9133330

N-[1-(2,5-dimethylphenyl)ethyl]-4-fluorobenzenesulfonamide

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_3312
Screen concentration 71.4 μM
Source Chembridge (Drug-like library)
PubChem CID 17617324
SMILES CC1=CC(=C(C=C1)C)C(C)NS(=O)(=O)C2=CC=C(C=C2)F
Standardized SMILES CC(NS(=O)(=O)c1ccc(F)cc1)c2cc(C)ccc2C
Molecular weight 307.383
ALogP 3.88
H-bond donor count 1
H-bond acceptor count 4
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 2.05
% growth inhibition (Hom. pool) 5.54


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 17617324
Download HIP data (tab-delimited text)  (excel)
Gene:ALG2(YGL065C)|FD-Score:4.48|P-value:3.68E-6|Clearance:0.31||SGD DESC:Mannosyltransferase that catalyzes two consecutive steps in the N-linked glycosylation pathway; alg2 mutants exhibit temperature-sensitive growth and abnormal accumulation of the lipid-linked oligosaccharide Man2GlcNAc2-PP-Dol Gene:FAS1(YKL182W)|FD-Score:3.31|P-value:4.62E-4|Clearance:0.31||SGD DESC:Beta subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains acetyltransacylase, dehydratase, enoyl reductase, malonyl transacylase, and palmitoyl transacylase activities Gene:NOP15(YNL110C)|FD-Score:4.32|P-value:7.68E-6|Clearance:0.31||SGD DESC:Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis; localizes to both nucleolus and cytoplasm Gene:PRP38(YGR075C)|FD-Score:3.71|P-value:1.04E-4|Clearance:0.31||SGD DESC:Unique component of the U4/U6.U5 tri-snRNP particle, required for conformational changes which result in the catalytic activation of the spliceosome; dispensible for spliceosome assembly Gene:RRB1(YMR131C)|FD-Score:3.88|P-value:5.32E-5|Clearance:0.31||SGD DESC:Essential nuclear protein involved in early steps of ribosome biogenesis; physically interacts with the ribosomal protein Rpl3p Gene:SCL1(YGL011C)|FD-Score:4.07|P-value:2.33E-5|Clearance:0.31||SGD DESC:Alpha 1 subunit of the 20S proteasome involved in the degradation of ubiquitinated substrates; 20S proteasome is the core complex of the 26S proteasome; essential for growth; detected in the mitochondria Gene:SEC31(YDL195W)|FD-Score:3.36|P-value:3.96E-4|Clearance:0.31||SGD DESC:Component of the Sec13p-Sec31p complex of the COPII vesicle coat, required for vesicle formation in ER to Golgi transport; mutant has increased aneuploidy tolerance Gene:SWI1(YPL016W)|FD-Score:3.2|P-value:6.95E-4|Clearance:0.31||SGD DESC:Subunit of the SWI/SNF chromatin remodeling complex; regulates transcription by remodeling chromatin; required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2; can form the prion [SWI+]; human homolog ARID1A is a candidate tumor suppressor gene in breast cancer Gene:VRG4(YGL225W)|FD-Score:3.52|P-value:2.14E-4|Clearance:0.31||SGD DESC:Golgi GDP-mannose transporter; regulates Golgi function and glycosylation in Golgi Gene:YGR190C(YGR190C_d)|FD-Score:3.46|P-value:2.71E-4|Clearance:0.31||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene HIP1/YGR191W Gene:YHC1(YLR298C)|FD-Score:3.47|P-value:2.60E-4|Clearance:0.31||SGD DESC:Component of the U1 snRNP complex required for pre-mRNA splicing; putative ortholog of human U1C protein, which is involved in formation of a complex between U1 snRNP and the pre-mRNA 5' splice site Gene:YJL202C(YJL202C_d)|FD-Score:4.23|P-value:1.16E-5|Clearance:0.31||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 3' end of essential PRP21 gene encoding a subunit of the SF3a splicing factor complex Gene:ALG2(YGL065C)|FD-Score:4.48|P-value:3.68E-6|Clearance:0.31||SGD DESC:Mannosyltransferase that catalyzes two consecutive steps in the N-linked glycosylation pathway; alg2 mutants exhibit temperature-sensitive growth and abnormal accumulation of the lipid-linked oligosaccharide Man2GlcNAc2-PP-Dol Gene:FAS1(YKL182W)|FD-Score:3.31|P-value:4.62E-4|Clearance:0.31||SGD DESC:Beta subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains acetyltransacylase, dehydratase, enoyl reductase, malonyl transacylase, and palmitoyl transacylase activities Gene:NOP15(YNL110C)|FD-Score:4.32|P-value:7.68E-6|Clearance:0.31||SGD