9137951

4-[4-[(2-fluorophenyl)methoxy]-1,2,5-thiadiazol-3-yl]morpholine

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_3267
Screen concentration 49.5 μM
Source Chembridge (Drug-like library)
PubChem CID 16643986
SMILES C1COCCN1C2=NSN=C2OCC3=CC=CC=C3F
Standardized SMILES Fc1ccccc1COc2nsnc2N3CCOCC3
Molecular weight 295.3326
ALogP 2.89
H-bond donor count 0
H-bond acceptor count 7
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 9.96
% growth inhibition (Hom. pool) 9.53


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 16643986
Download HIP data (tab-delimited text)  (excel)
Gene:ACC1(YNR016C)|FD-Score:3.79|P-value:7.42E-5|Clearance:0.22||SGD DESC:Acetyl-CoA carboxylase, biotin containing enzyme; catalyzes the carboxylation of cytosolic acetyl-CoA to form malonyl-CoA and regulates histone acetylation by regulating the availablity of acetyl-CoA; required for de novo biosynthesis of long-chain fatty acids; Gene:BET1(YIL004C)|FD-Score:3.58|P-value:1.74E-4|Clearance:0.22||SGD DESC:Type II membrane protein required for vesicular transport between the endoplasmic reticulum and Golgi complex; v-SNARE with similarity to synaptobrevins Gene:GLC7(YER133W)|FD-Score:-3.71|P-value:1.02E-4|Clearance:0||SGD DESC:Type 1 serine/threonine protein phosphatase catalytic subunit; involved in various processes including glycogen metabolism, sporulation, mitosis; accumulates at mating projections by interaction with Afr1p; interacts with many regulatory subunits; involved in regulation of the nucleocytoplasmic shuttling of Hxk2p; import into nucleus is inhibited during spindle assembly checkpoint arrest Gene:MGE1(YOR232W)|FD-Score:3.23|P-value:6.29E-4|Clearance:0.28||SGD DESC:Mitochondrial matrix cochaperone, acts as a nucleotide release factor for Ssc1p in protein translocation and folding; also acts as cochaperone for Ssq1p in folding of Fe-S cluster proteins; homolog of E. coli GrpE Gene:RSC9(YML127W)|FD-Score:4.06|P-value:2.43E-5|Clearance:0.27||SGD DESC:Component of the RSC chromatin remodeling complex; DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway Gene:UTP14(YML093W)|FD-Score:3.36|P-value:3.92E-4|Clearance:0.13||SGD DESC:Subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit Gene:UTP4(YDR324C)|FD-Score:5.08|P-value:1.87E-7|Clearance:1.02||SGD DESC:Subunit of U3-containing 90S preribosome and Small Subunit (SSU) processome complexes involved in production of 18S rRNA and assembly of small ribosomal subunit; member of t-Utp subcomplex involved with transcription of 35S rRNA transcript Gene:ACC1(YNR016C)|FD-Score:3.79|P-value:7.42E-5|Clearance:0.22||SGD DESC:Acetyl-CoA carboxylase, biotin containing enzyme; catalyzes the carboxylation of cytosolic acetyl-CoA to form malonyl-CoA and regulates histone acetylation by regulating the availablity of acetyl-CoA; required for de novo biosynthesis of long-chain fatty acids; Gene:BET1(YIL004C)|FD-Score:3.58|P-value:1.74E-4|Clearance:0.22||SGD DESC:Type II membrane protein required for vesicular transport between the endoplasmic reticulum and Golgi complex; v-SNARE with similarity to synaptobrevins Gene:GLC7(YER133W)|FD-Score:-3.71|P-value:1.02E-4|Clearance:0||SGD DESC:Type 1 serine/threonine protein phosphatase catalytic subunit; involved in various processes including glycogen metabolism, sporulation, mitosis; accumulates at mating projections by interaction with Afr1p; interacts with many regulatory subunits; involved in regulation of the nucleocytoplasmic shuttling of Hxk2p; import into nucleus is inhibited during spindle assembly checkpoint arrest Gene:MGE1(YOR232W)|FD-Score:3.23|P-value:6.29E-4|Clearance:0.28||SGD DESC:Mitochondrial matrix cochaperone, acts as a nucleotide release factor for Ssc1p in protein translocation and folding; also acts as cochaperone for Ssq1p in folding of Fe-S cluster proteins; homolog of E. coli GrpE Gene:RSC9(YML127W)|FD-Score:4.06|P-value:2.43E-5|Clearance:0.27||SGD DESC:Component of the RSC chromatin remodeling complex; DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway Gene:UTP14(YML093W)|FD-Score:3.36|P-value:3.92E-4|Clearance:0.13||SGD DESC:Subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit Gene:UTP4(YDR324C)|FD-Score:5.08|P-value:1.87E-7|Clearance:1.02||SGD DESC:Subunit of U3-containing 90S preribosome and Small Subunit (SSU) processome complexes involved in production of 18S rRNA and assembly of small ribosomal subunit; member of t-Utp subcomplex involved with transcription of 35S rRNA transcript

