Deletion Strain | FD score | P-value | Gene | Gene Description |
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YMR206W_p | 8.09 | 3.02E-16 | YMR206W_p | Putative protein of unknown function; not an essential gene; YMR206W has a paralog, YNR014W, that arose from the whole genome duplication |
YNL230C | 5.59 | 1.14E-8 | ELA1 | Elongin A; F-box protein that forms a heterodimer with Elc1p and is required for ubiquitin-dependent degradation of the RNA Polymerase II subunit Rpo21p; subunit of the Elongin-Cullin-Socs (ECS) ligase complex |
YKR089C | 5.24 | 7.84E-8 | TGL4 | Multifunctional triacylglycerol lipase, steryl ester hydrolase, and Ca2+-independent phospholipase A2; catalyzes acyl-CoA dependent acylation of LPA to PA; required with Tgl3p for timely bud formation; phosphorylated and activated by Cdc28p |
YDR221W | 5.18 | 1.11E-7 | GTB1 | Glucosidase II beta subunit, forms a complex with alpha subunit Rot2p; involved in removal of two glucose residues from N-linked glycans during glycoprotein biogenesis in the ER; relocalizes from ER to cytoplasm upon DNA replication stress |
YGL010W_p | 5.06 | 2.07E-7 | YGL010W_p | Putative protein of unknown function; YGL010W is not an essential gene |
YLR150W | 4.79 | 8.23E-7 | STM1 | Protein required for optimal translation under nutrient stress; perturbs association of Yef3p with ribosomes; involved in TOR signaling; binds G4 quadruplex and purine motif triplex nucleic acid; helps maintain telomere structure; protein abundance increases in response to DNA replication stress; serves as a ribosome preservation factor both during quiescence and recovery |
YGL041C-B_p | 4.72 | 1.19E-6 | YGL041C-B_p | Putative protein of unknown function; identified by fungal homology and RT-PCR |
YKL062W | 4.62 | 1.92E-6 | MSN4 | Transcriptional activator; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of responsive genes, inducing gene expression; MSN4 has a paralog, MSN2, that arose from the whole genome duplication |
YMR246W | 4.62 | 1.94E-6 | FAA4 | Long chain fatty acyl-CoA synthetase; activates imported fatty acids with a preference for C12:0-C16:0 chain lengths; functions in long chain fatty acid import; important for survival during stationary phase; localized to lipid particles; involved in sphingolipid-to-glycerolipid metabolism; forms cytoplasmic foci upon DNA replication stress; FAA4 has a paralog, FAA1, that arose from the whole genome duplication |
YBR041W | 4.57 | 2.43E-6 | FAT1 | Very long chain fatty acyl-CoA synthetase and long chain fatty acid transporter; activates imported fatty acids with a preference for very long lengths (C20-C26); has a separate function in the transport of long chain fatty acids |
YMR322C_p | 4.53 | 2.93E-6 | SNO4_p | Possible chaperone and cysteine protease, similar to bacterial Hsp31 and yeast Hsp31p, Hsp32p, and Hsp33p; DJ-1/ThiJ/PfpI superfamily member; predicted involvement in pyridoxine metabolism; induced by mild heat stress and copper deprivation |
YGR176W_d | 4.50 | 3.43E-6 | YGR176W_d | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
YOR124C | 4.37 | 6.34E-6 | UBP2 | Ubiquitin-specific protease that removes ubiquitin from ubiquitinated proteins; interacts with Rsp5p and is required for MVB sorting of membrane proteins; can cleave polyubiquitin and has isopeptidase activity |
YGL013C | 4.22 | 1.20E-5 | PDR1 | Transcription factor that regulates the pleiotropic drug response; zinc cluster protein that is a master regulator involved in recruiting other zinc cluster proteins to pleiotropic drug response elements (PDREs) to fine tune the regulation of multidrug resistance genes; PDR1 has a paralog, PDR3, that arose from the whole genome duplication |
YER093C-A | 4.21 | 1.25E-5 | AIM11 | Protein of unknown function; null mutant is viable but shows increased loss of mitochondrial genome and synthetic interaction with prohibitin (phb1); contains an intron; YER093C-A has a paralog, YBL059W, that arose from the whole genome duplication |