9134821

5-amino-N-(2-ethylphenyl)-1-phenyltriazole-4-carboxamide

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_3245
Screen concentration 49.5 μM
Source Chembridge (Drug-like library)
PubChem CID 17014901
SMILES CCC1=CC=CC=C1NC(=O)C2=C(N(N=N2)C3=CC=CC=C3)N
Standardized SMILES CCc1ccccc1NC(=O)c2nnn(c2N)c3ccccc3
Molecular weight 307.3498
ALogP 3.12
H-bond donor count 2
H-bond acceptor count 4
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 9.1
% growth inhibition (Hom. pool) 4.63


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 17014901
Download HIP data (tab-delimited text)  (excel)
Gene:ACT1(YFL039C)|FD-Score:3.68|P-value:1.18E-4|Clearance:0.13||SGD DESC:Actin, structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions Gene:BET4(YJL031C)|FD-Score:-3.52|P-value:2.18E-4|Clearance:0||SGD DESC:Alpha subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p Gene:ECM9(YKR004C)|FD-Score:3.84|P-value:6.12E-5|Clearance:0.07||SGD DESC:Non-essential protein of unknown function Gene:ERG12(YMR208W)|FD-Score:-3.5|P-value:2.34E-4|Clearance:0||SGD DESC:Mevalonate kinase, acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate Gene:GPI11(YDR302W)|FD-Score:3.15|P-value:8.05E-4|Clearance:0.1||SGD DESC:ER membrane protein involved in a late step of glycosylphosphatidylinositol (GPI) anchor assembly; involved in the addition of phosphoethanolamine to the multiply mannosylated GPI intermediate; human PIG-Fp is a functional homolog Gene:HSF1(YGL073W)|FD-Score:3.17|P-value:7.59E-4|Clearance:0.02||SGD DESC:Trimeric heat shock transcription factor, activates multiple genes in response to stresses that include hyperthermia; recognizes variable heat shock elements (HSEs) consisting of inverted NGAAN repeats; posttranslationally regulated Gene:NOC4(YPR144C)|FD-Score:-3.42|P-value:3.14E-4|Clearance:0||SGD DESC:Nucleolar protein, forms a complex with Nop14p that mediates maturation and nuclear export of 40S ribosomal subunits Gene:RFA1(YAR007C)|FD-Score:4.53|P-value:2.94E-6|Clearance:0.53||SGD DESC:Subunit of heterotrimeric Replication Protein A (RPA), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination Gene:RFC3(YNL290W)|FD-Score:-3.17|P-value:7.63E-4|Clearance:0||SGD DESC:Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon Gene:RPC40(YPR110C)|FD-Score:3.54|P-value:1.98E-4|Clearance:0.01||SGD DESC:RNA polymerase subunit AC40, common to RNA polymerase I and III Gene:RPO26(YPR187W)|FD-Score:-3.37|P-value:3.71E-4|Clearance:0||SGD DESC:RNA polymerase subunit ABC23, common to RNA polymerases I, II, and III; part of central core; similar to bacterial omega subunit Gene:SEC13(YLR208W)|FD-Score:-3.3|P-value:4.81E-4|Clearance:0||SGD DESC:Structural component of 3 distinct complexes; subunit of Nup84 nuclear pore sub-complex (NPC), COPII vesicle coat, and Seh1-associated (SEA) complex; COPII vesicle coat is required for ER to Golgi transport; the Nup84 subcomplex contributes to nucleocytoplasmic transport, NPC biogenesis and processes that may require localization of chromosomes at the nuclear periphery, including transcription; homologous to human SEC13; abundance increases under DNA replication stress Gene:TFG1(YGR186W)|FD-Score:4|P-value:3.16E-5|Clearance:0.16||SGD DESC:TFIIF (Transcription Factor II) largest subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP74 Gene:YLR076C(YLR076C_d)|FD-Score:3.44|P-value:2.90E-4|Clearance:0.27||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential gene RPL10 which encodes the ribosomal protein L10 Gene:YML6(YML025C)|FD-Score:3.77|P-value:8.00E-5|Clearance:0.1||SGD DESC:Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L4 ribosomal protein and human mitoribosomal MRP-L4 protein; essential for viability, unlike most other mitoribosomal proteins Gene:YNL114C(YNL114C_d)|FD-Score:3.54|P-value:2.03E-4|Clearance:0.1||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF RPC19/YNL113W, an RNA polymerase subunit Gene:ACT1(YFL039C)|FD-Score:3.68|P-value:1.18E-4|Clearance:0.13||SGD DESC:Actin, structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions Gene:BET4(YJL031C)|FD-Score:-3.52|P-value:2.18E-4|Clearance:0||SGD DESC:Alpha subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p Gene:ECM9(YKR004C)|FD-Score:3.84|P-value:6.12E-5|Clearance:0.07||SGD DESC:Non-essential protein of unknown function Gene:ERG12(YMR208W)|FD-Score:-3.5|P-value:2.34E-4|Clearance:0||SGD DESC:Mevalonate kinase, acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate Gene:GPI11(YDR302W)|FD-Score:3.15|P-value:8.05E-4|Clearance:0.1||SGD DESC:ER membrane protein involved in a late step of glycosylphosphatidylinositol (GPI) anchor assembly; involved in the addition of phosphoethanolamine to the multiply mannosylated GPI intermediate; human PIG-Fp is a functional homolog Gene:HSF1(YGL073W)|FD-Score:3.17|P-value:7.59E-4|Clearance:0.02||SGD DESC:Trimeric heat shock transcription factor, activates multiple genes in response to stresses that include hyperthermia; recognizes variable heat shock elements (HSEs) consisting of inverted NGAAN repeats; posttranslationally regulated Gene:NOC4(YPR144C)|FD-Score:-3.42|P-value:3.14E-4|Clearance:0||SGD DESC:Nucleolar protein, forms a complex with Nop14p that mediates maturation and nuclear export of 40S