9133757

3-(8-chloro-2,3,3a,4,5,9b-hexahydrofuro[3,2-c]quinolin-4-yl)phenol

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_3239
Screen concentration 49.5 μM
Source Chembridge (Drug-like library)
PubChem CID 17036923
SMILES C1COC2C1C(NC3=C2C=C(C=C3)Cl)C4=CC(=CC=C4)O
Standardized SMILES Oc1cccc(c1)C2Nc3ccc(Cl)cc3C4OCCC24
Molecular weight 301.7674
ALogP 3.42
H-bond donor count 2
H-bond acceptor count 3
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 5.21
% growth inhibition (Hom. pool) 5.69


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 17036923
Download HIP data (tab-delimited text)  (excel)
Gene:ILS1(YBL076C)|FD-Score:-3.21|P-value:6.69E-4|Clearance:0||SGD DESC:Cytoplasmic isoleucine-tRNA synthetase, target of the G1-specific inhibitor reveromycin A Gene:RIB5(YBR256C)|FD-Score:3.66|P-value:1.24E-4|Clearance:0.51||SGD DESC:Riboflavin synthase; catalyzes the last step of the riboflavin biosynthesis pathway Gene:SCL1(YGL011C)|FD-Score:3.15|P-value:8.16E-4|Clearance:0.26||SGD DESC:Alpha 1 subunit of the 20S proteasome involved in the degradation of ubiquitinated substrates; 20S proteasome is the core complex of the 26S proteasome; essential for growth; detected in the mitochondria Gene:ILS1(YBL076C)|FD-Score:-3.21|P-value:6.69E-4|Clearance:0||SGD DESC:Cytoplasmic isoleucine-tRNA synthetase, target of the G1-specific inhibitor reveromycin A Gene:RIB5(YBR256C)|FD-Score:3.66|P-value:1.24E-4|Clearance:0.51||SGD DESC:Riboflavin synthase; catalyzes the last step of the riboflavin biosynthesis pathway Gene:SCL1(YGL011C)|FD-Score:3.15|P-value:8.16E-4|Clearance:0.26||SGD DESC:Alpha 1 subunit of the 20S proteasome involved in the degradation of ubiquitinated substrates; 20S proteasome is the core complex of the 26S proteasome; essential for growth; detected in the mitochondria

