9138069

N-[3-(4-fluorophenyl)propyl]benzenesulfonamide

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_3275
Screen concentration 49.5 μM
Source Chembridge (Drug-like library)
PubChem CID 17617007
SMILES C1=CC=C(C=C1)S(=O)(=O)NCCCC2=CC=C(C=C2)F
Standardized SMILES Fc1ccc(CCCNS(=O)(=O)c2ccccc2)cc1
Molecular weight 293.3564
ALogP 3.31
H-bond donor count 1
H-bond acceptor count 4
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 5.55
% growth inhibition (Hom. pool) 7.05


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 17617007
Download HIP data (tab-delimited text)  (excel)
Gene:CRM1(YGR218W)|FD-Score:-3.36|P-value:3.86E-4|Clearance:0||SGD DESC:Major karyopherin, involved in export of proteins, RNAs, and ribosomal subunits from the nucleus; exportin Gene:MCD1(YDL003W)|FD-Score:3.11|P-value:9.24E-4|Clearance:0.02||SGD DESC:Essential alpha-kleisin subunit of the cohesin complex; required for sister chromatid cohesion in mitosis and meiosis; apoptosis induces cleavage and translocation of a C-terminal fragment to mitochondria; expression peaks in S phase Gene:NSP1(YJL041W)|FD-Score:4.68|P-value:1.42E-6|Clearance:0.93||SGD DESC:FG-nucleoporin component of central core of the nuclear pore complex (NPC); also part of the NPC nuclear basket; contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; found in stable complex with Nup82p, Gle2p and two other FG-nucleoporins (Nup159p and Nup116p); also found in stable complex with Nic96p and two other FG-nucleoproteins (Nup49p and Nup57p); forms foci at the nuclear periphery upon DNA replication stress Gene:PGS1(YCL004W)|FD-Score:-3.9|P-value:4.83E-5|Clearance:0||SGD DESC:Phosphatidylglycerolphosphate synthase, catalyzes the synthesis of phosphatidylglycerolphosphate from CDP-diacylglycerol and sn-glycerol 3-phosphate in the first committed and rate-limiting step of cardiolipin biosynthesis Gene:SRM1(YGL097W)|FD-Score:3.63|P-value:1.42E-4|Clearance:0.52||SGD DESC:Nucleotide exchange factor for Gsp1p, localizes to the nucleus, required for nucleocytoplasmic trafficking of macromolecules; suppressor of the pheromone response pathway; potentially phosphorylated by Cdc28p Gene:TSR1(YDL060W)|FD-Score:-3.18|P-value:7.32E-4|Clearance:0||SGD DESC:Protein required for processing of 20S pre-rRNA in the cytoplasm; associates with pre-40S ribosomal particles; inhibits the premature association of 60S subunits with assembling 40S subunits in the cytoplasm; similar to Bms1p; relocalizes from nucleus to cytoplasm upon DNA replication stress Gene:YBR089W(YBR089W_d)|FD-Score:-3.41|P-value:3.22E-4|Clearance:0||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps the verified gene POL30 Gene:YGL069C(YGL069C_d)|FD-Score:3.09|P-value:9.85E-4|Clearance:0.06||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 92% of ORF overlaps the uncharacterized ORF YGL068W; deletion in cyr1 mutant results in loss of stress resistance Gene:YMR290W-A(YMR290W-A_d)|FD-Score:3.75|P-value:8.80E-5|Clearance:0.12||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential HAS1 gene which encodes an ATP-dependent RNA helicase Gene:CRM1(YGR218W)|FD-Score:-3.36|P-value:3.86E-4|Clearance:0||SGD DESC:Major karyopherin, involved in export of proteins, RNAs, and ribosomal subunits from the nucleus; exportin Gene:MCD1(YDL003W)|FD-Score:3.11|P-value:9.24E-4|Clearance:0.02||SGD DESC:Essential alpha-kleisin subunit of the cohesin complex; required for sister chromatid cohesion in mitosis and meiosis; apoptosis induces cleavage and translocation of a C-terminal fragment to mitochondria; expression peaks in S phase Gene:NSP1(YJL041W)|FD-Score:4.68|P-value:1.42E-6|Clearance:0.93||SGD DESC:FG-nucleoporin component of central core of the nuclear pore complex (NPC); also part of the NPC nuclear basket; contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; found in stable complex with Nup82p, Gle2p and two other FG-nucleoporins (Nup159p and