Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YOL026C | 6.12 | 4.63E-10 | 0.82 | MIM1 | Mitochondrial protein required for outer membrane protein import; cooperates with Tom70p to import the subset of proteins with multiple alpha-helical transmembrane segments, including Ugo1p, Tom20p, and others; present in a complex with Mim2p in the outer membrane that may create a local environment to facilitate membrane insertion of substrate proteins; also has a role in assembly of Tom20p into the TOM complex |
YDL196W_d | 5.30 | 5.68E-8 | 0.19 | YDL196W_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame is located in promoter region of essential gene SEC31 |
YNR035C | 5.11 | 1.61E-7 | 0.27 | ARC35 | Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches; required for cortical localization of calmodulin |
YLR316C | 4.85 | 6.32E-7 | 0.32 | TAD3 | Subunit of tRNA-specific adenosine-34 deaminase, forms a heterodimer with Tad2p that converts adenosine to inosine at the wobble position of several tRNAs |
YHR101C | 4.53 | 2.94E-6 | 0.43 | BIG1 | Integral membrane protein of the endoplasmic reticulum, required for normal content of cell wall beta-1,6-glucan |
YDR510W | 4.10 | 2.11E-5 | 0.11 | SMT3 | Ubiquitin-like protein of the SUMO family, conjugated to lysine residues of target proteins; regulates chromatid cohesion, chromosome segregation, APC-mediated proteolysis, DNA replication and septin ring dynamics; phosphorylated at Ser2 |
YDR280W | 3.99 | 3.36E-5 | 0.11 | RRP45 | Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp45p (PM/SCL-75, EXOSC9); protein abundance increases in response to DNA replication stress |
YGL099W | 3.87 | 5.37E-5 | 0.02 | LSG1 | Putative GTPase involved in 60S ribosomal subunit biogenesis; required for the release of Nmd3p from 60S subunits in the cytoplasm |
YNR016C | 3.85 | 5.91E-5 | 0.08 | ACC1 | Acetyl-CoA carboxylase, biotin containing enzyme; catalyzes the carboxylation of cytosolic acetyl-CoA to form malonyl-CoA and regulates histone acetylation by regulating the availablity of acetyl-CoA; required for de novo biosynthesis of long-chain fatty acids; |
YDR373W | 3.77 | 8.11E-5 | 0.00 | FRQ1 | N-myristoylated calcium-binding protein that may have a role in intracellular signaling through its regulation of the phosphatidylinositol 4-kinase Pik1p; member of the recoverin/frequenin branch of the EF-hand superfamily |
YER133W | 3.77 | 8.15E-5 | 0.01 | GLC7 | Type 1 serine/threonine protein phosphatase catalytic subunit; involved in various processes including glycogen metabolism, sporulation, mitosis; accumulates at mating projections by interaction with Afr1p; interacts with many regulatory subunits; involved in regulation of the nucleocytoplasmic shuttling of Hxk2p; import into nucleus is inhibited during spindle assembly checkpoint arrest |
YLR197W | 3.76 | 8.65E-5 | 0.09 | NOP56 | Essential evolutionarily-conserved nucleolar protein component of the box C/D snoRNP complexes that direct 2'-O-methylation of pre-rRNA during its maturation; overexpression causes spindle orientation defects |
YPL235W | 3.67 | 1.22E-4 | 0.02 | RVB2 | ATP-dependent DNA helicase, also known as reptin; member of the AAA+ and RuvB protein families, similar to Rvb1p; conserved component of multiple complexes including the INO80 complex, the Swr1 complex, and the R2TP complex (Rvb1-Rvb2-Tah1-Pih1); involved in multiple processes such as chromatin remodeling, box C/D snoRNP assembly, and RNA polymerase II assembly |
YBL004W | 3.65 | 1.33E-4 | 0.11 | UTP20 | Component of the small-subunit (SSU) processome, which is involved in the biogenesis of the 18S rRNA |
YLR359W | 3.54 | 2.01E-4 | 0.14 | ADE13 | Adenylosuccinate lyase, catalyzes two steps in the 'de novo' purine nucleotide biosynthetic pathway; expression is repressed by adenine and activated by Bas1p and Pho2p; mutations in human ortholog ADSL cause adenylosuccinase deficiency |