9135583

methyl 4-[(2-ethoxyphenyl)carbamoyl]benzoate

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_3250
Screen concentration 49.5 μM
Source Chembridge (Drug-like library)
PubChem CID 7699353
SMILES CCOC1=CC=CC=C1NC(=O)C2=CC=C(C=C2)C(=O)OC
Standardized SMILES CCOc1ccccc1NC(=O)c2ccc(cc2)C(=O)OC
Molecular weight 299.3212
ALogP 2.8
H-bond donor count 1
H-bond acceptor count 4
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 6.56
% growth inhibition (Hom. pool) 2.69


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 7699353
Download HIP data (tab-delimited text)  (excel)
Gene:DML1(YMR211W)|FD-Score:3.18|P-value:7.29E-4|Clearance:0||SGD DESC:Essential protein involved in mtDNA inheritance, may also function in the partitioning of the mitochondrial organelle or in the segregation of chromosomes, exhibits regions similar to members of a GTPase family Gene:EFB1(YAL003W)|FD-Score:-3.16|P-value:7.81E-4|Clearance:0||SGD DESC:Translation elongation factor 1 beta; stimulates nucleotide exchange to regenerate EF-1 alpha-GTP for the next elongation cycle; part of the EF-1 complex, which facilitates binding of aminoacyl-tRNA to the ribosomal A site Gene:NOC4(YPR144C)|FD-Score:3.2|P-value:6.93E-4|Clearance:0.01||SGD DESC:Nucleolar protein, forms a complex with Nop14p that mediates maturation and nuclear export of 40S ribosomal subunits Gene:NOP56(YLR197W)|FD-Score:3.18|P-value:7.31E-4|Clearance:0.01||SGD DESC:Essential evolutionarily-conserved nucleolar protein component of the box C/D snoRNP complexes that direct 2'-O-methylation of pre-rRNA during its maturation; overexpression causes spindle orientation defects Gene:NSL1(YPL233W)|FD-Score:-3.23|P-value:6.26E-4|Clearance:0||SGD DESC:Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; required for accurate chromosome segregation Gene:RER2(YBR002C)|FD-Score:3.55|P-value:1.91E-4|Clearance:0.35||SGD DESC:Cis-prenyltransferase involved in dolichol synthesis; participates in endoplasmic reticulum (ER) protein sorting Gene:RPL30(YGL030W)|FD-Score:3.18|P-value:7.47E-4|Clearance:0.01||SGD DESC:Ribosomal 60S subunit protein L30; involved in pre-rRNA processing in the nucleolus; autoregulates splicing of its transcript; homologous to mammalian ribosomal protein L30, no bacterial homolog Gene:RRP46(YGR095C)|FD-Score:3.92|P-value:4.37E-5|Clearance:0.37||SGD DESC:Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp46p (EXOSC5) Gene:TFC6(YDR362C)|FD-Score:-4.52|P-value:3.10E-6|Clearance:0||SGD DESC:One of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); part of TFIIIC TauB domain that binds BoxB promoter sites of tRNA and other genes; cooperates with Tfc3p in DNA binding; human homolog is TFIIIC-110 Gene:TIF11(YMR260C)|FD-Score:3.16|P-value:7.77E-4|Clearance:0.14||SGD DESC:Translation initiation factor eIF1A, essential protein that forms a complex with Sui1p (eIF1) and the 40S ribosomal subunit and scans for the start codon; C-terminus associates with Fun12p (eIF5B); N terminus interacts with eIF2 and eIF3 Gene:DML1(YMR211W)|FD-Score:3.18|P-value:7.29E-4|Clearance:0||SGD DESC:Essential protein involved in mtDNA inheritance, may also function in the partitioning of the mitochondrial organelle or in the segregation of chromosomes, exhibits regions similar to members of a GTPase family Gene:EFB1(YAL003W)|FD-Score:-3.16|P-value:7.81E-4|Clearance:0||SGD DESC:Translation elongation factor 1 beta; stimulates nucleotide exchange to regenerate EF-1 alpha-GTP for the next elongation cycle; part of the EF-1 complex, which facilitates binding of aminoacyl-tRNA to the ribosomal A site Gene:NOC4(YPR144C)|FD-Score:3.2|P-value:6.93E-4|Clearance:0.01||SGD