Nup116p); also found in stable complex with Nic96p and two other FG-nucleoproteins (Nup49p and Nup57p); forms foci at the nuclear periphery upon DNA replication stress Gene:PGS1(YCL004W)|FD-Score:-3.9|P-value:4.83E-5|Clearance:0||SGD DESC:Phosphatidylglycerolphosphate synthase, catalyzes the synthesis of phosphatidylglycerolphosphate from CDP-diacylglycerol and sn-glycerol 3-phosphate in the first committed and rate-limiting step of cardiolipin biosynthesis Gene:SRM1(YGL097W)|FD-Score:3.63|P-value:1.42E-4|Clearance:0.52||SGD DESC:Nucleotide exchange factor for Gsp1p, localizes to the nucleus, required for nucleocytoplasmic trafficking of macromolecules; suppressor of the pheromone response pathway; potentially phosphorylated by Cdc28p Gene:TSR1(YDL060W)|FD-Score:-3.18|P-value:7.32E-4|Clearance:0||SGD DESC:Protein required for processing of 20S pre-rRNA in the cytoplasm; associates with pre-40S ribosomal particles; inhibits the premature association of 60S subunits with assembling 40S subunits in the cytoplasm; similar to Bms1p; relocalizes from nucleus to cytoplasm upon DNA replication stress Gene:YBR089W(YBR089W_d)|FD-Score:-3.41|P-value:3.22E-4|Clearance:0||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps the verified gene POL30 Gene:YGL069C(YGL069C_d)|FD-Score:3.09|P-value:9.85E-4|Clearance:0.06||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 92% of ORF overlaps the uncharacterized ORF YGL068W; deletion in cyr1 mutant results in loss of stress resistance Gene:YMR290W-A(YMR290W-A_d)|FD-Score:3.75|P-value:8.80E-5|Clearance:0.12||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential HAS1 gene which encodes an ATP-dependent RNA helicase

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 17617007
Download HOP data (tab-delimited text)  (excel)
Gene:ACO1(YLR304C)|FD-Score:-3.21|P-value:6.71E-4||SGD DESC:Aconitase, required for the tricarboxylic acid (TCA) cycle and also independently required for mitochondrial genome maintenance; phosphorylated; component of the mitochondrial nucleoid; mutation leads to glutamate auxotrophy Gene:ALG5(YPL227C)|FD-Score:4.12|P-value:1.89E-5||SGD DESC:UDP-glucose:dolichyl-phosphate glucosyltransferase, involved in asparagine-linked glycosylation in the endoplasmic reticulum Gene:BOI1(YBL085W)|FD-Score:-3.82|P-value:6.76E-5||SGD DESC:Protein implicated in polar growth; functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; relocalizes from bud neck to cytoplasm upon DNA replication stress; BOI1 has a paralog, BOI2, that arose from the whole genome duplication Gene:CHS3(YBR023C)|FD-Score:-3.19|P-value:7.05E-4||SGD DESC:Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan Gene:DUG2(YBR281C)|FD-Score:-3.4|P-value:3.39E-4||SGD DESC:Component of glutamine amidotransferase (GATase II); forms a complex with Dug3p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p) Gene:FYV12(YOR183W_p)|FD-Score:3.36|P-value:3.91E-4||SGD DESC:Protein of unknown function, required for survival upon exposure to K1 killer toxin Gene:GCN20(YFR009W)|FD-Score:3.34|P-value:4.12E-4||SGD DESC:Positive regulator of the Gcn2p kinase activity, forms a complex with Gcn1p; proposed to stimulate Gcn2p activation by an uncharged tRNA Gene:GET3(YDL100C)|FD-Score:-4.67|P-value:1.53E-6||SGD DESC:Guanine nucleotide exchange factor for Gpa1p; amplifies G protein signaling; subunit of the GET complex, which is involved in Golgi to ER trafficking and insertion of proteins into the ER membrane; has low-level ATPase activity; protein abundance increases in response to DNA replication stress Gene:GPT2(YKR067W)|FD-Score:-3.78|P-value:7.82E-5||SGD DESC:Glycerol-3-phosphate/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase located in lipid particles and the ER; involved in the stepwise acylation of glycerol-3-phosphate and dihydroxyacetone in lipid biosynthesis; the most conserved motifs and functionally relevant residues are oriented