9135047

N-(2-methoxyphenyl)-4-methyl-2-pyridin-3-yl-1,3-thiazole-5-carboxamide

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_3251
Screen concentration 49.5 μM
Source Chembridge (Drug-like library)
PubChem CID 17682963
SMILES CC1=C(SC(=N1)C2=CN=CC=C2)C(=O)NC3=CC=CC=C3OC
Standardized SMILES COc1ccccc1NC(=O)c2sc(nc2C)c3cccnc3
Molecular weight 325.3849
ALogP 2.4
H-bond donor count 1
H-bond acceptor count 5
Response signature 60S ribosome export

Pool Growth Kinetics
% growth inhibition (Het. pool) 12.37
% growth inhibition (Hom. pool) 2.69


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 17682963
Download HIP data (tab-delimited text)  (excel)
Gene:ADE13(YLR359W)|FD-Score:3.64|P-value:1.36E-4|Clearance:0.04||SGD DESC:Adenylosuccinate lyase, catalyzes two steps in the 'de novo' purine nucleotide biosynthetic pathway; expression is repressed by adenine and activated by Bas1p and Pho2p; mutations in human ortholog ADSL cause adenylosuccinase deficiency Gene:AOS1(YPR180W)|FD-Score:3.6|P-value:1.57E-4|Clearance:0.33||SGD DESC:Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability Gene:DYS1(YHR068W)|FD-Score:3.28|P-value:5.25E-4|Clearance:0.13||SGD DESC:Deoxyhypusine synthase, catalyzes formation of deoxyhypusine, the first step in hypusine biosynthesis; triggers posttranslational hypusination of translation elongation factor eIF-5A and regulates its intracellular levels; tetrameric Gene:KRE5(YOR336W)|FD-Score:4.24|P-value:1.12E-5|Clearance:0.23||SGD DESC:Protein required for beta-1,6 glucan biosynthesis; mutations result in aberrant morphology and severe growth defects Gene:LSG1(YGL099W)|FD-Score:4.76|P-value:9.58E-7|Clearance:0.47||SGD DESC:Putative GTPase involved in 60S ribosomal subunit biogenesis; required for the release of Nmd3p from 60S subunits in the cytoplasm Gene:MCM10(YIL150C)|FD-Score:4.01|P-value:3.05E-5|Clearance:0.37||SGD DESC:Essential chromatin-associated protein involved in the initiation of DNA replication; required for the association of the MCM2-7 complex with replication origins Gene:NMD3(YHR170W)|FD-Score:5.84|P-value:2.63E-9|Clearance:1.08||SGD DESC:Protein involved in nuclear export of the large ribosomal subunit; acts as a Crm1p-dependent adapter protein for export of nascent ribosomal subunits through the nuclear pore complex Gene:NSP1(YJL041W)|FD-Score:4.3|P-value:8.72E-6|Clearance:0.06||SGD DESC:FG-nucleoporin component of central core of the nuclear pore complex (NPC); also part of the NPC nuclear basket; contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; found in stable complex with Nup82p, Gle2p and two other FG-nucleoporins (Nup159p and Nup116p); also found in stable complex with Nic96p and two other FG-nucleoproteins (Nup49p and Nup57p); forms foci at the nuclear periphery upon DNA replication stress Gene:PUP2(YGR253C)|FD-Score:-3.48|P-value:2.51E-4|Clearance:0||SGD DESC:Alpha 5 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit zeta Gene:RIB5(YBR256C)|FD-Score:-3.33|P-value:4.27E-4|Clearance:0||SGD DESC:Riboflavin synthase; catalyzes the last step of the riboflavin biosynthesis pathway Gene:RTT105(YER104W)|FD-Score:3.14|P-value:8.35E-4|Clearance:0.11||SGD DESC:Protein with a role in regulation of Ty1 transposition Gene:ADE13(YLR359W)|FD-Score:3.64|P-value:1.36E-4|Clearance:0.04||SGD DESC:Adenylosuccinate lyase, catalyzes two steps in the 'de novo' purine nucleotide biosynthetic pathway; expression is repressed by adenine and activated by Bas1p and Pho2p; mutations in human ortholog ADSL cause adenylosuccinase deficiency Gene:AOS1(YPR180W)|FD-Score:3.6|P-value:1.57E-4|Clearance:0.33||SGD DESC:Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability Gene:DYS1(YHR068W)|FD-Score:3.28|P-value:5.25E-4|Clearance:0.13||SGD DESC:Deoxyhypusine synthase, catalyzes formation of deoxyhypusine, the first step in hypusine biosynthesis; triggers posttranslational hypusination of translation elongation factor eIF-5A and regulates its intracellular levels; tetrameric