ribosomal subunits Gene:RFA1(YAR007C)|FD-Score:4.53|P-value:2.94E-6|Clearance:0.53||SGD DESC:Subunit of heterotrimeric Replication Protein A (RPA), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination Gene:RFC3(YNL290W)|FD-Score:-3.17|P-value:7.63E-4|Clearance:0||SGD DESC:Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon Gene:RPC40(YPR110C)|FD-Score:3.54|P-value:1.98E-4|Clearance:0.01||SGD DESC:RNA polymerase subunit AC40, common to RNA polymerase I and III Gene:RPO26(YPR187W)|FD-Score:-3.37|P-value:3.71E-4|Clearance:0||SGD DESC:RNA polymerase subunit ABC23, common to RNA polymerases I, II, and III; part of central core; similar to bacterial omega subunit Gene:SEC13(YLR208W)|FD-Score:-3.3|P-value:4.81E-4|Clearance:0||SGD DESC:Structural component of 3 distinct complexes; subunit of Nup84 nuclear pore sub-complex (NPC), COPII vesicle coat, and Seh1-associated (SEA) complex; COPII vesicle coat is required for ER to Golgi transport; the Nup84 subcomplex contributes to nucleocytoplasmic transport, NPC biogenesis and processes that may require localization of chromosomes at the nuclear periphery, including transcription; homologous to human SEC13; abundance increases under DNA replication stress Gene:TFG1(YGR186W)|FD-Score:4|P-value:3.16E-5|Clearance:0.16||SGD DESC:TFIIF (Transcription Factor II) largest subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP74 Gene:YLR076C(YLR076C_d)|FD-Score:3.44|P-value:2.90E-4|Clearance:0.27||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential gene RPL10 which encodes the ribosomal protein L10 Gene:YML6(YML025C)|FD-Score:3.77|P-value:8.00E-5|Clearance:0.1||SGD DESC:Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L4 ribosomal protein and human mitoribosomal MRP-L4 protein; essential for viability, unlike most other mitoribosomal proteins Gene:YNL114C(YNL114C_d)|FD-Score:3.54|P-value:2.03E-4|Clearance:0.1||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF RPC19/YNL113W, an RNA polymerase subunit

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 17014901
Download HOP data (tab-delimited text)  (excel)
Gene:ADO1(YJR105W)|FD-Score:5.01|P-value:2.74E-7||SGD DESC:Adenosine kinase, required for the utilization of S-adenosylmethionine (AdoMet); may be involved in recycling adenosine produced through the methyl cycle Gene:APL1(YJR005W)|FD-Score:3.1|P-value:9.61E-4||SGD DESC:Beta-adaptin, large subunit of the clathrin associated protein complex (AP-2); involved in vesicle mediated transport; similar to mammalian beta-chain of the clathrin associated protein complex Gene:BAP2(YBR068C)|FD-Score:-3.46|P-value:2.69E-4||SGD DESC:High-affinity leucine permease; functions as a branched-chain amino acid permease involved in uptake of leucine, isoleucine and valine; contains 12 predicted transmembrane domains; BAP2 has a paralog, BAP3, that arose from the whole genome duplication Gene:BIO5(YNR056C)|FD-Score:3.7|P-value:1.08E-4||SGD DESC:Putative transmembrane protein involved in the biotin biosynthesis pathway; responsible for uptake of 7-keto 8-aminopelargonic acid; BIO5 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis Gene:BNI1(YNL271C)|FD-Score:4.05|P-value:2.56E-5||SGD DESC:Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNR1 Gene:CAR2(YLR438W)|FD-Score:3.64|P-value:1.37E-4||SGD DESC:L-ornithine transaminase (OTAse); catalyzes the second step of arginine degradation, expression is dually-regulated by allophanate induction and a specific arginine induction process; not nitrogen catabolite repression sensitive; protein abundance increases in response to DNA replication stress Gene:CCW12(YLR110C)|FD-Score:3.2|P-value:6.92E-4||SGD DESC:Cell wall mannoprotein; plays a role in maintenance of newly synthesized areas of cell wall; localizes to periphery of small buds, septum region of larger buds, and shmoo tip; CCW12 has a paralog, YDR134C, that arose from the whole genome duplication Gene:CDC10(YCR002C)|FD-Score:4.17|P-value:1.51E-5||SGD DESC:Component of the septin ring, required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate to form filaments; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins between mother and daughter cells; N-terminus interacts with phosphatidylinositol-4,5-bisphosphate; protein abundance increases under DNA damage stress Gene:CLC1(YGR167W)|FD-Score:3.66|P-value:1.27E-4||SGD DESC:Clathrin light chain; subunit of the major coat protein involved in intracellular protein transport and endocytosis; thought to regulate clathrin function; two Clathrin heavy chains (CHC1) form the clathrin triskelion structural component; YGR167W Gene:COG6(YNL041C)|FD-Score:3.12|P-value:9.04E-4||SGD DESC:Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:CWC15(YDR163W)|FD-Score:3.27|P-value:5.31E-4||SGD DESC:Non-essential protein involved in pre-mRNA splicing, component of a complex containing Cef1p; has similarity to S. pombe Cwf15p Gene:DAP1(YPL170W)|FD-Score:3.76|P-value:8.57E-5||SGD DESC:Heme-binding protein involved in regulation of cytochrome P450 protein Erg11p; damage response protein, related to mammalian membrane progesterone receptors; mutations lead to defects in telomeres, mitochondria, and sterol synthesis Gene:DIN7(YDR263C)|FD-Score:-4.13|P-value:1.84E-5||SGD DESC:Mitochondrial