towards the ER lumen Gene:HPF1(YOL155C)|FD-Score:-3.21|P-value:6.70E-4||SGD DESC:Haze-protective mannoprotein that reduces the particle size of aggregated proteins in white wines Gene:MRPS35(YGR165W)|FD-Score:3.34|P-value:4.24E-4||SGD DESC:Mitochondrial ribosomal protein of the small subunit; null mutant does not grow on glycerol, is sensitive to 2,4-dichlorophenol, and accumulates large lipid droplets Gene:MTC7(YEL033W_p)|FD-Score:3.57|P-value:1.77E-4||SGD DESC:Predicted metabolic role based on network analysis derived from ChIP experiments, a large-scale deletion study and localization of transcription factor binding sites; null mutant is sensitive to temperature oscillation in a cdc13-1 mutant Gene:MTQ2(YDR140W)|FD-Score:6|P-value:9.73E-10||SGD DESC:S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; subunit of complex with Trm112p that methylates translation release factor Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; similar to E.coli PrmC Gene:OST6(YML019W)|FD-Score:3.36|P-value:3.88E-4||SGD DESC:Subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; similar to and partially functionally redundant with Ost3p Gene:PUB1(YNL016W)|FD-Score:-3.72|P-value:9.95E-5||SGD DESC:Poly (A)+ RNA-binding protein; abundant mRNP-component protein that binds mRNA and is required for stability of many mRNAs; component of glucose deprivation induced stress granules, involved in P-body-dependent granule assembly; protein abundance increases in response to DNA replication stress Gene:RGD2(YFL047W)|FD-Score:3.11|P-value:9.49E-4||SGD DESC:GTPase-activating protein (RhoGAP) for Cdc42p and Rho5p; relocalizes from bud neck to cytoplasm upon DNA replication stress Gene:RGT1(YKL038W)|FD-Score:3.64|P-value:1.37E-4||SGD DESC:Glucose-responsive transcription factor; regulates expression of several glucose transporter (HXT) genes in response to glucose; binds to promoters and acts both as a transcriptional activator and repressor; RGT1 has a paralog, EDS1, that arose from the whole genome duplication Gene:SCS2(YER120W)|FD-Score:-4.15|P-value:1.66E-5||SGD DESC:Integral ER membrane protein, regulates phospholipid metabolism; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PI4P levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; interacts with FFAT motif of Opi1p; involved in telomeric silencing; null shows inositol auxotrophy above 34 deg C; VAP homolog; SCS2 has a paralog, SCS22, that arose from the whole genome duplication Gene:SLM5(YCR024C)|FD-Score:-3.82|P-value:6.74E-5||SGD DESC:Mitochondrial asparaginyl-tRNA synthetase Gene:YBR178W(YBR178W_d)|FD-Score:-3.77|P-value:8.12E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR177C Gene:YBR220C(YBR220C_p)|FD-Score:3.35|P-value:4.06E-4||SGD DESC:Putative protein of unknown function; YBR220C is not an essential gene Gene:YDR003W-A(YDR003W-A_p)|FD-Score:4.05|P-value:2.52E-5||SGD DESC:Putative protein of unknown function; identified by expression profiling and mass spectrometry Gene:YDR509W(YDR509W_d)|FD-Score:3.7|P-value:1.09E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YER175W-A(YER175W-A_p)|FD-Score:-4.81|P-value:7.53E-7||SGD DESC:Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching Gene:YGR126W(YGR126W_p)|FD-Score:3.73|P-value:9.45E-5||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS Gene:YGR160W(YGR160W_d)|FD-Score:-3.54|P-value:2.00E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YHR035W(YHR035W_p)|FD-Score:3.66|P-value:1.25E-4||SGD DESC:Putative protein of unknown function; not an essential gene Gene:YIL029C(YIL029C_p)|FD-Score:5.01|P-value:2.76E-7||SGD DESC:Putative protein of unknown function; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO); YIL029C has paralog YPR071W Gene:YIR044C(YIR044C)|FD-Score:-3.18|P-value:7.38E-4||SGD DESC:Possible pseudogene in strain S288C; YIR044C and the adjacent ORF, YIR043C, together may encode a non-functional member of the conserved, often