9140064

2-[4-(2-methyl-3-phenyl-5-propylpyrazolo[1,5-a]pyrimidin-7-yl)piperazin-1-yl]ethanol

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_3326
Screen concentration 16.4 μM
Source Chembridge (Drug-like library)
PubChem CID 1868434
SMILES CCCC1=NC2=C(C(=NN2C(=C1)N3CCN(CC3)CCO)C)C4=CC=CC=C4
Standardized SMILES CCCc1cc(N2CCN(CCO)CC2)n3nc(C)c(c4ccccc4)c3n1
Molecular weight 379.4986
ALogP 3.43
H-bond donor count 1
H-bond acceptor count 5
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 21.3
% growth inhibition (Hom. pool) 9.56


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 1868434
Download HIP data (tab-delimited text)  (excel)
Gene:ARC40(YBR234C)|FD-Score:3.41|P-value:3.24E-4|Clearance:0.04||SGD DESC:Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches Gene:CBF5(YLR175W)|FD-Score:3.09|P-value:9.96E-4|Clearance:0.01||SGD DESC:Pseudouridine synthase catalytic subunit of box H/ACA small nucleolar ribonucleoprotein particles (snoRNPs), acts on both large and small rRNAs and on snRNA U2; mutations in human ortholog dyskerin cause the disorder dyskeratosis congenita Gene:CSE4(YKL049C)|FD-Score:-4.12|P-value:1.90E-5|Clearance:0||SGD DESC:Centromere protein that resembles histone H3; required for proper kinetochore function; homolog of human CENP-A; levels are regulated by E3 ubiquitin ligase Psh1p; Cse4p marks a subset of open chromatin; associated with promoters, accessible chromatin and RNA polymerase II-bound regions Gene:KRE29(YER038C)|FD-Score:5.15|P-value:1.28E-7|Clearance:0.36||SGD DESC:Subunit of the SMC5-SMC6 complex; this complex is involved in removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance Gene:NOG2(YNR053C)|FD-Score:4.86|P-value:5.94E-7|Clearance:0.36||SGD DESC:Putative GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation Gene:NUF2(YOL069W)|FD-Score:4.28|P-value:9.33E-6|Clearance:0.36||SGD DESC:Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering Gene:POL3(YDL102W)|FD-Score:3.93|P-value:4.27E-5|Clearance:0.36||SGD DESC:Catalytic subunit of DNA polymerase delta; required for chromosomal DNA replication during mitosis and meiosis, intragenic recombination, repair of double strand DNA breaks, and DNA replication during nucleotide excision repair (NER) Gene:RKI1(YOR095C)|FD-Score:3.37|P-value:3.80E-4|Clearance:0.05||SGD DESC:Ribose-5-phosphate ketol-isomerase, catalyzes the interconversion of ribose 5-phosphate and ribulose 5-phosphate in the pentose phosphate pathway; participates in pyridoxine biosynthesis Gene:RPG1(YBR079C)|FD-Score:4.18|P-value:1.47E-5|Clearance:0.36||SGD DESC:eIF3a subunit of the core complex of translation initiation factor 3 (eIF3), essential for translation; part of a Prt1p-Rpg1p-Nip1p subcomplex that stimulates binding of mRNA and tRNA(i)Met to ribosomes; involved in translation reinitiation Gene:RRP12(YPL012W)|FD-Score:3.57|P-value:1.77E-4|Clearance:0.16||SGD DESC:Protein required for export of the ribosomal subunits; associates with the RNA components of the pre-ribosomes; has a role in nuclear import in association with Pse1p; contains HEAT-repeats Gene:SEC5(YDR166C)|FD-Score:3.32|P-value:4.48E-4|Clearance:0.23||SGD DESC:Essential 107kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; involved in assembly of the exocyst complex; required with Sec3p for ER inheritance where it promotes anchoring of the cortical ER at the bud tip Gene:TID3(YIL144W)|FD-Score:3.37|P-value:3.72E-4|Clearance:0.01||SGD DESC:Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); conserved coiled-coil protein involved in chromosome segregation, spindle checkpoint activity, kinetochore assembly and clustering Gene:UTP20(YBL004W)|FD-Score:-3.2|P-value:6.85E-4|Clearance:0||SGD DESC:Component of the small-subunit (SSU) processome, which is involved in the biogenesis of the 18S rRNA Gene:YNL247W(YNL247W)|FD-Score:4.62|P-value:1.91E-6|Clearance:0.36||SGD DESC:Cysteinyl-tRNA synthetase; may interact with ribosomes, based on co-purification experiments Gene:YOR203W(YOR203W_d)|FD-Score:-4.25|P-value:1.05E-5|Clearance:0||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps 5' end of essential DED1 gene required for translation initiation Gene:ARC40(YBR234C)|FD-Score:3.41|P-value:3.24E-4|Clearance:0.04||SGD DESC:Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches Gene:CBF5(YLR175W)|FD-Score:3.09|P-value:9.96E-4|Clearance:0.01||SGD DESC:Pseudouridine synthase catalytic subunit of box H/ACA small nucleolar ribonucleoprotein particles (snoRNPs), acts on both large and small rRNAs and on snRNA U2; mutations in human ortholog dyskerin cause the disorder dyskeratosis congenita Gene:CSE4(YKL049C)|FD-Score:-4.12|P-value:1.90E-5|Clearance:0||SGD DESC:Centromere protein that resembles histone H3; required for proper kinetochore function; homolog