nuclease functioning in DNA repair and replication, modulates the stability of the mitochondrial genome, induced by exposure to mutagens, also induced during meiosis at a time nearly coincident with commitment to recombination Gene:DNF1(YER166W)|FD-Score:4.91|P-value:4.56E-7||SGD DESC:Aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane; contributes to endocytosis, protein transport and cell polarity; type 4 P-type ATPase Gene:DOA1(YKL213C)|FD-Score:3.3|P-value:4.86E-4||SGD DESC:WD repeat protein required for ubiquitin-mediated protein degradation; forms a complex with Cdc48p; plays a role in controlling cellular ubiquitin concentration; also promotes efficient NHEJ in postdiauxic/stationary phase; protein increases in abundance and relocalizes from nucleus to nuclear periphery upon DNA replication stress Gene:ECM18(YDR125C)|FD-Score:3.91|P-value:4.67E-5||SGD DESC:Protein of unknown function; ECM18 has a paralog, ICT1, that arose from the whole genome duplication Gene:EIS1(YMR031C)|FD-Score:3.87|P-value:5.38E-5||SGD DESC:Component of the eisosome required for proper eisosome assembly; similarity to Ykl050cp and Uso1p; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; protein increases in abundance and relocalizes from plasma membrane to cytoplasm upon DNA replication stress Gene:ELP3(YPL086C)|FD-Score:3.15|P-value:8.15E-4||SGD DESC:Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; exhibits histone acetyltransferase activity that is directed to histones H3 and H4; disruption confers resistance to K. lactis zymotoxin Gene:ERG28(YER044C)|FD-Score:3.23|P-value:6.13E-4||SGD DESC:Endoplasmic reticulum membrane protein, may facilitate protein-protein interactions between the Erg26p dehydrogenase and the Erg27p 3-ketoreductase and/or tether these enzymes to the ER, also interacts with Erg6p Gene:FAR3(YMR052W)|FD-Score:4|P-value:3.23E-5||SGD DESC:Protein of unknown function; involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far7p, Far8p, Far9p, Far10p, and Far11p; localizes to the endoplasmic reticulum; protein abundance increases in response to DNA replication stress Gene:FMP21(YBR269C_p)|FD-Score:3.28|P-value:5.20E-4||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:FUN14(YAL008W)|FD-Score:3.54|P-value:2.01E-4||SGD DESC:Mitochondrial protein of unknown function Gene:GAS4(YOL132W)|FD-Score:3.24|P-value:6.06E-4||SGD DESC:1,3-beta-glucanosyltransferase, involved with Gas2p in spore wall assembly; has similarity to Gas1p; localizes to the cell wall Gene:GCV2(YMR189W)|FD-Score:3.18|P-value:7.29E-4||SGD DESC:P subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of 5,10-methylene-THF in the cytoplasm Gene:ISU2(YOR226C)|FD-Score:3.44|P-value:2.94E-4||SGD DESC:Protein required for synthesis of iron-sulfur proteins; localized to the mitochondrial matrix; performs a scaffolding function in mitochondria during Fe/S cluster assembly; involved in Fe-S cluster assembly for both mitochondrial and cytosolic proteins; isu1 isu2 double mutant is inviable; protein abundance increases in response to DNA replication stress; evolutionarily conserved Gene:MDM35(YKL053C-A)|FD-Score:3.77|P-value:8.13E-5||SGD DESC:Mitochondrial intermembrane space protein; mutation affects mitochondrial distribution and morphology; contains twin cysteine-x9-cysteine motifs; protein abundance increases in response to DNA replication stress Gene:MSW1(YDR268W)|FD-Score:4.84|P-value:6.39E-7||SGD DESC:Mitochondrial tryptophanyl-tRNA synthetase Gene:PES4(YFR023W)|FD-Score:3.18|P-value:7.46E-4||SGD DESC:Poly(A) binding protein, suppressor of DNA polymerase epsilon mutation; PES4 has a paralog, MIP6, that arose from the whole genome duplication Gene:PHO80(YOL001W)|FD-Score:-3.22|P-value:6.42E-4||SGD DESC:Cyclin, interacts with cyclin-dependent kinase Pho85p; regulates the response to nutrient levels and environmental conditions, including the response to phosphate limitation and stress-dependent calcium signaling Gene:PPG1(YNR032W)|FD-Score:3.17|P-value:7.66E-4||SGD DESC:Putative serine/threonine protein phosphatase of the type 2A-like phosphatase family, required for glycogen accumulation; interacts with Tap42p, which binds to and regulates other protein phosphatases Gene:RCO1(YMR075W)|FD-Score:3.88|P-value:5.13E-5||SGD DESC:Essential subunit of the histone deacetylase Rpd3S complex; interacts with Eaf3p Gene:REC107(YJR021C)|FD-Score:-3.37|P-value:3.71E-4||SGD DESC:Protein involved in early stages of meiotic recombination; involved in coordination between the initiation of recombination and the first division of meiosis; part of a complex (Rec107p-Mei4p-Rec114p) required for ds break formation Gene:RPL20B(YOR312C)|FD-Score:3.26|P-value:5.67E-4||SGD DESC:Ribosomal 60S subunit protein L20B; homologous to mammalian ribosomal protein L18A, no bacterial homolog; RPL20B has a paralog, RPL20A, that arose from the whole genome duplication Gene:RPS16B(YDL083C)|FD-Score:3.67|P-value:1.22E-4||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S16 and bacterial S9; RPS16B has a paralog, RPS16A, that arose from the whole genome duplication Gene:RSA1(YPL193W)|FD-Score:4.66|P-value:1.59E-6||SGD DESC:Protein involved in the assembly of 60S ribosomal subunits; functionally interacts with Dbp6p; functions in a