9137218

N-butan-2-yl-2-(2-chlorophenoxy)propanamide

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_3262
Screen concentration 49.5 μM
Source Chembridge (Drug-like library)
PubChem CID 17650664
SMILES CCC(C)NC(=O)C(C)OC1=CC=CC=C1Cl
Standardized SMILES CCC(C)NC(=O)C(C)Oc1ccccc1Cl
Molecular weight 255.7405
ALogP 3.27
H-bond donor count 1
H-bond acceptor count 2
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 3.25
% growth inhibition (Hom. pool) 0


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 17650664
Download HIP data (tab-delimited text)  (excel)
Gene:CAK1(YFL029C)|FD-Score:3.57|P-value:1.81E-4|Clearance:0.35||SGD DESC:Cyclin-dependent kinase-activating kinase required for passage through the cell cycle, phosphorylates and activates Cdc28p; nucleotide-binding pocket differs significantly from those of most other protein kinases Gene:DUT1(YBR252W)|FD-Score:3.33|P-value:4.41E-4|Clearance:0.35||SGD DESC:deoxyuridine triphosphate diphosphatase (dUTPase); catalyzes hydrolysis of dUTP to dUMP and PPi, thereby preventing incorporation of uracil into DNA during replication; critical for the maintenance of genetic stability; also has diphosphatase activity on deoxyinosine triphosphate Gene:NUP159(YIL115C)|FD-Score:3.79|P-value:7.50E-5|Clearance:0.35||SGD DESC:FG-nucleoporin component of central core of the nuclear pore complex (NPC); also part of the NPC cytoplasmic filaments; contributes directly to nucleocytoplasmic transport; regulates ADP release from the ATP-dependent RNA helicase Dbp5p; forms a stable association with Nup82p, Gle2p and two other FG-nucleoporins (Nsp1p and Nup116p) Gene:ORC4(YPR162C)|FD-Score:-4.37|P-value:6.09E-6|Clearance:0||SGD DESC:Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing Gene:RNA14(YMR061W)|FD-Score:-3.35|P-value:3.99E-4|Clearance:0||SGD DESC:Component of the cleavage and polyadenylation factor I (CF I); CF 1, composed of the CF 1A complex (Rna14p, Rna15p, Clp1p, Pcf11p) and Hrp1, is involved in cleavage and polyadenylation of mRNA 3' ends; bridges interaction between Rna15p and Hrp1p in the CF I complex; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay; required for gene looping Gene:RPS13(YDR064W)|FD-Score:3.59|P-value:1.65E-4|Clearance:0.35||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S13 and bacterial S15 Gene:YGL069C(YGL069C_d)|FD-Score:-3.28|P-value:5.27E-4|Clearance:0||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 92% of ORF overlaps the uncharacterized ORF YGL068W; deletion in cyr1 mutant results in loss of stress resistance Gene:YJL009W(YJL009W_d)|FD-Score:-3.21|P-value:6.57E-4|Clearance:0||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps CCT8/YJL008C, a verified gene encoding a subunit of the cytosolic chaperonin Cct ring complex Gene:YLR230W(YLR230W_d)|FD-Score:-5.02|P-value:2.58E-7|Clearance:0||SGD DESC:Dubious open reading frame unlikely to encode a functional protein; overlaps 5' end of essential CDC42 gene which encodes a small Rho-like GTPase essential for establishment and maintenance of cell polarity Gene:CAK1(YFL029C)|FD-Score:3.57|P-value:1.81E-4|Clearance:0.35||SGD DESC:Cyclin-dependent kinase-activating kinase required for passage through the cell cycle, phosphorylates and activates Cdc28p; nucleotide-binding pocket differs significantly from those of most other protein kinases Gene:DUT1(YBR252W)|FD-Score:3.33|P-value:4.41E-4|Clearance:0.35||SGD DESC:deoxyuridine triphosphate diphosphatase (dUTPase); catalyzes hydrolysis of dUTP to dUMP and PPi, thereby preventing incorporation of uracil into DNA during replication; critical for the maintenance of genetic stability; also has diphosphatase activity on deoxyinosine triphosphate Gene:NUP159(YIL115C)|FD-Score:3.79|P-value:7.50E-5|Clearance:0.35||SGD DESC:FG-nucleoporin component of central core of the nuclear pore complex (NPC); also part of the NPC cytoplasmic filaments; contributes directly to nucleocytoplasmic transport; regulates ADP release from the ATP-dependent RNA helicase Dbp5p; forms a stable association with Nup82p, Gle2p and two other FG-nucleoporins (Nsp1p and