1315-0088

2,4-dibromo-6-[[(4,6-dimethyl-1,3-benzothiazol-2-yl)amino]methylidene]cyclohexa-2,4-dien-1-one

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_324
Screen concentration 19.6 μM
Source ChemDiv (Drug-like library)
PubChem CID 6787421
SMILES CC1=CC(=C2C(=C1)SC(=N2)NC=C3C=C(C=C(C3=O)Br)Br)C
Standardized SMILES Cc1cc(C)c2nc(N=Cc3cc(Br)cc(Br)c3O)sc2c1
Molecular weight 440.1523
ALogP 4.6
H-bond donor count 1
H-bond acceptor count 4
Response signature RSC & ERG11

Pool Growth Kinetics
% growth inhibition (Het. pool) 18.63
% growth inhibition (Hom. pool) 11.26


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 6787421
Download HIP data (tab-delimited text)  (excel)
Gene:ARP9(YMR033W)|FD-Score:3.95|P-value:3.83E-5|Clearance:0.02||SGD DESC:Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation Gene:DAD1(YDR016C)|FD-Score:5.58|P-value:1.19E-8|Clearance:0.49||SGD DESC:Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis Gene:DML1(YMR211W)|FD-Score:5.96|P-value:1.29E-9|Clearance:0.37||SGD DESC:Essential protein involved in mtDNA inheritance, may also function in the partitioning of the mitochondrial organelle or in the segregation of chromosomes, exhibits regions similar to members of a GTPase family Gene:ERG11(YHR007C)|FD-Score:4.44|P-value:4.54E-6|Clearance:0.02||SGD DESC:Lanosterol 14-alpha-demethylase; catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 family; associated and coordinately regulated with the P450 reductase Ncp1p Gene:GLN1(YPR035W)|FD-Score:3.45|P-value:2.78E-4|Clearance:0.16||SGD DESC:Glutamine synthetase (GS); synthesizes glutamine from glutamate and ammonia; with Glt1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source and by amino acid limitation; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress Gene:HSH49(YOR319W)|FD-Score:3.16|P-value:7.97E-4|Clearance:0.15||SGD DESC:U2-snRNP associated splicing factor with similarity to the mammalian splicing factor SAP49; proposed to function as a U2-snRNP assembly factor along with Hsh155p and binding partner Cus1p; contains two RNA recognition motifs (RRM) Gene:MED6(YHR058C)|FD-Score:3.2|P-value:6.97E-4|Clearance:0.04||SGD DESC:Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; protein abundance increases in response to DNA replication stress Gene:MED8(YBR193C)|FD-Score:4.23|P-value:1.19E-5|Clearance:0.11||SGD DESC:Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation Gene:NUS1(YDL193W)|FD-Score:3.27|P-value:5.44E-4|Clearance:0.07||SGD DESC:Putative prenyltransferase, required for cell viability; proposed to be involved in protein trafficking because tet-repressible mutant shows accumulation of hypoglycosylated forms of CPY Gene:RPC34(YNR003C)|FD-Score:3.58|P-value:1.71E-4|Clearance:0.13||SGD DESC:RNA polymerase III subunit C34; interacts with TFIIIB70 and is a key determinant in pol III recruitment by the preinitiation complex Gene:RSC58(YLR033W)|FD-Score:10.2|P-value:9.18E-25|Clearance:3.98||SGD DESC:Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance Gene:RSC8(YFR037C)|FD-Score:6|P-value:9.64E-10|Clearance:0.05||SGD DESC:Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters Gene:RSC9(YML127W)|FD-Score:6.23|P-value:2.34E-10|Clearance:0.23||SGD DESC:Component of the RSC chromatin remodeling complex; DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway Gene:SCM3(YDL139C)|FD-Score:3.94|P-value:4.13E-5|Clearance:0.35||SGD DESC:Nonhistone component of centromeric chromatin; binds stoichiometrically to CenH3-H4 histones, required for kinetochore assembly; required for G2/M progression and localization of Cse4p; may protect Cse4p from ubiquitylation; homolog of mammalian HJURP Gene:SFH1(YLR321C)|FD-Score:3.98|P-value:3.40E-5|Clearance:0.03||SGD DESC:Component of the RSC chromatin remodeling complex; essential gene required for cell cycle progression and maintenance of proper ploidy; phosphorylated in the G1 phase of the cell cycle; Snf5p paralog Gene:STH1(YIL126W)|FD-Score:4.67|P-value:1.48E-6|Clearance:0.24||SGD DESC:ATPase component of the RSC chromatin remodeling complex; required for expression of early meiotic genes; essential helicase-related protein homologous to Snf2p Gene:UTP20(YBL004W)|FD-Score:4.42|P-value:4.92E-6|Clearance:0.2||SGD DESC:Component of the small-subunit (SSU) processome, which is involved in the biogenesis of the 18S rRNA Gene:VRG4(YGL225W)|FD-Score:-3.35|P-value:4.07E-4|Clearance:0||SGD