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 16643986
Download HOP data (tab-delimited text)  (excel)
Gene:AEP3(YPL005W)|FD-Score:-3.43|P-value:2.99E-4||SGD DESC:Protein that may facilitate use of unformylated tRNA-Met in mitochondrial translation initiation; localized to the matrix face of the mitochondrial inner membrane; stabilizes the bicistronic AAP1-ATP6 mRNA Gene:ANT1(YPR128C)|FD-Score:3.25|P-value:5.86E-4||SGD DESC:Peroxisomal adenine nucleotide transporter; involved in beta-oxidation of medium-chain fatty acid; required for peroxisome proliferation Gene:ARO1(YDR127W)|FD-Score:5.85|P-value:2.48E-9||SGD DESC:Pentafunctional arom protein, catalyzes steps 2 through 6 in the biosynthesis of chorismate, which is a precursor to aromatic amino acids Gene:ARP6(YLR085C)|FD-Score:3.75|P-value:8.70E-5||SGD DESC:Actin-related protein that binds nucleosomes; a component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A Gene:BCH1(YMR237W)|FD-Score:3.66|P-value:1.28E-4||SGD DESC:Member of the ChAPs family (Chs5p-Arf1p-binding proteins); members include Bch1p, Bch2p, Bud7p, and Chs6p; ChAPs family proteins form the exomer complex with Chs5p to mediate export of specific cargo proteins from the Golgi to the plasma membrane; may interact with ribosomes; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress; BCH1 has a paralog, BUD7, that arose from the whole genome duplication Gene:BSC6(YOL137W)|FD-Score:4.04|P-value:2.68E-5||SGD DESC:Protein of unknown function containing 8 putative transmembrane seqments; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression Gene:COG8(YML071C)|FD-Score:-3.33|P-value:4.27E-4||SGD DESC:Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:CYT2(YKL087C)|FD-Score:-4.06|P-value:2.46E-5||SGD DESC:Cytochrome c1 heme lyase, involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase; links heme covalently to apocytochrome c1 Gene:DUS1(YML080W)|FD-Score:-3.12|P-value:9.09E-4||SGD DESC:Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus3p, and Dus4p; modifies pre-tRNA(Phe) at U17 Gene:ENT3(YJR125C)|FD-Score:3.58|P-value:1.75E-4||SGD DESC:Protein containing an N-terminal epsin-like domain involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p Gene:FRE7(YOL152W)|FD-Score:3.76|P-value:8.47E-5||SGD DESC:Putative ferric reductase with similarity to Fre2p; expression induced by low copper levels Gene:GLR1(YPL091W)|FD-Score:4.32|P-value:7.80E-6||SGD DESC:Cytosolic and mitochondrial glutathione oxidoreductase; converts oxidized glutathione to reduced glutathione; mitochondrial but not cytosolic form has a role in resistance to hyperoxia; protein abundance increases in response to DNA replication stress Gene:HFM1(YGL251C)|FD-Score:3.22|P-value:6.33E-4||SGD DESC:Meiosis specific DNA helicase involved in the conversion of double-stranded breaks to later recombination intermediates and in crossover control; catalyzes the unwinding of Holliday junctions; has ssDNA and dsDNA stimulated ATPase activity Gene:MET1(YKR069W)|FD-Score:3.32|P-value:4.48E-4||SGD DESC:S-adenosyl-L-methionine uroporphyrinogen III transmethylase, involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis Gene:OCT1(YKL134C)|FD-Score:-3.43|P-value:3.02E-4||SGD DESC:Mitochondrial intermediate peptidase, cleaves destabilizing N-terminal residues of a subset of proteins upon import, after their cleavage by mitochondrial processing peptidase (Mas1p-Mas2p); may contribute to mitochondrial iron homeostasis Gene:PHO86(YJL117W)|FD-Score:-3.3|P-value:4.90E-4||SGD