Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YGL099W | 6.41 | 7.36E-11 | 0.96 | LSG1 | Putative GTPase involved in 60S ribosomal subunit biogenesis; required for the release of Nmd3p from 60S subunits in the cytoplasm |
YML015C | 5.45 | 2.56E-8 | 0.95 | TAF11 | TFIID subunit (40 kDa), involved in RNA polymerase II transcription initiation, similar to histone H3 with atypical histone fold motif of Spt3-like transcription factors |
YDL195W | 4.49 | 3.51E-6 | 0.24 | SEC31 | Component of the Sec13p-Sec31p complex of the COPII vesicle coat, required for vesicle formation in ER to Golgi transport; mutant has increased aneuploidy tolerance |
YMR211W | 4.25 | 1.07E-5 | 0.38 | DML1 | Essential protein involved in mtDNA inheritance, may also function in the partitioning of the mitochondrial organelle or in the segregation of chromosomes, exhibits regions similar to members of a GTPase family |
YBR211C | 3.87 | 5.47E-5 | 0.01 | AME1 | Essential kinetochore protein associated with microtubules and SPBs; component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p); involved in spindle checkpoint maintenance; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-U and fission yeast Mis17; relative distribution to the nucleus increases upon DNA replication stress |
YGR099W | 3.85 | 5.80E-5 | 0.06 | TEL2 | Subunit of the ASTRA complex, involved in chromatin remodeling; subunit of the telomere cap complex DNA-binding protein specific to single-stranded yeast telomeric DNA repeats, required for telomere length regulation and telomere position effect; involved in the stability or biogenesis of PIKKs such as TORC1 |
YDL003W | 3.80 | 7.37E-5 | 0.07 | MCD1 | Essential alpha-kleisin subunit of the cohesin complex; required for sister chromatid cohesion in mitosis and meiosis; apoptosis induces cleavage and translocation of a C-terminal fragment to mitochondria; expression peaks in S phase |
YDL212W | 3.72 | 9.91E-5 | 0.17 | SHR3 | Endoplasmic reticulum packaging chaperone, required for incorporation of amino acid permeases into COPII coated vesicles for transport to the cell surface |
YGR218W | 3.56 | 1.88E-4 | 0.02 | CRM1 | Major karyopherin, involved in export of proteins, RNAs, and ribosomal subunits from the nucleus; exportin |
YIL104C | 3.53 | 2.06E-4 | 0.04 | SHQ1 | Chaperone protein required for the assembly of box H/ACA snoRNPs and thus for pre-rRNA processing, forms a complex with Naf1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; homology with known Hsp90p cochaperones |
YIR010W | 3.49 | 2.38E-4 | 0.05 | DSN1 | Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; important for chromosome segregation |
YCR052W | 3.44 | 2.87E-4 | 0.20 | RSC6 | Component of the RSC chromatin remodeling complex; essential for mitotic growth; homolog of SWI/SNF subunit Swp73p |
YDR224C | 3.25 | 5.84E-4 | 0.07 | HTB1 | Histone H2B, core histone protein required for chromatin assembly and chromosome function; nearly identical to HTB2; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation |
YIL143C | 3.18 | 7.39E-4 | 0.13 | SSL2 | Component of RNA polymerase transcription factor TFIIH holoenzyme; has DNA-dependent ATPase/helicase activity and is required, with Rad3p, for unwinding promoter DNA; interacts functionally with TFIIB and has roles in transcription start site selection and in gene looping to juxtapose initiation and termination regions; involved in DNA repair; homolog of human ERCC3 |
YHR170W | 3.05 | 0.00115 | 0.13 | NMD3 | Protein involved in nuclear export of the large ribosomal subunit; acts as a Crm1p-dependent adapter protein for export of nascent ribosomal subunits through the nuclear pore complex |