DESC:Nucleolar protein, forms a complex with Nop14p that mediates maturation and nuclear export of 40S ribosomal subunits Gene:NOP56(YLR197W)|FD-Score:3.18|P-value:7.31E-4|Clearance:0.01||SGD DESC:Essential evolutionarily-conserved nucleolar protein component of the box C/D snoRNP complexes that direct 2'-O-methylation of pre-rRNA during its maturation; overexpression causes spindle orientation defects Gene:NSL1(YPL233W)|FD-Score:-3.23|P-value:6.26E-4|Clearance:0||SGD DESC:Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; required for accurate chromosome segregation Gene:RER2(YBR002C)|FD-Score:3.55|P-value:1.91E-4|Clearance:0.35||SGD DESC:Cis-prenyltransferase involved in dolichol synthesis; participates in endoplasmic reticulum (ER) protein sorting Gene:RPL30(YGL030W)|FD-Score:3.18|P-value:7.47E-4|Clearance:0.01||SGD DESC:Ribosomal 60S subunit protein L30; involved in pre-rRNA processing in the nucleolus; autoregulates splicing of its transcript; homologous to mammalian ribosomal protein L30, no bacterial homolog Gene:RRP46(YGR095C)|FD-Score:3.92|P-value:4.37E-5|Clearance:0.37||SGD DESC:Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp46p (EXOSC5) Gene:TFC6(YDR362C)|FD-Score:-4.52|P-value:3.10E-6|Clearance:0||SGD DESC:One of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); part of TFIIIC TauB domain that binds BoxB promoter sites of tRNA and other genes; cooperates with Tfc3p in DNA binding; human homolog is TFIIIC-110 Gene:TIF11(YMR260C)|FD-Score:3.16|P-value:7.77E-4|Clearance:0.14||SGD DESC:Translation initiation factor eIF1A, essential protein that forms a complex with Sui1p (eIF1) and the 40S ribosomal subunit and scans for the start codon; C-terminus associates with Fun12p (eIF5B); N terminus interacts with eIF2 and eIF3

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 7699353
Download HOP data (tab-delimited text)  (excel)
Gene:BUD19(YJL188C_d)|FD-Score:3.46|P-value:2.72E-4||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 88% of ORF overlaps the verified gene RPL39; diploid mutant displays a weak budding pattern phenotype in a systematic assay Gene:CAF40(YNL288W)|FD-Score:-3.89|P-value:5.11E-5||SGD DESC:Evolutionarily conserved subunit of the CCR4-NOT complex involved in controlling mRNA initiation, elongation and degradation; binds Cdc39p Gene:CBS1(YDL069C)|FD-Score:3.83|P-value:6.38E-5||SGD DESC:Mitochondrial translational activator of the COB mRNA; membrane protein that interacts with translating ribosomes, acts on the COB mRNA 5'-untranslated leader Gene:CTF8(YHR191C)|FD-Score:3.14|P-value:8.46E-4||SGD DESC:Subunit of a complex with Ctf18p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion Gene:DAK2(YFL053W)|FD-Score:3.61|P-value:1.55E-4||SGD DESC:Dihydroxyacetone kinase, required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation Gene:DUF1(YOL087C)|FD-Score:3.35|P-value:4.01E-4||SGD DESC:Ubiquitin-binding protein of unknown function; contains one WD40 repeat in a beta-propeller fold; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; homolog of human WDR48/UAF1, which is involved in regulating the Fanconi anemia pathway; deletion mutant is sensitive to various chemicals including phenanthroline, sanguinarine, and nordihydroguaiaretic acid Gene:EFG1(YGR271C-A)|FD-Score:3.83|P-value:6.40E-5||SGD DESC:Essential protein required for maturation of 18S rRNA; null mutant is sensitive to hydroxyurea and is delayed in recovering from alpha-factor arrest; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus Gene:EXG2(YDR261C)|FD-Score:3.23|P-value:6.11E-4||SGD DESC:Exo-1,3-beta-glucanase, involved in cell wall beta-glucan