DESC:Endoplasmic reticulum (ER) resident protein; required for ER exit of the high-affinity phosphate transporter Pho84p, specifically required for packaging of Pho84p into COPII vesicles; protein abundance increases in response to DNA replication stress Gene:RGS2(YOR107W)|FD-Score:3.1|P-value:9.59E-4||SGD DESC:Negative regulator of glucose-induced cAMP signaling; directly activates the GTPase activity of the heterotrimeric G protein alpha subunit Gpa2p Gene:RML2(YEL050C)|FD-Score:3.46|P-value:2.65E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L2 ribosomal protein; fat21 mutant allele causes inability to utilize oleate and may interfere with activity of the Adr1p transcription factor Gene:SCP160(YJL080C)|FD-Score:-3.85|P-value:6.02E-5||SGD DESC:Essential RNA-binding G protein effector of mating response pathway, mainly associated with nuclear envelope and ER, interacts in mRNA-dependent manner with translating ribosomes via multiple KH domains, similar to vertebrate vigilins Gene:SHE9(YDR393W)|FD-Score:5.17|P-value:1.19E-7||SGD DESC:Mitochondrial inner membrane protein required for normal mitochondrial morphology, may be involved in fission of the inner membrane; forms a homo-oligomeric complex Gene:SMI1(YGR229C)|FD-Score:3.7|P-value:1.07E-4||SGD DESC:Protein involved in the regulation of cell wall synthesis; proposed to be involved in coordinating cell cycle progression with cell wall integrity Gene:TKL1(YPR074C)|FD-Score:3.6|P-value:1.58E-4||SGD DESC:Transketolase; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids; TKL1 has a paralog, TKL2, that arose from the whole genome duplication Gene:TUB3(YML124C)|FD-Score:4.41|P-value:5.23E-6||SGD DESC:Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; expressed at lower level than Tub1p; TUB3 has a paralog, TUB1, that arose from the whole genome duplication Gene:UBC11(YOR339C)|FD-Score:-3.51|P-value:2.25E-4||SGD DESC:Ubiquitin-conjugating enzyme most similar in sequence to Xenopus ubiquitin-conjugating enzyme E2-C, but not a true functional homolog of this E2; unlike E2-C, not required for the degradation of mitotic cyclin Clb2 Gene:UGA2(YBR006W)|FD-Score:3.36|P-value:3.96E-4||SGD DESC:Succinate semialdehyde dehydrogenase involved in the utilization of gamma-aminobutyrate (GABA) as a nitrogen source; part of the 4-aminobutyrate and glutamate degradation pathways; localized to the cytoplasm Gene:YAR028W(YAR028W_p)|FD-Score:-4.21|P-value:1.26E-5||SGD DESC:Putative integral membrane protein, member of DUP240 gene family; GFP-fusion protein is induced in response to the DNA-damaging agent MMS Gene:YDR008C(YDR008C_d)|FD-Score:-3.1|P-value:9.57E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YGR259C(YGR259C_d)|FD-Score:3.52|P-value:2.13E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF TNA1/YGR260W Gene:YHI9(YHR029C)|FD-Score:3.09|P-value:9.97E-4||SGD DESC:Protein of unknown function; null mutant is defective in unfolded protein response; possibly involved in a membrane regulation metabolic pathway; member of the PhzF superfamily, though most likely not involved in phenazine production Gene:YHK8(YHR048W_p)|FD-Score:3.64|P-value:1.39E-4||SGD DESC:Presumed antiporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; expression of gene is up-regulated in cells exhibiting reduced susceptibility to azoles Gene:YHR022C(YHR022C_p)|FD-Score:-3.67|P-value:1.21E-4||SGD DESC:Putative protein of unknown function; YHR022C is not an essential gene Gene:YIR007W(YIR007W_p)|FD-Score:-4.02|P-value:2.90E-5||SGD DESC:Putative glycosidase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YIR007W is a non-essential gene Gene:YOR022C(YOR022C_p)|FD-Score:3.88|P-value:5.16E-5||SGD DESC:Putative carboxylic ester hydrolase; similar to bovine phospholipase A1; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:YPR127W(YPR127W)|FD-Score:3.21|P-value:6.62E-4||SGD DESC:Putative pyridoxine 4-dehydrogenase; differentially expressed during alcoholic fermentation; expression activated