DESC:Golgi GDP-mannose transporter; regulates Golgi function and glycosylation in Golgi Gene:YDL196W(YDL196W_d)|FD-Score:5.09|P-value:1.80E-7|Clearance:0.42||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame is located in promoter region of essential gene SEC31 Gene:YLR140W(YLR140W_d)|FD-Score:3.29|P-value:5.00E-4|Clearance:0.02||SGD DESC:Dubious open reading frame unlikely to encode a functional protein; overlaps essential RRN5 gene which encodes a member of the UAF transcription factor involved in transcription of rDNA by RNA polymerase I Gene:YPD1(YDL235C)|FD-Score:4.12|P-value:1.93E-5|Clearance:0.13||SGD DESC:Phosphorelay intermediate protein, phosphorylated by the plasma membrane sensor Sln1p in response to osmotic stress and then in turn phosphorylates the response regulators Ssk1p in the cytosol and Skn7p in the nucleus Gene:ARP9(YMR033W)|FD-Score:3.95|P-value:3.83E-5|Clearance:0.02||SGD DESC:Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation Gene:DAD1(YDR016C)|FD-Score:5.58|P-value:1.19E-8|Clearance:0.49||SGD DESC:Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis Gene:DML1(YMR211W)|FD-Score:5.96|P-value:1.29E-9|Clearance:0.37||SGD DESC:Essential protein involved in mtDNA inheritance, may also function in the partitioning of the mitochondrial organelle or in the segregation of chromosomes, exhibits regions similar to members of a GTPase family Gene:ERG11(YHR007C)|FD-Score:4.44|P-value:4.54E-6|Clearance:0.02||SGD DESC:Lanosterol 14-alpha-demethylase; catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 family; associated and coordinately regulated with the P450 reductase Ncp1p Gene:GLN1(YPR035W)|FD-Score:3.45|P-value:2.78E-4|Clearance:0.16||SGD DESC:Glutamine synthetase (GS); synthesizes glutamine from glutamate and ammonia; with Glt1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source and by amino acid limitation; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress Gene:HSH49(YOR319W)|FD-Score:3.16|P-value:7.97E-4|Clearance:0.15||SGD DESC:U2-snRNP associated splicing factor with similarity to the mammalian splicing factor SAP49; proposed to function as a U2-snRNP assembly factor along with Hsh155p and binding partner Cus1p; contains two RNA recognition motifs (RRM) Gene:MED6(YHR058C)|FD-Score:3.2|P-value:6.97E-4|Clearance:0.04||SGD DESC:Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; protein abundance increases in response to DNA replication stress Gene:MED8(YBR193C)|FD-Score:4.23|P-value:1.19E-5|Clearance:0.11||SGD DESC:Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation Gene:NUS1(YDL193W)|FD-Score:3.27|P-value:5.44E-4|Clearance:0.07||SGD DESC:Putative prenyltransferase, required for cell viability; proposed to be involved in protein trafficking because tet-repressible mutant shows accumulation of hypoglycosylated forms of CPY Gene:RPC34(YNR003C)|FD-Score:3.58|P-value:1.71E-4|Clearance:0.13||SGD DESC:RNA polymerase III subunit C34; interacts with TFIIIB70 and is a key determinant in pol III recruitment by the preinitiation complex Gene:RSC58(YLR033W)|FD-Score:10.2|P-value:9.18E-25|Clearance:3.98||SGD DESC:Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance Gene:RSC8(YFR037C)|FD-Score:6|P-value:9.64E-10|Clearance:0.05||SGD DESC:Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters Gene:RSC9(YML127W)|FD-Score:6.23|P-value:2.34E-10|Clearance:0.23||SGD DESC:Component of the RSC chromatin remodeling complex; DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway Gene:SCM3(YDL139C)|FD-Score:3.94|P-value:4.13E-5|Clearance:0.35||SGD DESC:Nonhistone component of centromeric chromatin; binds stoichiometrically to CenH3-H4 histones, required for kinetochore assembly; required for G2/M progression and localization of Cse4p; may protect Cse4p from ubiquitylation; homolog of mammalian HJURP Gene:SFH1(YLR321C)|FD-Score:3.98|P-value:3.40E-5|Clearance:0.03||SGD DESC:Component of the RSC chromatin remodeling complex; essential gene required for cell cycle progression and maintenance of proper ploidy; phosphorylated in the G1 phase of the cell cycle; Snf5p paralog Gene:STH1(YIL126W)|FD-Score:4.67|P-value:1.48E-6|Clearance:0.24||SGD DESC:ATPase component of the RSC chromatin remodeling complex; required for expression of early meiotic genes; essential helicase-related protein homologous to Snf2p Gene:UTP20(YBL004W)|FD-Score:4.42|P-value:4.92E-6|Clearance:0.2||SGD