late nucleoplasmic step of the assembly Gene:SAN1(YDR143C)|FD-Score:3.81|P-value:7.01E-5||SGD DESC:Ubiquitin-protein ligase; involved in the proteasome-dependent degradation of aberrant nuclear proteins; targets substrates with regions of exposed hydrophobicity containing 5 or more contiguous hydrophobic residues; contains intrinsically disordered regions that contribute to substrate recognition Gene:SGE1(YPR198W)|FD-Score:5.06|P-value:2.10E-7||SGD DESC:Plasma membrane multidrug transporter of the major facilitator superfamily, acts as an extrusion permease; partial multicopy suppressor of gal11 mutations Gene:TDA5(YLR426W_p)|FD-Score:3.3|P-value:4.82E-4||SGD DESC:Putative protein of unknown function; detected in highly purified mitochondria in high-throughput studies; proposed to be involved in resistance to mechlorethamine and streptozotocin; null mutant sensitive to expression of top1-T722A allele Gene:TPS2(YDR074W)|FD-Score:5.56|P-value:1.32E-8||SGD DESC:Phosphatase subunit of the trehalose-6-P synthase/phosphatase complex; involved in synthesis of the storage carbohydrate trehalose; expression is induced by stress conditions and repressed by the Ras-cAMP pathway; protein abundance increases in response to DNA replication stress Gene:TRP3(YKL211C)|FD-Score:3.7|P-value:1.06E-4||SGD DESC:Indole-3-glycerol-phosphate synthase; forms bifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p Gene:TUF1(YOR187W)|FD-Score:4.37|P-value:6.18E-6||SGD DESC:Mitochondrial translation elongation factor Tu; comprises both GTPase and guanine nucleotide exchange factor activities, while these activities are found in separate proteins in S. pombe and humans Gene:VAN1(YML115C)|FD-Score:4.45|P-value:4.30E-6||SGD DESC:Component of the mannan polymerase I, which contains Van1p and Mnn9p and is involved in the first steps of mannan synthesis; mutants are vanadate-resistant Gene:WSC3(YOL105C)|FD-Score:-3.53|P-value:2.05E-4||SGD DESC:Partially redundant sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway involved in maintenance of cell wall integrity; involved in the response to heat shock and other stressors; regulates 1,3-beta-glucan synthesis Gene:YAR030C(YAR030C_d)|FD-Score:4.22|P-value:1.20E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YAR029W and the verified gene PRM9 Gene:YBR277C(YBR277C_d)|FD-Score:3.79|P-value:7.50E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR278W Gene:YDR008C(YDR008C_d)|FD-Score:-3.9|P-value:4.81E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YDR433W(YDR433W_d)|FD-Score:-3.28|P-value:5.20E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YER038W-A(YER038W-A_d)|FD-Score:3.11|P-value:9.42E-4||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 99% of ORF overlaps the verified gene HVG1; protein product detected in mitochondria Gene:YGR054W(YGR054W)|FD-Score:-3.99|P-value:3.33E-5||SGD DESC:Eukaryotic initiation factor (eIF) 2A; associates specifically with both 40S subunits and 80 S ribosomes, and interacts genetically with both eIF5b and eIF4E; homologous to mammalian eIF2A Gene:YHR210C(YHR210C_p)|FD-Score:4.21|P-value:1.27E-5||SGD DESC:Putative aldose 1-epimerase superfamily protein; non-essential gene; highly expressed under anaeorbic conditions Gene:YKR073C(YKR073C_d)|FD-Score:3.96|P-value:3.77E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YLR049C(YLR049C_p)|FD-Score:4.45|P-value:4.27E-6||SGD DESC:Putative protein of unknown function Gene:YMR057C(YMR057C_d)|FD-Score:3.31|P-value:4.72E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF AAC1 Gene:YMR087W(YMR087W)|FD-Score:3.75|P-value:8.74E-5||SGD DESC:Putative ADP-ribose-1''-monophosphatase that converts ADP-ribose-1''-monophosphate to ADP-ribose; may have a role in tRNA splicing; contains an A1pp domain Gene:YMR194C-A(YMR194C-A_d)|FD-Score:3.15|P-value:8.05E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YMR31(YFR049W)|FD-Score:3.45|P-value:2.80E-4||SGD DESC:Mitochondrial ribosomal protein of the small subunit, has similarity to human mitochondrial ribosomal protein MRP-S36 Gene:YNL190W(YNL190W_p)|FD-Score:-3.48|P-value:2.50E-4||SGD DESC:Hydrophilin essential in dessication-rehydration process; cell wall protein; contains a putative GPI-attachment site Gene:YOL162W(YOL162W_p)|FD-Score:3.87|P-value:5.43E-5||SGD DESC:Putative protein of unknown function; member of the Dal5p subfamily of the major facilitator family Gene:YPR098C(YPR098C)|FD-Score:4.28|P-value:9.24E-6||SGD DESC:Protein of unknown function, localized to the mitochondrial outer membrane Gene:YPT31(YER031C)|FD-Score:3.29|P-value:5.00E-4||SGD DESC:Rab family GTPase; involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi; YPT31 has a paralog, YPT32, that arose from the whole genome duplication Gene:ZIP1(YDR285W)|FD-Score:3.22|P-value:6.49E-4||SGD DESC:Transverse filament protein of the synaptonemal complex; required for normal levels of meiotic recombination and pairing between homologous chromosome during meiosis; potential Cdc28p substrate Gene:ADO1(YJR105W)|FD-Score:5.01|P-value:2.74E-7||SGD DESC:Adenosine kinase, required for the utilization of S-adenosylmethionine (AdoMet); may be involved in recycling adenosine produced through the methyl cycle Gene:APL1(YJR005W)|FD-Score:3.1|P-value:9.61E-4||SGD