by transcription factor YRM1/YOR172W; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus Gene:AEP3(YPL005W)|FD-Score:-3.43|P-value:2.99E-4||SGD DESC:Protein that may facilitate use of unformylated tRNA-Met in mitochondrial translation initiation; localized to the matrix face of the mitochondrial inner membrane; stabilizes the bicistronic AAP1-ATP6 mRNA Gene:ANT1(YPR128C)|FD-Score:3.25|P-value:5.86E-4||SGD DESC:Peroxisomal adenine nucleotide transporter; involved in beta-oxidation of medium-chain fatty acid; required for peroxisome proliferation Gene:ARO1(YDR127W)|FD-Score:5.85|P-value:2.48E-9||SGD DESC:Pentafunctional arom protein, catalyzes steps 2 through 6 in the biosynthesis of chorismate, which is a precursor to aromatic amino acids Gene:ARP6(YLR085C)|FD-Score:3.75|P-value:8.70E-5||SGD DESC:Actin-related protein that binds nucleosomes; a component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A Gene:BCH1(YMR237W)|FD-Score:3.66|P-value:1.28E-4||SGD DESC:Member of the ChAPs family (Chs5p-Arf1p-binding proteins); members include Bch1p, Bch2p, Bud7p, and Chs6p; ChAPs family proteins form the exomer complex with Chs5p to mediate export of specific cargo proteins from the Golgi to the plasma membrane; may interact with ribosomes; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress; BCH1 has a paralog, BUD7, that arose from the whole genome duplication Gene:BSC6(YOL137W)|FD-Score:4.04|P-value:2.68E-5||SGD DESC:Protein of unknown function containing 8 putative transmembrane seqments; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression Gene:COG8(YML071C)|FD-Score:-3.33|P-value:4.27E-4||SGD DESC:Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:CYT2(YKL087C)|FD-Score:-4.06|P-value:2.46E-5||SGD DESC:Cytochrome c1 heme lyase, involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase; links heme covalently to apocytochrome c1 Gene:DUS1(YML080W)|FD-Score:-3.12|P-value:9.09E-4||SGD DESC:Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus3p, and Dus4p; modifies pre-tRNA(Phe) at U17 Gene:ENT3(YJR125C)|FD-Score:3.58|P-value:1.75E-4||SGD DESC:Protein containing an N-terminal epsin-like domain involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p Gene:FRE7(YOL152W)|FD-Score:3.76|P-value:8.47E-5||SGD DESC:Putative ferric reductase with similarity to Fre2p; expression induced by low copper levels Gene:GLR1(YPL091W)|FD-Score:4.32|P-value:7.80E-6||SGD DESC:Cytosolic and mitochondrial glutathione oxidoreductase; converts oxidized glutathione to reduced glutathione; mitochondrial but not cytosolic form has a role in resistance to hyperoxia; protein abundance increases in response to DNA replication stress Gene:HFM1(YGL251C)|FD-Score:3.22|P-value:6.33E-4||SGD DESC:Meiosis specific DNA helicase involved in the conversion of double-stranded breaks to later recombination intermediates and in crossover control; catalyzes the unwinding of Holliday junctions; has ssDNA and dsDNA stimulated ATPase activity Gene:MET1(YKR069W)|FD-Score:3.32|P-value:4.48E-4||SGD DESC:S-adenosyl-L-methionine uroporphyrinogen III transmethylase, involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis Gene:OCT1(YKL134C)|FD-Score:-3.43|P-value:3.02E-4||SGD DESC:Mitochondrial intermediate peptidase, cleaves destabilizing N-terminal residues of a subset of proteins upon import, after their cleavage by mitochondrial processing peptidase (Mas1p-Mas2p); may contribute to mitochondrial iron homeostasis Gene:PHO86(YJL117W)|FD-Score:-3.3|P-value:4.90E-4||SGD DESC:Endoplasmic reticulum (ER) resident protein; required for ER exit of the high-affinity phosphate transporter Pho84p, specifically required for packaging of Pho84p into COPII vesicles; protein abundance increases in response to DNA replication stress Gene:RGS2(YOR107W)|FD-Score:3.1|P-value:9.59E-4||SGD DESC:Negative regulator of glucose-induced cAMP signaling; directly activates the GTPase activity of the heterotrimeric G protein alpha subunit Gpa2p