DESC:Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis; localizes to both nucleolus and cytoplasm Gene:PRP38(YGR075C)|FD-Score:3.71|P-value:1.04E-4|Clearance:0.31||SGD DESC:Unique component of the U4/U6.U5 tri-snRNP particle, required for conformational changes which result in the catalytic activation of the spliceosome; dispensible for spliceosome assembly Gene:RRB1(YMR131C)|FD-Score:3.88|P-value:5.32E-5|Clearance:0.31||SGD DESC:Essential nuclear protein involved in early steps of ribosome biogenesis; physically interacts with the ribosomal protein Rpl3p Gene:SCL1(YGL011C)|FD-Score:4.07|P-value:2.33E-5|Clearance:0.31||SGD DESC:Alpha 1 subunit of the 20S proteasome involved in the degradation of ubiquitinated substrates; 20S proteasome is the core complex of the 26S proteasome; essential for growth; detected in the mitochondria Gene:SEC31(YDL195W)|FD-Score:3.36|P-value:3.96E-4|Clearance:0.31||SGD DESC:Component of the Sec13p-Sec31p complex of the COPII vesicle coat, required for vesicle formation in ER to Golgi transport; mutant has increased aneuploidy tolerance Gene:SWI1(YPL016W)|FD-Score:3.2|P-value:6.95E-4|Clearance:0.31||SGD DESC:Subunit of the SWI/SNF chromatin remodeling complex; regulates transcription by remodeling chromatin; required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2; can form the prion [SWI+]; human homolog ARID1A is a candidate tumor suppressor gene in breast cancer Gene:VRG4(YGL225W)|FD-Score:3.52|P-value:2.14E-4|Clearance:0.31||SGD DESC:Golgi GDP-mannose transporter; regulates Golgi function and glycosylation in Golgi Gene:YGR190C(YGR190C_d)|FD-Score:3.46|P-value:2.71E-4|Clearance:0.31||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene HIP1/YGR191W Gene:YHC1(YLR298C)|FD-Score:3.47|P-value:2.60E-4|Clearance:0.31||SGD DESC:Component of the U1 snRNP complex required for pre-mRNA splicing; putative ortholog of human U1C protein, which is involved in formation of a complex between U1 snRNP and the pre-mRNA 5' splice site Gene:YJL202C(YJL202C_d)|FD-Score:4.23|P-value:1.16E-5|Clearance:0.31||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 3' end of essential PRP21 gene encoding a subunit of the SF3a splicing factor complex

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 17617324
Download HOP data (tab-delimited text)  (excel)
Gene:APC9(YLR102C)|FD-Score:-3.17|P-value:7.75E-4||SGD DESC:Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition Gene:BUD3(YCL014W)|FD-Score:3.66|P-value:1.26E-4||SGD DESC:Protein involved in bud-site selection and required for axial budding pattern; localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding Gene:CLA4(YNL298W)|FD-Score:-4.28|P-value:9.34E-6||SGD DESC:Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family, along with Ste20p and Skm1p; involved in septin ring assembly, vacuole inheritance, cytokinesis, sterol uptake regulation; phosphorylates Cdc3p and Cdc10p Gene:CSM1(YCR086W)|FD-Score:-3.1|P-value:9.58E-4||SGD DESC:Nucleolar protein that forms a complex with Lrs4p and then Mam1p at kinetochores during meiosis I to mediate accurate homolog segregation; required for condensin recruitment to the replication fork barrier site and rDNA repeat segregation Gene:DAS1(YJL149W)|FD-Score:3.85|P-value:5.89E-5||SGD DESC:Putative SCF ubiquitin ligase F-box protein; interacts physically with both Cdc53p and Skp1 and genetically with CDC34; similar to putative F-box protein YDR131C Gene:EFG1(YGR271C-A)|FD-Score:3.15|P-value:8.09E-4||SGD DESC:Essential protein required for maturation of 18S rRNA; null mutant is sensitive to hydroxyurea and is delayed in recovering from alpha-factor arrest; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus Gene:GMC2(YLR445W)|FD-Score:3.29|P-value:5.06E-4||SGD DESC:Protein involved in meiotic progression; mutants are delayed in meiotic nuclear division and are defective in synaptonemal complex assembly; transcription is regulated by Ume6p and induced in response to alpha factor Gene:GUF1(YLR289W)|FD-Score:-3.72|P-value:1.00E-4||SGD DESC:Mitochondrial matrix GTPase that associates with mitochondrial ribosomes; important for translation