| Deletion Strain | FD score | P-value | Gene | Gene Description |
|---|
| YMR216C | 5.44 | 2.72E-8 | SKY1 | SR protein kinase (SRPK) involved in regulating proteins involved in mRNA metabolism and cation homeostasis; similar to human SRPK1 |
| YJL112W | 5.40 | 3.41E-8 | MDV1 | Peripheral protein of cytosolic face of mitochondrial outer membrane; required for mitochondrial fission; interacts with Fis1p and with the dynamin-related GTPase Dnm1p; contains WD repeats; MDV1 has a paralog, CAF4, that arose from the whole genome duplication |
| YML124C | 5.17 | 1.16E-7 | TUB3 | Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; expressed at lower level than Tub1p; TUB3 has a paralog, TUB1, that arose from the whole genome duplication |
| YHR037W | 4.75 | 1.00E-6 | PUT2 | Delta-1-pyrroline-5-carboxylate dehydrogenase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; deficiency of the human homolog causes HPII, an autosomal recessive inborn error of metabolism |
| YMR087W | 4.74 | 1.08E-6 | YMR087W | Putative ADP-ribose-1''-monophosphatase that converts ADP-ribose-1''-monophosphate to ADP-ribose; may have a role in tRNA splicing; contains an A1pp domain |
| YOL101C | 4.57 | 2.38E-6 | IZH4 | Membrane protein involved in zinc ion homeostasis; member of the four-protein IZH family; expression induced by fatty acids and altered zinc levels; deletion reduces sensitivity to excess zinc; possible role in sterol metabolism; protein increases in abundance and relocalizes from nucleus to ER upon DNA replication stress |
| YBR069C | 4.19 | 1.40E-5 | TAT1 | Amino acid transporter for valine, leucine, isoleucine, and tyrosine; low-affinity tryptophan and histidine transporter; overexpression confers FK506 and FTY720 resistance; protein abundance increases in response to DNA replication stress |
| YML041C | 4.15 | 1.69E-5 | VPS71 | Nucleosome-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting |
| YOL012C | 4.05 | 2.61E-5 | HTZ1 | Histone variant H2AZ, exchanged for histone H2A in nucleosomes by the SWR1 complex; involved in transcriptional regulation through prevention of the spread of silent heterochromatin |
| YDR509W_d | 3.99 | 3.33E-5 | YDR509W_d | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
| YAL011W | 3.95 | 3.84E-5 | SWC3 | Protein of unknown function, component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for formation of nuclear-associated array of smooth endoplasmic reticulum known as karmellae |
| YKR067W | 3.94 | 4.09E-5 | GPT2 | Glycerol-3-phosphate/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase located in lipid particles and the ER; involved in the stepwise acylation of glycerol-3-phosphate and dihydroxyacetone in lipid biosynthesis; the most conserved motifs and functionally relevant residues are oriented towards the ER lumen |
| YGR208W | 3.90 | 4.72E-5 | SER2 | Phosphoserine phosphatase of the phosphoglycerate pathway, involved in serine and glycine biosynthesis, expression is regulated by the available nitrogen source |
| YPR197C_d | 3.87 | 5.46E-5 | YPR197C_d | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
| YMR292W | 3.85 | 5.83E-5 | GOT1 | Homodimeric protein that is packaged into COPII vesicles and cycles between the ER and Golgi; involved in secretory transport but not directly required for aspects of transport assayed in vitro; may influence membrane composition |