DESC:Beta-adaptin, large subunit of the clathrin associated protein complex (AP-2); involved in vesicle mediated transport; similar to mammalian beta-chain of the clathrin associated protein complex Gene:BAP2(YBR068C)|FD-Score:-3.46|P-value:2.69E-4||SGD DESC:High-affinity leucine permease; functions as a branched-chain amino acid permease involved in uptake of leucine, isoleucine and valine; contains 12 predicted transmembrane domains; BAP2 has a paralog, BAP3, that arose from the whole genome duplication Gene:BIO5(YNR056C)|FD-Score:3.7|P-value:1.08E-4||SGD DESC:Putative transmembrane protein involved in the biotin biosynthesis pathway; responsible for uptake of 7-keto 8-aminopelargonic acid; BIO5 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis Gene:BNI1(YNL271C)|FD-Score:4.05|P-value:2.56E-5||SGD DESC:Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNR1 Gene:CAR2(YLR438W)|FD-Score:3.64|P-value:1.37E-4||SGD DESC:L-ornithine transaminase (OTAse); catalyzes the second step of arginine degradation, expression is dually-regulated by allophanate induction and a specific arginine induction process; not nitrogen catabolite repression sensitive; protein abundance increases in response to DNA replication stress Gene:CCW12(YLR110C)|FD-Score:3.2|P-value:6.92E-4||SGD DESC:Cell wall mannoprotein; plays a role in maintenance of newly synthesized areas of cell wall; localizes to periphery of small buds, septum region of larger buds, and shmoo tip; CCW12 has a paralog, YDR134C, that arose from the whole genome duplication Gene:CDC10(YCR002C)|FD-Score:4.17|P-value:1.51E-5||SGD DESC:Component of the septin ring, required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate to form filaments; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins between mother and daughter cells; N-terminus interacts with phosphatidylinositol-4,5-bisphosphate; protein abundance increases under DNA damage stress Gene:CLC1(YGR167W)|FD-Score:3.66|P-value:1.27E-4||SGD DESC:Clathrin light chain; subunit of the major coat protein involved in intracellular protein transport and endocytosis; thought to regulate clathrin function; two Clathrin heavy chains (CHC1) form the clathrin triskelion structural component; YGR167W Gene:COG6(YNL041C)|FD-Score:3.12|P-value:9.04E-4||SGD DESC:Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:CWC15(YDR163W)|FD-Score:3.27|P-value:5.31E-4||SGD DESC:Non-essential protein involved in pre-mRNA splicing, component of a complex containing Cef1p; has similarity to S. pombe Cwf15p Gene:DAP1(YPL170W)|FD-Score:3.76|P-value:8.57E-5||SGD DESC:Heme-binding protein involved in regulation of cytochrome P450 protein Erg11p; damage response protein, related to mammalian membrane progesterone receptors; mutations lead to defects in telomeres, mitochondria, and sterol synthesis Gene:DIN7(YDR263C)|FD-Score:-4.13|P-value:1.84E-5||SGD DESC:Mitochondrial nuclease functioning in DNA repair and replication, modulates the stability of the mitochondrial genome, induced by exposure to mutagens, also induced during meiosis at a time nearly coincident with commitment to recombination Gene:DNF1(YER166W)|FD-Score:4.91|P-value:4.56E-7||SGD DESC:Aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane; contributes to endocytosis, protein transport and cell polarity; type 4 P-type ATPase Gene:DOA1(YKL213C)|FD-Score:3.3|P-value:4.86E-4||SGD DESC:WD repeat protein required for ubiquitin-mediated protein degradation; forms a complex with Cdc48p; plays a role in controlling cellular ubiquitin concentration; also promotes efficient NHEJ in postdiauxic/stationary phase; protein increases in abundance and relocalizes from nucleus to nuclear periphery upon DNA replication stress Gene:ECM18(YDR125C)|FD-Score:3.91|P-value:4.67E-5||SGD DESC:Protein of unknown function; ECM18 has a paralog, ICT1, that arose from the whole genome duplication Gene:EIS1(YMR031C)|FD-Score:3.87|P-value:5.38E-5||SGD DESC:Component of the eisosome required for proper eisosome assembly; similarity to Ykl050cp and Uso1p; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; protein increases in abundance and relocalizes from plasma membrane to cytoplasm upon DNA replication stress Gene:ELP3(YPL086C)|FD-Score:3.15|P-value:8.15E-4||SGD DESC:Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; exhibits histone acetyltransferase activity that is directed to histones H3 and H4; disruption confers resistance to K. lactis zymotoxin Gene:ERG28(YER044C)|FD-Score:3.23|P-value:6.13E-4||SGD DESC:Endoplasmic reticulum membrane protein, may facilitate protein-protein interactions between the Erg26p dehydrogenase and the Erg27p 3-ketoreductase and/or tether these enzymes to the ER, also interacts with Erg6p Gene:FAR3(YMR052W)|FD-Score:4|P-value:3.23E-5||SGD DESC:Protein of unknown function; involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far7p, Far8p, Far9p, Far10p, and Far11p; localizes to the endoplasmic reticulum; protein abundance increases in response to DNA replication stress Gene:FMP21(YBR269C_p)|FD-Score:3.28|P-value:5.20E-4||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:FUN14(YAL008W)|FD-Score:3.54|P-value:2.01E-4||SGD DESC:Mitochondrial protein of unknown function Gene:GAS4(YOL132W)|FD-Score:3.24|P-value:6.06E-4||SGD