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 17036923
Download HOP data (tab-delimited text)  (excel)
Gene:AIF1(YNR074C)|FD-Score:-3.45|P-value:2.78E-4||SGD DESC:Mitochondrial cell death effector that translocates to the nucleus in response to apoptotic stimuli, homolog of mammalian Apoptosis-Inducing Factor, putative reductase Gene:ARF2(YDL137W)|FD-Score:4.07|P-value:2.38E-5||SGD DESC:ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated formation vesicles in intracellular trafficking within the Golgi; ARF2 has a paralog, ARF1, that arose from the whole genome duplication Gene:CLB5(YPR120C)|FD-Score:3.64|P-value:1.35E-4||SGD DESC:B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1 phase Gene:GPM2(YDL021W)|FD-Score:3.87|P-value:5.42E-5||SGD DESC:Homolog of Gpm1p phosphoglycerate mutase, which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional derivative of a gene duplication event Gene:MRP2(YPR166C)|FD-Score:4.78|P-value:8.94E-7||SGD DESC:Mitochondrial ribosomal protein of the small subunit Gene:OPI11(YPR044C_d)|FD-Score:3.52|P-value:2.17E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene RPL43A/YPR043W; deletion confers sensitivity to GSAO Gene:PES4(YFR023W)|FD-Score:3.31|P-value:4.65E-4||SGD DESC:Poly(A) binding protein, suppressor of DNA polymerase epsilon mutation; PES4 has a paralog, MIP6, that arose from the whole genome duplication Gene:SPH1(YLR313C)|FD-Score:3.57|P-value:1.77E-4||SGD DESC:Protein involved in shmoo formation and bipolar bud site selection; homologous to Spa2p, localizes to sites of polarized growth in a cell cycle dependent- and Spa2p-dependent manner, interacts with MAPKKs Mkk1p, Mkk2p, and Ste7p Gene:TCB1(YOR086C)|FD-Score:-4.47|P-value:4.00E-6||SGD DESC:Lipid-binding ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; contains three calcium and lipid binding domains; non-tagged protein also localizes to mitochondria; C-termini of Tcb1p, Tcb2p and Tcb3p interact Gene:UPC2(YDR213W)|FD-Score:3.69|P-value:1.11E-4||SGD DESC:Sterol regulatory element binding protein; induces transcription of sterol biosynthetic genes and of DAN/TIR gene products; relocates from intracellular membranes to perinuclear foci on sterol depletion; UPC2 has a paralog, ECM22, that arose from the whole genome duplication Gene:YGL041C(YGL041C_d)|FD-Score:3.3|P-value:4.89E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YIL025C(YIL025C_d)|FD-Score:3.69|P-value:1.10E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:AIF1(YNR074C)|FD-Score:-3.45|P-value:2.78E-4||SGD DESC:Mitochondrial cell death effector that translocates to the nucleus in response to apoptotic stimuli, homolog of mammalian Apoptosis-Inducing Factor, putative reductase Gene:ARF2(YDL137W)|FD-Score:4.07|P-value:2.38E-5||SGD DESC:ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated formation vesicles in intracellular trafficking within the Golgi; ARF2 has a paralog, ARF1, that arose from the whole genome duplication Gene:CLB5(YPR120C)|FD-Score:3.64|P-value:1.35E-4||SGD DESC:B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1 phase Gene:GPM2(YDL021W)|FD-Score:3.87|P-value:5.42E-5||SGD DESC:Homolog of Gpm1p phosphoglycerate mutase, which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional derivative of a gene duplication event Gene:MRP2(YPR166C)|FD-Score:4.78|P-value:8.94E-7||SGD DESC:Mitochondrial ribosomal protein of the small subunit Gene:OPI11(YPR044C_d)|FD-Score:3.52|P-value:2.17E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene RPL43A/YPR043W; deletion confers sensitivity to GSAO Gene:PES4(YFR023W)|FD-Score:3.31|P-value:4.65E-4||SGD DESC:Poly(A) binding protein, suppressor of DNA polymerase epsilon mutation; PES4 has a paralog, MIP6, that arose from the whole genome duplication Gene:SPH1(YLR313C)|FD-Score:3.57|P-value:1.77E-4||SGD DESC:Protein involved in shmoo formation and bipolar bud site selection; homologous to Spa2p, localizes to sites of polarized growth in a cell cycle dependent- and Spa2p-dependent manner, interacts with MAPKKs Mkk1p, Mkk2p, and Ste7p Gene:TCB1(YOR086C)|FD-Score:-4.47|P-value:4.00E-6||SGD DESC:Lipid-binding ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; contains three calcium and lipid binding domains; non-tagged protein also localizes to mitochondria; C-termini of Tcb1p, Tcb2p and Tcb3p interact Gene:UPC2(YDR213W)|FD-Score:3.69|P-value:1.11E-4||SGD DESC:Sterol regulatory element binding protein; induces transcription of sterol biosynthetic genes and of DAN/TIR gene products; relocates from intracellular membranes to perinuclear foci on sterol depletion; UPC2 has a paralog, ECM22, that arose from the whole genome duplication Gene:YGL041C(YGL041C_d)|FD-Score:3.3|P-value:4.89E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YIL025C(YIL025C_d)|FD-Score:3.69|P-value:1.10E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YBR256C3.661.24E-40.52RIB5Riboflavin synthase; catalyzes the last step of the riboflavin biosynthesis pathway
YGL011C3.158.16E-40.26SCL1Alpha 1 subunit of the 20S proteasome involved in the degradation of ubiquitinated substrates; 20S proteasome is the core complex of the 26S proteasome; essential for growth; detected in the mitochondria
YER094C2.890.001930.07PUP3Beta 3 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit C10
YPL210C2.820.002420.04SRP72Core component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane
YDR170C2.780.002760.03SEC7Guanine nucleotide exchange factor (GEF) for ADP ribosylation factors involved in proliferation of the Golgi, intra-Golgi transport and ER-to-Golgi transport; found in the cytoplasm and on Golgi-associated coated vesicles
YER003C2.740.003040.00PMI40Mannose-6-phosphate isomerase, catalyzes the interconversion of fructose-6-P and mannose-6-P; required for early steps in protein mannosylation
YLR275W2.740.003050.24SMD2Core Sm protein Sm D2; part of heteroheptameric complex (with Smb1p, Smd1p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D2
YPL075W2.510.006100.06GCR1Transcriptional activator of genes involved in glycolysis; DNA-binding protein that interacts and functions with the transcriptional activator Gcr2p
YDL105W2.450.007162.44E-4NSE4Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair
YOR174W2.450.007160.08MED4Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
YLR005W2.370.008870.02SSL1Component of the core form of RNA polymerase transcription factor TFIIH, which has both protein kinase and DNA-dependent ATPase/helicase activities and is essential for transcription and nucleotide excision repair; interacts with Tfb4p
YJL050W2.350.009400.07MTR4ATP-dependent 3'-5' RNA helicase of the DExD/H family; involved in nuclear RNA processing and degradation both as a component of TRAMP complex and in TRAMP-independent processes; TRAMP unwinds RNA duplexes, with Mtr4p unwinding activity stimulated by Pap2p/Air2p but not dependent on ongoing polyadenylation; contains an arch domain, with two coiled-coil arms/stalks and a globular fist/KOW domain, which has RNA binding activity and is required for 5.8S rRNA processing
YLR033W2.280.011400.03RSC58Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance
YGR048W2.250.012300.01UFD1Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase; polyubiquitin binding protein that assists in the dislocation of misfolded, ERAD substrates that are subsequently delivered to the proteasome for degradation; involved in regulated destruction of ER membrane proteins such as HMG-CoA reductase (Hmg1/2p) and cytoplasmic proteins (Fbp1p); involved in mobilizing membrane bound transaction factors by regulated Ub/proteasome-dependent processing (RUP)
YPR182W2.240.012700.05SMX3Core Sm protein Sm F; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Sme1p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm F

