-Score:3.71|P-value:1.05E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized gene YCR087C-A; YCR087W is not an essential gene Gene:YPL067C(YPL067C_p)|FD-Score:3.31|P-value:4.67E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YPL067C is not an essential gene Gene:CGI121(YML036W)|FD-Score:-3.35|P-value:4.05E-4||SGD DESC:Component of the EKC/KEOPS complex with Bud32p, Kae1p, Pcc1p, and Gon7p; EKC/KEOPS complex is required for t6A tRNA modification and may have roles in telomere maintenance and transcription; Cgi121p is dispensable for tRNA modification Gene:NMA1(YLR328W)|FD-Score:-4.7|P-value:1.31E-6||SGD DESC:Nicotinic acid mononucleotide adenylyltransferase; catalyzes the transfer of the adenylyl moiety of ATP to nicotinamide mononucleotide to form NAD; involved in pathways of NAD biosynthesis, including the de novo, NAD(+) salvage, and nicotinamide riboside salvage pathways; NMA1 has a paralog, NMA2, that arose from the whole genome duplication Gene:PEX12(YMR026C)|FD-Score:-3.34|P-value:4.21E-4||SGD DESC:C3HC4-type RING-finger peroxin and E3 ubiquitin ligase, required for peroxisome biogenesis and peroxisomal matrix protein import; forms translocation subcomplex with Pex2p and Pex10p; mutations in human homolog cause peroxisomal disorder Gene:PPG1(YNR032W)|FD-Score:-3.76|P-value:8.62E-5||SGD DESC:Putative serine/threonine protein phosphatase of the type 2A-like phosphatase family, required for glycogen accumulation; interacts with Tap42p, which binds to and regulates other protein phosphatases Gene:PPN1(YDR452W)|FD-Score:-3.11|P-value:9.31E-4||SGD DESC:Vacuolar endopolyphosphatase with a role in phosphate metabolism; functions as a homodimer; relocalizes from vacuole to cytoplasm upon DNA replication stress Gene:PPR1(YLR014C)|FD-Score:-3.19|P-value:7.17E-4||SGD DESC:Zinc finger transcription factor containing a Zn(2)-Cys(6) binuclear cluster domain, positively regulates transcription of URA1, URA3, URA4, and URA10, which are involved in de novo pyrimidine biosynthesis, in response to pyrimidine starvation; activity may be modulated by interaction with Tup1p Gene:RTA1(YGR213C)|FD-Score:3.49|P-value:2.43E-4||SGD DESC:Protein involved in 7-aminocholesterol resistance; has seven potential membrane-spanning regions; expression is induced under both low-heme and low-oxygen conditions; member of the fungal lipid-translocating exporter (LTE) family of protein Gene:SUR7(YML052W)|FD-Score:3.18|P-value:7.47E-4||SGD DESC:Plasma membrane protein that localizes to furrow-like invaginations (MCC patches); component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants Gene:TRP2(YER090W)|FD-Score:-3.34|P-value:4.12E-4||SGD DESC:Anthranilate synthase, catalyzes the initial step of tryptophan biosynthesis, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp3p Gene:VPS1(YKR001C)|FD-Score:-3.35|P-value:4.04E-4||SGD DESC:Dynamin-like GTPase required for vacuolar sorting; also involved in actin cytoskeleton organization, endocytosis, late Golgi-retention of some proteins, regulation of peroxisome biogenesis Gene:VPS52(YDR484W)|FD-Score:-4.21|P-value:1.27E-5||SGD DESC:Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; involved in localization of actin and chitin Gene:YCR087W(YCR087W_d)|FD-Score:3.71|P-value:1.05E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized gene YCR087C-A; YCR087W is not an essential gene Gene:YPL067C(YPL067C_p)|FD-Score:3.31|P-value:4.67E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YPL067C is not an essential gene

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YKR025W3.304.79E-40.33RPC37RNA polymerase III subunit C37
YDR331W3.294.94E-40.33GPI8ER membrane glycoprotein subunit of the glycosylphosphatidylinositol transamidase complex that adds glycosylphosphatidylinositol (GPI) anchors to newly synthesized proteins; human PIG-K protein is a functional homolog