Gene:KRE5(YOR336W)|FD-Score:4.24|P-value:1.12E-5|Clearance:0.23||SGD DESC:Protein required for beta-1,6 glucan biosynthesis; mutations result in aberrant morphology and severe growth defects Gene:LSG1(YGL099W)|FD-Score:4.76|P-value:9.58E-7|Clearance:0.47||SGD DESC:Putative GTPase involved in 60S ribosomal subunit biogenesis; required for the release of Nmd3p from 60S subunits in the cytoplasm Gene:MCM10(YIL150C)|FD-Score:4.01|P-value:3.05E-5|Clearance:0.37||SGD DESC:Essential chromatin-associated protein involved in the initiation of DNA replication; required for the association of the MCM2-7 complex with replication origins Gene:NMD3(YHR170W)|FD-Score:5.84|P-value:2.63E-9|Clearance:1.08||SGD DESC:Protein involved in nuclear export of the large ribosomal subunit; acts as a Crm1p-dependent adapter protein for export of nascent ribosomal subunits through the nuclear pore complex Gene:NSP1(YJL041W)|FD-Score:4.3|P-value:8.72E-6|Clearance:0.06||SGD DESC:FG-nucleoporin component of central core of the nuclear pore complex (NPC); also part of the NPC nuclear basket; contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; found in stable complex with Nup82p, Gle2p and two other FG-nucleoporins (Nup159p and Nup116p); also found in stable complex with Nic96p and two other FG-nucleoproteins (Nup49p and Nup57p); forms foci at the nuclear periphery upon DNA replication stress Gene:PUP2(YGR253C)|FD-Score:-3.48|P-value:2.51E-4|Clearance:0||SGD DESC:Alpha 5 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit zeta Gene:RIB5(YBR256C)|FD-Score:-3.33|P-value:4.27E-4|Clearance:0||SGD DESC:Riboflavin synthase; catalyzes the last step of the riboflavin biosynthesis pathway Gene:RTT105(YER104W)|FD-Score:3.14|P-value:8.35E-4|Clearance:0.11||SGD DESC:Protein with a role in regulation of Ty1 transposition

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 17682963
Download HOP data (tab-delimited text)  (excel)
Gene:ASE1(YOR058C)|FD-Score:3.96|P-value:3.69E-5||SGD DESC:Mitotic spindle midzone localized protein; microtubule-associated protein (MAP) family member; required for spindle elongation and stabilization; undergoes cell cycle-regulated degradation by anaphase promoting complex; potential Cdc28p substrate; relative distribution to microtubules decreases upon DNA replication stress Gene:BAS1(YKR099W)|FD-Score:3.67|P-value:1.23E-4||SGD DESC:Myb-related transcription factor involved in regulating basal and induced expression of genes of the purine and histidine biosynthesis pathways; also involved in regulation of meiotic recombination at specific genes Gene:BNA2(YJR078W)|FD-Score:3.33|P-value:4.41E-4||SGD DESC:Putative tryptophan 2,3-dioxygenase or indoleamine 2,3-dioxygenase, required for de novo biosynthesis of NAD from tryptophan via kynurenine; interacts genetically with telomere capping gene CDC13; regulated by Hst1p and Aftp Gene:BTS1(YPL069C)|FD-Score:3.2|P-value:6.99E-4||SGD DESC:Geranylgeranyl diphosphate synthase, increases the intracellular pool of geranylgeranyl diphosphate, suppressor of bet2 mutation that causes defective geranylgeranylation of small GTP-binding proteins that mediate vesicular traffic Gene:CNA1(YLR433C)|FD-Score:4.25|P-value:1.07E-5||SGD DESC:Calcineurin A; one isoform (the other is CMP2) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1 Gene:COG5(YNL051W)|FD-Score:-4.09|P-value:2.18E-5||SGD DESC:Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:DOM34(YNL001W)|FD-Score:-4.57|P-value:2.41E-6||SGD DESC:Protein that facilitates ribosomal subunit dissociation; acts when translation is stalled, with binding partner Hbs1p; required for RNA cleavage in no-go decay, but reports conflict on endonuclease activity; Pelota ortholog; protein abundance increases in response to DNA replication stress; DOM34 has a paralog, YCL001W-B, that arose from the whole genome duplication Gene:FAR11(YNL127W)|FD-Score:3.34|P-value:4.19E-4||SGD DESC:Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far8p, Far9p, and Far10p; has