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YPR166C4.788.94E-7MRP2Mitochondrial ribosomal protein of the small subunit
YDL137W4.072.38E-5ARF2ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated formation vesicles in intracellular trafficking within the Golgi; ARF2 has a paralog, ARF1, that arose from the whole genome duplication
YDL021W3.875.42E-5GPM2Homolog of Gpm1p phosphoglycerate mutase, which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional derivative of a gene duplication event
YIL025C_d3.691.10E-4YIL025C_dDubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR213W3.691.11E-4UPC2Sterol regulatory element binding protein; induces transcription of sterol biosynthetic genes and of DAN/TIR gene products; relocates from intracellular membranes to perinuclear foci on sterol depletion; UPC2 has a paralog, ECM22, that arose from the whole genome duplication
YPR120C3.641.35E-4CLB5B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1 phase
YLR313C3.571.77E-4SPH1Protein involved in shmoo formation and bipolar bud site selection; homologous to Spa2p, localizes to sites of polarized growth in a cell cycle dependent- and Spa2p-dependent manner, interacts with MAPKKs Mkk1p, Mkk2p, and Ste7p
YPR044C_d3.522.17E-4OPI11_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene RPL43A/YPR043W; deletion confers sensitivity to GSAO
YFR023W3.314.65E-4PES4Poly(A) binding protein, suppressor of DNA polymerase epsilon mutation; PES4 has a paralog, MIP6, that arose from the whole genome duplication
YGL041C_d3.304.89E-4YGL041C_dDubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR222W_p3.070.00107YDR222W_pProtein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YMR060C3.030.00123SAM37Component of the Sorting and Assembly Machinery (SAM or TOB complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their outer membrane insertion; contributes to SAM complex stability
YNL299W2.970.00150TRF5Non-canonical poly(A) polymerase, involved in nuclear RNA degradation as a component of the TRAMP complex; catalyzes polyadenylation of hypomodified tRNAs, and snoRNA and rRNA precursors; overlapping but non-redundant functions with Pap2p
YKL161C2.940.00164KDX1Protein kinase implicated in the Slt2p mitogen-activated (MAP) kinase signaling pathway; interacts with numerous components in the mating pheromone and CWI MAPK pathways; associates with Rlm1p
YBR288C2.910.00182APM3Mu3-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway

GO enrichment analysis for SGTC_3239
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.1049.56E-16SGTC_32279130768 49.5 μMChembridge (Drug-like library)177208990.134146
0.0961.54E-13SGTC_32569138902 49.5 μMChembridge (Drug-like library)172287730.0657895PDR1
0.0857.35E-11SGTC_13161272-0050 65.9 μMChemDiv (Drug-like library)73403920.0555556
0.0808.50E-10SGTC_25354',4'-dimethoxydalbergione 51.2 μMMicrosource (Natural product library)3641060.0394737DNA damage response
0.0731.61E-8SGTC_32419133421 49.5 μMChembridge (Drug-like library)170182210.125PDR1
0.0672.79E-7SGTC_32689137683 49.5 μMChembridge (Drug-like library)19532280.0519481
0.0663.86E-7SGTC_32739137859 49.5 μMChembridge (Drug-like library)23772340.0547945
0.0631.21E-6SGTC_2598perillyl alcohol 100.0 μMMicrosource (Natural product library)108190.0909091
0.0612.37E-6SGTC_2703st077852 53.4 μMTimTec (Natural product derivative library)62818360.0659341
0.0595.85E-6SGTC_30359091303 49.5 μMChembridge (Drug-like library)252370020.0810811
0.0571.31E-5SGTC_24275545055 42.8 μMMiscellaneous53728580.0540541
0.0571.39E-5SGTC_2532xanthone 78.9 μMMicrosource (Natural product library)70200.0877193
0.0571.40E-5SGTC_30369090181 49.5 μMChembridge (Drug-like library)252365860.0649351
0.0561.52E-5SGTC_8730591-4978 488.0 μMChemDiv (Drug-like library)33051450.0641026
0.0552.46E-5SGTC_1990st072050 59.8 μMTimTec (Natural product derivative library)172339480.0769231

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_1923st05845819.1 μM0.2741943534982TimTec (Natural product derivative library)240.253982.85713
SGTC_465cgp-3715741 μM0.2615382688ICCB bioactive library324.224944.12612
SGTC_23609040895200 μM0.2419354914414Chembridge (Fragment library)239.6551.24613RPP1 & pyrimidine depletion
SGTC_448monastrol171 μM0.2361112987927ICCB bioactive library292.353442.45934
SGTC_1781st03872566.3 μM0.2307694270275TimTec (Natural product derivative library)301.767443.50413NEO1
SGTC_1805st05001360.3 μM0.2285714037144TimTec (Natural product derivative library)331.836484.38313
SGTC_11473809-104512.3 μM0.22807325925ChemDiv (Drug-like library)293.402723.42322
SGTC_1090efavirenz20.7 μM0.22222264139Miscellaneous315.674974.38115
SGTC_1846st05624414.8 μM0.2205885393182TimTec (Natural product derivative library)286.709744.24713
SGTC_2094077-0173175.59 μM0.21739115993494ChemDiv (Drug-like library)284.740223.53903