Nup116p) Gene:ORC4(YPR162C)|FD-Score:-4.37|P-value:6.09E-6|Clearance:0||SGD DESC:Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing Gene:RNA14(YMR061W)|FD-Score:-3.35|P-value:3.99E-4|Clearance:0||SGD DESC:Component of the cleavage and polyadenylation factor I (CF I); CF 1, composed of the CF 1A complex (Rna14p, Rna15p, Clp1p, Pcf11p) and Hrp1, is involved in cleavage and polyadenylation of mRNA 3' ends; bridges interaction between Rna15p and Hrp1p in the CF I complex; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay; required for gene looping Gene:RPS13(YDR064W)|FD-Score:3.59|P-value:1.65E-4|Clearance:0.35||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S13 and bacterial S15 Gene:YGL069C(YGL069C_d)|FD-Score:-3.28|P-value:5.27E-4|Clearance:0||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 92% of ORF overlaps the uncharacterized ORF YGL068W; deletion in cyr1 mutant results in loss of stress resistance Gene:YJL009W(YJL009W_d)|FD-Score:-3.21|P-value:6.57E-4|Clearance:0||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps CCT8/YJL008C, a verified gene encoding a subunit of the cytosolic chaperonin Cct ring complex Gene:YLR230W(YLR230W_d)|FD-Score:-5.02|P-value:2.58E-7|Clearance:0||SGD DESC:Dubious open reading frame unlikely to encode a functional protein; overlaps 5' end of essential CDC42 gene which encodes a small Rho-like GTPase essential for establishment and maintenance of cell polarity

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 17650664
Download HOP data (tab-delimited text)  (excel)
Gene:ASM4(YDL088C)|FD-Score:3.59|P-value:1.66E-4||SGD DESC:FG-nucleoporin component of central core of nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport; induces membrane tubulation, which may contribute to nuclear pore assembly; ASM4 has a paralog, NUP53, that arose from the whole genome duplication Gene:EIS1(YMR031C)|FD-Score:-3.85|P-value:5.92E-5||SGD DESC:Component of the eisosome required for proper eisosome assembly; similarity to Ykl050cp and Uso1p; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; protein increases in abundance and relocalizes from plasma membrane to cytoplasm upon DNA replication stress Gene:EMP47(YFL048C)|FD-Score:3.5|P-value:2.31E-4||SGD DESC:Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport Gene:FRM2(YCL026C-A)|FD-Score:3.58|P-value:1.73E-4||SGD DESC:Type II nitroreductase, using NADH as reductant; mutants are defective in fatty acid mediated repression of genes involved in fatty acid biosynthesis indicative of a role in lipid signaling; involved in the oxidative stress response; transcription induction by cadmium and selenite indicates a possible role in the metal stress response; expression induced in cells treated with the mycotoxin patulin Gene:GAL80(YML051W)|FD-Score:4.18|P-value:1.46E-5||SGD DESC:Transcriptional regulator involved in the repression of GAL genes in the absence of galactose; inhibits transcriptional activation by Gal4p; inhibition relieved by Gal3p or Gal1p binding Gene:HPR1(YDR138W)|FD-Score:-3.28|P-value:5.27E-4||SGD DESC:Subunit of THO/TREX complexes that couple transcription elongation with mitotic recombination and with mRNA metabolism and export, subunit of an RNA Pol II complex; regulates lifespan; involved in telomere maintenance; similar to Top1p Gene:LSM12(YHR121W)|FD-Score:3.1|P-value:9.62E-4||SGD DESC:Protein of unknown function that may function in RNA processing; interacts with Pbp1p and Pbp4p and associates with ribosomes; contains an RNA-binding LSM domain and an AD domain; GFP-fusion protein is induced by the DNA-damaging agent MMS; relative distribution to the nucleus increases upon DNA replication stress Gene:MAC1(YMR021C)|FD-Score:-3.1|P-value:9.74E-4||SGD DESC:Copper-sensing transcription factor involved in regulation of genes required for high affinity copper transport Gene:MRS3(YJL133W)|FD-Score:5.56|P-value:1.38E-8||SGD DESC:Iron transporter, mediates Fe2+ transport across inner mito membrane; mitochondrial carrier family member; active under low-iron conditions; may transport other cations; MRS3 has a paralog, MRS4, that arose