Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
---|
YKL210W | 3.36 | 3.93E-4 | 0.13 | UBA1 | Ubiquitin activating enzyme (E1); involved in ubiquitin-mediated protein degradation and essential for viability; protein abundance increases in response to DNA replication stress |
YDR473C | 3.27 | 5.37E-4 | 0.13 | PRP3 | Splicing factor, component of the U4/U6-U5 snRNP complex |
YBR121C | 3.23 | 6.30E-4 | 0.13 | GRS1 | Cytoplasmic and mitochondrial glycyl-tRNA synthase; ligates glycine to the cognate anticodon-bearing tRNA; transcription termination factor that may interact with the 3'-end of pre-mRNA to promote 3'-end formation; GRS1 has a paralog, GRS2, that arose from the whole genome duplication |
YLR007W | 3.09 | 9.95E-4 | 0.06 | NSE1 | Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair |
YLR045C | 3.03 | 0.00122 | 0.04 | STU2 | Microtubule-associated protein (MAP) of the XMAP215/Dis1 family; regulates microtubule dynamics during spindle orientation and metaphase chromosome alignment; interacts with spindle pole body component Spc72p |
YGR265W_d | 2.99 | 0.00141 | 0.12 | YGR265W_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MES1/YGR264C, which encodes methionyl-tRNA synthetase |
YML049C | 2.86 | 0.00209 | 0.06 | RSE1 | Protein involved in pre-mRNA splicing; component of the pre-spliceosome; associates with U2 snRNA; involved in ER to Golgi transport |
YJR076C | 2.81 | 0.00251 | 0.00 | CDC11 | Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate with other rods to form filaments; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins between mother and daughter cells |
YKL059C | 2.80 | 0.00255 | 0.07 | MPE1 | Essential conserved subunit of CPF (cleavage and polyadenylation factor), plays a role in 3' end formation of mRNA via the specific cleavage and polyadenylation of pre-mRNA, contains a putative RNA-binding zinc knuckle motif |
YOR204W | 2.73 | 0.00315 | 0.02 | DED1 | ATP-dependent DEAD (Asp-Glu-Ala-Asp)-box RNA helicase, required for translation initiation of all yeast mRNAs; mutations in human DEAD-box DBY are a frequent cause of male infertility |
YBL035C | 2.72 | 0.00330 | 0.02 | POL12 | B subunit of DNA polymerase alpha-primase complex, required for initiation of DNA replication during mitotic and premeiotic DNA synthesis; also functions in telomere capping and length regulation |
YOR254C | 2.70 | 0.00351 | 0.04 | SEC63 | Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER |
YPR180W | 2.66 | 0.00390 | 0.07 | AOS1 | Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability |
YFL024C | 2.59 | 0.00477 | 0.11 | EPL1 | Subunit of NuA4, an essential histone H4/H2A acetyltransferase complex; conserved region at N-terminus is essential for interaction with the NPC (nucleosome core particle); required for autophagy; homologous to Drosophila Enhancer of Polycomb |
YMR213W | 2.48 | 0.00654 | 0.03 | CEF1 | Essential splicing factor; associated with Prp19p and the spliceosome, contains an N-terminal c-Myb DNA binding motif necessary for cell viability but not for Prp19p association, evolutionarily conserved and homologous to S. pombe Cdc5p |