subtelomerically-encoded Cos protein family Gene:YKL068W-A(YKL068W-A_p)|FD-Score:4.23|P-value:1.15E-5||SGD DESC:Putative protein of unknown function; identified by homology to <i>Ashbya gossypii</i> Gene:YOL097W-A(YOL097W-A_p)|FD-Score:3.18|P-value:7.29E-4||SGD DESC:Putative protein of unknown function; identified by expression profiling and mass spectrometry Gene:YPL080C(YPL080C_d)|FD-Score:5.15|P-value:1.33E-7||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YPQ1(YOL092W_p)|FD-Score:3.37|P-value:3.77E-4||SGD DESC:Putative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; member of the PQ-loop family, with seven transmembrane domains; similar to mammalian PQLC2 vacuolar transporter Gene:ACO1(YLR304C)|FD-Score:-3.21|P-value:6.71E-4||SGD DESC:Aconitase, required for the tricarboxylic acid (TCA) cycle and also independently required for mitochondrial genome maintenance; phosphorylated; component of the mitochondrial nucleoid; mutation leads to glutamate auxotrophy Gene:ALG5(YPL227C)|FD-Score:4.12|P-value:1.89E-5||SGD DESC:UDP-glucose:dolichyl-phosphate glucosyltransferase, involved in asparagine-linked glycosylation in the endoplasmic reticulum Gene:BOI1(YBL085W)|FD-Score:-3.82|P-value:6.76E-5||SGD DESC:Protein implicated in polar growth; functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; relocalizes from bud neck to cytoplasm upon DNA replication stress; BOI1 has a paralog, BOI2, that arose from the whole genome duplication Gene:CHS3(YBR023C)|FD-Score:-3.19|P-value:7.05E-4||SGD DESC:Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan Gene:DUG2(YBR281C)|FD-Score:-3.4|P-value:3.39E-4||SGD DESC:Component of glutamine amidotransferase (GATase II); forms a complex with Dug3p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p) Gene:FYV12(YOR183W_p)|FD-Score:3.36|P-value:3.91E-4||SGD DESC:Protein of unknown function, required for survival upon exposure to K1 killer toxin Gene:GCN20(YFR009W)|FD-Score:3.34|P-value:4.12E-4||SGD DESC:Positive regulator of the Gcn2p kinase activity, forms a complex with Gcn1p; proposed to stimulate Gcn2p activation by an uncharged tRNA Gene:GET3(YDL100C)|FD-Score:-4.67|P-value:1.53E-6||SGD DESC:Guanine nucleotide exchange factor for Gpa1p; amplifies G protein signaling; subunit of the GET complex, which is involved in Golgi to ER trafficking and insertion of proteins into the ER membrane; has low-level ATPase activity; protein abundance increases in response to DNA replication stress Gene:GPT2(YKR067W)|FD-Score:-3.78|P-value:7.82E-5||SGD DESC:Glycerol-3-phosphate/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase located in lipid particles and the ER; involved in the stepwise acylation of glycerol-3-phosphate and dihydroxyacetone in lipid biosynthesis; the most conserved motifs and functionally relevant residues are oriented towards the ER lumen Gene:HPF1(YOL155C)|FD-Score:-3.21|P-value:6.70E-4||SGD DESC:Haze-protective mannoprotein that reduces the particle size of aggregated proteins in white wines Gene:MRPS35(YGR165W)|FD-Score:3.34|P-value:4.24E-4||SGD DESC:Mitochondrial ribosomal protein of the small subunit; null mutant does not grow on glycerol, is sensitive to 2,4-dichlorophenol, and accumulates large lipid droplets Gene:MTC7(YEL033W_p)|FD-Score:3.57|P-value:1.77E-4||SGD DESC:Predicted metabolic role based on network analysis derived from ChIP experiments, a large-scale deletion study and localization of transcription factor binding sites; null mutant is sensitive to temperature oscillation in a cdc13-1 mutant Gene:MTQ2(YDR140W)|FD-Score:6|P-value:9.73E-10||SGD DESC:S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; subunit of complex with Trm112p that methylates translation release factor Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; similar to E.coli PrmC Gene:OST6(YML019W)|FD-Score:3.36|P-value:3.88E-4||SGD DESC:Subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; similar