from the whole genome duplication Gene:PEP3(YLR148W)|FD-Score:-3.68|P-value:1.18E-4||SGD DESC:Component of CORVET tethering complex; vacuolar peripheral membrane protein that promotes vesicular docking/fusion reactions in conjunction with SNARE proteins, required for vacuolar biogenesis Gene:PFD1(YJL179W)|FD-Score:-3.27|P-value:5.35E-4||SGD DESC:Subunit of heterohexameric prefoldin, which binds cytosolic chaperonin and transfers target proteins to it; involved in the biogenesis of actin and of alpha- and gamma-tubulin Gene:PNS1(YOR161C)|FD-Score:-3.32|P-value:4.44E-4||SGD DESC:Protein of unknown function; has similarity to Torpedo californica tCTL1p, which is postulated to be a choline transporter, neither null mutation nor overexpression affects choline transport Gene:RMD8(YFR048W)|FD-Score:-3.31|P-value:4.65E-4||SGD DESC:Cytosolic protein required for sporulation Gene:SFT2(YBL102W)|FD-Score:3.57|P-value:1.80E-4||SGD DESC:Non-essential tetra-spanning membrane protein found mostly in the late Golgi, can suppress some sed5 alleles; may be part of the transport machinery, but precise function is unknown; similar to mammalian syntaxin 5 Gene:SKI7(YOR076C)|FD-Score:3.14|P-value:8.35E-4||SGD DESC:Coupling protein that mediates interactions between the Ski complex and the cytoplasmic exosome during 3'-5' RNA degradation; eRF3-like domain targets nonstop mRNA for degradation; null mutants have superkiller phenotype Gene:SLI1(YGR212W)|FD-Score:-3.14|P-value:8.58E-4||SGD DESC:N-acetyltransferase, confers resistance to the sphingolipid biosynthesis inhibitor myriocin (ISP-1) by converting it into N-acetyl-myriocin, co-operates with Ypk1p in mediating resistance to myriocin Gene:UBC11(YOR339C)|FD-Score:3.41|P-value:3.23E-4||SGD DESC:Ubiquitin-conjugating enzyme most similar in sequence to Xenopus ubiquitin-conjugating enzyme E2-C, but not a true functional homolog of this E2; unlike E2-C, not required for the degradation of mitotic cyclin Clb2 Gene:VPS51(YKR020W)|FD-Score:-3.2|P-value:6.86E-4||SGD DESC:Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; links the (VFT/GARP) complex to the SNARE Tlg1p Gene:VPS52(YDR484W)|FD-Score:-4.53|P-value:2.91E-6||SGD DESC:Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; involved in localization of actin and chitin Gene:YDL032W(YDL032W_d)|FD-Score:3.28|P-value:5.17E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene SLM3/YDL033C; YDL032W is not an essential gene Gene:YIR007W(YIR007W_p)|FD-Score:3.44|P-value:2.87E-4||SGD DESC:Putative glycosidase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YIR007W is a non-essential gene Gene:ASM4(YDL088C)|FD-Score:3.59|P-value:1.66E-4||SGD DESC:FG-nucleoporin component of central core of nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport; induces membrane tubulation, which may contribute to nuclear pore assembly; ASM4 has a paralog, NUP53, that arose from the whole genome duplication Gene:EIS1(YMR031C)|FD-Score:-3.85|P-value:5.92E-5||SGD DESC:Component of the eisosome required for proper eisosome assembly; similarity to Ykl050cp and Uso1p; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; protein increases in abundance and relocalizes from plasma membrane to cytoplasm upon DNA replication stress Gene:EMP47(YFL048C)|FD-Score:3.5|P-value:2.31E-4||SGD DESC:Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport Gene:FRM2(YCL026C-A)|FD-Score:3.58|P-value:1.73E-4||SGD DESC:Type II nitroreductase, using NADH as reductant; mutants are defective in fatty acid mediated repression of genes involved in fatty acid biosynthesis indicative of a role in lipid signaling; involved in the oxidative stress response; transcription induction by cadmium and selenite indicates a possible role in the metal stress response; expression induced in cells treated with the mycotoxin patulin Gene:GAL80(YML051W)|FD-Score:4.18|P-value:1.46E-5||SGD DESC:Transcriptional regulator involved in the repression of GAL genes in the absence of galactose; inhibits transcriptional activation by Gal4p; inhibition relieved by Gal3p or Gal1p binding Gene:HPR1(YDR138W)|FD-Score:-3.28|P-value:5.27E-4||SGD DESC:Subunit of THO/TREX complexes that couple transcription elongation with mitotic recombination and with mRNA metabolism and export, subunit of an RNA Pol II complex; regulates lifespan; involved in telomere maintenance; similar to Top1p Gene:LSM12(YHR121W)|FD-Score:3.1|P-value:9.62E-4||SGD DESC:Protein of unknown function that may function in RNA processing; interacts with Pbp1p and Pbp4p and associates with ribosomes; contains an RNA-binding LSM domain and an AD domain; GFP-fusion protein is induced by the DNA-damaging agent MMS; relative distribution to the nucleus increases upon DNA replication stress Gene:MAC1(YMR021C)|FD-Score:-3.1|P-value:9.74E-4||SGD DESC:Copper-sensing transcription factor involved in regulation of genes required for high affinity copper transport Gene:MRS3(YJL133W)|FD-Score:5.56|P-value:1.38E-8||SGD DESC:Iron transporter, mediates Fe2+ transport across inner mito membrane; mitochondrial carrier family member; active under low-iron conditions; may transport other cations; MRS3 has a paralog, MRS4, that arose from the whole genome duplication Gene:PEP3(YLR148W)|FD-Score:-3.68|P-value:1.18E-4||SGD DESC:Component of CORVET tethering complex; vacuolar peripheral membrane protein that promotes vesicular docking/fusion reactions in conjunction with SNARE proteins, required for vacuolar biogenesis Gene:PFD1(YJL179W)|FD-Score:-3.27|P-value:5.35E-4||SGD DESC:Subunit of heterohexameric prefoldin, which binds cytosolic chaperonin and transfers target proteins to it; involved in the biogenesis of actin and of alpha- and gamma-tubulin Gene:PNS1(YOR161C)|FD-Score:-3.32|P-value:4.44E-4||SGD DESC:Protein of unknown function; has similarity to Torpedo californica tCTL1p, which is postulated to be a choline transporter, neither null mutation nor overexpression affects choline transport Gene:RMD8(YFR048W)|FD-Score:-3.31|P-value:4.65E-4||SGD DESC:Cytosolic protein required for sporulation Gene:SFT2(YBL102W)|FD-Score:3.57|P-value:1.80E-4||SGD DESC:Non-essential tetra-spanning membrane protein found mostly in the late Golgi, can suppress some sed5 alleles; may be part of the transport machinery, but precise function is unknown; similar to mammalian syntaxin 5 Gene:SKI7(YOR076C)|FD-Score:3.14|P-value:8.35E-4||SGD DESC:Coupling protein that mediates interactions between the Ski complex and the cytoplasmic exosome during 3'-5' RNA degradation; eRF3-like domain targets nonstop mRNA for degradation; null mutants have superkiller phenotype Gene:SLI1(YGR212W)|FD-Score:-3.14|P-value:8.58E-4||SGD DESC:N-acetyltransferase, confers resistance to the sphingolipid biosynthesis inhibitor myriocin (ISP-1) by converting it into N-acetyl-myriocin, co-operates with Ypk1p in mediating resistance to myriocin Gene:UBC11(YOR339C)|FD-Score:3.41|P-value:3.23E-4||SGD DESC:Ubiquitin-conjugating enzyme most similar in sequence to Xenopus ubiquitin-conjugating enzyme E2-C, but not a true functional homolog of this E2; unlike E2-C, not required for the degradation of mitotic cyclin Clb2 Gene:VPS51(YKR020W)|FD-Score:-3.2|P-value:6.86E-4||SGD DESC:Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; links the (VFT/GARP) complex to the SNARE Tlg1p Gene:VPS52(YDR484W)|FD-Score:-4.53|P-value:2.91E-6||SGD DESC:Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; involved in localization of actin and chitin Gene:YDL032W(YDL032W_d)|FD-Score:3.28|P-value:5.17E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene SLM3/YDL033C; YDL032W is not an essential gene Gene:YIR007W(YIR007W_p)|FD-Score:3.44|P-value:2.87E-4||SGD DESC:Putative glycosidase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YIR007W is a non-essential gene

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YIL115C3.797.50E-50.35NUP159FG-nucleoporin component of central core of the nuclear pore complex (NPC); also part of the NPC cytoplasmic filaments; contributes directly to nucleocytoplasmic transport; regulates ADP release from the ATP-dependent RNA helicase Dbp5p; forms a stable association with Nup82p, Gle2p and two other FG-nucleoporins (Nsp1p and Nup116p)
