Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
---|
YER133W | 4.52 | 3.03E-6 | 0.76 | GLC7 | Type 1 serine/threonine protein phosphatase catalytic subunit; involved in various processes including glycogen metabolism, sporulation, mitosis; accumulates at mating projections by interaction with Afr1p; interacts with many regulatory subunits; involved in regulation of the nucleocytoplasmic shuttling of Hxk2p; import into nucleus is inhibited during spindle assembly checkpoint arrest |
YBR109C | 4.36 | 6.41E-6 | 0.76 | CMD1 | Calmodulin; Ca++ binding protein that regulates Ca++ independent processes (mitosis, bud growth, actin organization, endocytosis, etc.) and Ca++ dependent processes (stress-activated pathways), targets include Nuf1p, Myo2p and calcineurin |
YIL091C | 4.07 | 2.32E-5 | 0.76 | UTP25 | Nucleolar protein required for 35S pre-RNA processing and 40S ribosomal subunit biogenesis |
YKL058W | 3.98 | 3.41E-5 | 0.76 | TOA2 | TFIIA small subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; homologous to smallest subunit of human and Drosophila TFIIA; protein abundance increases in response to DNA replication stress |
YAL034W-A | 3.22 | 6.30E-4 | 0.05 | MTW1 | Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; critical to kinetochore assembly |
YKL059C | 3.18 | 7.41E-4 | 0.16 | MPE1 | Essential conserved subunit of CPF (cleavage and polyadenylation factor), plays a role in 3' end formation of mRNA via the specific cleavage and polyadenylation of pre-mRNA, contains a putative RNA-binding zinc knuckle motif |
YOR103C | 3.02 | 0.00126 | 0.11 | OST2 | Epsilon subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins |
YNL260C_p | 2.91 | 0.00179 | 0.04 | LTO1_p | Essential protein that forms a complex with Rli1p and Yae1p; ortholog of human ORAOV1, which is overexpressed in solid tumors; inviability of null mutant under standard conditions is complemented by overexpression of ORAOV1; essential for growth under standard (aerobic) conditions but not under anaerobic conditions; may have a role in protection of ribosomal assembly and function from damage due to reactive oxygen species |
YOR004W | 2.88 | 0.00202 | 0.04 | UTP23 | Component of the small subunit processome, involved in 40S ribosomal subunit biogenesis; interacts with snR30 and is required for dissociation of snR30 from large pre-ribosomal particles; has homology to PINc domain protein Fcf1p, although the PINc domain of Utp23p is not required for function; essential protein |
YNL149C | 2.83 | 0.00232 | 0.30 | PGA2 | Essential protein required for maturation of Gas1p and Pho8p; involved in protein trafficking; GFP-fusion protein localizes to the ER and YFP-fusion protein to the nuclear envelope-ER network; null mutants have a cell separation defect |
YJL081C | 2.53 | 0.00576 | 0.01 | ARP4 | Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes |
YPR165W | 2.51 | 0.00598 | 0.06 | RHO1 | GTP-binding protein of the rho subfamily of Ras-like proteins, involved in establishment of cell polarity; regulates protein kinase C (Pkc1p) and the cell wall synthesizing enzyme 1,3-beta-glucan synthase (Fks1p and Gsc2p) |
YLR339C_d | 2.45 | 0.00705 | 0.11 | YLR339C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential gene RPP0 |
YHR101C | 2.35 | 0.00948 | 3.31E-5 | BIG1 | Integral membrane protein of the endoplasmic reticulum, required for normal content of cell wall beta-1,6-glucan |
YNL102W | 2.35 | 0.00948 | 0.09 | POL1 | Catalytic subunit of the DNA polymerase I alpha-primase complex, required for the initiation of DNA replication during mitotic DNA synthesis and premeiotic DNA synthesis |