Deletion Strain | FD score | P-value | Gene | Gene Description |
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YDR260C | 8.31 | 4.67E-17 | SWM1 | Subunit of the anaphase-promoting complex, which is an E3 ubiquitin ligase that regulates the metaphase-anaphase transition and exit from mitosis; required for activation of the daughter-specific gene expression and spore wall maturation |
YOR323C | 7.40 | 6.84E-14 | PRO2 | Gamma-glutamyl phosphate reductase, catalyzes the second step in proline biosynthesis |
YDR333C_p | 6.55 | 2.95E-11 | RQC1_p | Component of the ribosome quality control complex (RQC); RQC (Rqc1p-Ltn1p-Tae2p-Cdc48p-Npl4p-Ufd1p), is a ribosome-bound complex required for the degradation of polypeptides arising from stalled translation; required along with Ltn1p for recruitment of the Cdc48p-Npl4p-Ufd1p AAA ATPase complex to the RQC |
YLR191W | 5.49 | 2.06E-8 | PEX13 | Integral peroxisomal membrane protein required for translocation of peroxisomal matrix proteins, interacts with the PTS1 signal recognition factor Pex5p and the PTS2 signal recognition factor Pex7p, forms a complex with Pex14p and Pex17p |
YAL067W-A_p | 5.24 | 7.96E-8 | YAL067W-A_p | Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching |
YKR003W | 5.19 | 1.08E-7 | OSH6 | Member of an oxysterol-binding protein family; overlapping, redundant functions in sterol metabolism and which collectively perform a function essential for viability; GFP-fusion protein localizes to the cell periphery; overexpression extends lifespan by promoting vacuolar fusion |
YBL011W | 5.18 | 1.12E-7 | SCT1 | Glycerol 3-phosphate/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase of the glycerolipid biosynthesis pathway, prefers 16-carbon fatty acids, similar to Gpt2p, gene is constitutively transcribed |
YGR290W_d | 5.08 | 1.88E-7 | YGR290W_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; putative HLH protein; partially overlaps the verified ORF MAL11/YGR289C (a high-affinity maltose transporter) |
YLR373C | 4.57 | 2.45E-6 | VID22 | Glycosylated integral membrane protein localized to the plasma membrane; plays a role in fructose-1,6-bisphosphatase (FBPase) degradation; involved in FBPase transport from the cytosol to Vid (vacuole import and degradation) vesicles |
YHR210C_p | 4.44 | 4.44E-6 | YHR210C_p | Putative aldose 1-epimerase superfamily protein; non-essential gene; highly expressed under anaeorbic conditions |
YGR087C | 4.25 | 1.09E-5 | PDC6 | Minor isoform of pyruvate decarboxylase, decarboxylates pyruvate to acetaldehyde, involved in amino acid catabolism; transcription is glucose- and ethanol-dependent, and is strongly induced during sulfur limitation |
YML112W | 4.21 | 1.30E-5 | CTK3 | Gamma subunit of C-terminal domain kinase I; CTDK-I phosphorylates RNA polymerase II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and also phosphorylates ribosomal protein Rps2p to increase translational fidelity; protein abundance increases in response to DNA replication stress |
YPL074W | 4.10 | 2.08E-5 | YTA6 | Putative ATPase of the CDC48/PAS1/SEC18 (AAA) family; localized to the cortex of mother cells but not to daughter cells; relocalizes from cytoplasm to plasma membrane foci upon DNA replication stress |
YDL115C | 4.08 | 2.25E-5 | IWR1 | RNA polymerase II transport factor, conserved from yeast to humans; also has a role in transporting RNA polymerase III into the nucleus; interacts with most of the RNAP II subunits; nucleo-cytoplasmic shuttling protein; deletion causes hypersensitivity to K1 killer toxin; protein increases in abundance and relocalizes from nucleus to cytoplasm upon DNA replication stress |
YLR130C | 3.97 | 3.53E-5 | ZRT2 | Low-affinity zinc transporter of the plasma membrane; transcription is induced under low-zinc conditions by the Zap1p transcription factor |