similarity to the N- and C-termini of N. crassa HAM-2 Gene:FRA2(YGL220W)|FD-Score:-3.25|P-value:5.83E-4||SGD DESC:Protein involved in negative regulation of transcription of iron regulon; forms an iron independent complex with Fra2p, Grx3p, and Grx4p; null mutant fails to repress iron regulon and is sensitive to nickel Gene:FYV4(YHR059W)|FD-Score:3.37|P-value:3.80E-4||SGD DESC:Protein of unknown function, required for survival upon exposure to K1 killer toxin Gene:GRR1(YJR090C)|FD-Score:3.68|P-value:1.18E-4||SGD DESC:F-box protein component of the SCF ubiquitin-ligase complex; involved in carbon catabolite repression, glucose-dependent divalent cation transport, high-affinity glucose transport, morphogenesis, and sulfite detoxification Gene:KTR6(YPL053C)|FD-Score:3.64|P-value:1.36E-4||SGD DESC:Probable mannosylphosphate transferase; involved in the synthesis of core oligosaccharides in protein glycosylation pathway; member of the KRE2/MNT1 mannosyltransferase family; KTR6 has a paralog, KRE2, that arose from the whole genome duplication Gene:MHF2(YDL160C-A)|FD-Score:3.21|P-value:6.53E-4||SGD DESC:Component of the heterotetrameric MHF histone-fold complex; in humans the MMF complex interacts with both DNA and Mph1p ortholog FANCM to stabilize and remodel blocked replication forks and repair damaged DNA; mhf2 srs2 double mutants are MMS hypersensitive; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-X, also known as MHF2 Gene:MRN1(YPL184C)|FD-Score:3.65|P-value:1.33E-4||SGD DESC:RNA-binding protein that may be involved in translational regulation; binds specific categories of mRNAs, including those that contain upstream open reading frames (uORFs) and internal ribosome entry sites (IRES); interacts genetically with chromatin remodelers and splicing factors, linking chromatin state, splicing and as a result mRNA maturation Gene:MSS1(YMR023C)|FD-Score:-3.4|P-value:3.42E-4||SGD DESC:Mitochondrial protein, forms a heterodimer complex with Mto1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; similar to human GTPBP3 Gene:NIF3(YGL221C)|FD-Score:3.19|P-value:7.23E-4||SGD DESC:Protein of unknown function, similar to Listeria monocytogenes major sigma factor (rpoD gene product); the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:PBP1(YGR178C)|FD-Score:4.06|P-value:2.42E-5||SGD DESC:Component of glucose deprivation induced stress granules; involved in P-body-dependent granule assembly; similar to human ataxin-2; interacts with Pab1p to regulate mRNA polyadenylation; interacts with Mkt1p to regulate HO translation; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress Gene:RTC6(YPL183W-A)|FD-Score:-4.19|P-value:1.41E-5||SGD DESC:Protein involved in translation; mutants have defects in biogenesis of nuclear ribosomes; sequence similar to prokaryotic ribosomal protein L36, may be a mitochondrial ribosomal protein; protein abundance increases in response to DNA replication stress Gene:SPO16(YHR153C)|FD-Score:3.7|P-value:1.09E-4||SGD DESC:Meiosis-specific protein involved in synaptonemal complex assembly; implicated in regulation of crossover formation; required for sporulation Gene:SSN3(YPL042C)|FD-Score:-3.32|P-value:4.57E-4||SGD DESC:Cyclin-dependent protein kinase, component of RNA polymerase II holoenzyme; involved in phosphorylation of the RNA polymerase II C-terminal domain; involved in glucose repression Gene:VBA1(YMR088C)|FD-Score:3.84|P-value:6.23E-5||SGD DESC:Permease of basic amino acids in the vacuolar membrane Gene:VMA7(YGR020C)|FD-Score:3.56|P-value:1.83E-4||SGD DESC:Subunit F of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane Gene:VPS70(YJR126C)|FD-Score:3.52|P-value:2.17E-4||SGD DESC:Protein of unknown function involved in vacuolar protein sorting Gene:YBL062W(YBL062W_d)|FD-Score:3.41|P-value:3.22E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YHR097C(YHR097C_p)|FD-Score:3.67|P-value:1.20E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus Gene:YLR400W(YLR400W_d)|FD-Score:3.69|P-value:1.12E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YMR057C(YMR057C_d)|FD-Score:3.56|P-value:1.84E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF AAC1 Gene:YOL013W-B(YOL013W-B_d)|FD-Score:3.1|P-value:9.66E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the long terminal repeat (LTR) of a Ty1 element Gene:YPR003C(YPR003C_p)|FD-Score:3.1|P-value:9.70E-4||SGD DESC:Putative sulfate permease; physically interacts with Hsp82p; green fluorescent protein (GFP)-fusion protein localizes to the ER; YPR003C is not an essential gene Gene:YPR053C(YPR053C_d)|FD-Score:-3.47|P-value:2.64E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene NHP6A/YPR052C Gene:ASE1(YOR058C)|FD-Score:3.96|P-value:3.69E-5||SGD DESC:Mitotic spindle midzone localized protein; microtubule-associated protein (MAP) family member; required for spindle elongation and stabilization; undergoes cell cycle-regulated degradation by anaphase promoting complex; potential Cdc28p substrate; relative distribution to microtubules decreases upon DNA replication stress Gene:BAS1(YKR099W)|FD-Score:3.67|P-value:1.23E-4||SGD DESC:Myb-related transcription factor involved in regulating basal and induced expression of genes of the purine and histidine biosynthesis pathways; also involved in regulation of meiotic recombination at specific genes Gene:BNA2(YJR078W)|FD-Score:3.33|P-value:4.41E-4||SGD DESC:Putative tryptophan 2,3-dioxygenase or indoleamine 2,3-dioxygenase, required for de novo biosynthesis of NAD from tryptophan via kynurenine; interacts genetically with telomere capping gene CDC13; regulated by Hst1p and Aftp Gene:BTS1(YPL069C)|FD-Score:3.2|P-value:6.99E-4||SGD DESC:Geranylgeranyl diphosphate synthase, increases the intracellular pool of geranylgeranyl diphosphate, suppressor of bet2 mutation that causes defective geranylgeranylation of small GTP-binding proteins that mediate vesicular traffic Gene:CNA1(YLR433C)|FD-Score:4.25|P-value:1.07E-5||SGD DESC:Calcineurin A; one isoform (the other is CMP2) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1 Gene:COG5(YNL051W)|FD-Score:-4.09|P-value:2.18E-5||SGD DESC:Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:DOM34(YNL001W)|FD-Score:-4.57|P-value:2.41E-6||SGD DESC:Protein that facilitates ribosomal subunit dissociation; acts when translation is stalled, with binding partner Hbs1p; required for RNA cleavage in no-go decay, but reports conflict on endonuclease activity; Pelota ortholog; protein abundance increases in response to DNA replication stress; DOM34 has a paralog, YCL001W-B, that arose from the whole genome duplication Gene:FAR11(YNL127W)|FD-Score:3.34|P-value:4.19E-4||SGD DESC:Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far8p, Far9p, and Far10p; has similarity to the N- and C-termini of N. crassa HAM-2 Gene:FRA2(YGL220W)|FD-Score:-3.25|P-value:5.83E-4||SGD DESC:Protein involved in negative regulation of transcription of iron regulon; forms an iron independent complex with Fra2p, Grx3p, and Grx4p; null mutant fails to repress iron regulon and is sensitive to nickel Gene:FYV4(YHR059W)|FD-Score:3.37|P-value:3.80E-4||SGD DESC:Protein of unknown function, required for survival upon exposure to K1 killer toxin Gene:GRR1(YJR090C)|FD-Score:3.68|P-value:1.18E-4||SGD DESC:F-box protein component of the SCF ubiquitin-ligase complex; involved in carbon catabolite repression, glucose-dependent divalent cation transport, high-affinity glucose transport, morphogenesis, and sulfite detoxification Gene:KTR6(YPL053C)|FD-Score:3.64|P-value:1.36E-4||SGD DESC:Probable mannosylphosphate transferase; involved in the synthesis of core oligosaccharides in protein glycosylation pathway; member of the KRE2/MNT1 mannosyltransferase family; KTR6 has a paralog, KRE2, that arose from the whole genome duplication Gene:MHF2(YDL160C-A)|FD-Score:3.21|P-value:6.53E-4||SGD DESC:Component of the heterotetrameric MHF histone-fold complex; in humans the MMF complex interacts with both DNA and Mph1p ortholog FANCM to stabilize and