DESC:1,3-beta-glucanosyltransferase, involved with Gas2p in spore wall assembly; has similarity to Gas1p; localizes to the cell wall Gene:GCV2(YMR189W)|FD-Score:3.18|P-value:7.29E-4||SGD DESC:P subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of 5,10-methylene-THF in the cytoplasm Gene:ISU2(YOR226C)|FD-Score:3.44|P-value:2.94E-4||SGD DESC:Protein required for synthesis of iron-sulfur proteins; localized to the mitochondrial matrix; performs a scaffolding function in mitochondria during Fe/S cluster assembly; involved in Fe-S cluster assembly for both mitochondrial and cytosolic proteins; isu1 isu2 double mutant is inviable; protein abundance increases in response to DNA replication stress; evolutionarily conserved Gene:MDM35(YKL053C-A)|FD-Score:3.77|P-value:8.13E-5||SGD DESC:Mitochondrial intermembrane space protein; mutation affects mitochondrial distribution and morphology; contains twin cysteine-x9-cysteine motifs; protein abundance increases in response to DNA replication stress Gene:MSW1(YDR268W)|FD-Score:4.84|P-value:6.39E-7||SGD DESC:Mitochondrial tryptophanyl-tRNA synthetase Gene:PES4(YFR023W)|FD-Score:3.18|P-value:7.46E-4||SGD DESC:Poly(A) binding protein, suppressor of DNA polymerase epsilon mutation; PES4 has a paralog, MIP6, that arose from the whole genome duplication Gene:PHO80(YOL001W)|FD-Score:-3.22|P-value:6.42E-4||SGD DESC:Cyclin, interacts with cyclin-dependent kinase Pho85p; regulates the response to nutrient levels and environmental conditions, including the response to phosphate limitation and stress-dependent calcium signaling Gene:PPG1(YNR032W)|FD-Score:3.17|P-value:7.66E-4||SGD DESC:Putative serine/threonine protein phosphatase of the type 2A-like phosphatase family, required for glycogen accumulation; interacts with Tap42p, which binds to and regulates other protein phosphatases Gene:RCO1(YMR075W)|FD-Score:3.88|P-value:5.13E-5||SGD DESC:Essential subunit of the histone deacetylase Rpd3S complex; interacts with Eaf3p Gene:REC107(YJR021C)|FD-Score:-3.37|P-value:3.71E-4||SGD DESC:Protein involved in early stages of meiotic recombination; involved in coordination between the initiation of recombination and the first division of meiosis; part of a complex (Rec107p-Mei4p-Rec114p) required for ds break formation Gene:RPL20B(YOR312C)|FD-Score:3.26|P-value:5.67E-4||SGD DESC:Ribosomal 60S subunit protein L20B; homologous to mammalian ribosomal protein L18A, no bacterial homolog; RPL20B has a paralog, RPL20A, that arose from the whole genome duplication Gene:RPS16B(YDL083C)|FD-Score:3.67|P-value:1.22E-4||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S16 and bacterial S9; RPS16B has a paralog, RPS16A, that arose from the whole genome duplication Gene:RSA1(YPL193W)|FD-Score:4.66|P-value:1.59E-6||SGD DESC:Protein involved in the assembly of 60S ribosomal subunits; functionally interacts with Dbp6p; functions in a late nucleoplasmic step of the assembly Gene:SAN1(YDR143C)|FD-Score:3.81|P-value:7.01E-5||SGD DESC:Ubiquitin-protein ligase; involved in the proteasome-dependent degradation of aberrant nuclear proteins; targets substrates with regions of exposed hydrophobicity containing 5 or more contiguous hydrophobic residues; contains intrinsically disordered regions that contribute to substrate recognition Gene:SGE1(YPR198W)|FD-Score:5.06|P-value:2.10E-7||SGD DESC:Plasma membrane multidrug transporter of the major facilitator superfamily, acts as an extrusion permease; partial multicopy suppressor of gal11 mutations Gene:TDA5(YLR426W_p)|FD-Score:3.3|P-value:4.82E-4||SGD DESC:Putative protein of unknown function; detected in highly purified mitochondria in high-throughput studies; proposed to be involved in resistance to mechlorethamine and streptozotocin; null mutant sensitive to expression of top1-T722A allele Gene:TPS2(YDR074W)|FD-Score:5.56|P-value:1.32E-8||SGD DESC:Phosphatase subunit of the trehalose-6-P synthase/phosphatase complex; involved in synthesis of the storage carbohydrate trehalose; expression is induced by stress conditions and repressed by the Ras-cAMP pathway; protein abundance increases in response to DNA replication stress Gene:TRP3(YKL211C)|FD-Score:3.7|P-value:1.06E-4||SGD DESC:Indole-3-glycerol-phosphate synthase; forms bifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p Gene:TUF1(YOR187W)|FD-Score:4.37|P-value:6.18E-6||SGD DESC:Mitochondrial translation elongation factor Tu; comprises both GTPase and guanine nucleotide exchange factor activities, while these activities are found in separate proteins in S. pombe and humans Gene:VAN1(YML115C)|FD-Score:4.45|P-value:4.30E-6||SGD DESC:Component of the mannan polymerase I, which contains Van1p and Mnn9p and is involved in the first steps of mannan synthesis; mutants are vanadate-resistant Gene:WSC3(YOL105C)|FD-Score:-3.53|P-value:2.05E-4||SGD DESC:Partially redundant sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway involved in maintenance of cell wall integrity; involved in the response to heat shock and other stressors; regulates 1,3-beta-glucan synthesis Gene:YAR030C(YAR030C_d)|FD-Score:4.22|P-value:1.20E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YAR029W and the verified gene PRM9 Gene:YBR277C(YBR277C_d)|FD-Score:3.79|P-value:7.50E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR278W