assembly; may be anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor Gene:HNT3(YOR258W)|FD-Score:-3.71|P-value:1.03E-4||SGD DESC:DNA 5' AMP hydrolase involved in DNA repair; member of the histidine triad (HIT) superfamily of nucleotide-binding proteins; homolog of Aprataxin, a Hint related protein that is mutated in individuals with ataxia with oculomotor apraxia; relative distribution to nuclear foci decreases upon DNA replication stress Gene:JIP3(YLR331C_d)|FD-Score:3.47|P-value:2.59E-4||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2 Gene:MSB1(YOR188W)|FD-Score:6.42|P-value:6.89E-11||SGD DESC:Protein of unknown function; may be involved in positive regulation of 1,3-beta-glucan synthesis and the Pkc1p-MAPK pathway; multicopy suppressor of temperature-sensitive mutations in CDC24 and CDC42, and of mutations in BEM4; potential Cdc28p substrate; relocalizes from bud neck to cytoplasm upon DNA replication stress Gene:NMA111(YNL123W)|FD-Score:4.83|P-value:6.97E-7||SGD DESC:Serine protease and general molecular chaperone; involved in response to heat stress and promotion of apoptosis; may contribute to lipid homeostasis; sequence similarity to the mammalian Omi/HtrA2 family of serine proteases Gene:PDH1(YPR002W)|FD-Score:-3.75|P-value:8.94E-5||SGD DESC:Mitochondrial protein that participates in respiration, induced by diauxic shift; homologous to E. coli PrpD, may take part in the conversion of 2-methylcitrate to 2-methylisocitrate Gene:PDR8(YLR266C)|FD-Score:3.99|P-value:3.28E-5||SGD DESC:Transcription factor; targets include ATP-binding cassette (ABC) transporters, major facilitator superfamily transporters, and other genes involved in the pleiotropic drug resistance (PDR) phenomenon; PDR8 has a paralog, YRR1, that arose from the whole genome duplication Gene:PPG1(YNR032W)|FD-Score:4.4|P-value:5.46E-6||SGD DESC:Putative serine/threonine protein phosphatase of the type 2A-like phosphatase family, required for glycogen accumulation; interacts with Tap42p, which binds to and regulates other protein phosphatases Gene:PPQ1(YPL179W)|FD-Score:-3.22|P-value:6.39E-4||SGD DESC:Putative protein serine/threonine phosphatase; null mutation enhances efficiency of translational suppressors Gene:QRI5(YLR204W)|FD-Score:5.45|P-value:2.50E-8||SGD DESC:Mitochondrial inner membrane protein, required for accumulation of spliced COX1 mRNA; may have an additional role in translation of COX1 mRNA Gene:RPL37A(YLR185W)|FD-Score:3.13|P-value:8.71E-4||SGD DESC:Ribosomal 60S subunit protein L37A; homologous to mammalian ribosomal protein L37, no bacterial homolog; RPL37A has a paralog, RPL37B, that arose from the whole genome duplication Gene:SGE1(YPR198W)|FD-Score:4.23|P-value:1.19E-5||SGD DESC:Plasma membrane multidrug transporter of the major facilitator superfamily, acts as an extrusion permease; partial multicopy suppressor of gal11 mutations Gene:SHB17(YKR043C)|FD-Score:4.45|P-value:4.29E-6||SGD DESC:Sedoheptulose bisphosphatase involved in riboneogenesis; dephosphorylates sedoheptulose 1,7-bisphosphate, which is converted via the nonoxidative pentose phosphate pathway to ribose-5-phosphate; facilitates the conversion of glycolytic intermediates to pentose phosphate units; also has fructose 1,6-bisphosphatase activity but this is probably not biologically relevant, since deletion does not affect FBP levels; GFP-fusion protein localizes to the cytoplasm and nucleus Gene:SWA2(YDR320C)|FD-Score:3.37|P-value:3.79E-4||SGD DESC:Auxilin-like protein involved in vesicular transport; clathrin-binding protein required for uncoating of clathrin-coated vesicles Gene:TAT1(YBR069C)|FD-Score:3.31|P-value:4.70E-4||SGD