under temperature and nutrient stress; may have a role in translational fidelity; similar to bacterial LepA elongation factor Gene:GYP1(YOR070C)|FD-Score:-3.64|P-value:1.39E-4||SGD DESC:Cis-golgi GTPase-activating protein (GAP) for the Rab family members Ypt1p (in vivo) and for Ypt1p, Sec4p, Ypt7p, and Ypt51p (in vitro); involved in vesicle docking and fusion Gene:HUB1(YNR032C-A)|FD-Score:3.45|P-value:2.81E-4||SGD DESC:Ubiquitin-like protein modifier; promotes alternative splicing of SRC1 pre-mRNA; binds non-covalently to the HIND domain of Snu66, may function in modification of Sph1p and Hbt1p, functionally complemented by the human or S. pombe ortholog; mechanism of Hub1p adduct formation not yet clear Gene:IKI1(YHR187W)|FD-Score:3.4|P-value:3.43E-4||SGD DESC:Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; iki1 mutations confer resistance to the K. lactis toxin zymocin Gene:ISA1(YLL027W)|FD-Score:3.47|P-value:2.62E-4||SGD DESC:Protein required for maturation of mitochondrial [4Fe-4S] proteins; functions in a complex with Isa2p and possibly Iba57p; isa1 deletion causes loss of mitochondrial DNA and respiratory deficiency; depletion reduces growth on nonfermentable carbon sources; functional ortholog of bacterial A-type ISC proteins Gene:IZH1(YDR492W)|FD-Score:4.05|P-value:2.53E-5||SGD DESC:Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family; transcription is regulated directly by Zap1p, expression induced by zinc deficiency and fatty acids; deletion increases sensitivity to elevated zinc Gene:MLP2(YIL149C)|FD-Score:4.38|P-value:5.96E-6||SGD DESC:Myosin-like protein associated with the nuclear envelope, connects the nuclear pore complex with the nuclear interior; involved in the Tel1p pathway that controls telomere length Gene:MRP7(YNL005C)|FD-Score:3.89|P-value:5.06E-5||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:MYO4(YAL029C)|FD-Score:4.3|P-value:8.44E-6||SGD DESC:Type V myosin motor involved in actin-based transport of cargos; required for mRNA transport, including ASH1 mRNA, and facilitating the growth and movement of ER tubules into the growing bud along with She3p; MYO4 has a paralog, MYO2, that arose from the whole genome duplication Gene:PCA1(YBR295W)|FD-Score:4.35|P-value:6.90E-6||SGD DESC:Cadmium transporting P-type ATPase; may also have a role in copper and iron homeostasis; stabilized by Cd binding, which prevents ubiquitination; S288C and other lab strains contain a G970R mutation which eliminates Cd transport function Gene:POR1(YNL055C)|FD-Score:-3.82|P-value:6.62E-5||SGD DESC:Mitochondrial porin (voltage-dependent anion channel); outer membrane protein required for the maintenance of mitochondrial osmotic stability and mitochondrial membrane permeability; phosphorylated; protein abundance increases in response to DNA replication stress; POR1 has a paralog, POR2, that arose from the whole genome duplication Gene:RPS25A(YGR027C)|FD-Score:3.53|P-value:2.09E-4||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S25, no bacterial homolog; RPS25A has a paralog, RPS25B, that arose from the whole genome duplication Gene:SNT1(YCR033W)|FD-Score:3.41|P-value:3.21E-4||SGD DESC:Subunit of the Set3C deacetylase complex that interacts directly with the Set3C subunit, Sif2p; putative DNA-binding protein; mutant has increased aneuploidy tolerance Gene:THI2(YBR240C)|FD-Score:-3.12|P-value:9.07E-4||SGD DESC:Transcriptional activator of thiamine biosynthetic genes; interacts with regulatory factor Thi3p to control expression of thiamine biosynthetic genes with respect to thiamine availability; acts together with Pdc2p to respond to thiaminediphosphate demand, possibly as related to carbon source availability; zinc finger protein of the Zn(II)2Cys6 type Gene:UBP1(YDL122W)|FD-Score:3.14|P-value:8.35E-4||SGD DESC:Ubiquitin-specific protease that removes ubiquitin from ubiquitinated proteins; cleaves at the C terminus of ubiquitin fusions irrespective of their size; capable of cleaving polyubiquitin chains Gene:YBL028C(YBL028C)|FD-Score:3.36|P-value:3.92E-4||SGD DESC:Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis Gene:YBL071C(YBL071C_d)|FD-Score:-3.85|P-value:5.95E-5||SGD DESC:Dubious open reading frame, predicted protein contains a peroxisomal targeting signal Gene:YBR174C(YBR174C_d)|FD-Score:3.54|P-value:1.98E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YBR175W; null mutant is viable and sporulation defective Gene:YCR101C(YCR101C_p)|FD-Score:3.56|P-value:1.88E-4||SGD DESC:Putative protein of unknown function; localizes to the membrane fraction; YCR101C is not an essential gene Gene:YDR379C-A(YDR379C-A)|FD-Score:-4.77|P-value:9.33E-7||SGD DESC:Protein involved in the assembly of the mitochondrial succinate dehydrogenase complex; mutations in human ortholog SDHAF1 are associated with infantile leukoencephalopathy Gene:YDR417C(YDR417C_d)|FD-Score:3.16|P-value:7.92E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RPL12B/YDR418W Gene:YFR035C(YFR035C_p)|FD-Score:-6.13|P-value:4.41E-10||SGD DESC:Putative protein of unknown function, deletion mutant exhibits synthetic phenotype with alpha-synuclein Gene:YGL118C(YGL118C_d)|FD-Score:3.4|P-value:3.38E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YGL218W(YGL218W_d)|FD-Score:3.28|P-value:5.17E-4||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 93% of ORF overlaps the verified gene MDM34; deletion in cyr1 mutant results in loss of stress resistance Gene:YGR035C(YGR035C_p)|FD-Score:-4.18|P-value:1.48E-5||SGD DESC:Putative protein of unknown function, potential Cdc28p substrate; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance Gene:YGR291C(YGR291C_d)|FD-Score:-3.27|P-value:5.35E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YHR112C(YHR112C)|FD-Score:3.21|P-value:6.68E-4||SGD DESC:Protein of unknown function; localizes to the cytoplasm and nucleus; overexpression affects protein trafficking through the endocytic pathway Gene:YJR087W(YJR087W_d)|FD-Score:3.1|P-value:9.73E-4||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified genes STE18 and ECM2 Gene:YKR078W(YKR078W)|FD-Score:-3.38|P-value:3.65E-4||SGD DESC:Cytoplasmic protein of unknown function, has similarity to Vps5p; potential Cdc28p substrate; contains a Phox homology (PX) domain and specifically binds phosphatidylinositol 3-phosphate (PtdIns-3-P) Gene:YMR102C(YMR102C_p)|FD-Score:-4.87|P-value:5.65E-7||SGD DESC:Protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; mutant shows increased resistance to azoles; YMR102C is not an essential gene Gene:YNG1(YOR064C)|FD-Score:3.26|P-value:5.64E-4||SGD DESC:Subunit of the NuA3 histone acetyltransferase complex that acetylates histone H3; contains PHD finger domain that interacts with methylated histone H3, has similarity to the human tumor suppressor ING1 Gene:YNL203C(YNL203C_d)|FD-Score:-3.19|P-value:7.08E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YOL162W(YOL162W_p)|FD-Score:3.13|P-value:8.74E-4||SGD DESC:Putative protein of unknown function; member of the Dal5p subfamily of the major facilitator family Gene:YOR186W(YOR186W_p)|FD-Score:-4.93|P-value:4.19E-7||SGD DESC:Putative protein of unknown function; proper regulation of expression during heat stress is sphingolipid-dependent; YOR186W has a paralog, YLR297W, that arose from the whole genome duplication Gene:APC9(YLR102C)|FD-Score:-3.17|P-value:7.75E-4||SGD DESC:Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition Gene:BUD3(YCL014W)|FD-Score:3.66|P-value:1.26E-4||SGD DESC:Protein involved in bud-site selection and required for axial budding pattern; localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding Gene:CLA4(YNL298W)|FD-Score:-4.28|P-value:9.34E-6||SGD DESC:Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family, along with Ste20p and Skm1p; involved in septin ring assembly, vacuole inheritance, cytokinesis, sterol uptake regulation; phosphorylates Cdc3p and Cdc10p Gene:CSM1(YCR086W)|FD-Score:-3.1|P-value:9.58E-4||SGD DESC:Nucleolar protein that forms a complex with Lrs4p and then Mam1p at kinetochores during meiosis I to mediate accurate homolog segregation; required for condensin recruitment to the replication fork barrier site and rDNA repeat