YOR372C2.960.001510.22NDD1Transcriptional activator essential for nuclear division; localized to the nucleus; essential component of the mechanism that activates the expression of a set of late-S-phase-specific genes
YGR172C2.750.003030.05YIP1Integral membrane protein required for the biogenesis of ER-derived COPII transport vesicles; interacts with Yif1p and Yos1p; localizes to the Golgi, the ER, and COPII vesicles; homolog of human YIPF4
YNR038W2.700.003480.18DBP6Essential protein involved in ribosome biogenesis; putative ATP-dependent RNA helicase of the DEAD-box protein family
YOL120C2.520.005870.07RPL18ARibosomal 60S subunit protein L18A; intron of RPL18A pre-mRNA forms stem-loop structures that are a target for Rnt1p cleavage leading to degradation; homologous to mammalian ribosomal protein L18, no bacterial homolog; RPL18A has a paralog, RPL18B, that arose from the whole genome duplication
YJR112W2.450.007170.13NNF1Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; required for accurate chromosome segregation
YOR143C2.320.010100.01THI80Thiamine pyrophosphokinase, phosphorylates thiamine to produce the coenzyme thiamine pyrophosphate (thiamine diphosphate)
YHR172W2.310.010400.02SPC97Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque
YOR224C2.290.011000.02RPB8RNA polymerase subunit ABC14.5, common to RNA polymerases I, II, and III
YPL011C2.270.011700.11TAF3TFIID subunit (47 kDa), involved in promoter binding and RNA polymerase II transcription initiation
YHL015W2.160.015400.01RPS20Protein component of the small (40S) ribosomal subunit; overproduction suppresses mutations affecting RNA polymerase III-dependent transcription; homologous to mammalian ribosomal protein S20 and bacterial S10
YER148W2.150.015800.04SPT15TATA-binding protein, general transcription factor that interacts with other factors to form the preinitiation complex at promoters, essential for viability
YMR013C2.110.017600.02SEC59Dolichol kinase, catalyzes the terminal step in dolichyl monophosphate (Dol-P) biosynthesis; required for viability and for normal rates of lipid intermediate synthesis and protein N-glycosylation
YDR429C2.090.018300.07TIF35eIF3g subunit of the core complex of translation initiation factor 3 (eIF3), which is essential for translation; stimulates resumption of ribosomal scanning during translation reinitiation

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YCR087W_d3.711.05E-4YCR087W_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized gene YCR087C-A; YCR087W is not an essential gene
YGR213C3.492.43E-4RTA1Protein involved in 7-aminocholesterol resistance; has seven potential membrane-spanning regions; expression is induced under both low-heme and low-oxygen conditions; member of the fungal lipid-translocating exporter (LTE) family of protein
YPL067C_p3.314.67E-4YPL067C_pPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YPL067C is not an essential gene
YML052W3.187.47E-4SUR7Plasma membrane protein that localizes to furrow-like invaginations (MCC patches); component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants
YMR245W_d3.060.00111YMR245W_dDubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOR005C3.040.00119DNL4DNA ligase required for nonhomologous end-joining (NHEJ), forms stable heterodimer with required cofactor Lif1p, interacts with Nej1p; involved in meiosis, not essential for vegetative growth
YKL214C2.990.00139YRA2Member of the REF (RNA and export factor binding proteins) family; when overexpressed, can substitute for the function of Yra1p in export of poly(A)+ mRNA from the nucleus
YNL307C2.980.00144MCK1Protein serine/threonine/tyrosine (dual-specificity) kinase; involved in control of chromosome segregation and in regulating entry into meiosis; interacts with Clb2p and Mih1p; inhibits Clb2p-Cdk1 activity; related to mammalian glycogen synthase kinases of the GSK-3 family