remodel blocked replication forks and repair damaged DNA; mhf2 srs2 double mutants are MMS hypersensitive; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-X, also known as MHF2 Gene:MRN1(YPL184C)|FD-Score:3.65|P-value:1.33E-4||SGD DESC:RNA-binding protein that may be involved in translational regulation; binds specific categories of mRNAs, including those that contain upstream open reading frames (uORFs) and internal ribosome entry sites (IRES); interacts genetically with chromatin remodelers and splicing factors, linking chromatin state, splicing and as a result mRNA maturation Gene:MSS1(YMR023C)|FD-Score:-3.4|P-value:3.42E-4||SGD DESC:Mitochondrial protein, forms a heterodimer complex with Mto1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; similar to human GTPBP3 Gene:NIF3(YGL221C)|FD-Score:3.19|P-value:7.23E-4||SGD DESC:Protein of unknown function, similar to Listeria monocytogenes major sigma factor (rpoD gene product); the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:PBP1(YGR178C)|FD-Score:4.06|P-value:2.42E-5||SGD DESC:Component of glucose deprivation induced stress granules; involved in P-body-dependent granule assembly; similar to human ataxin-2; interacts with Pab1p to regulate mRNA polyadenylation; interacts with Mkt1p to regulate HO translation; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress Gene:RTC6(YPL183W-A)|FD-Score:-4.19|P-value:1.41E-5||SGD DESC:Protein involved in translation; mutants have defects in biogenesis of nuclear ribosomes; sequence similar to prokaryotic ribosomal protein L36, may be a mitochondrial ribosomal protein; protein abundance increases in response to DNA replication stress Gene:SPO16(YHR153C)|FD-Score:3.7|P-value:1.09E-4||SGD DESC:Meiosis-specific protein involved in synaptonemal complex assembly; implicated in regulation of crossover formation; required for sporulation Gene:SSN3(YPL042C)|FD-Score:-3.32|P-value:4.57E-4||SGD DESC:Cyclin-dependent protein kinase, component of RNA polymerase II holoenzyme; involved in phosphorylation of the RNA polymerase II C-terminal domain; involved in glucose repression Gene:VBA1(YMR088C)|FD-Score:3.84|P-value:6.23E-5||SGD DESC:Permease of basic amino acids in the vacuolar membrane Gene:VMA7(YGR020C)|FD-Score:3.56|P-value:1.83E-4||SGD DESC:Subunit F of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane Gene:VPS70(YJR126C)|FD-Score:3.52|P-value:2.17E-4||SGD DESC:Protein of unknown function involved in vacuolar protein sorting Gene:YBL062W(YBL062W_d)|FD-Score:3.41|P-value:3.22E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YHR097C(YHR097C_p)|FD-Score:3.67|P-value:1.20E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus Gene:YLR400W(YLR400W_d)|FD-Score:3.69|P-value:1.12E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YMR057C(YMR057C_d)|FD-Score:3.56|P-value:1.84E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF AAC1 Gene:YOL013W-B(YOL013W-B_d)|FD-Score:3.1|P-value:9.66E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the long terminal repeat (LTR) of a Ty1 element Gene:YPR003C(YPR003C_p)|FD-Score:3.1|P-value:9.70E-4||SGD DESC:Putative sulfate permease; physically interacts with Hsp82p; green fluorescent protein (GFP)-fusion protein localizes to the ER; YPR003C is not an essential gene Gene:YPR053C(YPR053C_d)|FD-Score:-3.47|P-value:2.64E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene NHP6A/YPR052C

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YHR170W5.842.63E-91.08NMD3Protein involved in nuclear export of the large ribosomal subunit; acts as a Crm1p-dependent adapter protein for export of nascent ribosomal subunits through the nuclear pore complex
YGL099W4.769.58E-70.47LSG1Putative GTPase involved in 60S ribosomal subunit biogenesis; required for the release of Nmd3p from 60S subunits in the cytoplasm