Gene:RML2(YEL050C)|FD-Score:3.46|P-value:2.65E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L2 ribosomal protein; fat21 mutant allele causes inability to utilize oleate and may interfere with activity of the Adr1p transcription factor Gene:SCP160(YJL080C)|FD-Score:-3.85|P-value:6.02E-5||SGD DESC:Essential RNA-binding G protein effector of mating response pathway, mainly associated with nuclear envelope and ER, interacts in mRNA-dependent manner with translating ribosomes via multiple KH domains, similar to vertebrate vigilins Gene:SHE9(YDR393W)|FD-Score:5.17|P-value:1.19E-7||SGD DESC:Mitochondrial inner membrane protein required for normal mitochondrial morphology, may be involved in fission of the inner membrane; forms a homo-oligomeric complex Gene:SMI1(YGR229C)|FD-Score:3.7|P-value:1.07E-4||SGD DESC:Protein involved in the regulation of cell wall synthesis; proposed to be involved in coordinating cell cycle progression with cell wall integrity Gene:TKL1(YPR074C)|FD-Score:3.6|P-value:1.58E-4||SGD DESC:Transketolase; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids; TKL1 has a paralog, TKL2, that arose from the whole genome duplication Gene:TUB3(YML124C)|FD-Score:4.41|P-value:5.23E-6||SGD DESC:Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; expressed at lower level than Tub1p; TUB3 has a paralog, TUB1, that arose from the whole genome duplication Gene:UBC11(YOR339C)|FD-Score:-3.51|P-value:2.25E-4||SGD DESC:Ubiquitin-conjugating enzyme most similar in sequence to Xenopus ubiquitin-conjugating enzyme E2-C, but not a true functional homolog of this E2; unlike E2-C, not required for the degradation of mitotic cyclin Clb2 Gene:UGA2(YBR006W)|FD-Score:3.36|P-value:3.96E-4||SGD DESC:Succinate semialdehyde dehydrogenase involved in the utilization of gamma-aminobutyrate (GABA) as a nitrogen source; part of the 4-aminobutyrate and glutamate degradation pathways; localized to the cytoplasm Gene:YAR028W(YAR028W_p)|FD-Score:-4.21|P-value:1.26E-5||SGD DESC:Putative integral membrane protein, member of DUP240 gene family; GFP-fusion protein is induced in response to the DNA-damaging agent MMS Gene:YDR008C(YDR008C_d)|FD-Score:-3.1|P-value:9.57E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YGR259C(YGR259C_d)|FD-Score:3.52|P-value:2.13E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF TNA1/YGR260W Gene:YHI9(YHR029C)|FD-Score:3.09|P-value:9.97E-4||SGD DESC:Protein of unknown function; null mutant is defective in unfolded protein response; possibly involved in a membrane regulation metabolic pathway; member of the PhzF superfamily, though most likely not involved in phenazine production Gene:YHK8(YHR048W_p)|FD-Score:3.64|P-value:1.39E-4||SGD DESC:Presumed antiporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; expression of gene is up-regulated in cells exhibiting reduced susceptibility to azoles Gene:YHR022C(YHR022C_p)|FD-Score:-3.67|P-value:1.21E-4||SGD DESC:Putative protein of unknown function; YHR022C is not an essential gene Gene:YIR007W(YIR007W_p)|FD-Score:-4.02|P-value:2.90E-5||SGD DESC:Putative glycosidase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YIR007W is a non-essential gene Gene:YOR022C(YOR022C_p)|FD-Score:3.88|P-value:5.16E-5||SGD DESC:Putative carboxylic ester hydrolase; similar to bovine phospholipase A1; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:YPR127W(YPR127W)|FD-Score:3.21|P-value:6.62E-4||SGD DESC:Putative pyridoxine 4-dehydrogenase; differentially expressed during alcoholic fermentation; expression activated by transcription factor YRM1/YOR172W; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YDR324C5.081.87E-71.02UTP4Subunit of U3-containing 90S preribosome and Small Subunit (SSU) processome complexes involved in production of 18S rRNA and assembly of small ribosomal subunit; member of t-Utp subcomplex involved with transcription of 35S rRNA transcript
YML127W4.062.43E-50.27RSC9Component of the RSC chromatin remodeling complex; DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway
YNR016C3.797.42E-50.22ACC1Acetyl-CoA carboxylase, biotin containing enzyme; catalyzes the carboxylation of cytosolic acetyl-CoA to form malonyl-CoA and regulates histone acetylation by regulating the availablity of acetyl-CoA; required for de novo biosynthesis of long-chain fatty acids;
YIL004C3.581.74E-40.22BET1Type II membrane protein required for vesicular transport between the endoplasmic reticulum and Golgi complex; v-SNARE with similarity to synaptobrevins
YML093W3.363.92E-40.13UTP14Subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit
YOR232W3.236.29E-40.28MGE1Mitochondrial matrix cochaperone, acts as a nucleotide release factor for Ssc1p in protein translocation and folding; also acts as cochaperone for Ssq1p in folding of Fe-S cluster proteins; homolog of E. coli GrpE
YLR355C2.950.001590.00ILV5Bifunctional acetohydroxyacid reductoisomerase and mtDNA binding protein; involved in branched-chain amino acid biosynthesis and maintenance of wild-type mitochondrial DNA; found in mitochondrial nucleoids
YFR002W2.950.001600.21NIC96Linker nucleoporin component of the nuclear pore complex (NPC); also part of the NPC nuclear basket; contributes to nucleocytoplasmic transport and NPC biogenesis; forms stable associations with three FG-nucleoporins (Nsp1p, Nup57p, and Nup49p)
YDR303C2.740.003080.22RSC3Component of the RSC chromatin remodeling complex; essential gene required for maintenance of proper ploidy and regulation of ribosomal protein genes and the cell wall/stress response; highly similar to Rsc30p
YPL169C2.520.005870.06MEX67Poly(A)RNA binding protein involved in nuclear mRNA export, component of the nuclear pore; ortholog of human TAP
YBL041W2.460.006870.01PRE7Beta 6 subunit of the 20S proteasome
YGL112C2.450.007150.01TAF6Subunit (60 kDa) of TFIID and SAGA complexes, involved in transcription initiation of RNA polymerase II and in chromatin modification, similar to histone H4
YOR362C2.440.007310.03PRE10Alpha 7 subunit of the 20S proteasome; protein abundance increases in response to DNA replication stress
YPR165W2.410.007890.03RHO1GTP-binding protein of the rho subfamily of Ras-like proteins, involved in establishment of cell polarity; regulates protein kinase C (Pkc1p) and the cell wall synthesizing enzyme 1,3-beta-glucan synthase (Fks1p and Gsc2p)
YBR252W2.390.008515.15E-4DUT1deoxyuridine triphosphate diphosphatase (dUTPase); catalyzes hydrolysis of dUTP to dUMP and PPi, thereby preventing incorporation of uracil into DNA during replication; critical for the maintenance of genetic stability; also has diphosphatase activity on deoxyinosine triphosphate

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YDR127W5.852.48E-9ARO1Pentafunctional arom protein, catalyzes steps 2 through 6 in the biosynthesis of chorismate, which is a precursor to aromatic amino acids
YDR393W5.171.19E-7SHE9Mitochondrial inner membrane protein required for normal mitochondrial morphology, may be involved in fission of the inner membrane; forms a homo-oligomeric complex
YML124C4.415.23E-6TUB3Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; expressed at lower level than Tub1p; TUB3 has a paralog, TUB1, that arose from the whole genome duplication
YPL091W4.327.80E-6GLR1Cytosolic and mitochondrial glutathione oxidoreductase; converts oxidized glutathione to reduced glutathione; mitochondrial but not cytosolic form has a role in resistance to hyperoxia; protein abundance increases in response to DNA replication stress
YOL137W4.042.68E-5BSC6Protein of unknown function containing 8 putative transmembrane seqments; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression
YOR022C_p3.885.16E-5YOR022C_pPutative carboxylic ester hydrolase; similar to bovine phospholipase A1; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YOL152W3.768.47E-5FRE7Putative ferric reductase with similarity to Fre2p; expression induced by low copper levels
YLR085C3.758.70E-5ARP6Actin-related protein that binds nucleosomes; a component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A