segregation Gene:DAS1(YJL149W)|FD-Score:3.85|P-value:5.89E-5||SGD DESC:Putative SCF ubiquitin ligase F-box protein; interacts physically with both Cdc53p and Skp1 and genetically with CDC34; similar to putative F-box protein YDR131C Gene:EFG1(YGR271C-A)|FD-Score:3.15|P-value:8.09E-4||SGD DESC:Essential protein required for maturation of 18S rRNA; null mutant is sensitive to hydroxyurea and is delayed in recovering from alpha-factor arrest; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus Gene:GMC2(YLR445W)|FD-Score:3.29|P-value:5.06E-4||SGD DESC:Protein involved in meiotic progression; mutants are delayed in meiotic nuclear division and are defective in synaptonemal complex assembly; transcription is regulated by Ume6p and induced in response to alpha factor Gene:GUF1(YLR289W)|FD-Score:-3.72|P-value:1.00E-4||SGD DESC:Mitochondrial matrix GTPase that associates with mitochondrial ribosomes; important for translation under temperature and nutrient stress; may have a role in translational fidelity; similar to bacterial LepA elongation factor Gene:GYP1(YOR070C)|FD-Score:-3.64|P-value:1.39E-4||SGD DESC:Cis-golgi GTPase-activating protein (GAP) for the Rab family members Ypt1p (in vivo) and for Ypt1p, Sec4p, Ypt7p, and Ypt51p (in vitro); involved in vesicle docking and fusion Gene:HUB1(YNR032C-A)|FD-Score:3.45|P-value:2.81E-4||SGD DESC:Ubiquitin-like protein modifier; promotes alternative splicing of SRC1 pre-mRNA; binds non-covalently to the HIND domain of Snu66, may function in modification of Sph1p and Hbt1p, functionally complemented by the human or S. pombe ortholog; mechanism of Hub1p adduct formation not yet clear Gene:IKI1(YHR187W)|FD-Score:3.4|P-value:3.43E-4||SGD DESC:Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; iki1 mutations confer resistance to the K. lactis toxin zymocin Gene:ISA1(YLL027W)|FD-Score:3.47|P-value:2.62E-4||SGD DESC:Protein required for maturation of mitochondrial [4Fe-4S] proteins; functions in a complex with Isa2p and possibly Iba57p; isa1 deletion causes loss of mitochondrial DNA and respiratory deficiency; depletion reduces growth on nonfermentable carbon sources; functional ortholog of bacterial A-type ISC proteins Gene:IZH1(YDR492W)|FD-Score:4.05|P-value:2.53E-5||SGD DESC:Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family; transcription is regulated directly by Zap1p, expression induced by zinc deficiency and fatty acids; deletion increases sensitivity to elevated zinc Gene:MLP2(YIL149C)|FD-Score:4.38|P-value:5.96E-6||SGD DESC:Myosin-like protein associated with the nuclear envelope, connects the nuclear pore complex with the nuclear interior; involved in the Tel1p pathway that controls telomere length Gene:MRP7(YNL005C)|FD-Score:3.89|P-value:5.06E-5||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:MYO4(YAL029C)|FD-Score:4.3|P-value:8.44E-6||SGD DESC:Type V myosin motor involved in actin-based transport of cargos; required for mRNA transport, including ASH1 mRNA, and facilitating the growth and movement of ER tubules into the growing bud along with She3p; MYO4 has a paralog, MYO2, that arose from the whole genome duplication Gene:PCA1(YBR295W)|FD-Score:4.35|P-value:6.90E-6||SGD DESC:Cadmium transporting P-type ATPase; may also have a role in copper and iron homeostasis; stabilized by Cd binding, which prevents ubiquitination; S288C and other lab strains contain a G970R mutation which eliminates Cd transport function Gene:POR1(YNL055C)|FD-Score:-3.82|P-value:6.62E-5||SGD DESC:Mitochondrial porin (voltage-dependent anion channel); outer membrane protein required for the maintenance of mitochondrial osmotic stability and mitochondrial membrane permeability; phosphorylated; protein abundance increases in response to DNA replication stress; POR1 has a paralog, POR2, that arose from the whole genome duplication Gene:RPS25A(YGR027C)|FD-Score:3.53|P-value:2.09E-4||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S25, no bacterial homolog; RPS25A has a paralog, RPS25B, that arose from the whole genome duplication Gene:SNT1(YCR033W)|FD-Score:3.41|P-value:3.21E-4||SGD DESC:Subunit of the Set3C deacetylase complex that interacts directly with the Set3C subunit, Sif2p; putative DNA-binding protein; mutant has increased aneuploidy tolerance Gene:THI2(YBR240C)|FD-Score:-3.12|P-value:9.07E-4||SGD DESC:Transcriptional activator of thiamine biosynthetic genes; interacts with regulatory factor Thi3p to control expression of thiamine biosynthetic genes with respect to thiamine availability; acts together with Pdc2p to respond to thiaminediphosphate demand, possibly as related to carbon source availability; zinc finger protein of the Zn(II)2Cys6 type Gene:UBP1(YDL122W)|FD-Score:3.14|P-value:8.35E-4||SGD DESC:Ubiquitin-specific protease that removes ubiquitin from ubiquitinated proteins; cleaves at the C terminus of ubiquitin fusions irrespective of their size; capable of cleaving polyubiquitin chains Gene:YBL028C(YBL028C)|FD-Score:3.36|P-value:3.92E-4||SGD DESC:Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis Gene:YBL071C(YBL071C_d)|FD-Score:-3.85|P-value:5.95E-5||SGD DESC:Dubious open reading frame, predicted protein contains a peroxisomal targeting signal Gene:YBR174C(YBR174C_d)|FD-Score:3.54|P-value:1.98E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YBR175W; null mutant is viable and sporulation defective Gene:YCR101C(YCR101C_p)|FD-Score:3.56|P-value:1.88E-4||SGD DESC:Putative protein of unknown function; localizes to the membrane fraction; YCR101C is not an essential gene Gene:YDR379C-A(YDR379C-A)|FD-Score:-4.77|P-value:9.33E-7||SGD DESC:Protein involved in the assembly of the mitochondrial succinate dehydrogenase complex; mutations in human ortholog SDHAF1 are associated with infantile leukoencephalopathy Gene:YDR417C(YDR417C_d)|FD-Score:3.16|P-value:7.92E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RPL12B/YDR418W Gene:YFR035C(YFR035C_p)|FD-Score:-6.13|P-value:4.41E-10||SGD DESC:Putative protein of unknown function, deletion mutant exhibits synthetic phenotype with alpha-synuclein Gene:YGL118C(YGL118C_d)|FD-Score:3.4|P-value:3.38E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YGL218W(YGL218W_d)|FD-Score:3.28|P-value:5.17E-4||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 93% of ORF overlaps the verified gene MDM34; deletion in cyr1 mutant results in loss of stress resistance Gene:YGR035C(YGR035C_p)|FD-Score:-4.18|P-value:1.48E-5||SGD DESC:Putative protein of unknown function, potential Cdc28p substrate; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance Gene:YGR291C(YGR291C_d)|FD-Score:-3.27|P-value:5.35E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YHR112C(YHR112C)|FD-Score:3.21|P-value:6.68E-4||SGD DESC:Protein of unknown function; localizes to the cytoplasm and nucleus; overexpression affects protein trafficking through the endocytic pathway Gene:YJR087W(YJR087W_d)|FD-Score:3.1|P-value:9.73E-4||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified genes STE18 and ECM2 Gene:YKR078W(YKR078W)|FD-Score:-3.38|P-value:3.65E-4||SGD DESC:Cytoplasmic protein of unknown function, has similarity to Vps5p; potential Cdc28p substrate; contains a Phox homology (PX) domain and specifically binds phosphatidylinositol 3-phosphate (PtdIns-3-P) Gene:YMR102C(YMR102C_p)|FD-Score:-4.87|P-value:5.65E-7||SGD DESC:Protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; mutant shows increased resistance to azoles; YMR102C is not an essential gene Gene:YNG1(YOR064C)|FD-Score:3.26|P-value:5.64E-4||SGD DESC:Subunit of the NuA3 histone acetyltransferase complex that acetylates histone H3; contains PHD finger domain that interacts with methylated histone H3, has similarity to the human tumor suppressor ING1 Gene:YNL203C(YNL203C_d)|FD-Score:-3.19|P-value:7.08E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YOL162W(YOL162W_p)|FD-Score:3.13|P-value:8.74E-4||SGD DESC:Putative protein of unknown function; member of the Dal5p subfamily of the major facilitator family Gene:YOR186W(YOR186W_p)|FD-Score:-4.93|P-value:4.19E-7||SGD DESC:Putative protein of unknown function; proper regulation of expression during heat stress is sphingolipid-dependent; YOR186W has a paralog, YLR297W, that arose from the whole genome duplication