YJL041W4.308.72E-60.06NSP1FG-nucleoporin component of central core of the nuclear pore complex (NPC); also part of the NPC nuclear basket; contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; found in stable complex with Nup82p, Gle2p and two other FG-nucleoporins (Nup159p and Nup116p); also found in stable complex with Nic96p and two other FG-nucleoproteins (Nup49p and Nup57p); forms foci at the nuclear periphery upon DNA replication stress
YOR336W4.241.12E-50.23KRE5Protein required for beta-1,6 glucan biosynthesis; mutations result in aberrant morphology and severe growth defects
YIL150C4.013.05E-50.37MCM10Essential chromatin-associated protein involved in the initiation of DNA replication; required for the association of the MCM2-7 complex with replication origins
YLR359W3.641.36E-40.04ADE13Adenylosuccinate lyase, catalyzes two steps in the 'de novo' purine nucleotide biosynthetic pathway; expression is repressed by adenine and activated by Bas1p and Pho2p; mutations in human ortholog ADSL cause adenylosuccinase deficiency
YPR180W3.601.57E-40.33AOS1Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
YHR068W3.285.25E-40.13DYS1Deoxyhypusine synthase, catalyzes formation of deoxyhypusine, the first step in hypusine biosynthesis; triggers posttranslational hypusination of translation elongation factor eIF-5A and regulates its intracellular levels; tetrameric
YER104W3.148.35E-40.11RTT105Protein with a role in regulation of Ty1 transposition
YDL004W3.040.001200.02ATP16Delta subunit of the central stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated
YJL005W3.020.001270.02CYR1Adenylate cyclase, required for cAMP production and cAMP-dependent protein kinase signaling; the cAMP pathway controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation
YLR197W3.000.001370.09NOP56Essential evolutionarily-conserved nucleolar protein component of the box C/D snoRNP complexes that direct 2'-O-methylation of pre-rRNA during its maturation; overexpression causes spindle orientation defects
YIL068C2.910.001830.02SEC6Essential 88kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; anchors the assembled complex to sites of secretion; interacts with SM-like protein and SNARE regulator Sec1p and may recruit it to sites of secretion; interacts with Sec9p and inhibits formation of the t-SNARE complex between Sec9p and Sso1p
YPR035W2.880.001980.11GLN1Glutamine synthetase (GS); synthesizes glutamine from glutamate and ammonia; with Glt1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source and by amino acid limitation; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress
YDR002W2.770.002810.13YRB1Ran GTPase binding protein; involved in nuclear protein import and RNA export, ubiquitin-mediated protein degradation during the cell cycle; shuttles between the nucleus and cytoplasm; is essential; homolog of human RanBP1

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YLR433C4.251.07E-5CNA1Calcineurin A; one isoform (the other is CMP2) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1
YGR178C4.062.42E-5PBP1Component of glucose deprivation induced stress granules; involved in P-body-dependent granule assembly; similar to human ataxin-2; interacts with Pab1p to regulate mRNA polyadenylation; interacts with Mkt1p to regulate HO translation; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress
YOR058C3.963.69E-5ASE1Mitotic spindle midzone localized protein; microtubule-associated protein (MAP) family member; required for spindle elongation and stabilization; undergoes cell cycle-regulated degradation by anaphase promoting complex; potential Cdc28p substrate; relative distribution to microtubules decreases upon DNA replication stress
YMR088C3.846.23E-5VBA1Permease of basic amino acids in the vacuolar membrane
YHR153C3.701.09E-4SPO16Meiosis-specific protein involved in synaptonemal complex assembly; implicated in regulation of crossover formation; required for sporulation
YLR400W_d3.691.12E-4YLR400W_dDubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YJR090C3.681.18E-4GRR1F-box protein component of the SCF ubiquitin-ligase complex; involved in carbon catabolite repression, glucose-dependent divalent cation transport, high-affinity glucose transport, morphogenesis, and sulfite detoxification