DESC:Component of the small-subunit (SSU) processome, which is involved in the biogenesis of the 18S rRNA Gene:VRG4(YGL225W)|FD-Score:-3.35|P-value:4.07E-4|Clearance:0||SGD DESC:Golgi GDP-mannose transporter; regulates Golgi function and glycosylation in Golgi Gene:YDL196W(YDL196W_d)|FD-Score:5.09|P-value:1.80E-7|Clearance:0.42||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame is located in promoter region of essential gene SEC31 Gene:YLR140W(YLR140W_d)|FD-Score:3.29|P-value:5.00E-4|Clearance:0.02||SGD DESC:Dubious open reading frame unlikely to encode a functional protein; overlaps essential RRN5 gene which encodes a member of the UAF transcription factor involved in transcription of rDNA by RNA polymerase I Gene:YPD1(YDL235C)|FD-Score:4.12|P-value:1.93E-5|Clearance:0.13||SGD DESC:Phosphorelay intermediate protein, phosphorylated by the plasma membrane sensor Sln1p in response to osmotic stress and then in turn phosphorylates the response regulators Ssk1p in the cytosol and Skn7p in the nucleus

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 6787421
Download HOP data (tab-delimited text)  (excel)
Gene:ALG3(YBL082C)|FD-Score:-3.65|P-value:1.34E-4||SGD DESC:Dolichol-P-Man dependent alpha(1-3) mannosyltransferase, involved in the synthesis of dolichol-linked oligosaccharide donor for N-linked glycosylation of proteins Gene:ALO1(YML086C)|FD-Score:3.21|P-value:6.58E-4||SGD DESC:D-Arabinono-1,4-lactone oxidase, catalyzes the final step in biosynthesis of dehydro-D-arabinono-1,4-lactone, which is protective against oxidative stress Gene:ATP11(YNL315C)|FD-Score:3.77|P-value:8.06E-5||SGD DESC:Molecular chaperone, required for the assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase Gene:BOI2(YER114C)|FD-Score:4.44|P-value:4.43E-6||SGD DESC:Protein implicated in polar growth, functionally redundant with Boi1p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; BOI2 has a paralog, BOI1, that arose from the whole genome duplication Gene:COG6(YNL041C)|FD-Score:3.57|P-value:1.79E-4||SGD DESC:Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:CTS1(YLR286C)|FD-Score:-3.2|P-value:6.96E-4||SGD DESC:Endochitinase, required for cell separation after mitosis; transcriptional activation during the G1 phase of the cell cycle is mediated by transcription factor Ace2p Gene:FRE4(YNR060W)|FD-Score:3.28|P-value:5.19E-4||SGD DESC:Ferric reductase, reduces a specific subset of siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels Gene:GTF1(YGR102C)|FD-Score:3.2|P-value:6.90E-4||SGD DESC:Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; transposon insertion mutant is salt sensitive and null mutant has growth defects; non-tagged protein is detected in purified mitochondria Gene:IRS4(YKR019C)|FD-Score:4.8|P-value:7.76E-7||SGD DESC:EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; IRS4 has a paralog, TAX4, that arose from the whole genome duplication Gene:KRE28(YDR532C)|FD-Score:-3.27|P-value:5.37E-4||SGD DESC:Subunit of a kinetochore-microtubule binding complex with Spc105p that bridges centromeric heterochromatin and kinetochore MAPs and motors, and is also required for sister chromatid bi-orientation and kinetochore binding of SAC components Gene:MET22(YOL064C)|FD-Score:-3.54|P-value:2.03E-4||SGD DESC:Bisphosphate-3'-nucleotidase, involved in salt tolerance and methionine biogenesis; dephosphorylates 3'-phosphoadenosine-5'-phosphate and 3'-phosphoadenosine-5'-phosphosulfate, intermediates of the sulfate assimilation pathway Gene:MRPL15(YLR312W-A)|FD-Score:3.81|P-value:6.89E-5||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:NGG1(YDR176W)|FD-Score:3.95|P-value:3.84E-5||SGD DESC:Transcriptional regulator involved in glucose repression of Gal4p-regulated genes; component of transcriptional adaptor and histone acetyltransferase complexes, the ADA complex, the SAGA complex, and the SLIK complex Gene:OAF3(YKR064W)|FD-Score:3.25|P-value:5.75E-4||SGD DESC:Putative transcriptional repressor with Zn(2)-Cys(6) finger; negatively regulates transcription in response to oleate levels, based on mutant phenotype and localization to oleate-responsive promoters; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; forms nuclear foci upon DNA replication stress Gene:PUF4(YGL014W)|FD-Score:-3.66|P-value:1.27E-4||SGD DESC:Member of the PUF protein family, which is defined by the presence of Pumilio homology