to and partially functionally redundant with Ost3p Gene:PUB1(YNL016W)|FD-Score:-3.72|P-value:9.95E-5||SGD DESC:Poly (A)+ RNA-binding protein; abundant mRNP-component protein that binds mRNA and is required for stability of many mRNAs; component of glucose deprivation induced stress granules, involved in P-body-dependent granule assembly; protein abundance increases in response to DNA replication stress Gene:RGD2(YFL047W)|FD-Score:3.11|P-value:9.49E-4||SGD DESC:GTPase-activating protein (RhoGAP) for Cdc42p and Rho5p; relocalizes from bud neck to cytoplasm upon DNA replication stress Gene:RGT1(YKL038W)|FD-Score:3.64|P-value:1.37E-4||SGD DESC:Glucose-responsive transcription factor; regulates expression of several glucose transporter (HXT) genes in response to glucose; binds to promoters and acts both as a transcriptional activator and repressor; RGT1 has a paralog, EDS1, that arose from the whole genome duplication Gene:SCS2(YER120W)|FD-Score:-4.15|P-value:1.66E-5||SGD DESC:Integral ER membrane protein, regulates phospholipid metabolism; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PI4P levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; interacts with FFAT motif of Opi1p; involved in telomeric silencing; null shows inositol auxotrophy above 34 deg C; VAP homolog; SCS2 has a paralog, SCS22, that arose from the whole genome duplication Gene:SLM5(YCR024C)|FD-Score:-3.82|P-value:6.74E-5||SGD DESC:Mitochondrial asparaginyl-tRNA synthetase Gene:YBR178W(YBR178W_d)|FD-Score:-3.77|P-value:8.12E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR177C Gene:YBR220C(YBR220C_p)|FD-Score:3.35|P-value:4.06E-4||SGD DESC:Putative protein of unknown function; YBR220C is not an essential gene Gene:YDR003W-A(YDR003W-A_p)|FD-Score:4.05|P-value:2.52E-5||SGD DESC:Putative protein of unknown function; identified by expression profiling and mass spectrometry Gene:YDR509W(YDR509W_d)|FD-Score:3.7|P-value:1.09E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YER175W-A(YER175W-A_p)|FD-Score:-4.81|P-value:7.53E-7||SGD DESC:Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching Gene:YGR126W(YGR126W_p)|FD-Score:3.73|P-value:9.45E-5||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS Gene:YGR160W(YGR160W_d)|FD-Score:-3.54|P-value:2.00E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YHR035W(YHR035W_p)|FD-Score:3.66|P-value:1.25E-4||SGD DESC:Putative protein of unknown function; not an essential gene Gene:YIL029C(YIL029C_p)|FD-Score:5.01|P-value:2.76E-7||SGD DESC:Putative protein of unknown function; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO); YIL029C has paralog YPR071W Gene:YIR044C(YIR044C)|FD-Score:-3.18|P-value:7.38E-4||SGD DESC:Possible pseudogene in strain S288C; YIR044C and the adjacent ORF, YIR043C, together may encode a non-functional member of the conserved, often subtelomerically-encoded Cos protein family Gene:YKL068W-A(YKL068W-A_p)|FD-Score:4.23|P-value:1.15E-5||SGD DESC:Putative protein of unknown function; identified by homology to <i>Ashbya gossypii</i> Gene:YOL097W-A(YOL097W-A_p)|FD-Score:3.18|P-value:7.29E-4||SGD DESC:Putative protein of unknown function; identified by expression profiling and mass spectrometry Gene:YPL080C(YPL080C_d)|FD-Score:5.15|P-value:1.33E-7||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YPQ1(YOL092W_p)|FD-Score:3.37|P-value:3.77E-4||SGD DESC:Putative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; member of the PQ-loop family, with seven transmembrane domains; similar to mammalian PQLC2 vacuolar transporter

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YJL041W4.681.42E-60.93NSP1FG-nucleoporin component of central core of the nuclear pore complex (NPC); also part of the NPC nuclear basket; contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; found in stable complex with Nup82p, Gle2p and two other FG-nucleoporins (Nup159p and Nup116p); also found in stable complex with Nic96p and two other FG-nucleoproteins (Nup49p and Nup57p); forms foci at the nuclear periphery upon DNA replication stress