Gene:YDR008C(YDR008C_d)|FD-Score:-3.9|P-value:4.81E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YDR433W(YDR433W_d)|FD-Score:-3.28|P-value:5.20E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YER038W-A(YER038W-A_d)|FD-Score:3.11|P-value:9.42E-4||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 99% of ORF overlaps the verified gene HVG1; protein product detected in mitochondria Gene:YGR054W(YGR054W)|FD-Score:-3.99|P-value:3.33E-5||SGD DESC:Eukaryotic initiation factor (eIF) 2A; associates specifically with both 40S subunits and 80 S ribosomes, and interacts genetically with both eIF5b and eIF4E; homologous to mammalian eIF2A Gene:YHR210C(YHR210C_p)|FD-Score:4.21|P-value:1.27E-5||SGD DESC:Putative aldose 1-epimerase superfamily protein; non-essential gene; highly expressed under anaeorbic conditions Gene:YKR073C(YKR073C_d)|FD-Score:3.96|P-value:3.77E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YLR049C(YLR049C_p)|FD-Score:4.45|P-value:4.27E-6||SGD DESC:Putative protein of unknown function Gene:YMR057C(YMR057C_d)|FD-Score:3.31|P-value:4.72E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF AAC1 Gene:YMR087W(YMR087W)|FD-Score:3.75|P-value:8.74E-5||SGD DESC:Putative ADP-ribose-1''-monophosphatase that converts ADP-ribose-1''-monophosphate to ADP-ribose; may have a role in tRNA splicing; contains an A1pp domain Gene:YMR194C-A(YMR194C-A_d)|FD-Score:3.15|P-value:8.05E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YMR31(YFR049W)|FD-Score:3.45|P-value:2.80E-4||SGD DESC:Mitochondrial ribosomal protein of the small subunit, has similarity to human mitochondrial ribosomal protein MRP-S36 Gene:YNL190W(YNL190W_p)|FD-Score:-3.48|P-value:2.50E-4||SGD DESC:Hydrophilin essential in dessication-rehydration process; cell wall protein; contains a putative GPI-attachment site Gene:YOL162W(YOL162W_p)|FD-Score:3.87|P-value:5.43E-5||SGD DESC:Putative protein of unknown function; member of the Dal5p subfamily of the major facilitator family Gene:YPR098C(YPR098C)|FD-Score:4.28|P-value:9.24E-6||SGD DESC:Protein of unknown function, localized to the mitochondrial outer membrane Gene:YPT31(YER031C)|FD-Score:3.29|P-value:5.00E-4||SGD DESC:Rab family GTPase; involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi; YPT31 has a paralog, YPT32, that arose from the whole genome duplication Gene:ZIP1(YDR285W)|FD-Score:3.22|P-value:6.49E-4||SGD DESC:Transverse filament protein of the synaptonemal complex; required for normal levels of meiotic recombination and pairing between homologous chromosome during meiosis; potential Cdc28p substrate

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YAR007C4.532.94E-60.53RFA1Subunit of heterotrimeric Replication Protein A (RPA), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination
YGR186W4.003.16E-50.16TFG1TFIIF (Transcription Factor II) largest subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP74
YKR004C3.846.12E-50.07ECM9Non-essential protein of unknown function
YML025C3.778.00E-50.10YML6Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L4 ribosomal protein and human mitoribosomal MRP-L4 protein; essential for viability, unlike most other mitoribosomal proteins
YFL039C3.681.18E-40.14ACT1Actin, structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions
YPR110C3.541.98E-40.01RPC40RNA polymerase subunit AC40, common to RNA polymerase I and III
YNL114C_d3.542.03E-40.10YNL114C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF RPC19/YNL113W, an RNA polymerase subunit
YLR076C_d3.442.90E-40.27YLR076C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential gene RPL10 which encodes the ribosomal protein L10
YGL073W3.177.59E-40.02HSF1Trimeric heat shock transcription factor, activates multiple genes in response to stresses that include hyperthermia; recognizes variable heat shock elements (HSEs) consisting of inverted NGAAN repeats; posttranslationally regulated
YDR302W3.158.05E-40.10GPI11ER membrane protein involved in a late step of glycosylphosphatidylinositol (GPI) anchor assembly; involved in the addition of phosphoethanolamine to the multiply mannosylated GPI intermediate; human PIG-Fp is a functional homolog
YNR017W3.050.001140.04TIM23Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); involved in protein import into mitochondrial matrix and inner membrane; with Tim17p, contributes to architecture and function of the import channel
YPL255W3.010.001300.00BBP1Protein required for the spindle pole body (SPB) duplication, localized at the central plaque periphery; forms a complex with a nuclear envelope protein Mps2p and SPB components Spc29p and Kar1p; required for mitotic functions of Cdc5p
YBL076C3.010.001310.00ILS1Cytoplasmic isoleucine-tRNA synthetase, target of the G1-specific inhibitor reveromycin A
YOL026C3.010.001320.09MIM1Mitochondrial protein required for outer membrane protein import; cooperates with Tom70p to import the subset of proteins with multiple alpha-helical transmembrane segments, including Ugo1p, Tom20p, and others; present in a complex with Mim2p in the outer membrane that may create a local environment to facilitate membrane insertion of substrate proteins; also has a role in assembly of Tom20p into the TOM complex