of human CENP-A; levels are regulated by E3 ubiquitin ligase Psh1p; Cse4p marks a subset of open chromatin; associated with promoters, accessible chromatin and RNA polymerase II-bound regions Gene:KRE29(YER038C)|FD-Score:5.15|P-value:1.28E-7|Clearance:0.36||SGD DESC:Subunit of the SMC5-SMC6 complex; this complex is involved in removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance Gene:NOG2(YNR053C)|FD-Score:4.86|P-value:5.94E-7|Clearance:0.36||SGD DESC:Putative GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation Gene:NUF2(YOL069W)|FD-Score:4.28|P-value:9.33E-6|Clearance:0.36||SGD DESC:Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering Gene:POL3(YDL102W)|FD-Score:3.93|P-value:4.27E-5|Clearance:0.36||SGD DESC:Catalytic subunit of DNA polymerase delta; required for chromosomal DNA replication during mitosis and meiosis, intragenic recombination, repair of double strand DNA breaks, and DNA replication during nucleotide excision repair (NER) Gene:RKI1(YOR095C)|FD-Score:3.37|P-value:3.80E-4|Clearance:0.05||SGD DESC:Ribose-5-phosphate ketol-isomerase, catalyzes the interconversion of ribose 5-phosphate and ribulose 5-phosphate in the pentose phosphate pathway; participates in pyridoxine biosynthesis Gene:RPG1(YBR079C)|FD-Score:4.18|P-value:1.47E-5|Clearance:0.36||SGD DESC:eIF3a subunit of the core complex of translation initiation factor 3 (eIF3), essential for translation; part of a Prt1p-Rpg1p-Nip1p subcomplex that stimulates binding of mRNA and tRNA(i)Met to ribosomes; involved in translation reinitiation Gene:RRP12(YPL012W)|FD-Score:3.57|P-value:1.77E-4|Clearance:0.16||SGD DESC:Protein required for export of the ribosomal subunits; associates with the RNA components of the pre-ribosomes; has a role in nuclear import in association with Pse1p; contains HEAT-repeats Gene:SEC5(YDR166C)|FD-Score:3.32|P-value:4.48E-4|Clearance:0.23||SGD DESC:Essential 107kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; involved in assembly of the exocyst complex; required with Sec3p for ER inheritance where it promotes anchoring of the cortical ER at the bud tip Gene:TID3(YIL144W)|FD-Score:3.37|P-value:3.72E-4|Clearance:0.01||SGD DESC:Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); conserved coiled-coil protein involved in chromosome segregation, spindle checkpoint activity, kinetochore assembly and clustering Gene:UTP20(YBL004W)|FD-Score:-3.2|P-value:6.85E-4|Clearance:0||SGD DESC:Component of the small-subunit (SSU) processome, which is involved in the biogenesis of the 18S rRNA Gene:YNL247W(YNL247W)|FD-Score:4.62|P-value:1.91E-6|Clearance:0.36||SGD DESC:Cysteinyl-tRNA synthetase; may interact with ribosomes, based on co-purification experiments Gene:YOR203W(YOR203W_d)|FD-Score:-4.25|P-value:1.05E-5|Clearance:0||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps 5' end of essential DED1 gene required for translation initiation

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 1868434
Download HOP data (tab-delimited text)  (excel)
Gene:ABP140(YOR239W)|FD-Score:3.78|P-value:7.81E-5||SGD DESC:AdoMet-dependent tRNA methyltransferase and actin binding protein; C-terminal domain is responsible for 3-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA-Thr and tRNA-Ser and contains an S-adenosylmethionine (AdoMet) binding motif; N-terminal actin binding sequence interacts with actin filaments and localizes to actin patches and cables; N- and C-terminal domains are encoded in separate ORFs that are translated into one protein via a +1 frameshift Gene:ALE1(YOR175C)|FD-Score:-3.61|P-value:1.55E-4||SGD DESC:Broad-specificity lysophospholipid acyltransferase, part of MBOAT family of membrane-bound O-acyltransferases; key component of Lands cycle; may have role in fatty acid exchange at sn-2 position of mature glycerophospholipids Gene:ATG18(YFR021W)|FD-Score:4.57|P-value:2.39E-6||SGD DESC:Phosphoinositide binding protein; required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; binds both phosphatidylinositol (3,5)-bisphosphate and phosphatidylinositol 3-phosphate; WD-40 repeat protein; relocalizes from vacuole to cytoplasm upon DNA replication stress; has 4 mammalian homologs WIPI1, WIPI2, WIPI3 and WIPI4/WDR45; mutations in human WDR45 cause static encephalopathy of childhood with neurodegeneration in adulthood Gene:BNI1(YNL271C)|FD-Score:-3.85|P-value:5.87E-5||SGD DESC:Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNR1 Gene:BSD2(YBR290W)|FD-Score:3.26|P-value:5.52E-4||SGD DESC:Heavy metal ion homeostasis protein, facilitates trafficking of Smf1p and Smf2p metal transporters to the vacuole where they are degraded, controls metal ion transport, prevents metal hyperaccumulation, functions in copper detoxification Gene:COA3(YJL062W-A)|FD-Score:-3.41|P-value:3.25E-4||SGD DESC:Mitochondrial inner membrane protein that participates in regulation of COX1 translation, Cox1p stabilization, and cytochrome oxidase assembly Gene:COG6(YNL041C)|FD-Score:-3.31|P-value:4.73E-4||SGD DESC:Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:COG7(YGL005C)|FD-Score:-3.92|P-value:4.47E-5||SGD DESC:Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:CPA1(YOR303W)|FD-Score:-3.68|P-value:1.16E-4||SGD DESC:Small subunit of carbamoyl phosphate synthetase, which catalyzes a step in the synthesis of citrulline, an arginine precursor; translationally regulated by an attenuator peptide encoded by YOR302W within the CPA1 mRNA 5'-leader Gene:CSM4(YPL200W)|FD-Score:6.48|P-value:4.60E-11||SGD DESC:Protein required for accurate chromosome segregation during meiosis; involved in meiotic telomere clustering (bouquet formation) and telomere-led rapid prophase movements Gene:DFG5(YMR238W)|FD-Score:5.1|P-value:1.72E-7||SGD DESC:Putative mannosidase, essential glycosylphosphatidylinositol (GPI)-anchored membrane protein required for cell wall biogenesis in bud formation, involved in filamentous growth, homologous to Dcw1p Gene:DIG1(YPL049C)|FD-Score:6.22|P-value:2.54E-10||SGD DESC:MAP kinase-responsive inhibitor of the Ste12p transcription factor, involved in the regulation of mating-specific genes and the invasive growth pathway; related regulators Dig1p and Dig2p bind to Ste12p Gene:ECI1(YLR284C)|FD-Score:3.63|P-value:1.44E-4||SGD DESC:Peroxisomal delta3,delta2-enoyl-CoA isomerase, hexameric protein that converts 3-hexenoyl-CoA to trans-2-hexenoyl-CoA, essential for the beta-oxidation of unsaturated fatty acids, oleate-induced Gene:EDC1(YGL222C)|FD-Score:5.26|P-value:7.38E-8||SGD DESC:RNA-binding protein that activates mRNA decapping directly; binds to the mRNA substrate and enhances the activity of the decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress Gene:ERG5(YMR015C)|FD-Score:-4.16|P-value:1.60E-5||SGD DESC:C-22 sterol desaturase, a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis; may be a target of azole antifungal drugs Gene:ERV29(YGR284C)|FD-Score:3.68|P-value:1.16E-4||SGD DESC:Protein localized to COPII-coated vesicles; involved in vesicle formation and incorporation of specific secretory cargo; protein abundance increases in response to DNA replication stress Gene:FET4(YMR319C)|FD-Score:-4.74|P-value:1.07E-6||SGD DESC:Low-affinity Fe(II) transporter of the plasma membrane Gene:FMP48(YGR052W_p)|FD-Score:6.16|P-value:3.52E-10||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; induced by treatment with 8-methoxypsoralen and UVA irradiation Gene:FMT1(YBL013W)|FD-Score:3.33|P-value:4.30E-4||SGD DESC:Methionyl-tRNA formyltransferase, catalyzes the formylation of initiator Met-tRNA in mitochondria; potential Cdc28p substrate Gene:GET2(YER083C)|FD-Score:4.42|P-value:4.83E-6||SGD DESC:Subunit of the GET complex; involved in insertion of proteins into the ER membrane; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for meiotic nuclear division Gene:HAL1(YPR005C)|FD-Score:-3.14|P-value:8.38E-4||SGD DESC:Cytoplasmic protein involved in halotolerance; decreases intracellular Na+ (via Ena1p) and increases intracellular K+ by decreasing efflux; expression repressed by Ssn6p-Tup1p and Sko1p and induced by NaCl, KCl, and sorbitol through Gcn4p Gene:HIS1(YER055C)|FD-Score:3.19|P-value:7.02E-4||SGD DESC:ATP phosphoribosyltransferase, a hexameric enzyme, catalyzes the first step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control Gene:HOR7(YMR251W-A)|FD-Score:3.85|P-value:5.97E-5||SGD DESC:Protein of unknown function; overexpression suppresses Ca2+ sensitivity of mutants lacking inositol phosphorylceramide mannosyltransferases Csg1p and Csh1p; transcription is induced under hyperosmotic stress and repressed by alpha factor; HOR7 has a paralog, DDR2, that arose from the whole genome duplication Gene:HRD3(YLR207W)|FD-Score:-3.15|P-value:8.13E-4||SGD DESC:Resident protein of the ER membrane that plays a central role in ER-associated protein degradation (ERAD), forms HRD complex with Hrd1p and ERAD determinants that engages in lumen to cytosol communication and coordination of ERAD events Gene:HXT14(YNL318C)|FD-Score:3.75|P-value:9.00E-5||SGD DESC:Protein with similarity to hexose transporter family members, expression is induced in low glucose and repressed in high glucose; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:IKI3(YLR384C)|FD-Score:3.33|P-value:4.33E-4||SGD DESC:Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; maintains structural integrity of Elongator; homolog of human IKAP, mutations in which cause familial dysautonomia (FD) Gene:IZH2(YOL002C)|FD-Score:3.83|P-value:6.48E-5||SGD DESC:Plasma membrane protein involved in zinc homeostasis and osmotin-induced apoptosis; transcription regulated by Zap1p, zinc and fatty acid levels; similar to mammalian adiponectins; deletion increases sensitivity to elevated zinc Gene:KRE6(YPR159W)|FD-Score:6.41|P-value:7.47E-11||SGD DESC:Type II integral membrane protein required for beta-1,6 glucan biosynthesis; putative beta-glucan synthase; localizes to the ER, plasma membrane, sites of polarized growth and secretory vesicles; functionally redundant with Skn1p Gene:LAS21(YJL062W)|FD-Score:-3.3|P-value:4.83E-4||SGD DESC:Integral plasma membrane protein involved in the synthesis of the glycosylphosphatidylinositol (GPI) core structure; mutations affect cell wall integrity Gene:MDH3(YDL078C)|FD-Score:3.16|P-value:7.81E-4||SGD DESC:Peroxisomal malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in the glyoxylate cycle Gene:MOG1(YJR074W)|FD-Score:-3.35|P-value:4.09E-4||SGD DESC:Conserved nuclear protein that interacts with GTP-Gsp1p, which is a Ran homolog of the Ras GTPase family, and stimulates nucleotide release, involved in nuclear protein import, nucleotide release is inhibited by Yrb1p Gene:MPM1(YJL066C)|FD-Score:4.25|P-value:1.08E-5||SGD DESC:Mitochondrial intermembrane space protein of unknown function Gene:MRH1(YDR033W)|FD-Score:3.13|P-value:8.89E-4||SGD DESC:Protein that localizes primarily to the plasma membrane; also found at the nuclear envelope; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; MRH1 has a paralog, YRO2, that arose from the whole genome duplication Gene:MRP7(YNL005C)|FD-Score:-3.26|P-value:5.57E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:MRPL31(YKL138C)|FD-Score:-4.54|P-value:2.75E-6||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:MRPL37(YBR268W)|FD-Score:8.75|P-value:1.07E-18||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:MSS11(YMR164C)|FD-Score:3.34|P-value:4.23E-4||SGD DESC:Transcription factor involved in regulation of invasive growth and starch degradation; controls the activation of FLO11 and STA2 in response to nutritional signals Gene:MTC3(YGL226W)|FD-Score:3.81|P-value:6.85E-5||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; mtc3 is synthetically sick with cdc13-1 Gene:NRT1(YOR071C)|FD-Score:-3.12|P-value:8.90E-4||SGD DESC:High-affinity nicotinamide riboside transporter; also transports thiamine with low affinity; shares sequence similarity with Thi7p and Thi72p; proposed to be involved in 5-fluorocytosine sensitivity Gene:OSW1(YOR255W)|FD-Score:3.18|P-value:7.38E-4||SGD DESC:Protein involved in sporulation; required for the construction of the outer spore wall layers; required for proper localization of Spo14p Gene:PDB1(YBR221C)|FD-Score:-3.15|P-value:8.21E-4||SGD DESC:E1 beta subunit of the pyruvate dehydrogenase (PDH) complex, which is an evolutionarily-conserved multi-protein complex found in mitochondria Gene:PDR18(YNR070W_p)|FD-Score:-3.44|P-value:2.93E-4||SGD DESC:Putative transporter of the ATP-binding cassette (ABC) family, implicated in pleiotropic drug resistance; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:PET54(YGR222W)|FD-Score:-3.64|P-value:1.36E-4||SGD DESC:Mitochondrial inner membrane protein; binds to the 5' UTR of the COX3 mRNA to activate its translation together with Pet122p and Pet494p; also binds to the COX1 Group I intron AI5 beta to facilitate exon ligation during splicing Gene:PEX22(YAL055W)|FD-Score:3.27|P-value:5.30E-4||SGD DESC:Putative peroxisomal membrane protein required for import of peroxisomal proteins, functionally complements a Pichia pastoris pex22 mutation Gene:PTK1(YKL198C)|FD-Score:-3.68|P-value:1.17E-4||SGD DESC:Putative serine/threonine protein kinase that regulates spermine uptake; involved in polyamine transport; possible mitochondrial protein Gene:RPA14(YDR156W)|FD-Score:-3.82|P-value:6.80E-5||SGD DESC:RNA polymerase I subunit A14 Gene:RPL7B(YPL198W)|FD-Score:4.29|P-value:8.83E-6||SGD DESC:Ribosomal 60S subunit protein L7B; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2); homologous to mammalian ribosomal protein L7 and bacterial L30; RPL7B has a paralog, RPL7A, that arose from the whole genome duplication Gene:RSM23(YGL129C)|FD-Score:-3.1|P-value:9.56E-4||SGD DESC:Mitochondrial ribosomal protein of the small subunit, has similarity to mammalian apoptosis mediator proteins; null mutation prevents induction of apoptosis by overproduction of metacaspase Mca1p Gene:SFB2(YNL049C)|FD-Score:3.12|P-value:8.89E-4||SGD DESC:Component of the Sec23p-Sfb2p heterodimer of the COPII vesicle coat, required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sec24p and Sfb3p Gene:SPG3(YDR504C)|FD-Score:-3.12|P-value:8.89E-4||SGD DESC:Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources Gene:SPP1(YPL138C)|FD-Score:-3.32|P-value:4.51E-4||SGD DESC:Subunit of COMPASS (Set1C), a complex which methylates histone H3 on lysine 4 and is required in telomeric transcriptional silencing; interacts with Orc2p; PHD finger domain protein similar to human CGBP, an unmethylated CpG binding protein Gene:SPT10(YJL127C)|FD-Score:3.34|P-value:4.26E-4||SGD DESC:Putative histone acetylase with a role in transcriptional silencing, sequence-specific activator of histone genes, binds specifically and cooperatively to pairs of UAS elements in core histone promoters, functions at or near the TATA box Gene:SUM1(YDR310C)|FD-Score:4.12|P-value:1.91E-5||SGD DESC:Transcriptional repressor required for mitotic repression of middle sporulation-specific genes; also acts as general replication initiation factor; involved in telomere maintenance, chromatin silencing; regulated by pachytene checkpoint Gene:SVP26(YHR181W)|FD-Score:5.13|P-value:1.47E-7||SGD DESC:Integral membrane protein of the early Golgi apparatus and endoplasmic reticulum, involved in COP II vesicle transport; may also function to promote retention of proteins in the early Golgi compartment Gene:TDA8(YAL064C-A_p)|FD-Score:4.7|P-value:1.33E-6||SGD DESC:Putative protein of unknown function; null mutant is sensitive to expression of the top1-T722A allele; not an essential gene Gene:TGS1(YPL157W)|FD-Score:3.09|P-value:9.90E-4||SGD DESC:Trimethyl guanosine synthase, conserved nucleolar methyl transferase that converts the m(7)G cap structure of snRNAs, snoRNAs, and telomerase TLC1 RNA to m(2,2,7)G; also required for nucleolar assembly and splicing of meiotic pre-mRNAs Gene:THI22(YPR121W)|FD-Score:6.98|P-value:1.48E-12||SGD DESC:Protein with similarity to hydroxymethylpyrimidine phosphate kinases; member of a gene family with THI20 and THI21; not required for thiamine biosynthesis Gene:TOS2(YGR221C)|FD-Score:-3.79|P-value:7.40E-5||SGD DESC:Protein involved in localization of Cdc24p to the site of bud growth; may act as a membrane anchor; localizes to the bud neck and bud tip; potentially phosphorylated by Cdc28p Gene:YAL018C(YAL018C_p)|FD-Score:4.07|P-value:2.31E-5||SGD DESC:Putative protein of unknown function Gene:YBR063C(YBR063C_p)|FD-Score:3.28|P-value:5.10E-4||SGD DESC:Putative protein of unknown function; YBR063C is not an essential gene Gene:YBR090C(YBR090C_p)|FD-Score:-4.33|P-value:7.40E-6||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus Gene:YBR200W-A(YBR200W-A_p)|FD-Score:3.89|P-value:4.97E-5||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR Gene:YCR095W-A(YCR095W-A_p)|FD-Score:4.33|P-value:7.37E-6||SGD DESC:Putative protein of unknown function Gene:YDR169C-A(YDR169C-A_p)|FD-Score:3.66|P-value:1.24E-4||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR Gene:YFR035C(YFR035C_p)|FD-Score:11.6|P-value:1.37E-31||SGD DESC:Putative protein of unknown function, deletion mutant exhibits synthetic phenotype with alpha-synuclein Gene:YIL092W(YIL092W_p)|FD-Score:3.69|P-value:1.11E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus Gene:YKR045C(YKR045C_p)|FD-Score:3.24|P-value:5.90E-4||SGD DESC:Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm Gene:YLR202C(YLR202C_d)|FD-Score:-3.91|P-value:4.67E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YLR201C; ORF contains a putative intron Gene:YMR013W-A(YMR013W-A_d)|FD-Score:3.1|P-value:9.76E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the characterized snoRNA gene snR73 Gene:YMR135W-A(YMR135W-A_d)|FD-Score:-3.57|P-value:1.77E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YMR279C(YMR279C)|FD-Score:3.4|P-value:3.41E-4||SGD DESC:Putative boron transporter involved in boron efflux and resistance; overexpression mutant but not null mutant displays boron tolerance phenotype; identified as a heat-induced gene in a high-throughout screen; YMR279C is not an essential gene; YMR279C has a paralog, ATR1, that arose from the whole genome duplication Gene:YNL035C(YNL035C_p)|FD-Score:5.35|P-value:4.50E-8||SGD DESC:Protein of unknown function; contains WD-40 domains; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YNL035C is not an essential gene; protein abundance increases in response to DNA replication stress Gene:YNL203C(YNL203C_d)|FD-Score:3.21|P-value:6.59E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YNR040W(YNR040W_p)|FD-Score:-3.19|P-value:7.06E-4||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:YOR131C(YOR131C_p)|FD-Score:3.45|P-value:2.81E-4||SGD DESC:Putative haloacid dehalogenase-like hydrolase; non-essential gene; overexpression causes a cell cycle delay or arrest; protein abundance increases in response to DNA replication stress Gene:YPT11(YNL304W)|FD-Score:3.21|P-value:6.65E-4||SGD DESC:Rab family GTPase that interacts with the C-terminal tail domain of Myo2p; mediates distribution of mitochondria and endoplasmic reticuli to daughter cells Gene:ABP140(YOR239W)|FD-Score:3.78|P-value:7.81E-5||SGD DESC:AdoMet-dependent tRNA methyltransferase and actin binding protein; C-terminal domain is responsible for 3-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA-Thr and tRNA-Ser and contains an S-adenosylmethionine (AdoMet) binding motif; N-terminal actin binding sequence interacts with actin filaments and localizes to actin patches and cables; N- and C-terminal domains are encoded in separate ORFs that are translated into one protein via a +1 frameshift Gene:ALE1(YOR175C)|FD-Score:-3.61|P-value:1.55E-4||SGD DESC:Broad-specificity lysophospholipid acyltransferase, part of MBOAT family of membrane-bound O-acyltransferases; key component of Lands cycle; may have role in fatty acid exchange at sn-2 position of mature glycerophospholipids Gene:ATG18(YFR021W)|FD-Score:4.57|P-value:2.39E-6||SGD DESC:Phosphoinositide binding protein; required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; binds both phosphatidylinositol (3,5)-bisphosphate and phosphatidylinositol 3-phosphate; WD-40 repeat protein; relocalizes from vacuole to cytoplasm upon DNA replication stress; has 4 mammalian homologs WIPI1, WIPI2, WIPI3 and WIPI4/WDR45; mutations in human WDR45 cause static encephalopathy of childhood with neurodegeneration in adulthood Gene:BNI1(YNL271C)|FD-Score:-3.85|P-value:5.87E-5||SGD DESC:Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNR1 Gene:BSD2(YBR290W)|FD-Score:3.26|P-value:5.52E-4||SGD DESC:Heavy metal ion homeostasis protein, facilitates trafficking of Smf1p and Smf2p metal transporters to the vacuole where they are degraded, controls metal ion transport, prevents metal hyperaccumulation, functions in copper detoxification Gene:COA3(YJL062W-A)|FD-Score:-3.41|P-value:3.25E-4||SGD DESC:Mitochondrial inner membrane protein that participates in regulation of COX1 translation, Cox1p stabilization, and cytochrome oxidase assembly Gene:COG6(YNL041C)|FD-Score:-3.31|P-value:4.73E-4||SGD DESC:Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:COG7(YGL005C)|FD-Score:-3.92|P-value:4.47E-5||SGD DESC:Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:CPA1(YOR303W)|FD-Score:-3.68|P-value:1.16E-4||SGD DESC:Small subunit of carbamoyl phosphate synthetase, which catalyzes a step in the synthesis of citrulline, an arginine precursor; translationally regulated by an attenuator peptide encoded by YOR302W within the CPA1 mRNA 5'-leader Gene:CSM4(YPL200W)|FD-Score:6.48|P-value:4.60E-11||SGD DESC:Protein required for accurate chromosome segregation during meiosis; involved in meiotic telomere clustering (bouquet formation) and telomere-led rapid prophase movements Gene:DFG5(YMR238W)|FD-Score:5.1|P-value:1.72E-7||SGD DESC:Putative mannosidase, essential glycosylphosphatidylinositol (GPI)-anchored membrane protein required for cell wall biogenesis in bud formation, involved in filamentous growth, homologous to Dcw1p Gene:DIG1(YPL049C)|FD-Score:6.22|P-value:2.54E-10||SGD DESC:MAP kinase-responsive inhibitor of the Ste12p transcription factor, involved in the regulation of mating-specific genes and the invasive growth pathway; related regulators Dig1p and Dig2p bind to Ste12p Gene:ECI1(YLR284C)|FD-Score:3.63|P-value:1.44E-4||SGD DESC:Peroxisomal delta3,delta2-enoyl-CoA isomerase, hexameric protein that converts 3-hexenoyl-CoA to trans-2-hexenoyl-CoA, essential for the beta-oxidation of unsaturated fatty acids, oleate-induced Gene:EDC1(YGL222C)|FD-Score:5.26|P-value:7.38E-8||SGD DESC:RNA-binding protein that activates mRNA decapping directly; binds to the mRNA substrate and enhances the activity of the decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress Gene:ERG5(YMR015C)|FD-Score:-4.16|P-value:1.60E-5||SGD DESC:C-22 sterol desaturase, a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis; may be a target of azole antifungal drugs Gene:ERV29(YGR284C)|FD-Score:3.68|P-value:1.16E-4||SGD DESC:Protein localized to COPII-coated vesicles; involved in vesicle formation and incorporation of specific secretory cargo; protein abundance increases in response to DNA replication stress Gene:FET4(YMR319C)|FD-Score:-4.74|P-value:1.07E-6||SGD DESC:Low-affinity Fe(II) transporter of the plasma membrane Gene:FMP48(YGR052W_p)|FD-Score:6.16|P-value:3.52E-10||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; induced by treatment with 8-methoxypsoralen and UVA irradiation Gene:FMT1(YBL013W)|FD-Score:3.33|P-value:4.30E-4||SGD DESC:Methionyl-tRNA formyltransferase, catalyzes the formylation of initiator Met-tRNA in mitochondria; potential Cdc28p substrate Gene:GET2(YER083C)|FD-Score:4.42|P-value:4.83E-6||SGD DESC:Subunit of the GET complex; involved in insertion of proteins into the ER membrane; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for meiotic nuclear division Gene:HAL1(YPR005C)|FD-Score:-3.14|P-value:8.38E-4||SGD DESC:Cytoplasmic protein involved in halotolerance; decreases intracellular Na+ (via Ena1p) and increases intracellular K+ by decreasing efflux; expression repressed by Ssn6p-Tup1p and Sko1p and induced by NaCl, KCl, and sorbitol through Gcn4p Gene:HIS1(YER055C)|FD-Score:3.19|P-value:7.02E-4||SGD DESC:ATP phosphoribosyltransferase, a hexameric enzyme, catalyzes the first step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control Gene:HOR7(YMR251W-A)|FD-Score:3.85|P-value:5.97E-5||SGD DESC:Protein of unknown function; overexpression suppresses Ca2+ sensitivity of mutants lacking inositol phosphorylceramide mannosyltransferases Csg1p and Csh1p; transcription is induced under hyperosmotic stress and repressed by alpha factor; HOR7 has a paralog, DDR2, that arose from the whole genome duplication Gene:HRD3(YLR207W)|FD-Score:-3.15|P-value:8.13E-4||SGD DESC:Resident protein of the ER membrane that plays a central role in ER-associated protein degradation (ERAD), forms HRD complex with Hrd1p and ERAD determinants that engages in lumen to cytosol communication and coordination of ERAD events Gene:HXT14(YNL318C)|FD-Score:3.75|P-value:9.00E-5||SGD DESC:Protein with similarity to hexose transporter family members, expression is induced in low glucose and repressed in high glucose; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:IKI3(YLR384C)|FD-Score:3.33|P-value:4.33E-4||SGD DESC:Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; maintains structural integrity of Elongator; homolog of human IKAP, mutations in which cause familial dysautonomia (FD) Gene:IZH2(YOL002C)|FD-Score:3.83|P-value:6.48E-5||SGD DESC:Plasma membrane protein involved in zinc homeostasis and osmotin-induced apoptosis; transcription regulated by Zap1p, zinc and fatty acid levels; similar to mammalian adiponectins; deletion increases sensitivity to elevated zinc Gene:KRE6(YPR159W)|FD-Score:6.41|P-value:7.47E-11||SGD DESC:Type II integral membrane protein required for beta-1,6 glucan biosynthesis; putative beta-glucan synthase; localizes to the ER, plasma membrane, sites of polarized growth and secretory vesicles; functionally redundant with Skn1p Gene:LAS21(YJL062W)|FD-Score:-3.3|P-value:4.83E-4||SGD DESC:Integral plasma membrane protein involved in the synthesis of the glycosylphosphatidylinositol (GPI) core structure; mutations affect cell wall integrity Gene:MDH3(YDL078C)|FD-Score:3.16|P-value:7.81E-4||SGD DESC:Peroxisomal malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in the glyoxylate cycle Gene:MOG1(YJR074W)|FD-Score:-3.35|P-value:4.09E-4||SGD DESC:Conserved nuclear protein that interacts with GTP-Gsp1p, which is a Ran homolog of the Ras GTPase family, and stimulates nucleotide release, involved in nuclear protein import, nucleotide release is inhibited by Yrb1p Gene:MPM1(YJL066C)|FD-Score:4.25|P-value:1.08E-5||SGD DESC:Mitochondrial intermembrane space protein of unknown function Gene:MRH1(YDR033W)|FD-Score:3.13|P-value:8.89E-4||SGD DESC:Protein that localizes primarily to the plasma membrane; also found at the nuclear envelope; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; MRH1 has a paralog, YRO2, that arose from the whole genome duplication Gene:MRP7(YNL005C)|FD-Score:-3.26|P-value:5.57E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:MRPL31(YKL138C)|FD-Score:-4.54|P-value:2.75E-6||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:MRPL37(YBR268W)|FD-Score:8.75|P-value:1.07E-18||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:MSS11(YMR164C)|FD-Score:3.34|P-value:4.23E-4||SGD DESC:Transcription factor involved in regulation of invasive growth and starch degradation; controls the activation of FLO11 and STA2 in response to nutritional signals Gene:MTC3(YGL226W)|FD-Score:3.81|P-value:6.85E-5||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; mtc3 is synthetically sick with cdc13-1 Gene:NRT1(YOR071C)|FD-Score:-3.12|P-value:8.90E-4||SGD DESC:High-affinity nicotinamide riboside transporter; also transports thiamine with low affinity; shares sequence similarity with Thi7p and Thi72p; proposed to be involved in 5-fluorocytosine sensitivity Gene:OSW1(YOR255W)|FD-Score:3.18|P-value:7.38E-4||SGD DESC:Protein involved in sporulation; required for the construction of the outer spore wall layers; required for proper localization of Spo14p Gene:PDB1(YBR221C)|FD-Score:-3.15|P-value:8.21E-4||SGD DESC:E1 beta subunit of the pyruvate dehydrogenase (PDH) complex, which is an evolutionarily-conserved multi-protein complex found in mitochondria Gene:PDR18(YNR070W_p)|FD-Score:-3.44|P-value:2.93E-4||SGD DESC:Putative transporter of the ATP-binding cassette (ABC) family, implicated in pleiotropic drug