domains that confer RNA binding activity; preferentially binds mRNAs encoding nucleolar ribosomal RNA-processing factors Gene:RAS2(YNL098C)|FD-Score:-3.18|P-value:7.39E-4||SGD DESC:GTP-binding protein that regulates the nitrogen starvation response, sporulation, and filamentous growth; farnesylation and palmitoylation required for activity and localization to plasma membrane; homolog of mammalian Ras proto-oncogenes Gene:RDH54(YBR073W)|FD-Score:3.52|P-value:2.18E-4||SGD DESC:DNA-dependent ATPase; stimulates strand exchange by modifying the topology of double-stranded DNA; involved in recombinational repair of DNA double-strand breaks during mitosis and meiosis; proposed to be involved in crossover interference; interacts with Dmc1p; stimulates Dmc1p and Rad51p Gene:RGM1(YMR182C)|FD-Score:-3.64|P-value:1.35E-4||SGD DESC:Putative zinc finger DNA binding transcription factor; contains two N-terminal C2H2 zinc fingers and C-terminal proline rich domain; overproduction impairs cell growth and induces expression of genes involved in monosaccharide catabolism and aldehyde metabolism; regulates expression of of Y-prime telomeric elements and subtelomeric COS genes; RGM1 has a paralog, USV1, that arose from the whole genome duplication Gene:RIF1(YBR275C)|FD-Score:-3.14|P-value:8.54E-4||SGD DESC:Protein that binds to the Rap1p C-terminus and acts synergistically with Rif2p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation Gene:RPL35A(YDL191W)|FD-Score:3.43|P-value:3.03E-4||SGD DESC:Ribosomal 60S subunit protein L35A; homologous to mammalian ribosomal protein L35 and bacterial L29; RPL35A has a paralog, RPL35B, that arose from the whole genome duplication Gene:RTG3(YBL103C)|FD-Score:3.3|P-value:4.87E-4||SGD DESC:Basic helix-loop-helix-leucine zipper (bHLH/Zip) transcription factor that forms a complex with another bHLH/Zip protein, Rtg1p, to activate the retrograde (RTG) and TOR pathways Gene:SAS3(YBL052C)|FD-Score:3.72|P-value:9.88E-5||SGD DESC:Histone acetyltransferase catalytic subunit of NuA3 complex that acetylates histone H3, involved in transcriptional silencing; homolog of the mammalian MOZ proto-oncogene; mutant has aneuploidy tolerance; sas3gcn5 double mutation is lethal Gene:SCO1(YBR037C)|FD-Score:5.08|P-value:1.88E-7||SGD DESC:Copper-binding protein of mitochondrial inner membrane; required for cytochrome c oxidase activity and respiration; may function to deliver copper to cytochrome c oxidase; similar to thioredoxins; SCO1 has a paralog, SCO2, that arose from the whole genome duplication Gene:SLM5(YCR024C)|FD-Score:3.15|P-value:8.30E-4||SGD DESC:Mitochondrial asparaginyl-tRNA synthetase Gene:SNX4(YJL036W)|FD-Score:-3.31|P-value:4.62E-4||SGD DESC:Sorting nexin, involved in retrieval of late-Golgi SNAREs from post-Golgi endosomes to the trans-Golgi network and in cytoplasm to vacuole transport; contains a PX phosphoinositide-binding domain; forms complexes with Snx41p and with Atg20p Gene:SOH1(YGL127C)|FD-Score:3.28|P-value:5.21E-4||SGD DESC:Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; involved in telomere maintenance; conserved with other metazoan MED31 subunits Gene:TRP2(YER090W)|FD-Score:-3.86|P-value:5.61E-5||SGD DESC:Anthranilate synthase, catalyzes the initial step of tryptophan biosynthesis, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp3p Gene:TWF1(YGR080W)|FD-Score:5.25|P-value:7.74E-8||SGD DESC:Twinfilin, highly conserved actin monomer-sequestering protein involved in regulation of the cortical actin cytoskeleton, composed of two cofilin-like regions, localizes actin monomers to sites of rapid filament assembly Gene:UBP7(YIL156W)|FD-Score:4.14|P-value:1.70E-5||SGD DESC:Ubiquitin-specific protease that cleaves ubiquitin-protein fusions Gene:YER135C(YER135C_d)|FD-Score:-3.82|P-value:6.70E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein; YER135C is not an essential gene Gene:YGR228W(YGR228W_d)|FD-Score:3.23|P-value:6.28E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SMI1/YGR229C Gene:YKR104W(YKR104W)|FD-Score:4.51|P-value:3.25E-6||SGD DESC:Putative transporter of the multidrug resistance-associated protein (MRP) subfamily; contains a stop codon in S288C; adjacent ORFs YKR103W and YKR104W are merged in different strain backgrounds Gene:YLR279W(YLR279W_d)|FD-Score:5.06|P-value:2.06E-7||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YMR155W(YMR155W_p)|FD-Score:-3.35|P-value:3.98E-4||SGD