YHR097C_p3.671.20E-4YHR097C_pPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus
YKR099W3.671.23E-4BAS1Myb-related transcription factor involved in regulating basal and induced expression of genes of the purine and histidine biosynthesis pathways; also involved in regulation of meiotic recombination at specific genes
YPL184C3.651.33E-4MRN1RNA-binding protein that may be involved in translational regulation; binds specific categories of mRNAs, including those that contain upstream open reading frames (uORFs) and internal ribosome entry sites (IRES); interacts genetically with chromatin remodelers and splicing factors, linking chromatin state, splicing and as a result mRNA maturation
YPL053C3.641.36E-4KTR6Probable mannosylphosphate transferase; involved in the synthesis of core oligosaccharides in protein glycosylation pathway; member of the KRE2/MNT1 mannosyltransferase family; KTR6 has a paralog, KRE2, that arose from the whole genome duplication
YGR020C3.561.83E-4VMA7Subunit F of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane
YMR057C_d3.561.84E-4YMR057C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF AAC1
YJR126C3.522.17E-4VPS70Protein of unknown function involved in vacuolar protein sorting
YBL062W_d3.413.22E-4YBL062W_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data

GO enrichment analysis for SGTC_3251
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.1771.04E-42SGTC_618k072-0232 33.2 μMChemDiv (Drug-like library)58727560.19718360S ribosome export
0.1697.71E-39SGTC_7651319-0117 244.0 μMChemDiv (Drug-like library)34877460.19318260S ribosome export
0.1674.00E-38SGTC_1983454-2873 16.2 μMChemDiv (Drug-like library)7109570.13888960S ribosome export
0.1653.42E-37SGTC_1913914-0123 66.5 μMChemDiv (Drug-like library)31444120.12820560S ribosome export
0.1541.35E-32SGTC_970535-0701 19.1 μMChemDiv (Drug-like library)28320130.085365960S ribosome export
0.1503.84E-31SGTC_1350933-0004 26.3 μMChemDiv (Drug-like library)212306170.10256460S ribosome export
0.1491.01E-30SGTC_850868-0259 160.1 μMChemDiv (Drug-like library)831730.14492860S ribosome export
0.1461.23E-29SGTC_1958st076513 41.9 μMTimTec (Natural product derivative library)7321220.10666760S ribosome export
0.1461.88E-29SGTC_8103825-7150 143.0 μMChemDiv (Drug-like library)223304110.22368460S ribosome export
0.1381.80E-26SGTC_1971st069429 63.5 μMTimTec (Natural product derivative library)12465220.20270360S ribosome export
0.1375.94E-26SGTC_29839022671 13.0 μMChembridge (Drug-like library)64051610.096774260S ribosome export
0.1343.60E-25SGTC_1070indatraline 8.8 μMNIH Clinical Collection103144720.095890460S ribosome export
0.1331.02E-24SGTC_1829berberine 14.4 μMTimTec (Natural product derivative library)23530.10714360S ribosome export
0.1313.70E-24SGTC_15924',5'-dihydroxyflavone 8.8 μMTimTec (Pure natural product library)6886690.18571460S ribosome export
0.1271.28E-22SGTC_1775st081588 35.2 μMTimTec (Natural product derivative library)14264430.10227360S ribosome export

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_3233913234049.47 μM0.73584917682950Chembridge (Drug-like library)329.803983.08314
SGTC_3215912994249.47 μM0.70909117682944Chembridge (Drug-like library)323.412083.36114
SGTC_3337914434233.55 μM0.62517682949Chembridge (Drug-like library)313.3493832.62415
SGTC_3269913782349.47 μM0.61403517682936Chembridge (Drug-like library)309.38552.9041460S ribosome export
SGTC_3229913220449.47 μM0.49253717682924Chembridge (Drug-like library)327.443843.16914
SGTC_21625663267200 μM0.4655176456493Chembridge (Fragment library)298.78843.05625
SGTC_20535265679138 μM0.428571764595Chembridge (Fragment library)233.286242.55113
SGTC_8261683-5028118 μM0.38983722377ChemDiv (Drug-like library)261.703583.26212
SGTC_1090132-003633.7 μM0.38333367274ChemDiv (Drug-like library)293.31663.26423
SGTC_9363005-4620401 μM0.369231777207ChemDiv (Drug-like library)295.296021.48515