Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YGR253C | 4.17 | 1.55E-5 | 1.16 | PUP2 | Alpha 5 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit zeta |
YKL035W | 3.01 | 0.00130 | 0.01 | UGP1 | UDP-glucose pyrophosphorylase (UGPase); catalyses the reversible formation of UDP-Glc from glucose 1-phosphate and UTP, involved in a wide variety of metabolic pathways, expression modulated by Pho85p through Pho4p; UGP1 has a paralog, YHL012W, that arose from the whole genome duplication |
YLR409C | 3.00 | 0.00136 | 0.24 | UTP21 | Subunit of U3-containing 90S preribosome and Small Subunit (SSU) processome complexes involved in production of 18S rRNA and assembly of small ribosomal subunit; synthetic defect with STI1 Hsp90 cochaperone; human homolog linked to glaucoma |
YOR340C | 2.76 | 0.00291 | 0.01 | RPA43 | RNA polymerase I subunit A43 |
YOR257W | 2.74 | 0.00303 | 0.31 | CDC31 | Calcium-binding component of the spindle pole body (SPB) half-bridge, required for SPB duplication in mitosis and meiosis II; homolog of mammalian centrin; binds multiubiquitinated proteins and is involved in proteasomal protein degradation |
YDR341C | 2.43 | 0.00750 | 0.04 | YDR341C | Arginyl-tRNA synthetase, proposed to be cytoplasmic but the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies |
YOR160W | 2.39 | 0.00834 | 0.02 | MTR10 | Nuclear import receptor; mediates the nuclear localization of proteins involved in mRNA-nucleus export; promotes dissociation of mRNAs from the nucleus-cytoplasm mRNA shuttling protein Npl3p; required for retrograde import of mature tRNAs; relocalizes from cytoplasm to the nuclear periphery upon DNA replication stress |
YNL062C | 2.37 | 0.00878 | 0.08 | GCD10 | Subunit of tRNA (1-methyladenosine) methyltransferase with Gcd14p, required for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression |
YCL041C_d | 2.30 | 0.01080 | 0.02 | YCL041C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps both the verified gene PDI1/YCL043C and the uncharacterized gene YCL042W |
YPL210C | 2.28 | 0.01130 | 0.06 | SRP72 | Core component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane |
YBR038W | 2.22 | 0.01330 | 0.04 | CHS2 | Chitin synthase II; catalyzes transfer of N-acetylglucosamine (GlcNAc) to chitin upon activation of zymogenic form; required for chitin synthesis in the primary septum during cytokinesis; localization regulated by Cdk1p during mitosis; phosphorylation by Dbf2p kinase regulates its dynamics and chitin synthesis during cytokinesis |
YOR353C | 2.18 | 0.01480 | 0.02 | SOG2 | Key component of the RAM signaling network, required for proper cell morphogenesis and cell separation after mitosis |
YPR082C | 2.16 | 0.01560 | 0.02 | DIB1 | 17-kDa component of the U4/U6aU5 tri-snRNP, plays an essential role in pre-mRNA splicing, orthologue of hDIM1, the human U5-specific 15-kDa protein |
YOR176W | 2.13 | 0.01650 | 0.03 | HEM15 | Ferrochelatase, a mitochondrial inner membrane protein, catalyzes the insertion of ferrous iron into protoporphyrin IX, the eighth and final step in the heme biosynthetic pathway |
YDL139C | 2.11 | 0.01760 | 0.06 | SCM3 | Nonhistone component of centromeric chromatin; binds stoichiometrically to CenH3-H4 histones, required for kinetochore assembly; required for G2/M progression and localization of Cse4p; may protect Cse4p from ubiquitylation; homolog of mammalian HJURP |