DESC:Amino acid transporter for valine, leucine, isoleucine, and tyrosine; low-affinity tryptophan and histidine transporter; overexpression confers FK506 and FTY720 resistance; protein abundance increases in response to DNA replication stress Gene:TPS2(YDR074W)|FD-Score:4.29|P-value:8.85E-6||SGD DESC:Phosphatase subunit of the trehalose-6-P synthase/phosphatase complex; involved in synthesis of the storage carbohydrate trehalose; expression is induced by stress conditions and repressed by the Ras-cAMP pathway; protein abundance increases in response to DNA replication stress Gene:TRP5(YGL026C)|FD-Score:4.49|P-value:3.64E-6||SGD DESC:Tryptophan synthase, catalyzes the last step of tryptophan biosynthesis; regulated by the general control system of amino acid biosynthesis Gene:VID24(YBR105C)|FD-Score:4.24|P-value:1.11E-5||SGD DESC:GID Complex regulatory subunit; binds GID Complex in response to glucose through interactions with complex member Vid28p; regulates fructose-1,6-bisphosphatase (FBPase) targeting to the vacuole; promotes proteasome-dependent catabolite degradation of FBPase; peripheral membrane protein located at Vid (vacuole import and degradation) vesicles Gene:VPS69(YPR087W_d)|FD-Score:3.22|P-value:6.45E-4||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 85% of ORF overlaps the verified gene SRP54; deletion causes a vacuolar protein sorting defect Gene:YGR050C(YGR050C_p)|FD-Score:3.68|P-value:1.15E-4||SGD DESC:Protein of unknown function; mRNA identified as translated by ribosome profiling data Gene:YHR022C(YHR022C_p)|FD-Score:-3.3|P-value:4.76E-4||SGD DESC:Putative protein of unknown function; YHR022C is not an essential gene Gene:YPL041C(YPL041C_p)|FD-Score:5|P-value:2.80E-7||SGD DESC:Protein of unknown function involved in maintenance of proper telomere length Gene:BUD19(YJL188C_d)|FD-Score:3.46|P-value:2.72E-4||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 88% of ORF overlaps the verified gene RPL39; diploid mutant displays a weak budding pattern phenotype in a systematic assay Gene:CAF40(YNL288W)|FD-Score:-3.89|P-value:5.11E-5||SGD DESC:Evolutionarily conserved subunit of the CCR4-NOT complex involved in controlling mRNA initiation, elongation and degradation; binds Cdc39p Gene:CBS1(YDL069C)|FD-Score:3.83|P-value:6.38E-5||SGD DESC:Mitochondrial translational activator of the COB mRNA; membrane protein that interacts with translating ribosomes, acts on the COB mRNA 5'-untranslated leader Gene:CTF8(YHR191C)|FD-Score:3.14|P-value:8.46E-4||SGD DESC:Subunit of a complex with Ctf18p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion Gene:DAK2(YFL053W)|FD-Score:3.61|P-value:1.55E-4||SGD DESC:Dihydroxyacetone kinase, required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation Gene:DUF1(YOL087C)|FD-Score:3.35|P-value:4.01E-4||SGD DESC:Ubiquitin-binding protein of unknown function; contains one WD40 repeat in a beta-propeller fold; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; homolog of human WDR48/UAF1, which is involved in regulating the Fanconi anemia pathway; deletion mutant is sensitive to various chemicals including phenanthroline, sanguinarine, and nordihydroguaiaretic acid Gene:EFG1(YGR271C-A)|FD-Score:3.83|P-value:6.40E-5||SGD DESC:Essential protein required for maturation of 18S rRNA; null mutant is sensitive to hydroxyurea and is delayed in recovering from alpha-factor arrest; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus Gene:EXG2(YDR261C)|FD-Score:3.23|P-value:6.11E-4||SGD DESC:Exo-1,3-beta-glucanase, involved in cell wall beta-glucan assembly; may be anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor Gene:HNT3(YOR258W)|FD-Score:-3.71|P-value:1.03E-4||SGD DESC:DNA 5' AMP hydrolase involved in DNA repair; member of the histidine triad (HIT) superfamily of nucleotide-binding proteins; homolog of Aprataxin, a Hint related protein that is mutated in individuals with ataxia with oculomotor apraxia; relative distribution to nuclear foci decreases upon DNA replication stress Gene:JIP3(YLR331C_d)|FD-Score:3.47|P-value:2.59E-4||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2 Gene:MSB1(YOR188W)|FD-Score:6.42|P-value:6.89E-11||SGD DESC:Protein of unknown function; may be involved in positive regulation of 1,3-beta-glucan synthesis and the Pkc1p-MAPK pathway; multicopy suppressor of temperature-sensitive mutations in CDC24 and CDC42, and of mutations in BEM4; potential Cdc28p substrate; relocalizes from bud neck to cytoplasm upon DNA replication stress Gene:NMA111(YNL123W)|FD-Score:4.83|P-value:6.97E-7||SGD DESC:Serine protease and general molecular chaperone; involved in response to heat stress and promotion of apoptosis; may contribute to lipid homeostasis; sequence similarity to the mammalian Omi/HtrA2 family of serine proteases Gene:PDH1(YPR002W)|FD-Score:-3.75|P-value:8.94E-5||SGD DESC:Mitochondrial protein that participates in respiration, induced by diauxic shift; homologous to E. coli PrpD, may take part in the conversion of 2-methylcitrate to 2-methylisocitrate Gene:PDR8(YLR266C)|FD-Score:3.99|P-value:3.28E-5||SGD DESC:Transcription factor; targets include ATP-binding cassette (ABC) transporters, major facilitator superfamily transporters, and other genes involved in the pleiotropic drug resistance (PDR) phenomenon; PDR8 has a paralog, YRR1, that arose from the whole genome duplication Gene:PPG1(YNR032W)|FD-Score:4.4|P-value:5.46E-6||SGD DESC:Putative serine/threonine protein phosphatase of the type 2A-like phosphatase family, required for glycogen accumulation; interacts with Tap42p, which binds to and regulates other protein phosphatases Gene:PPQ1(YPL179W)|FD-Score:-3.22|P-value:6.39E-4||SGD DESC:Putative protein serine/threonine phosphatase; null mutation enhances efficiency of translational suppressors Gene:QRI5(YLR204W)|FD-Score:5.45|P-value:2.50E-8||SGD DESC:Mitochondrial inner membrane protein, required for accumulation of spliced COX1 mRNA; may have an additional role in translation of COX1 mRNA Gene:RPL37A(YLR185W)|FD-Score:3.13|P-value:8.71E-4||SGD DESC:Ribosomal 60S subunit protein L37A; homologous to mammalian ribosomal protein L37, no bacterial homolog; RPL37A has a paralog, RPL37B, that arose from the whole genome duplication Gene:SGE1(YPR198W)|FD-Score:4.23|P-value:1.19E-5||SGD DESC:Plasma membrane multidrug transporter of the major facilitator superfamily, acts as an extrusion permease; partial multicopy suppressor of gal11 mutations Gene:SHB17(YKR043C)|FD-Score:4.45|P-value:4.29E-6||SGD DESC:Sedoheptulose bisphosphatase involved in riboneogenesis; dephosphorylates sedoheptulose 1,7-bisphosphate, which is converted via the nonoxidative pentose phosphate pathway to ribose-5-phosphate; facilitates the conversion of glycolytic intermediates to pentose phosphate units; also has fructose 1,6-bisphosphatase activity but this is probably not biologically relevant, since deletion does not affect FBP levels; GFP-fusion protein localizes to the cytoplasm and nucleus Gene:SWA2(YDR320C)|FD-Score:3.37|P-value:3.79E-4||SGD DESC:Auxilin-like protein involved in vesicular transport; clathrin-binding protein required for uncoating of clathrin-coated vesicles Gene:TAT1(YBR069C)|FD-Score:3.31|P-value:4.70E-4||SGD DESC:Amino acid transporter for valine, leucine, isoleucine, and