Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YPR178W | 6.17 | 3.37E-10 | 2.25 | PRP4 | Splicing factor, component of the U4/U6-U5 snRNP complex |
YCR072C | 3.92 | 4.48E-5 | 0.33 | RSA4 | WD-repeat protein involved in ribosome biogenesis; may interact with ribosomes; required for maturation and efficient intra-nuclear transport or pre-60S ribosomal subunits, localizes to the nucleolus |
YGL099W | 3.59 | 1.65E-4 | 0.24 | LSG1 | Putative GTPase involved in 60S ribosomal subunit biogenesis; required for the release of Nmd3p from 60S subunits in the cytoplasm |
YDR355C_d | 3.35 | 3.98E-4 | 0.68 | YDR355C_d | Dubious: Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified essential ORF SPC110/YDR356W |
YJR065C | 2.68 | 0.00372 | 0.08 | ARP3 | Essential component of the Arp2/3 complex, which is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity |
YLR106C | 2.59 | 0.00475 | 0.01 | MDN1 | Huge dynein-related AAA-type ATPase (midasin), forms extended pre-60S particle with the Rix1 complex (Rix1p-Ipi1p-Ipi3p); acts in removal of ribosomal biogenesis factors at successive steps of pre-60S assembly and export from nucleus |
YDR180W | 2.58 | 0.00494 | 0.09 | SCC2 | Subunit of cohesin loading factor (Scc2p-Scc4p), a complex required for loading of cohesin complexes onto chromosomes; involved in establishing sister chromatid cohesion during DSB repair via histone H2AX; evolutionarily-conserved adherin |
YPL128C | 2.49 | 0.00637 | 0.07 | TBF1 | Telobox-containing general regulatory factor; binds TTAGGG repeats within subtelomeric anti-silencing regions (STARs), blocking silent chromatin propagation; binds majority of snoRNA gene promoters, required for full snoRNA expression; caps DSB flanked by long T2AG3 repeats and blocks checkpoint activation |
YDL221W_d | 2.42 | 0.00783 | 0.06 | YDL221W_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the 3' end of essential gene CDC13 |
YFL045C | 2.35 | 0.00931 | 0.04 | SEC53 | Phosphomannomutase, involved in synthesis of GDP-mannose and dolichol-phosphate-mannose; required for folding and glycosylation of secretory proteins in the ER lumen |
YDR328C | 2.32 | 0.01020 | 0.02 | SKP1 | Evolutionarily conserved kinetochore protein; part of multiple protein complexes, including the SCF ubiquitin ligase complex, the CBF3 complex that binds centromeric DNA, and the RAVE complex that regulates assembly of the V-ATPase; protein abundance increases in response to DNA replication stress |
YML125C | 2.30 | 0.01080 | 0.08 | PGA3 | Putative cytochrome b5 reductase, localized to the plasma membrane; may be involved in regulation of lifespan; required for maturation of Gas1p and Pho8p, proposed to be involved in protein trafficking; PGA3 has a paralog, AIM33, that arose from the whole genome duplication |
YKL036C_d | 2.21 | 0.01350 | 0.10 | YKL036C_d | Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the essential gene UGP1 gene and uncharacterized ORF YKL037W |
YNL260C_p | 2.11 | 0.01750 | 0.04 | LTO1_p | Essential protein that forms a complex with Rli1p and Yae1p; ortholog of human ORAOV1, which is overexpressed in solid tumors; inviability of null mutant under standard conditions is complemented by overexpression of ORAOV1; essential for growth under standard (aerobic) conditions but not under anaerobic conditions; may have a role in protection of ribosomal assembly and function from damage due to reactive oxygen species |
YJL061W | 2.07 | 0.01940 | 0.01 | NUP82 | Linker nucleoporin component of the nuclear pore complex (NPC); also part of the NPC cytoplasmic filaments; contributes to nucleocytoplasmic transport and NPC biogenesis; forms stable associations with three FG-nucleoporins (Nsp1p, Nup159p, and Nup116p) |