YDR064W3.591.65E-40.35RPS13Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S13 and bacterial S15
YFL029C3.571.81E-40.35CAK1Cyclin-dependent kinase-activating kinase required for passage through the cell cycle, phosphorylates and activates Cdc28p; nucleotide-binding pocket differs significantly from those of most other protein kinases
YBR252W3.334.41E-40.35DUT1deoxyuridine triphosphate diphosphatase (dUTPase); catalyzes hydrolysis of dUTP to dUMP and PPi, thereby preventing incorporation of uracil into DNA during replication; critical for the maintenance of genetic stability; also has diphosphatase activity on deoxyinosine triphosphate
YGL113W2.970.001470.02SLD3Protein involved in the initiation of DNA replication; required for proper assembly of replication proteins at the origins of replication; interacts with Cdc45p; localizes to nuclear foci that become diffuse upon DNA replication stress
YDR311W2.950.001590.19TFB1Subunit of TFIIH and nucleotide excision repair factor 3 complexes, required for nucleotide excision repair, target for transcriptional activators
YLR198C_d2.760.002870.14YLR198C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene SIK1/YLR197W
YPL010W2.620.004440.09RET3Zeta subunit of the coatomer complex (COPI), which coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER
YNL221C2.520.005790.04POP1Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; binds to the RPR1 RNA subunit in RNase P
YMR298W2.480.006490.05LIP1Ceramide synthase subunit; single-span ER membrane protein associated with Lag1p and Lac1p and required for ceramide synthase activity, null mutant grows extremely slowly and is defective in ceramide synthesis
YBR234C2.440.007440.04ARC40Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches
YDL193W2.400.008190.10NUS1Putative prenyltransferase, required for cell viability; proposed to be involved in protein trafficking because tet-repressible mutant shows accumulation of hypoglycosylated forms of CPY
YDR170C2.300.010800.02SEC7Guanine nucleotide exchange factor (GEF) for ADP ribosylation factors involved in proliferation of the Golgi, intra-Golgi transport and ER-to-Golgi transport; found in the cytoplasm and on Golgi-associated coated vesicles
YGL074C_d2.280.011300.04YGL074C_dDubious open reading frame unlikely to encode a functional protein; overlaps 5' end of essential HSF1 gene encoding heat shock transcription factor
YKL186C2.240.012600.02MTR2mRNA transport regulator, essential nuclear protein; Mex67p and Mtr2p form a mRNA export complex which binds to RNA

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YJL133W5.561.38E-8MRS3Iron transporter, mediates Fe2+ transport across inner mito membrane; mitochondrial carrier family member; active under low-iron conditions; may transport other cations; MRS3 has a paralog, MRS4, that arose from the whole genome duplication
YML051W4.181.46E-5GAL80Transcriptional regulator involved in the repression of GAL genes in the absence of galactose; inhibits transcriptional activation by Gal4p; inhibition relieved by Gal3p or Gal1p binding
YDL088C3.591.66E-4ASM4FG-nucleoporin component of central core of nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport; induces membrane tubulation, which may contribute to nuclear pore assembly; ASM4 has a paralog, NUP53, that arose from the whole genome duplication
YCL026C-A3.581.73E-4FRM2Type II nitroreductase, using NADH as reductant; mutants are defective in fatty acid mediated repression of genes involved in fatty acid biosynthesis indicative of a role in lipid signaling; involved in the oxidative stress response; transcription induction by cadmium and selenite indicates a possible role in the metal stress response; expression induced in cells treated with the mycotoxin patulin
YBL102W3.571.80E-4SFT2Non-essential tetra-spanning membrane protein found mostly in the late Golgi, can suppress some sed5 alleles; may be part of the transport machinery, but precise function is unknown; similar to mammalian syntaxin 5
YFL048C3.502.31E-4EMP47Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport
YIR007W_p3.442.87E-4YIR007W_pPutative glycosidase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YIR007W is a non-essential gene
YOR339C3.413.23E-4UBC11Ubiquitin-conjugating enzyme most similar in sequence to Xenopus ubiquitin-conjugating enzyme E2-C, but not a true functional homolog of this E2; unlike E2-C, not required for the degradation of mitotic cyclin Clb2
YDL032W_d3.285.17E-4YDL032W_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene SLM3/YDL033C; YDL032W is not an essential gene
YOR076C3.148.35E-4SKI7Coupling protein that mediates interactions between the Ski complex and the cytoplasmic exosome during 3'-5' RNA degradation; eRF3-like domain targets nonstop mRNA for degradation; null mutants have superkiller phenotype
YHR121W3.109.62E-4LSM12Protein of unknown function that may function in RNA processing; interacts with Pbp1p and Pbp4p and associates with ribosomes; contains an RNA-binding LSM domain and an AD domain; GFP-fusion protein is induced by the DNA-damaging agent MMS; relative distribution to the nucleus increases upon DNA replication stress
YJR078W3.090.00100BNA2Putative tryptophan 2,3-dioxygenase or indoleamine 2,3-dioxygenase, required for de novo biosynthesis of NAD from tryptophan via kynurenine; interacts genetically with telomere capping gene CDC13; regulated by Hst1p and Aftp
YLR304C3.060.00109ACO1Aconitase, required for the tricarboxylic acid (TCA) cycle and also independently required for mitochondrial genome maintenance; phosphorylated; component of the mitochondrial nucleoid; mutation leads to glutamate auxotrophy
YHL006C3.060.00111SHU1Component of the Shu complex, which promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p function
YCR024C3.020.00128SLM5Mitochondrial asparaginyl-tRNA synthetase

GO enrichment analysis for SGTC_3262
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.1288.04E-23SGTC_32659137266 49.5 μMChembridge (Drug-like library)172242650.171875
0.0822.80E-10SGTC_28197996655 46.4 μMChembridge (Drug-like library)64569600.173913
0.0714.68E-8SGTC_32269131256 49.5 μMChembridge (Drug-like library)171780730.131579
0.0691.20E-7SGTC_7661391-0721 126.0 μMChemDiv (Drug-like library)10209190.115385
0.0691.27E-7SGTC_32709137563 49.5 μMChembridge (Drug-like library)170157240.15625RPP1 & pyrimidine depletion
0.0672.86E-7SGTC_13321480-0653 17.5 μMChemDiv (Drug-like library)57494380.152542TSC3-RPN4
0.0647.18E-7SGTC_28639028737 58.4 μMChembridge (Drug-like library)64609170.15942
0.0612.54E-6SGTC_28869058944 52.0 μMChembridge (Drug-like library)49499290.267857
0.0603.65E-6SGTC_32309131665 49.5 μMChembridge (Drug-like library)159437200.152542
0.0595.21E-6SGTC_32619137475 49.5 μMChembridge (Drug-like library)170276900.0666667RPP1 & pyrimidine depletion
0.0571.00E-5SGTC_28619024595 19.5 μMChembridge (Drug-like library)164828100.246377
0.0571.01E-5SGTC_1931273-0060 1.6 μMChemDiv (Drug-like library)28473930.135593ergosterol biosynthesis
0.0571.27E-5SGTC_24215690543 90.7 μMChembridge (Fragment library)33979930.0882353
0.0525.97E-5SGTC_57miconazole 162.5 nMChemDiv (Drug-like library)41890.132353ergosterol depletion effects on membrane
0.0526.04E-5SGTC_30869117350 49.5 μMChembridge (Drug-like library)26792650.128571

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_3248913556249.47 μM0.517650701Chembridge (Drug-like library)293.78853.62312
SGTC_2841900476138.96 μM0.3962262991039Chembridge (Drug-like library)289.756744.08412amide catabolism
SGTC_2876905990325.97 μM0.370376916095Chembridge (Drug-like library)283.364843.91312
SGTC_2856902292519.48 μM0.3392864944862Chembridge (Drug-like library)287.3287234.11213
SGTC_2817799534271.43 μM0.32758618879975Chembridge (Drug-like library)361.20053.63606
SGTC_74000s-0487160.28 μM0.320755677548ChemDiv (Drug-like library)277.702982.87223
SGTC_3146909560949.47 μM0.3174617173999Chembridge (Drug-like library)380.268363.9104
SGTC_3160910021649.47 μM0.312517191039Chembridge (Drug-like library)359.849883.73204
SGTC_3156909993149.47 μM0.31034518111053Chembridge (Drug-like library)344.835243.85903
SGTC_2793732513181.82 μM0.3090914176441Chembridge (Drug-like library)287.3287234.08213