YGR229C3.701.07E-4SMI1Protein involved in the regulation of cell wall synthesis; proposed to be involved in coordinating cell cycle progression with cell wall integrity
YMR237W3.661.28E-4BCH1Member of the ChAPs family (Chs5p-Arf1p-binding proteins); members include Bch1p, Bch2p, Bud7p, and Chs6p; ChAPs family proteins form the exomer complex with Chs5p to mediate export of specific cargo proteins from the Golgi to the plasma membrane; may interact with ribosomes; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress; BCH1 has a paralog, BUD7, that arose from the whole genome duplication
YHR048W_p3.641.39E-4YHK8_pPresumed antiporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; expression of gene is up-regulated in cells exhibiting reduced susceptibility to azoles
YPR074C3.601.58E-4TKL1Transketolase; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids; TKL1 has a paralog, TKL2, that arose from the whole genome duplication
YJR125C3.581.75E-4ENT3Protein containing an N-terminal epsin-like domain involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p
YGR259C_d3.522.13E-4YGR259C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF TNA1/YGR260W
YEL050C3.462.65E-4RML2Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L2 ribosomal protein; fat21 mutant allele causes inability to utilize oleate and may interfere with activity of the Adr1p transcription factor

GO enrichment analysis for SGTC_3267
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.1284.39E-23SGTC_21325317594 122.7 μMChembridge (Fragment library)7945770.0547945SWF1 & branched chain AA biosynthesis
0.1254.06E-22SGTC_13261431-2094 10.8 μMChemDiv (Drug-like library)6162780.09375tubulin folding & SWR complex
0.1225.96E-21SGTC_2607solasodine 47.4 μMMicrosource (Natural product library)67106420.0425532
0.1171.60E-19SGTC_21866124449 200.0 μMChembridge (Fragment library)38341820.0958904RSC complex & mRNA processing
0.1094.70E-17SGTC_12263909-7979 35.4 μMChemDiv (Drug-like library)66155100.142857
0.1081.12E-16SGTC_1656st012921 11.0 μMTimTec (Natural product derivative library)67328210.115942
0.1001.04E-14SGTC_2534helenine 20.1 μMMicrosource (Natural product library)727240.0526316RSC complex & mRNA processing
0.0991.97E-14SGTC_31469095609 49.5 μMChembridge (Drug-like library)171739990.141026
0.0992.88E-14SGTC_13742889-5571 141.0 μMChemDiv (Drug-like library)28532810.125RSC complex & mRNA processing
0.0985.86E-14SGTC_29769009005 19.5 μMChembridge (Drug-like library)29931480.0789474
0.0961.83E-13SGTC_12131315-0166 115.0 μMChemDiv (Drug-like library)7684010.0789474
0.0913.24E-12SGTC_1652st011932 78.0 μMTimTec (Natural product derivative library)15510760.0933333RSC complex & mRNA processing
0.0895.98E-12SGTC_6731082-0474 110.0 μMChemDiv (Drug-like library)30980460.0704225RSC complex & mRNA processing
0.0895.99E-12SGTC_6383970-0837 4.1 μMChemDiv (Drug-like library)41184510.0972222
0.0872.10E-11SGTC_13521496-0991 99.0 μMChemDiv (Drug-like library)30000390.109375tubulin folding & SWR complex

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_3318913901438.62 μM0.74468116643984Chembridge (Drug-like library)291.368683.17406
SGTC_1824st05372368.6 μM0.315789675225TimTec (Natural product derivative library)291.347083.39704
SGTC_1709st03317939.1 μM0.28125573381TimTec (Natural product derivative library)339.1563834.09304
SGTC_2009401229712.05 μM0.27586245595307Chembridge (Fragment library)244.6930631.03923cell wall signaling
SGTC_235890371574 μM0.2711862388925Chembridge (Fragment library)231.250520.20513
SGTC_20104012422159 μM0.254545952393Chembridge (Fragment library)212.676021.59713
SGTC_3086911735049.47 μM0.252679265Chembridge (Drug-like library)365.3760432.27207
SGTC_3019908197149.47 μM0.24637716451803Chembridge (Drug-like library)357.448223.99703
SGTC_3071911741749.47 μM0.24590245595590Chembridge (Drug-like library)297.820263.46213fatty acid desaturase (OLE1)
SGTC_3046909221249.47 μM0.24242425236637Chembridge (Drug-like library)328.3806433.404