DESC:Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen Gene:YMR265C(YMR265C_p)|FD-Score:3.12|P-value:9.17E-4||SGD DESC:Putative protein of unknown function Gene:YOL085C(YOL085C_d)|FD-Score:3.17|P-value:7.58E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOL085W-A Gene:YPL088W(YPL088W_p)|FD-Score:3.93|P-value:4.20E-5||SGD DESC:Putative aryl alcohol dehydrogenase; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance Gene:YRR1(YOR162C)|FD-Score:4.38|P-value:6.06E-6||SGD DESC:Zn2-Cys6 zinc-finger transcription factor; activates genes involved in multidrug resistance; paralog of Yrm1p, acting on an overlapping set of target genes; YRR1 has a paralog, PDR8, that arose from the whole genome duplication Gene:YSP3(YOR003W)|FD-Score:3.33|P-value:4.29E-4||SGD DESC:Putative precursor to the subtilisin-like protease III Gene:YUR1(YJL139C)|FD-Score:3.6|P-value:1.60E-4||SGD DESC:Mannosyltransferase involved in protein N-glycosylation; member of the KTR1 family; located in the Golgi apparatus; YUR1 has a paralog, KTR2, that arose from the whole genome duplication Gene:ALG3(YBL082C)|FD-Score:-3.65|P-value:1.34E-4||SGD DESC:Dolichol-P-Man dependent alpha(1-3) mannosyltransferase, involved in the synthesis of dolichol-linked oligosaccharide donor for N-linked glycosylation of proteins Gene:ALO1(YML086C)|FD-Score:3.21|P-value:6.58E-4||SGD DESC:D-Arabinono-1,4-lactone oxidase, catalyzes the final step in biosynthesis of dehydro-D-arabinono-1,4-lactone, which is protective against oxidative stress Gene:ATP11(YNL315C)|FD-Score:3.77|P-value:8.06E-5||SGD DESC:Molecular chaperone, required for the assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase Gene:BOI2(YER114C)|FD-Score:4.44|P-value:4.43E-6||SGD DESC:Protein implicated in polar growth, functionally redundant with Boi1p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; BOI2 has a paralog, BOI1, that arose from the whole genome duplication Gene:COG6(YNL041C)|FD-Score:3.57|P-value:1.79E-4||SGD DESC:Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:CTS1(YLR286C)|FD-Score:-3.2|P-value:6.96E-4||SGD DESC:Endochitinase, required for cell separation after mitosis; transcriptional activation during the G1 phase of the cell cycle is mediated by transcription factor Ace2p Gene:FRE4(YNR060W)|FD-Score:3.28|P-value:5.19E-4||SGD DESC:Ferric reductase, reduces a specific subset of siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels Gene:GTF1(YGR102C)|FD-Score:3.2|P-value:6.90E-4||SGD DESC:Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; transposon insertion mutant is salt sensitive and null mutant has growth defects; non-tagged protein is detected in purified mitochondria Gene:IRS4(YKR019C)|FD-Score:4.8|P-value:7.76E-7||SGD DESC:EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; IRS4 has a paralog, TAX4, that arose from the whole genome duplication Gene:KRE28(YDR532C)|FD-Score:-3.27|P-value:5.37E-4||SGD DESC:Subunit of a kinetochore-microtubule binding complex with Spc105p that bridges centromeric heterochromatin and kinetochore MAPs and motors, and is also required for sister chromatid bi-orientation and kinetochore binding of SAC components Gene:MET22(YOL064C)|FD-Score:-3.54|P-value:2.03E-4||SGD DESC:Bisphosphate-3'-nucleotidase, involved in salt tolerance and methionine biogenesis; dephosphorylates 3'-phosphoadenosine-5'-phosphate and 3'-phosphoadenosine-5'-phosphosulfate, intermediates of the sulfate assimilation pathway Gene:MRPL15(YLR312W-A)|FD-Score:3.81|P-value:6.89E-5||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:NGG1(YDR176W)|FD-Score:3.95|P-value:3.84E-5||SGD DESC:Transcriptional regulator involved in glucose repression of Gal4p-regulated genes; component of transcriptional adaptor and histone acetyltransferase complexes, the ADA complex, the SAGA complex, and the SLIK complex Gene:OAF3(YKR064W)|FD-Score:3.25|P-value:5.75E-4||SGD DESC:Putative transcriptional repressor with Zn(2)-Cys(6) finger; negatively regulates transcription in response to oleate levels, based on mutant phenotype and localization to oleate-responsive promoters; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; forms nuclear foci upon DNA replication stress Gene:PUF4(YGL014W)|FD-Score:-3.66|P-value:1.27E-4||SGD DESC:Member of the PUF protein family, which is defined by the presence of Pumilio homology domains that confer RNA binding