tyrosine; low-affinity tryptophan and histidine transporter; overexpression confers FK506 and FTY720 resistance; protein abundance increases in response to DNA replication stress Gene:TPS2(YDR074W)|FD-Score:4.29|P-value:8.85E-6||SGD DESC:Phosphatase subunit of the trehalose-6-P synthase/phosphatase complex; involved in synthesis of the storage carbohydrate trehalose; expression is induced by stress conditions and repressed by the Ras-cAMP pathway; protein abundance increases in response to DNA replication stress Gene:TRP5(YGL026C)|FD-Score:4.49|P-value:3.64E-6||SGD DESC:Tryptophan synthase, catalyzes the last step of tryptophan biosynthesis; regulated by the general control system of amino acid biosynthesis Gene:VID24(YBR105C)|FD-Score:4.24|P-value:1.11E-5||SGD DESC:GID Complex regulatory subunit; binds GID Complex in response to glucose through interactions with complex member Vid28p; regulates fructose-1,6-bisphosphatase (FBPase) targeting to the vacuole; promotes proteasome-dependent catabolite degradation of FBPase; peripheral membrane protein located at Vid (vacuole import and degradation) vesicles Gene:VPS69(YPR087W_d)|FD-Score:3.22|P-value:6.45E-4||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 85% of ORF overlaps the verified gene SRP54; deletion causes a vacuolar protein sorting defect Gene:YGR050C(YGR050C_p)|FD-Score:3.68|P-value:1.15E-4||SGD DESC:Protein of unknown function; mRNA identified as translated by ribosome profiling data Gene:YHR022C(YHR022C_p)|FD-Score:-3.3|P-value:4.76E-4||SGD DESC:Putative protein of unknown function; YHR022C is not an essential gene Gene:YPL041C(YPL041C_p)|FD-Score:5|P-value:2.80E-7||SGD DESC:Protein of unknown function involved in maintenance of proper telomere length

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YGR095C3.924.37E-50.37RRP46Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp46p (EXOSC5)
YBR002C3.551.91E-40.35RER2Cis-prenyltransferase involved in dolichol synthesis; participates in endoplasmic reticulum (ER) protein sorting
YPR144C3.206.93E-40.01NOC4Nucleolar protein, forms a complex with Nop14p that mediates maturation and nuclear export of 40S ribosomal subunits
YMR211W3.187.29E-40.00DML1Essential protein involved in mtDNA inheritance, may also function in the partitioning of the mitochondrial organelle or in the segregation of chromosomes, exhibits regions similar to members of a GTPase family
YLR197W3.187.31E-40.01NOP56Essential evolutionarily-conserved nucleolar protein component of the box C/D snoRNP complexes that direct 2'-O-methylation of pre-rRNA during its maturation; overexpression causes spindle orientation defects
YGL030W3.187.47E-40.01RPL30Ribosomal 60S subunit protein L30; involved in pre-rRNA processing in the nucleolus; autoregulates splicing of its transcript; homologous to mammalian ribosomal protein L30, no bacterial homolog
YMR260C3.167.77E-40.14TIF11Translation initiation factor eIF1A, essential protein that forms a complex with Sui1p (eIF1) and the 40S ribosomal subunit and scans for the start codon; C-terminus associates with Fun12p (eIF5B); N terminus interacts with eIF2 and eIF3
YLL008W3.030.001230.12DRS1Nucleolar DEAD-box protein required for ribosome assembly and function, including synthesis of 60S ribosomal subunits; constituent of 66S pre-ribosomal particles
YML025C2.910.001798.53E-4YML6Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L4 ribosomal protein and human mitoribosomal MRP-L4 protein; essential for viability, unlike most other mitoribosomal proteins