YMR290W-A_d3.758.80E-50.12YMR290W-A_dDubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential HAS1 gene which encodes an ATP-dependent RNA helicase
YGL097W3.631.42E-40.52SRM1Nucleotide exchange factor for Gsp1p, localizes to the nucleus, required for nucleocytoplasmic trafficking of macromolecules; suppressor of the pheromone response pathway; potentially phosphorylated by Cdc28p
YDL003W3.119.24E-40.02MCD1Essential alpha-kleisin subunit of the cohesin complex; required for sister chromatid cohesion in mitosis and meiosis; apoptosis induces cleavage and translocation of a C-terminal fragment to mitochondria; expression peaks in S phase
YGL069C_d3.099.85E-40.06YGL069C_dDubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 92% of ORF overlaps the uncharacterized ORF YGL068W; deletion in cyr1 mutant results in loss of stress resistance
YJL195C_d3.030.001220.02YJL195C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL194W/CDC6
YDR177W3.010.001320.04UBC1Ubiquitin-conjugating enzyme; mediates selective degradation of short-lived and abnormal proteins; plays a role in vesicle biogenesis and ER-associated protein degradation (ERAD); component of the cellular stress response; protein abundance increases in response to DNA replication stress
YPL016W2.960.001510.09SWI1Subunit of the SWI/SNF chromatin remodeling complex; regulates transcription by remodeling chromatin; required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2; can form the prion [SWI+]; human homolog ARID1A is a candidate tumor suppressor gene in breast cancer
YLR009W2.870.002030.03RLP24Essential protein required for ribosomal large subunit biogenesis; associated with pre-60S ribosomal subunits; stimulates the ATPase activity of Afg2p, which is required for release of Rlp24p from the pre-60S particle; has similarity to Rpl24Ap and Rpl24Bp
YLR145W2.840.002260.01RMP1Subunit of RNase MRP, which processes pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; unlike most subunits, not shared between RNase MRP and nuclear RNase P
YDL016C_d2.830.002320.07YDL016C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CDC7/YDL153C, the catalytic subunit of a complex that regulates DNA replication
YPL238C_d2.760.002860.02YPL238C_dDubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified essential gene SUI3/YPL237W
YMR236W2.740.003080.01TAF9Subunit (17 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification, similar to histone H3
YOR262W2.730.003160.02GPN2Putative GTPase with a role in biogenesis of RNA pol II and polIII; may be involved in assembly of RNA polymerases II and III and in their transport into the nucleus; contains a Gly-Pro-Asn motif in the G domain; similar to Npa3p and Gpn3p; highly conserved across species and homologous to human gene GPN2/ATPBD1B; required for establishment of sister chromatid cohesion
YPR113W2.710.003360.05PIS1Phosphatidylinositol synthase, required for biosynthesis of phosphatidylinositol, which is a precursor for polyphosphoinositides, sphingolipids, and glycolipid anchors for some of the plasma membrane proteins

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YDR140W6.009.73E-10MTQ2S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; subunit of complex with Trm112p that methylates translation release factor Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; similar to E.coli PrmC
YPL080C_d5.151.33E-7YPL080C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YIL029C_p5.012.76E-7YIL029C_pPutative protein of unknown function; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO); YIL029C has paralog YPR071W
YKL068W-A_p4.231.15E-5YKL068W-A_pPutative protein of unknown function; identified by homology to Ashbya gossypii
YPL227C4.121.89E-5ALG5UDP-glucose:dolichyl-phosphate glucosyltransferase, involved in asparagine-linked glycosylation in the endoplasmic reticulum