YHL006C2.970.00147SHU1Component of the Shu complex, which promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p function
YER130C_p2.920.00175YER130C_pProtein of unknown function; transcription is regulated by Haa1p, Sok2p and Zap1p transcriptional activators; computational analysis suggests a role as a transcription factor; C. albicans homolog (MNL1) plays a role in adaptation to stress
YDR072C2.890.00192IPT1Inositolphosphotransferase, involved in synthesis of mannose-(inositol-P)2-ceramide (M(IP)2C), the most abundant sphingolipid; can mutate to resistance to the antifungals syringomycin E and DmAMP1 and to K. lactis zymocin
YNL109W_d2.780.00271YNL109W_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YNL108C
YMR039C2.770.00282SUB1Transcriptional coactivator; facilitates elongation through factors that modify RNAP II; role in peroxide resistance involving Rad2p; role in the hyperosmotic stress response through polymerase recruitment at RNAP II and RNAP III genes; protein abundance increases in response to DNA replication stress
YOR086C2.750.00300TCB1Lipid-binding ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; contains three calcium and lipid binding domains; non-tagged protein also localizes to mitochondria; C-termini of Tcb1p, Tcb2p and Tcb3p interact
YMR166C_p2.720.00327YMR166C_pPredicted transporter of the mitochondrial inner membrane; has similarity to human mitochondrial ATP-Mg/Pi carriers; YMR166C is not an essential gene

GO enrichment analysis for SGTC_3230
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID		 Tanimoto
Score		 Response
Signature
0.2214.41E-66SGTC_32269131256 49.5 μMChembridge (Drug-like library)171780730.105263
0.1382.55E-26SGTC_30869117350 49.5 μMChembridge (Drug-like library)26792650.115942
0.1232.69E-21SGTC_30969117468 49.5 μMChembridge (Drug-like library)413163110.0606061
0.1041.39E-15SGTC_21675876490 200.0 μMChembridge (Fragment library)6865340.0892857
0.0978.79E-14SGTC_21435623677 140.5 μMChembridge (Fragment library)53753130.0793651
0.0921.08E-12SGTC_840443-0269 128.8 μMChemDiv (Drug-like library)61500580.109375
0.0921.81E-12SGTC_1096rimcazole 32.2 μMNIH Clinical Collection185281190.0793651
0.0905.19E-12SGTC_28799041815 71.4 μMChembridge (Drug-like library)49429710.22807
0.0881.30E-11SGTC_9383126-1755 342.0 μMChemDiv (Drug-like library)17777710.0952381
0.0871.92E-11SGTC_2491paeonol 100.0 μMMicrosource (Natural product library)110920.134615
0.0848.38E-11SGTC_21075363541 170.2 μMChembridge (Fragment library)2440520.211538
0.0832.13E-10SGTC_2763lisinopril 49.3 μMMiscellaneous53621190.0617284
0.0822.82E-10SGTC_1805st050013 60.3 μMTimTec (Natural product derivative library)40371440.153846
0.0815.81E-10SGTC_24355706476 10.6 μMMiscellaneous57253750.106061
0.0732.03E-8SGTC_31119122088 49.5 μMChembridge (Drug-like library)168767040.0985916

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count		 H-bond
acceptor
count		 Response
Signature
SGTC_3354915161271.43 μM0.44444427261949Chembridge (Drug-like library)334.433183.78715
SGTC_23809035439200 μM0.3809526462575Chembridge (Fragment library)201.693142.33922endomembrane recycling
SGTC_2825799809458.44 μM0.3333332987815Chembridge (Drug-like library)418.506543.07407fatty acid desaturase (OLE1)
SGTC_7014424-0219185 μM0.3194442911779ChemDiv (Drug-like library)470.988344.58415calcium & mitochondrial duress
SGTC_3314913586059.43 μM0.31578925252478Chembridge (Drug-like library)346.872722.8805
SGTC_1633st00566467.9 μM0.32063822TimTec (Natural product derivative library)208.253642.88503
SGTC_1632st00565090 μM0.2941182759605TimTec (Natural product derivative library)222.280223.34103
SGTC_12910993-00255.79 μM0.274514353356ChemDiv (Drug-like library)254.280563.53613
SGTC_2813797179971.43 μM0.2711862234054Chembridge (Drug-like library)309.380662.81115
SGTC_2870903852812.99 μM0.2678576463316Chembridge (Drug-like library)325.810443.17804