YPL016W2.910.001800.04SWI1Subunit of the SWI/SNF chromatin remodeling complex; regulates transcription by remodeling chromatin; required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2; can form the prion [SWI+]; human homolog ARID1A is a candidate tumor suppressor gene in breast cancer
YPR086W2.870.002050.12SUA7Transcription factor TFIIB, a general transcription factor required for transcription initiation and start site selection by RNA polymerase II
YDR302W2.760.002930.20GPI11ER membrane protein involved in a late step of glycosylphosphatidylinositol (GPI) anchor assembly; involved in the addition of phosphoethanolamine to the multiply mannosylated GPI intermediate; human PIG-Fp is a functional homolog
YIL142W2.550.005320.03CCT2Subunit beta of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
YBL077W_d2.530.005750.03YBL077W_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene ILS1/YBL076C
YGL092W2.500.006190.08NUP145Essential protein with distinct roles in two nuclear pore subcomplexes; catalyzes its own proteolytic cleavage in vivo to generate a C-terminal fragment that is a structural component of the Nup84p subcomplex (with roles in NPC biogenesis and localization of genes to the nuclear periphery), and an N-terminal fragment that is one of several FG-nucleoporins within the NPC central core directly responsible for nucleocytoplasmic transport; homologous to human NUP98

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YOR188W6.426.89E-11MSB1Protein of unknown function; may be involved in positive regulation of 1,3-beta-glucan synthesis and the Pkc1p-MAPK pathway; multicopy suppressor of temperature-sensitive mutations in CDC24 and CDC42, and of mutations in BEM4; potential Cdc28p substrate; relocalizes from bud neck to cytoplasm upon DNA replication stress
YLR204W5.452.50E-8QRI5Mitochondrial inner membrane protein, required for accumulation of spliced COX1 mRNA; may have an additional role in translation of COX1 mRNA
YPL041C_p5.002.80E-7YPL041C_pProtein of unknown function involved in maintenance of proper telomere length
YNL123W4.836.97E-7NMA111Serine protease and general molecular chaperone; involved in response to heat stress and promotion of apoptosis; may contribute to lipid homeostasis; sequence similarity to the mammalian Omi/HtrA2 family of serine proteases
YGL026C4.493.64E-6TRP5Tryptophan synthase, catalyzes the last step of tryptophan biosynthesis; regulated by the general control system of amino acid biosynthesis
YKR043C4.454.29E-6SHB17Sedoheptulose bisphosphatase involved in riboneogenesis; dephosphorylates sedoheptulose 1,7-bisphosphate, which is converted via the nonoxidative pentose phosphate pathway to ribose-5-phosphate; facilitates the conversion of glycolytic intermediates to pentose phosphate units; also has fructose 1,6-bisphosphatase activity but this is probably not biologically relevant, since deletion does not affect FBP levels; GFP-fusion protein localizes to the cytoplasm and nucleus
YNR032W4.405.46E-6PPG1Putative serine/threonine protein phosphatase of the type 2A-like phosphatase family, required for glycogen accumulation; interacts with Tap42p, which binds to and regulates other protein phosphatases
YDR074W4.298.85E-6TPS2Phosphatase subunit of the trehalose-6-P synthase/phosphatase complex; involved in synthesis of the storage carbohydrate trehalose; expression is induced by stress conditions and repressed by the Ras-cAMP pathway; protein abundance increases in response to DNA replication stress
YBR105C4.241.11E-5VID24GID Complex regulatory subunit; binds GID Complex in response to glucose through interactions with complex member Vid28p; regulates fructose-1,6-bisphosphatase (FBPase) targeting to the vacuole; promotes proteasome-dependent catabolite degradation of FBPase; peripheral membrane protein located at Vid (vacuole import and degradation) vesicles
