Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YGR114C_d | 4.77 | 9.42E-7 | 0.97 | YGR114C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps 5' end of the essential gene SPT6 |
YNL247W | 4.28 | 9.44E-6 | 0.97 | YNL247W | Cysteinyl-tRNA synthetase; may interact with ribosomes, based on co-purification experiments |
YOR146W_d | 3.30 | 4.76E-4 | 0.08 | YOR146W_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene PNO1/YOR145C |
YLR316C | 3.23 | 6.23E-4 | 0.01 | TAD3 | Subunit of tRNA-specific adenosine-34 deaminase, forms a heterodimer with Tad2p that converts adenosine to inosine at the wobble position of several tRNAs |
YLR116W | 3.21 | 6.56E-4 | 0.03 | MSL5 | Component of the commitment complex, which defines the first step in the splicing pathway; essential protein that interacts with Mud2p and Prp40p, forming a bridge between the intron ends; also involved in nuclear retention of pre-mRNA |
YGL225W | 3.19 | 7.19E-4 | 0.13 | VRG4 | Golgi GDP-mannose transporter; regulates Golgi function and glycosylation in Golgi |
YNR011C | 3.06 | 0.00112 | 0.11 | PRP2 | RNA-dependent ATPase in the DEAH-box family, required for activation of the spliceosome before the first transesterification step in RNA splicing; orthologous to human protein DHX16 |
YDL139C | 2.95 | 0.00158 | 0.05 | SCM3 | Nonhistone component of centromeric chromatin; binds stoichiometrically to CenH3-H4 histones, required for kinetochore assembly; required for G2/M progression and localization of Cse4p; may protect Cse4p from ubiquitylation; homolog of mammalian HJURP |
YOR117W | 2.90 | 0.00186 | 0.02 | RPT5 | One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; recruited to the GAL1-10 promoter region upon induction of transcription; similar to human TBP1 |
YDR164C | 2.88 | 0.00196 | 0.08 | SEC1 | Sm-like protein involved in docking and fusion of exocytic vesicles; binds to assembled SNARE complexes at the membrane and stimulates membrane fusion; localization to sites of secretion (bud neck and bud tip) is dependent on SNARE function |
YBL077W_d | 2.80 | 0.00254 | 0.11 | YBL077W_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene ILS1/YBL076C |
YCR057C | 2.69 | 0.00357 | 0.02 | PWP2 | Conserved 90S pre-ribosomal component essential for proper endonucleolytic cleavage of the 35 S rRNA precursor at A0, A1, and A2 sites; contains eight WD-repeats; PWP2 deletion leads to defects in cell cycle and bud morphogenesis |
YDR182W | 2.67 | 0.00379 | 0.02 | CDC1 | Putative lipid phosphatase of the endoplasmic reticulum; shows Mn2+ dependence and may affect Ca2+ signaling; mutants display actin and general growth defects and pleiotropic defects in cell cycle progression and organelle distribution |
YHL015W | 2.65 | 0.00407 | 0.01 | RPS20 | Protein component of the small (40S) ribosomal subunit; overproduction suppresses mutations affecting RNA polymerase III-dependent transcription; homologous to mammalian ribosomal protein S20 and bacterial S10 |
YOR217W | 2.64 | 0.00420 | 0.01 | RFC1 | Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon |