Deletion Strain | FD score | P-value | Gene | Gene Description |
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YPR060C | 16.10 | 2.33E-58 | ARO7 | Chorismate mutase, catalyzes the conversion of chorismate to prephenate to initiate the tyrosine/phenylalanine-specific branch of aromatic amino acid biosynthesis |
YIR023W | 14.80 | 1.18E-49 | DAL81 | Positive regulator of genes in multiple nitrogen degradation pathways; contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism |
YDR011W | 11.40 | 3.51E-30 | SNQ2 | Plasma membrane ATP-binding cassette (ABC) transporter, multidrug transporter involved in multidrug resistance and resistance to singlet oxygen species |
YDR010C_d | 10.60 | 1.75E-26 | YDR010C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
YDR333C_p | 8.38 | 2.60E-17 | RQC1_p | Component of the ribosome quality control complex (RQC); RQC (Rqc1p-Ltn1p-Tae2p-Cdc48p-Npl4p-Ufd1p), is a ribosome-bound complex required for the degradation of polypeptides arising from stalled translation; required along with Ltn1p for recruitment of the Cdc48p-Npl4p-Ufd1p AAA ATPase complex to the RQC |
YOR290C | 7.11 | 5.99E-13 | SNF2 | Catalytic subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; contains DNA-stimulated ATPase activity; functions interdependently in transcriptional activation with Snf5p and Snf6p |
YPL254W | 6.82 | 4.40E-12 | HFI1 | Adaptor protein required for structural integrity of the SAGA complex, a histone acetyltransferase-coactivator complex that is involved in global regulation of gene expression through acetylation and transcription functions |
YLR191W | 6.82 | 4.52E-12 | PEX13 | Integral peroxisomal membrane protein required for translocation of peroxisomal matrix proteins, interacts with the PTS1 signal recognition factor Pex5p and the PTS2 signal recognition factor Pex7p, forms a complex with Pex14p and Pex17p |
YDR253C | 6.57 | 2.55E-11 | MET32 | Zinc-finger DNA-binding transcription factor; involved in transcriptional regulation of the methionine biosynthetic genes; MET32 has a paralog, MET31, that arose from the whole genome duplication |
YML112W | 6.37 | 9.34E-11 | CTK3 | Gamma subunit of C-terminal domain kinase I; CTDK-I phosphorylates RNA polymerase II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and also phosphorylates ribosomal protein Rps2p to increase translational fidelity; protein abundance increases in response to DNA replication stress |
YBR015C | 6.33 | 1.26E-10 | MNN2 | Alpha-1,2-mannosyltransferase, responsible for addition of the first alpha-1,2-linked mannose to form the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment |
YER150W | 6.27 | 1.76E-10 | SPI1 | GPI-anchored cell wall protein involved in weak acid resistance; basal expression requires Msn2p/Msn4p; expression is induced under conditions of stress and during the diauxic shift; similar to Sed1p |
YDR127W | 6.16 | 3.71E-10 | ARO1 | Pentafunctional arom protein, catalyzes steps 2 through 6 in the biosynthesis of chorismate, which is a precursor to aromatic amino acids |
YCR044C | 5.92 | 1.58E-9 | PER1 | Protein of the endoplasmic reticulum, required for GPI-phospholipase A2 activity that remodels the GPI anchor as a prerequisite for association of GPI-anchored proteins with lipid rafts; functionally complemented by human ortholog PERLD1 |
YJR073C | 5.87 | 2.14E-9 | OPI3 | Phospholipid methyltransferase (methylene-fatty-acyl-phospholipid synthase), catalyzes the last two steps in phosphatidylcholine biosynthesis |