YPR198W4.231.19E-5SGE1Plasma membrane multidrug transporter of the major facilitator superfamily, acts as an extrusion permease; partial multicopy suppressor of gal11 mutations
YLR266C3.993.28E-5PDR8Transcription factor; targets include ATP-binding cassette (ABC) transporters, major facilitator superfamily transporters, and other genes involved in the pleiotropic drug resistance (PDR) phenomenon; PDR8 has a paralog, YRR1, that arose from the whole genome duplication
YDL069C3.836.38E-5CBS1Mitochondrial translational activator of the COB mRNA; membrane protein that interacts with translating ribosomes, acts on the COB mRNA 5'-untranslated leader
YGR271C-A3.836.40E-5EFG1Essential protein required for maturation of 18S rRNA; null mutant is sensitive to hydroxyurea and is delayed in recovering from alpha-factor arrest; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus
YGR050C_p3.681.15E-4YGR050C_pProtein of unknown function; mRNA identified as translated by ribosome profiling data
YFL053W3.611.55E-4DAK2Dihydroxyacetone kinase, required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation

GO enrichment analysis for SGTC_3250
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.0823.04E-10SGTC_22287354201 200.0 μMChembridge (Fragment library)7534510.09375endomembrane recycling
0.0814.75E-10SGTC_32259130819 49.5 μMChembridge (Drug-like library)45471210.181818amide catabolism
0.0731.99E-8SGTC_1613st002381 52.1 μMTimTec (Natural product derivative library)5511670.164384
0.0722.65E-8SGTC_18835-benzylidenerhodanine 20.0 μMMiscellaneous12732100.103448TRP & mitochondrial translation
0.0714.32E-8SGTC_8003448-7362 155.0 μMChemDiv (Drug-like library)159919130.150685translation
0.0699.46E-8SGTC_32589138477 49.5 μMChembridge (Drug-like library)49703550.151899
0.0691.28E-7SGTC_1716st033144 30.6 μMTimTec (Natural product derivative library)6746170.254237
0.0691.35E-7SGTC_28899059656 52.0 μMChembridge (Drug-like library)39498380.172414
0.0681.54E-7SGTC_7670929-0023 86.0 μMChemDiv (Drug-like library)12045630.280702TRP & mitochondrial translation
0.0682.03E-7SGTC_8490386-0493 241.0 μMChemDiv (Drug-like library)7261190.0909091
0.0672.65E-7SGTC_12251216-0074 20.6 μMChemDiv (Drug-like library)42414660.107143
0.0672.83E-7SGTC_10462001-0062 216.0 μMChemDiv (Drug-like library)7397780.202899
0.0673.11E-7SGTC_1290088-0017 176.6 μMChemDiv (Drug-like library)1824460.224138
0.0663.62E-7SGTC_30919116372 49.5 μMChembridge (Drug-like library)171697930.339286
0.0663.75E-7SGTC_32569138902 49.5 μMChembridge (Drug-like library)172287730.140625PDR1

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_2998906676271.43 μM0.6382984945196Chembridge (Drug-like library)297.348363.54713RPP1 & pyrimidine depletion
SGTC_3067911743149.47 μM0.517150885Chembridge (Drug-like library)285.337663.30813
SGTC_9861493-048384 μM0.48936240079ChemDiv (Drug-like library)256.256681.31914
SGTC_8261683-5028118 μM0.44898722377ChemDiv (Drug-like library)261.703583.26212
SGTC_9363005-4620401 μM0.444444777207ChemDiv (Drug-like library)295.296021.48515
SGTC_3072911641949.47 μM0.43859617170162Chembridge (Drug-like library)331.793423.62113ERG2
SGTC_2864903475547.6 μM0.4363644930451Chembridge (Drug-like library)361.393862.58124
SGTC_1759st04305970 μM0.431373669426TimTec (Natural product derivative library)285.29462.45314amide catabolism
SGTC_3184910875849.47 μM0.428571902885Chembridge (Drug-like library)241.28512.94712
SGTC_2861902459519.48 μM0.4262316482810Chembridge (Drug-like library)401.886562.9914