activity; preferentially binds mRNAs encoding nucleolar ribosomal RNA-processing factors Gene:RAS2(YNL098C)|FD-Score:-3.18|P-value:7.39E-4||SGD DESC:GTP-binding protein that regulates the nitrogen starvation response, sporulation, and filamentous growth; farnesylation and palmitoylation required for activity and localization to plasma membrane; homolog of mammalian Ras proto-oncogenes Gene:RDH54(YBR073W)|FD-Score:3.52|P-value:2.18E-4||SGD DESC:DNA-dependent ATPase; stimulates strand exchange by modifying the topology of double-stranded DNA; involved in recombinational repair of DNA double-strand breaks during mitosis and meiosis; proposed to be involved in crossover interference; interacts with Dmc1p; stimulates Dmc1p and Rad51p Gene:RGM1(YMR182C)|FD-Score:-3.64|P-value:1.35E-4||SGD DESC:Putative zinc finger DNA binding transcription factor; contains two N-terminal C2H2 zinc fingers and C-terminal proline rich domain; overproduction impairs cell growth and induces expression of genes involved in monosaccharide catabolism and aldehyde metabolism; regulates expression of of Y-prime telomeric elements and subtelomeric COS genes; RGM1 has a paralog, USV1, that arose from the whole genome duplication Gene:RIF1(YBR275C)|FD-Score:-3.14|P-value:8.54E-4||SGD DESC:Protein that binds to the Rap1p C-terminus and acts synergistically with Rif2p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation Gene:RPL35A(YDL191W)|FD-Score:3.43|P-value:3.03E-4||SGD DESC:Ribosomal 60S subunit protein L35A; homologous to mammalian ribosomal protein L35 and bacterial L29; RPL35A has a paralog, RPL35B, that arose from the whole genome duplication Gene:RTG3(YBL103C)|FD-Score:3.3|P-value:4.87E-4||SGD DESC:Basic helix-loop-helix-leucine zipper (bHLH/Zip) transcription factor that forms a complex with another bHLH/Zip protein, Rtg1p, to activate the retrograde (RTG) and TOR pathways Gene:SAS3(YBL052C)|FD-Score:3.72|P-value:9.88E-5||SGD DESC:Histone acetyltransferase catalytic subunit of NuA3 complex that acetylates histone H3, involved in transcriptional silencing; homolog of the mammalian MOZ proto-oncogene; mutant has aneuploidy tolerance; sas3gcn5 double mutation is lethal Gene:SCO1(YBR037C)|FD-Score:5.08|P-value:1.88E-7||SGD DESC:Copper-binding protein of mitochondrial inner membrane; required for cytochrome c oxidase activity and respiration; may function to deliver copper to cytochrome c oxidase; similar to thioredoxins; SCO1 has a paralog, SCO2, that arose from the whole genome duplication Gene:SLM5(YCR024C)|FD-Score:3.15|P-value:8.30E-4||SGD DESC:Mitochondrial asparaginyl-tRNA synthetase Gene:SNX4(YJL036W)|FD-Score:-3.31|P-value:4.62E-4||SGD DESC:Sorting nexin, involved in retrieval of late-Golgi SNAREs from post-Golgi endosomes to the trans-Golgi network and in cytoplasm to vacuole transport; contains a PX phosphoinositide-binding domain; forms complexes with Snx41p and with Atg20p Gene:SOH1(YGL127C)|FD-Score:3.28|P-value:5.21E-4||SGD DESC:Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; involved in telomere maintenance; conserved with other metazoan MED31 subunits Gene:TRP2(YER090W)|FD-Score:-3.86|P-value:5.61E-5||SGD DESC:Anthranilate synthase, catalyzes the initial step of tryptophan biosynthesis, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp3p Gene:TWF1(YGR080W)|FD-Score:5.25|P-value:7.74E-8||SGD DESC:Twinfilin, highly conserved actin monomer-sequestering protein involved in regulation of the cortical actin cytoskeleton, composed of two cofilin-like regions, localizes actin monomers to sites of rapid filament assembly Gene:UBP7(YIL156W)|FD-Score:4.14|P-value:1.70E-5||SGD DESC:Ubiquitin-specific protease that cleaves ubiquitin-protein fusions Gene:YER135C(YER135C_d)|FD-Score:-3.82|P-value:6.70E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein; YER135C is not an essential gene Gene:YGR228W(YGR228W_d)|FD-Score:3.23|P-value:6.28E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SMI1/YGR229C Gene:YKR104W(YKR104W)|FD-Score:4.51|P-value:3.25E-6||SGD DESC:Putative transporter of the multidrug resistance-associated protein (MRP) subfamily; contains a stop codon in S288C; adjacent ORFs YKR103W and YKR104W are merged in different strain backgrounds Gene:YLR279W(YLR279W_d)|FD-Score:5.06|P-value:2.06E-7||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YMR155W(YMR155W_p)|FD-Score:-3.35|P-value:3.98E-4||SGD