| Deletion Strain | FD score | P-value | Gene | Gene Description |
|---|
| YIR023W | 12.20 | 1.98E-34 | DAL81 | Positive regulator of genes in multiple nitrogen degradation pathways; contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism |
| YER074W | 5.25 | 7.80E-8 | RPS24A | Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S24, no bacterial homolog; RPS24A has a paralog, RPS24B, that arose from the whole genome duplication |
| YMR142C | 5.00 | 2.92E-7 | RPL13B | Ribosomal 60S subunit protein L13B; not essential for viability; homologous to mammalian ribosomal protein L13, no bacterial homolog; RPL13B has a paralog, RPL13A, that arose from the whole genome duplication |
| YDR174W | 4.82 | 7.19E-7 | HMO1 | Chromatin associated high mobility group (HMG) family member involved in genome maintenance; rDNA-binding component of the Pol I transcription system; associates with a 5'-3' DNA helicase and Fpr1p, a prolyl isomerase |
| YAL019W | 4.59 | 2.21E-6 | FUN30 | Snf2p family member with ATP-dependent chromatin remodeling activity; has a role in silencing at the mating type locus, telomeres and centromeres; enriched at centromeres and is required for correct chromatin structure around centromeres, as well as at the boundary element of the silent HMR; recruited to DNA double-strand breaks (DSBs) where it promotes 5' strand resection of DSBs; potential Cdc28p substrate |
| YLR279W_d | 4.57 | 2.41E-6 | YLR279W_d | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
| YHR153C | 4.35 | 6.75E-6 | SPO16 | Meiosis-specific protein involved in synaptonemal complex assembly; implicated in regulation of crossover formation; required for sporulation |
| YFL036W | 4.33 | 7.41E-6 | RPO41 | Mitochondrial RNA polymerase; single subunit enzyme similar to those of T3 and T7 bacteriophages; requires a specificity subunit encoded by MTF1 for promoter recognition; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation |
| YPR014C_d | 4.23 | 1.17E-5 | YPR014C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPR014C is not an essential gene |
| YMR242C | 3.95 | 3.89E-5 | RPL20A | Ribosomal 60S subunit protein L20A; homologous to mammalian ribosomal protein L18A, no bacterial homolog; RPL20A has a paralog, RPL20B, that arose from the whole genome duplication |
| YAL067W-A_p | 3.82 | 6.75E-5 | YAL067W-A_p | Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching |
| YDR491C_d | 3.74 | 9.35E-5 | YDR491C_d | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
| YDR293C | 3.65 | 1.32E-4 | SSD1 | Translational repressor with a role in polar growth and wall integrity; regulated by Cbk1p phosphorylation to effect bud-specific translational control and localization of specific mRNAs; interacts with TOR pathway components; contains a functional N-terminal nuclear localization sequence and nucleocytoplasmic shuttling appears to be critical to Ssd1p function |
| YHR016C | 3.62 | 1.50E-4 | YSC84 | Actin-binding protein; involved in bundling of actin filaments and endocytosis of actin cortical patches; activity stimulated by Las17p; contains SH3 domain similar to Rvs167p; YSC84 has a paralog, LSB3, that arose from the whole genome duplication |
| YBR007C_p | 3.59 | 1.66E-4 | DSF2_p | Deletion suppressor of mpt5 mutation; relocalizes from bud neck to cytoplasm upon DNA replication stress |
