Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YMR033W | 5.87 | 2.18E-9 | 1.56 | ARP9 | Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation |
YPR165W | 5.78 | 3.85E-9 | 1.56 | RHO1 | GTP-binding protein of the rho subfamily of Ras-like proteins, involved in establishment of cell polarity; regulates protein kinase C (Pkc1p) and the cell wall synthesizing enzyme 1,3-beta-glucan synthase (Fks1p and Gsc2p) |
YMR290W-A_d | 4.21 | 1.27E-5 | 0.47 | YMR290W-A_d | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential HAS1 gene which encodes an ATP-dependent RNA helicase |
YOR210W | 3.74 | 9.24E-5 | 0.02 | RPB10 | RNA polymerase subunit ABC10-beta, common to RNA polymerases I, II, and III |
YFR002W | 3.72 | 9.96E-5 | 0.76 | NIC96 | Linker nucleoporin component of the nuclear pore complex (NPC); also part of the NPC nuclear basket; contributes to nucleocytoplasmic transport and NPC biogenesis; forms stable associations with three FG-nucleoporins (Nsp1p, Nup57p, and Nup49p) |
YLR275W | 2.96 | 0.00155 | 0.03 | SMD2 | Core Sm protein Sm D2; part of heteroheptameric complex (with Smb1p, Smd1p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D2 |
YOR074C | 2.93 | 0.00169 | 0.11 | CDC21 | Thymidylate synthase, required for de novo biosynthesis of pyrimidine deoxyribonucleotides; expression is induced at G1/S |
YHR186C | 2.82 | 0.00242 | 0.14 | KOG1 | Subunit of TORC1, a rapamycin-sensitive complex involved in growth control that contains Tor1p or Tor2p, Lst8p and Tco89p; contains four HEAT repeats and seven WD-40 repeats; may act as a scaffold protein to couple TOR and its effectors |
YNL113W | 2.68 | 0.00368 | 0.02 | RPC19 | RNA polymerase subunit AC19, common to RNA polymerases I and III |
YHR062C | 2.66 | 0.00393 | 0.01 | RPP1 | Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs |
YLR459W | 2.65 | 0.00404 | 0.07 | GAB1 | GPI transamidase subunit, involved in attachment of glycosylphosphatidylinositol (GPI) anchors to proteins; may have a role in recognition of the attachment signal or of the lipid portion of GPI |
YDL209C | 2.58 | 0.00499 | 0.00 | CWC2 | Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; binds directly to U6 snRNA; similar to S. pombe Cwf2 |
YKL144C | 2.57 | 0.00505 | 0.02 | RPC25 | RNA polymerase III subunit C25, required for transcription initiation; forms a heterodimer with Rpc17p; paralog of Rpb7p |
YBL026W | 2.56 | 0.00528 | 0.06 | LSM2 | Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress |
YJL019W | 2.50 | 0.00619 | 0.05 | MPS3 | Nuclear envelope protein required for SPB insertion; initiation of SPB duplication and nuclear fusion; acetylation of Mps3p by Eco1p regulates its role in nuclear organization; localizes to the SPB half bridge and at telomeres during meiosis; required with Ndj1p and Csm4p for meiotic bouquet formation and telomere-led rapid prophase movement; N-terminal acetylated by Eco1p |