DESC:Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen Gene:YMR265C(YMR265C_p)|FD-Score:3.12|P-value:9.17E-4||SGD DESC:Putative protein of unknown function Gene:YOL085C(YOL085C_d)|FD-Score:3.17|P-value:7.58E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOL085W-A Gene:YPL088W(YPL088W_p)|FD-Score:3.93|P-value:4.20E-5||SGD DESC:Putative aryl alcohol dehydrogenase; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance Gene:YRR1(YOR162C)|FD-Score:4.38|P-value:6.06E-6||SGD DESC:Zn2-Cys6 zinc-finger transcription factor; activates genes involved in multidrug resistance; paralog of Yrm1p, acting on an overlapping set of target genes; YRR1 has a paralog, PDR8, that arose from the whole genome duplication Gene:YSP3(YOR003W)|FD-Score:3.33|P-value:4.29E-4||SGD DESC:Putative precursor to the subtilisin-like protease III Gene:YUR1(YJL139C)|FD-Score:3.6|P-value:1.60E-4||SGD DESC:Mannosyltransferase involved in protein N-glycosylation; member of the KTR1 family; located in the Golgi apparatus; YUR1 has a paralog, KTR2, that arose from the whole genome duplication

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YLR033W10.209.18E-253.98RSC58Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance
YML127W6.232.34E-100.23RSC9Component of the RSC chromatin remodeling complex; DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway
YFR037C6.009.64E-100.05RSC8Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters
YMR211W5.961.29E-90.37DML1Essential protein involved in mtDNA inheritance, may also function in the partitioning of the mitochondrial organelle or in the segregation of chromosomes, exhibits regions similar to members of a GTPase family
YDR016C5.581.19E-80.49DAD1Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis
YDL196W_d5.091.80E-70.41YDL196W_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame is located in promoter region of essential gene SEC31
YIL126W4.671.48E-60.24STH1ATPase component of the RSC chromatin remodeling complex; required for expression of early meiotic genes; essential helicase-related protein homologous to Snf2p
YHR007C4.444.54E-60.02ERG11Lanosterol 14-alpha-demethylase; catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 family; associated and coordinately regulated with the P450 reductase Ncp1p
YBL004W4.424.92E-60.20UTP20Component of the small-subunit (SSU) processome, which is involved in the biogenesis of the 18S rRNA
YBR193C4.231.19E-50.11MED8Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
YDL235C4.121.93E-50.13YPD1Phosphorelay intermediate protein, phosphorylated by the plasma membrane sensor Sln1p in response to osmotic stress and then in turn phosphorylates the response regulators Ssk1p in the cytosol and Skn7p in the nucleus
YLR321C3.983.40E-50.03SFH1Component of the RSC chromatin remodeling complex; essential gene required for cell cycle progression and maintenance of proper ploidy; phosphorylated in the G1 phase of the cell cycle; Snf5p paralog
YMR033W3.953.83E-50.02ARP9Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation
YDL139C3.944.13E-50.35SCM3Nonhistone component of centromeric chromatin; binds stoichiometrically to CenH3-H4 histones, required for kinetochore assembly; required for G2/M progression and localization of Cse4p; may protect Cse4p from ubiquitylation; homolog of mammalian HJURP
YNR003C3.581.71E-40.13RPC34RNA polymerase III subunit C34; interacts with TFIIIB70 and is a key determinant in pol III recruitment by the preinitiation complex

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YGR080W5.257.74E-8TWF1Twinfilin, highly conserved actin monomer-sequestering protein involved in regulation of the cortical actin cytoskeleton, composed of two cofilin-like regions, localizes actin monomers to sites of rapid filament assembly
YBR037C5.081.88E-7SCO1Copper-binding protein of mitochondrial inner membrane; required for cytochrome c oxidase activity and respiration; may function to deliver copper to cytochrome c oxidase; similar to thioredoxins; SCO1 has a paralog, SCO2, that arose from the whole genome duplication
YLR279W_d5.062.06E-7YLR279W_dDubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YKR019C4.807.76E-7IRS4EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; IRS4 has a paralog, TAX4, that arose from the whole genome duplication
YKR104W4.513.25E-6YKR104WPutative transporter of the multidrug resistance-associated protein (MRP) subfamily; contains a stop codon in S288C; adjacent ORFs YKR103W and YKR104W are merged in different strain backgrounds
