Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YGL112C | 6.70 | 1.05E-11 | 1.23 | TAF6 | Subunit (60 kDa) of TFIID and SAGA complexes, involved in transcription initiation of RNA polymerase II and in chromatin modification, similar to histone H4 |
YJL202C_d | 5.47 | 2.31E-8 | 0.59 | YJL202C_d | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 3' end of essential PRP21 gene encoding a subunit of the SF3a splicing factor complex |
YDL060W | 4.87 | 5.57E-7 | 0.81 | TSR1 | Protein required for processing of 20S pre-rRNA in the cytoplasm; associates with pre-40S ribosomal particles; inhibits the premature association of 60S subunits with assembling 40S subunits in the cytoplasm; similar to Bms1p; relocalizes from nucleus to cytoplasm upon DNA replication stress |
YLR033W | 4.06 | 2.47E-5 | 0.10 | RSC58 | Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance |
YJL009W_d | 3.96 | 3.82E-5 | 0.21 | YJL009W_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps CCT8/YJL008C, a verified gene encoding a subunit of the cytosolic chaperonin Cct ring complex |
YDR301W | 3.74 | 9.05E-5 | 0.20 | CFT1 | RNA-binding subunit of the mRNA cleavage and polyadenylation factor; involved in poly(A) site recognition and required for both pre-mRNA cleavage and polyadenylation, 51% sequence similarity with mammalian AAUAA-binding subunit of CPSF |
YKL021C | 3.54 | 1.99E-4 | 0.06 | MAK11 | Protein involved in an early, nucleolar step of 60S ribosomal subunit biogenesis; essential for cell growth and replication of killer M1 dsRNA virus; contains four beta-transducin repeats |
YLR430W | 3.48 | 2.49E-4 | 0.05 | SEN1 | Presumed helicase and subunit of the Nrd1 complex (Nrd1p-Nab3p-Sen1p); complex interacts with the exosome to mediate 3' end formation of some mRNAs, snRNAs, snoRNAs, and CUTs; has a separate role in coordinating DNA replication with transcription, by associating with moving replication forks and preventing errors that occur when forks encounter transcribed regions; homolog of Senataxin, which is implicated in Ataxia-Oculomotor Apraxia 2 and a dominant form of ALS |
YKR004C | 3.44 | 2.95E-4 | 0.08 | ECM9 | Non-essential protein of unknown function |
YFR002W | 3.36 | 3.88E-4 | 0.14 | NIC96 | Linker nucleoporin component of the nuclear pore complex (NPC); also part of the NPC nuclear basket; contributes to nucleocytoplasmic transport and NPC biogenesis; forms stable associations with three FG-nucleoporins (Nsp1p, Nup57p, and Nup49p) |
YGR246C | 3.22 | 6.44E-4 | 0.12 | BRF1 | TFIIIB B-related factor, one of three subunits of RNA polymerase III transcription initiation factor TFIIIB, binds TFIIIC and TBP and recruits RNA pol III to promoters, amino-terminal half is homologous to TFIIB |
YOR340C | 3.10 | 9.74E-4 | 0.08 | RPA43 | RNA polymerase I subunit A43 |
YKL144C | 3.02 | 0.00128 | 0.02 | RPC25 | RNA polymerase III subunit C25, required for transcription initiation; forms a heterodimer with Rpc17p; paralog of Rpb7p |
YDR062W | 3.00 | 0.00136 | 0.00 | LCB2 | Component of serine palmitoyltransferase, responsible along with Lcb1p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine |
YPL044C_d | 3.00 | 0.00137 | 0.04 | YPL044C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NOP4/YPL043W |