YDR280W2.910.001780.00RRP45Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp45p (PM/SCL-75, EXOSC9); protein abundance increases in response to DNA replication stress

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YDR074W5.561.32E-8TPS2Phosphatase subunit of the trehalose-6-P synthase/phosphatase complex; involved in synthesis of the storage carbohydrate trehalose; expression is induced by stress conditions and repressed by the Ras-cAMP pathway; protein abundance increases in response to DNA replication stress
YPR198W5.062.10E-7SGE1Plasma membrane multidrug transporter of the major facilitator superfamily, acts as an extrusion permease; partial multicopy suppressor of gal11 mutations
YJR105W5.012.74E-7ADO1Adenosine kinase, required for the utilization of S-adenosylmethionine (AdoMet); may be involved in recycling adenosine produced through the methyl cycle
YER166W4.914.56E-7DNF1Aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane; contributes to endocytosis, protein transport and cell polarity; type 4 P-type ATPase
YDR268W4.846.39E-7MSW1Mitochondrial tryptophanyl-tRNA synthetase
YPL193W4.661.59E-6RSA1Protein involved in the assembly of 60S ribosomal subunits; functionally interacts with Dbp6p; functions in a late nucleoplasmic step of the assembly
YLR049C_p4.454.27E-6YLR049C_pPutative protein of unknown function
YML115C4.454.30E-6VAN1Component of the mannan polymerase I, which contains Van1p and Mnn9p and is involved in the first steps of mannan synthesis; mutants are vanadate-resistant
YOR187W4.376.18E-6TUF1Mitochondrial translation elongation factor Tu; comprises both GTPase and guanine nucleotide exchange factor activities, while these activities are found in separate proteins in S. pombe and humans
YPR098C4.289.24E-6YPR098CProtein of unknown function, localized to the mitochondrial outer membrane
YAR030C_d4.221.20E-5YAR030C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YAR029W and the verified gene PRM9
YHR210C_p4.211.27E-5YHR210C_pPutative aldose 1-epimerase superfamily protein; non-essential gene; highly expressed under anaeorbic conditions
YCR002C4.171.51E-5CDC10Component of the septin ring, required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate to form filaments; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins between mother and daughter cells; N-terminus interacts with phosphatidylinositol-4,5-bisphosphate; protein abundance increases under DNA damage stress
YNL271C4.052.56E-5BNI1Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNR1
YMR052W4.003.23E-5FAR3Protein of unknown function; involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far7p, Far8p, Far9p, Far10p, and Far11p; localizes to the endoplasmic reticulum; protein abundance increases in response to DNA replication stress

GO enrichment analysis for SGTC_3245
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID		 Tanimoto
Score		 Response
Signature
0.0809.47E-10SGTC_12520493-0875 34.8 μMChemDiv (Drug-like library)39609630.151515
0.0782.15E-9SGTC_1235benzylparaben 21.5 μMChemDiv (Drug-like library)71800.166667
0.0706.68E-8SGTC_11941488-0194 225.0 μMChemDiv (Drug-like library)13914520.0810811
0.0663.48E-7SGTC_9073448-6986 75.5 μMChemDiv (Drug-like library)5905820.141026
0.0664.17E-7SGTC_15892',5'-dimethoxyflavone 47.2 μMTimTec (Pure natural product library)6886670.101449
0.0631.34E-6SGTC_2422chlorphenesin carbamate 384.2 μMMiscellaneous27240.121212
0.0621.62E-6SGTC_21935925765 200.0 μMChembridge (Fragment library)8773700.327586
0.0621.59E-6SGTC_29819013952 39.0 μMChembridge (Drug-like library)29963440.171429
0.0622.08E-6SGTC_1117retinoic acid 1.1 μMTimTec (Natural product library)4447950.0641026
0.0595.19E-6SGTC_21185526350 200.0 μMChembridge (Fragment library)7435940.15625
0.0595.23E-6SGTC_1997st073024 93.8 μMTimTec (Natural product derivative library)6862680.177419
0.0587.03E-6SGTC_28819058953 52.0 μMChembridge (Drug-like library)171222490.169014
0.0571.05E-5SGTC_32509135583 49.5 μMChembridge (Drug-like library)76993530.278689
0.0561.63E-5SGTC_1853st056710 91.2 μMTimTec (Natural product derivative library)2691670.0769231amide catabolism
0.0552.58E-5SGTC_1794st048918 76.9 μMTimTec (Natural product derivative library)6723030.136986

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count		 H-bond
acceptor
count		 Response
Signature
SGTC_3274913829849.47 μM0.72340417015756Chembridge (Drug-like library)293.32322.66624
SGTC_3228913179949.47 μM0.59259317015818Chembridge (Drug-like library)307.349783.15224amide catabolism
SGTC_3225913081949.47 μM0.5555564547121Chembridge (Drug-like library)293.32322.66624amide catabolism
SGTC_3270913756349.47 μM0.517015724Chembridge (Drug-like library)293.32322.66624RPP1 & pyrimidine depletion
SGTC_21545570129200 μM0.444444673366Chembridge (Fragment library)227.261821.68413
SGTC_3355915105844.05 μM0.44067817015728Chembridge (Drug-like library)311.3136632.87125RNA processing & uracil transport
SGTC_3271913779849.47 μM0.4193556498326Chembridge (Drug-like library)299.370842.94824
SGTC_3090911769649.47 μM0.4181827923821Chembridge (Drug-like library)297.2475534.37915
SGTC_3079911751249.47 μM0.4098367185044Chembridge (Drug-like library)338.360522.91515
SGTC_3212912830749.47 μM0.40322627243542Chembridge (Drug-like library)350.213742.75424