| Deletion Strain | FD score | P-value | Gene | Gene Description |
|---|
| YOR188W | 6.42 | 6.89E-11 | MSB1 | Protein of unknown function; may be involved in positive regulation of 1,3-beta-glucan synthesis and the Pkc1p-MAPK pathway; multicopy suppressor of temperature-sensitive mutations in CDC24 and CDC42, and of mutations in BEM4; potential Cdc28p substrate; relocalizes from bud neck to cytoplasm upon DNA replication stress |
| YLR204W | 5.45 | 2.50E-8 | QRI5 | Mitochondrial inner membrane protein, required for accumulation of spliced COX1 mRNA; may have an additional role in translation of COX1 mRNA |
| YPL041C_p | 5.00 | 2.80E-7 | YPL041C_p | Protein of unknown function involved in maintenance of proper telomere length |
| YNL123W | 4.83 | 6.97E-7 | NMA111 | Serine protease and general molecular chaperone; involved in response to heat stress and promotion of apoptosis; may contribute to lipid homeostasis; sequence similarity to the mammalian Omi/HtrA2 family of serine proteases |
| YGL026C | 4.49 | 3.64E-6 | TRP5 | Tryptophan synthase, catalyzes the last step of tryptophan biosynthesis; regulated by the general control system of amino acid biosynthesis |
| YKR043C | 4.45 | 4.29E-6 | SHB17 | Sedoheptulose bisphosphatase involved in riboneogenesis; dephosphorylates sedoheptulose 1,7-bisphosphate, which is converted via the nonoxidative pentose phosphate pathway to ribose-5-phosphate; facilitates the conversion of glycolytic intermediates to pentose phosphate units; also has fructose 1,6-bisphosphatase activity but this is probably not biologically relevant, since deletion does not affect FBP levels; GFP-fusion protein localizes to the cytoplasm and nucleus |
| YNR032W | 4.40 | 5.46E-6 | PPG1 | Putative serine/threonine protein phosphatase of the type 2A-like phosphatase family, required for glycogen accumulation; interacts with Tap42p, which binds to and regulates other protein phosphatases |
| YDR074W | 4.29 | 8.85E-6 | TPS2 | Phosphatase subunit of the trehalose-6-P synthase/phosphatase complex; involved in synthesis of the storage carbohydrate trehalose; expression is induced by stress conditions and repressed by the Ras-cAMP pathway; protein abundance increases in response to DNA replication stress |
| YBR105C | 4.24 | 1.11E-5 | VID24 | GID Complex regulatory subunit; binds GID Complex in response to glucose through interactions with complex member Vid28p; regulates fructose-1,6-bisphosphatase (FBPase) targeting to the vacuole; promotes proteasome-dependent catabolite degradation of FBPase; peripheral membrane protein located at Vid (vacuole import and degradation) vesicles |
| YPR198W | 4.23 | 1.19E-5 | SGE1 | Plasma membrane multidrug transporter of the major facilitator superfamily, acts as an extrusion permease; partial multicopy suppressor of gal11 mutations |
| YLR266C | 3.99 | 3.28E-5 | PDR8 | Transcription factor; targets include ATP-binding cassette (ABC) transporters, major facilitator superfamily transporters, and other genes involved in the pleiotropic drug resistance (PDR) phenomenon; PDR8 has a paralog, YRR1, that arose from the whole genome duplication |
| YDL069C | 3.83 | 6.38E-5 | CBS1 | Mitochondrial translational activator of the COB mRNA; membrane protein that interacts with translating ribosomes, acts on the COB mRNA 5'-untranslated leader |
| YGR271C-A | 3.83 | 6.40E-5 | EFG1 | Essential protein required for maturation of 18S rRNA; null mutant is sensitive to hydroxyurea and is delayed in recovering from alpha-factor arrest; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus |
| YGR050C_p | 3.68 | 1.15E-4 | YGR050C_p | Protein of unknown function; mRNA identified as translated by ribosome profiling data |
| YFL053W | 3.61 | 1.55E-4 | DAK2 | Dihydroxyacetone kinase, required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation |