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YGL065C4.483.68E-60.31ALG2Mannosyltransferase that catalyzes two consecutive steps in the N-linked glycosylation pathway; alg2 mutants exhibit temperature-sensitive growth and abnormal accumulation of the lipid-linked oligosaccharide Man2GlcNAc2-PP-Dol
YNL110C4.327.68E-60.31NOP15Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis; localizes to both nucleolus and cytoplasm
YJL202C_d4.231.16E-50.31YJL202C_dDubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 3' end of essential PRP21 gene encoding a subunit of the SF3a splicing factor complex
YGL011C4.072.33E-50.31SCL1Alpha 1 subunit of the 20S proteasome involved in the degradation of ubiquitinated substrates; 20S proteasome is the core complex of the 26S proteasome; essential for growth; detected in the mitochondria
YMR131C3.885.32E-50.31RRB1Essential nuclear protein involved in early steps of ribosome biogenesis; physically interacts with the ribosomal protein Rpl3p
YGR075C3.711.04E-40.31PRP38Unique component of the U4/U6.U5 tri-snRNP particle, required for conformational changes which result in the catalytic activation of the spliceosome; dispensible for spliceosome assembly
YGL225W3.522.14E-40.31VRG4Golgi GDP-mannose transporter; regulates Golgi function and glycosylation in Golgi
YLR298C3.472.60E-40.31YHC1Component of the U1 snRNP complex required for pre-mRNA splicing; putative ortholog of human U1C protein, which is involved in formation of a complex between U1 snRNP and the pre-mRNA 5' splice site
YGR190C_d3.462.71E-40.31YGR190C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene HIP1/YGR191W
YDL195W3.363.96E-40.31SEC31Component of the Sec13p-Sec31p complex of the COPII vesicle coat, required for vesicle formation in ER to Golgi transport; mutant has increased aneuploidy tolerance
YKL182W3.314.62E-40.31FAS1Beta subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains acetyltransacylase, dehydratase, enoyl reductase, malonyl transacylase, and palmitoyl transacylase activities
YPL016W3.206.95E-40.31SWI1Subunit of the SWI/SNF chromatin remodeling complex; regulates transcription by remodeling chromatin; required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2; can form the prion [SWI+]; human homolog ARID1A is a candidate tumor suppressor gene in breast cancer
YBL040C2.890.001950.04ERD2HDEL receptor, an integral membrane protein that binds to the HDEL motif in proteins destined for retention in the endoplasmic reticulum; has a role in maintenance of normal levels of ER-resident proteins
YOR362C2.850.002190.02PRE10Alpha 7 subunit of the 20S proteasome; protein abundance increases in response to DNA replication stress
YKL022C2.830.002310.07CDC16Subunit of the anaphase-promoting complex/cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; required for sporulation

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YIL149C4.385.96E-6MLP2Myosin-like protein associated with the nuclear envelope, connects the nuclear pore complex with the nuclear interior; involved in the Tel1p pathway that controls telomere length
YBR295W4.356.90E-6PCA1Cadmium transporting P-type ATPase; may also have a role in copper and iron homeostasis; stabilized by Cd binding, which prevents ubiquitination; S288C and other lab strains contain a G970R mutation which eliminates Cd transport function
YAL029C4.308.44E-6MYO4Type V myosin motor involved in actin-based transport of cargos; required for mRNA transport, including ASH1 mRNA, and facilitating the growth and movement of ER tubules into the growing bud along with She3p; MYO4 has a paralog, MYO2, that arose from the whole genome duplication
YDR492W4.052.53E-5IZH1Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family; transcription is regulated directly by Zap1p, expression induced by zinc deficiency and fatty acids; deletion increases sensitivity to elevated zinc
YNL005C3.895.06E-5MRP7Mitochondrial ribosomal protein of the large subunit