YDR003W-A_p4.052.52E-5YDR003W-A_pPutative protein of unknown function; identified by expression profiling and mass spectrometry
YGR126W_p3.739.45E-5YGR126W_pPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS
YDR509W_d3.701.09E-4YDR509W_dDubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YHR035W_p3.661.25E-4YHR035W_pPutative protein of unknown function; not an essential gene
YKL038W3.641.37E-4RGT1Glucose-responsive transcription factor; regulates expression of several glucose transporter (HXT) genes in response to glucose; binds to promoters and acts both as a transcriptional activator and repressor; RGT1 has a paralog, EDS1, that arose from the whole genome duplication
YEL033W_p3.571.77E-4MTC7_pPredicted metabolic role based on network analysis derived from ChIP experiments, a large-scale deletion study and localization of transcription factor binding sites; null mutant is sensitive to temperature oscillation in a cdc13-1 mutant
YOL092W_p3.373.77E-4YPQ1_pPutative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; member of the PQ-loop family, with seven transmembrane domains; similar to mammalian PQLC2 vacuolar transporter
YML019W3.363.88E-4OST6Subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; similar to and partially functionally redundant with Ost3p
YOR183W_p3.363.91E-4FYV12_pProtein of unknown function, required for survival upon exposure to K1 killer toxin
YBR220C_p3.354.06E-4YBR220C_pPutative protein of unknown function; YBR220C is not an essential gene

GO enrichment analysis for SGTC_3275
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.0764.54E-9SGTC_1684st024538 14.6 μMTimTec (Natural product derivative library)67328590.0882353
0.0655.54E-7SGTC_28137971799 71.4 μMChembridge (Drug-like library)22340540.174603
0.0631.29E-6SGTC_1994063-0024 41.6 μMChemDiv (Drug-like library)3062150.203704
0.0621.58E-6SGTC_19215740136 50.0 μMMiscellaneous17742430.0833333TRP & mitochondrial translation
0.0595.47E-6SGTC_9891501-0895 10.3 μMChemDiv (Drug-like library)28301120.0895522
0.0561.69E-5SGTC_2698st077697 67.5 μMTimTec (Natural product derivative library)31544990.038961
0.0561.74E-5SGTC_1103duloxetine 36.1 μMNIH Clinical Collection608350.125
0.0561.93E-5SGTC_680986-0284 82.8 μMChemDiv (Drug-like library)4232780.140351
0.0552.15E-5SGTC_31639099914 49.5 μMChembridge (Drug-like library)162683680.0909091
0.0534.18E-5SGTC_2706st078239 82.5 μMTimTec (Natural product derivative library)154344920.1
0.0534.26E-5SGTC_1769st044406 64.4 μMTimTec (Natural product derivative library)6709030.123077
0.0534.52E-5SGTC_11720370-0043 85.0 μMChemDiv (Drug-like library)3765850.133333
0.0535.07E-5SGTC_2643anethole 100.0 μMMicrosource (Natural product library)6375630.0612245
0.0517.51E-5SGTC_29789011784 43.0 μMChembridge (Drug-like library)29949340.131148
0.0519.73E-5SGTC_8530419-0306 21.0 μMChemDiv (Drug-like library)7627130.0655738

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_3224913064349.47 μM0.68292717644395Chembridge (Drug-like library)323.3824233.29115RPP1 & pyrimidine depletion
SGTC_10533366-3204134 μM0.558143632071ChemDiv (Drug-like library)309.3558432.83415cell wall
SGTC_5694130-2812160 μM0.47619743552ChemDiv (Drug-like library)279.3298633.01614amide catabolism
SGTC_3259913848549.47 μM0.41666717646153Chembridge (Drug-like library)334.4083633.15315
SGTC_1992st07364323.3 μM0.3888893161292TimTec (Natural product derivative library)352.8109633.80924mitochondrial processes
SGTC_7580868-002916 μM0.333333762687ChemDiv (Drug-like library)327.3726634.04114
SGTC_9391165-047945.3 μM0.3255811377347ChemDiv (Drug-like library)359.182772.89513
SGTC_10034049-0218100 μM0.319149295161ChemDiv (Drug-like library)279.3298633.49514
SGTC_3238913347049.47 μM0.31253534688Chembridge (Drug-like library)275.365983.29613
SGTC_3272913741349.47 μM0.29411817614870Chembridge (Drug-like library)321.391362.6415