YER114C4.444.43E-6BOI2Protein implicated in polar growth, functionally redundant with Boi1p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; BOI2 has a paralog, BOI1, that arose from the whole genome duplication
YOR162C4.386.06E-6YRR1Zn2-Cys6 zinc-finger transcription factor; activates genes involved in multidrug resistance; paralog of Yrm1p, acting on an overlapping set of target genes; YRR1 has a paralog, PDR8, that arose from the whole genome duplication
YIL156W4.141.70E-5UBP7Ubiquitin-specific protease that cleaves ubiquitin-protein fusions
YDR176W3.953.84E-5NGG1Transcriptional regulator involved in glucose repression of Gal4p-regulated genes; component of transcriptional adaptor and histone acetyltransferase complexes, the ADA complex, the SAGA complex, and the SLIK complex
YPL088W_p3.934.20E-5YPL088W_pPutative aryl alcohol dehydrogenase; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance
YLR312W-A3.816.89E-5MRPL15Mitochondrial ribosomal protein of the large subunit
YNL315C3.778.06E-5ATP11Molecular chaperone, required for the assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase
YBL052C3.729.88E-5SAS3Histone acetyltransferase catalytic subunit of NuA3 complex that acetylates histone H3, involved in transcriptional silencing; homolog of the mammalian MOZ proto-oncogene; mutant has aneuploidy tolerance; sas3gcn5 double mutation is lethal
YJL139C3.601.60E-4YUR1Mannosyltransferase involved in protein N-glycosylation; member of the KTR1 family; located in the Golgi apparatus; YUR1 has a paralog, KTR2, that arose from the whole genome duplication
YNL041C3.571.79E-4COG6Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments

GO enrichment analysis for SGTC_324
biological processes

protein complexes

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.4063.86E-233SGTC_643k048-0106 28.4 μMChemDiv (Drug-like library)67639200.383333RSC & ERG11
0.3796.35E-201SGTC_329k048-0121 21.3 μMChemDiv (Drug-like library)68329020.4RSC & ERG11
0.3642.12E-184SGTC_322k048-0136 19.3 μMChemDiv (Drug-like library)68232820.353846RSC & ERG11
0.3075.00E-129SGTC_7830848-0141 92.7 μMChemDiv (Drug-like library)67550760.448276RSC & ERG11
0.2882.85E-113SGTC_331k048-0133 24.5 μMChemDiv (Drug-like library)68135820.410714RSC & ERG11
0.2887.39E-113SGTC_590k048-0076 22.4 μMChemDiv (Drug-like library)68328140.37931RSC & ERG11
0.2832.60E-109SGTC_203k066-0004 30.9 μMChemDiv (Drug-like library)67954120.354839RSC & ERG11
0.2605.82E-92SGTC_2881315-0019 35.1 μMChemDiv (Drug-like library)68114740.191176RSC & ERG11
0.2561.60E-88SGTC_21866124449 200.0 μMChembridge (Fragment library)38341820.0649351RSC complex & mRNA processing
0.2386.43E-77SGTC_9701315-0089 19.5 μMChemDiv (Drug-like library)68110830.207792RSC & ERG11
0.2368.87E-76SGTC_7093807-1509 243.0 μMChemDiv (Drug-like library)18866770.0789474RSC complex & mRNA processing
0.2301.03E-71SGTC_22297354935 190.0 μMChembridge (Fragment library)3181120.0422535RSC complex & mRNA processing
0.2281.31E-70SGTC_342k048-0088 23.3 μMChemDiv (Drug-like library)68205700.423729RSC & ERG11
0.2283.00E-70SGTC_1652st011932 78.0 μMTimTec (Natural product derivative library)15510760.0632911RSC complex & mRNA processing
0.2274.04E-70SGTC_2534helenine 20.1 μMMicrosource (Natural product library)727240.0379747RSC complex & mRNA processing

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_7461095-002546.6 μM0.586749286ChemDiv (Drug-like library)377.055081.73915RSC & ERG11
SGTC_7830848-014192.7 μM0.4482766755076ChemDiv (Drug-like library)414.1153.30114RSC & ERG11
SGTC_342k048-008823.3 μM0.4237296820570ChemDiv (Drug-like library)413.060743.1224RSC & ERG11
SGTC_13531498-12068.11 μM0.4150946756808ChemDiv (Drug-like library)371.024062.76223mitochondrial response to ROS
SGTC_331k048-013324.5 μM0.4107146813582ChemDiv (Drug-like library)356.012721.85413RSC & ERG11
SGTC_329k048-012121.3 μM0.46832902ChemDiv (Drug-like library)480.921193.58212RSC & ERG11
SGTC_1162k048-013020.1 μM0.46797406ChemDiv (Drug-like library)431.120624.52312Golgi
SGTC_643k048-010628.4 μM0.3833336763920ChemDiv (Drug-like library)419.49573.65213RSC & ERG11
SGTC_590k048-007622.4 μM0.379316832814ChemDiv (Drug-like library)407.4601833.87413RSC & ERG11
SGTC_203k066-000430.89 μM0.3548396795412ChemDiv (Drug-like library)501.165862.52816RSC & ERG11