YJL149W3.855.89E-5DAS1Putative SCF ubiquitin ligase F-box protein; interacts physically with both Cdc53p and Skp1 and genetically with CDC34; similar to putative F-box protein YDR131C
YCL014W3.661.26E-4BUD3Protein involved in bud-site selection and required for axial budding pattern; localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding
YCR101C_p3.561.88E-4YCR101C_pPutative protein of unknown function; localizes to the membrane fraction; YCR101C is not an essential gene
YBR174C_d3.541.98E-4YBR174C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YBR175W; null mutant is viable and sporulation defective
YGR027C3.532.09E-4RPS25AProtein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S25, no bacterial homolog; RPS25A has a paralog, RPS25B, that arose from the whole genome duplication
YLL027W3.472.62E-4ISA1Protein required for maturation of mitochondrial [4Fe-4S] proteins; functions in a complex with Isa2p and possibly Iba57p; isa1 deletion causes loss of mitochondrial DNA and respiratory deficiency; depletion reduces growth on nonfermentable carbon sources; functional ortholog of bacterial A-type ISC proteins
YNR032C-A3.452.81E-4HUB1Ubiquitin-like protein modifier; promotes alternative splicing of SRC1 pre-mRNA; binds non-covalently to the HIND domain of Snu66, may function in modification of Sph1p and Hbt1p, functionally complemented by the human or S. pombe ortholog; mechanism of Hub1p adduct formation not yet clear
YCR033W3.413.21E-4SNT1Subunit of the Set3C deacetylase complex that interacts directly with the Set3C subunit, Sif2p; putative DNA-binding protein; mutant has increased aneuploidy tolerance
YGL118C_d3.403.38E-4YGL118C_dDubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YHR187W3.403.43E-4IKI1Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; iki1 mutations confer resistance to the K. lactis toxin zymocin

GO enrichment analysis for SGTC_3312
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.0912.02E-12SGTC_2261,3-diallylurea 8.3 mMMiscellaneous745370.0408163
0.0905.52E-12SGTC_8940960-0238 55.9 μMChemDiv (Drug-like library)67419070.0769231
0.0809.51E-10SGTC_1994st072947 40.9 μMTimTec (Natural product derivative library)52865650.0512821
0.0715.83E-8SGTC_1724st037281 8.3 μMTimTec (Natural product derivative library)5741240.153846
0.0621.88E-6SGTC_1806st050005 60.3 μMTimTec (Natural product derivative library)51947650.0724638
0.0622.22E-6SGTC_1519esterone 74.0 μMTimTec (Pure natural product library)6980.0857143DNA intercalators
0.0603.97E-6SGTC_6470140-0236 81.0 μMChemDiv (Drug-like library)9908370.0740741
0.0587.83E-6SGTC_525k781-2675 26.7 μMChemDiv (Drug-like library)36511180.0952381redox potentiating
0.0571.07E-5SGTC_1772st048439 82.2 μMTimTec (Natural product derivative library)29270680.111111
0.0571.14E-5SGTC_7033875-0075 71.8 μMChemDiv (Drug-like library)28508140.0740741
0.0571.27E-5SGTC_33169136639 10.5 μMChembridge (Drug-like library)49036650.0632911
0.0561.62E-5SGTC_3620310-0100 9.0 μMChemDiv (Drug-like library)7902350.0724638RPP1 & pyrimidine depletion
0.0561.98E-5SGTC_2417cerulenin 830.0 nMICCB bioactive library52820540.0307692
0.0543.47E-5SGTC_9831491-0821 12.2 μMChemDiv (Drug-like library)464951130.180328
0.0526.07E-5SGTC_33139133968 57.0 μMChembridge (Drug-like library)14946430.0617284

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_10034049-0218100 μM0.477273295161ChemDiv (Drug-like library)279.3298633.49514
SGTC_5694130-2812160 μM0.444444743552ChemDiv (Drug-like library)279.3298633.01614amide catabolism
SGTC_7431275-0778158 μM0.3673472849257ChemDiv (Drug-like library)317.445724.10213excess fatty acid
SGTC_14294049-02059.46 μM0.3622774478ChemDiv (Drug-like library)344.1993433.75714
SGTC_3238913347049.47 μM0.3469393534688Chembridge (Drug-like library)275.365983.29613
SGTC_5414513-132194 μM0.34747515ChemDiv (Drug-like library)305.391963.51314
SGTC_10024049-0206172 μM0.3333334662749ChemDiv (Drug-like library)310.3008432.90316
SGTC_14324049-029868.4 μM0.326923741646ChemDiv (Drug-like library)299.2931462.71216
SGTC_389tpck16.7 μM0.321429439647Miscellaneous351.847723.38114
SGTC_10533366-3204134 μM0.3207553632071ChemDiv (Drug-like library)309.3558432.83415cell wall