resistance; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:PET54(YGR222W)|FD-Score:-3.64|P-value:1.36E-4||SGD DESC:Mitochondrial inner membrane protein; binds to the 5' UTR of the COX3 mRNA to activate its translation together with Pet122p and Pet494p; also binds to the COX1 Group I intron AI5 beta to facilitate exon ligation during splicing Gene:PEX22(YAL055W)|FD-Score:3.27|P-value:5.30E-4||SGD DESC:Putative peroxisomal membrane protein required for import of peroxisomal proteins, functionally complements a Pichia pastoris pex22 mutation Gene:PTK1(YKL198C)|FD-Score:-3.68|P-value:1.17E-4||SGD DESC:Putative serine/threonine protein kinase that regulates spermine uptake; involved in polyamine transport; possible mitochondrial protein Gene:RPA14(YDR156W)|FD-Score:-3.82|P-value:6.80E-5||SGD DESC:RNA polymerase I subunit A14 Gene:RPL7B(YPL198W)|FD-Score:4.29|P-value:8.83E-6||SGD DESC:Ribosomal 60S subunit protein L7B; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2); homologous to mammalian ribosomal protein L7 and bacterial L30; RPL7B has a paralog, RPL7A, that arose from the whole genome duplication Gene:RSM23(YGL129C)|FD-Score:-3.1|P-value:9.56E-4||SGD DESC:Mitochondrial ribosomal protein of the small subunit, has similarity to mammalian apoptosis mediator proteins; null mutation prevents induction of apoptosis by overproduction of metacaspase Mca1p Gene:SFB2(YNL049C)|FD-Score:3.12|P-value:8.89E-4||SGD DESC:Component of the Sec23p-Sfb2p heterodimer of the COPII vesicle coat, required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sec24p and Sfb3p Gene:SPG3(YDR504C)|FD-Score:-3.12|P-value:8.89E-4||SGD DESC:Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources Gene:SPP1(YPL138C)|FD-Score:-3.32|P-value:4.51E-4||SGD DESC:Subunit of COMPASS (Set1C), a complex which methylates histone H3 on lysine 4 and is required in telomeric transcriptional silencing; interacts with Orc2p; PHD finger domain protein similar to human CGBP, an unmethylated CpG binding protein Gene:SPT10(YJL127C)|FD-Score:3.34|P-value:4.26E-4||SGD DESC:Putative histone acetylase with a role in transcriptional silencing, sequence-specific activator of histone genes, binds specifically and cooperatively to pairs of UAS elements in core histone promoters, functions at or near the TATA box Gene:SUM1(YDR310C)|FD-Score:4.12|P-value:1.91E-5||SGD DESC:Transcriptional repressor required for mitotic repression of middle sporulation-specific genes; also acts as general replication initiation factor; involved in telomere maintenance, chromatin silencing; regulated by pachytene checkpoint Gene:SVP26(YHR181W)|FD-Score:5.13|P-value:1.47E-7||SGD DESC:Integral membrane protein of the early Golgi apparatus and endoplasmic reticulum, involved in COP II vesicle transport; may also function to promote retention of proteins in the early Golgi compartment Gene:TDA8(YAL064C-A_p)|FD-Score:4.7|P-value:1.33E-6||SGD DESC:Putative protein of unknown function; null mutant is sensitive to expression of the top1-T722A allele; not an essential gene Gene:TGS1(YPL157W)|FD-Score:3.09|P-value:9.90E-4||SGD DESC:Trimethyl guanosine synthase, conserved nucleolar methyl transferase that converts the m(7)G cap structure of snRNAs, snoRNAs, and telomerase TLC1 RNA to m(2,2,7)G; also required for nucleolar assembly and splicing of meiotic pre-mRNAs Gene:THI22(YPR121W)|FD-Score:6.98|P-value:1.48E-12||SGD DESC:Protein with similarity to hydroxymethylpyrimidine phosphate kinases; member of a gene family with THI20 and THI21; not required for thiamine biosynthesis Gene:TOS2(YGR221C)|FD-Score:-3.79|P-value:7.40E-5||SGD DESC:Protein involved in localization of Cdc24p to the site of bud growth; may act as a membrane anchor; localizes to the bud neck and bud tip; potentially phosphorylated by Cdc28p Gene:YAL018C(YAL018C_p)|FD-Score:4.07|P-value:2.31E-5||SGD DESC:Putative protein of unknown function Gene:YBR063C(YBR063C_p)|FD-Score:3.28|P-value:5.10E-4||SGD DESC:Putative protein of unknown function; YBR063C is not an essential gene Gene:YBR090C(YBR090C_p)|FD-Score:-4.33|P-value:7.40E-6||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus Gene:YBR200W-A(YBR200W-A_p)|FD-Score:3.89|P-value:4.97E-5||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR Gene:YCR095W-A(YCR095W-A_p)|FD-Score:4.33|P-value:7.37E-6||SGD DESC:Putative protein of unknown function Gene:YDR169C-A(YDR169C-A_p)|FD-Score:3.66|P-value:1.24E-4||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR Gene:YFR035C(YFR035C_p)|FD-Score:11.6|P-value:1.37E-31||SGD DESC:Putative protein of unknown function, deletion mutant exhibits synthetic phenotype with alpha-synuclein Gene:YIL092W(YIL092W_p)|FD-Score:3.69|P-value:1.11E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus Gene:YKR045C(YKR045C_p)|FD-Score:3.24|P-value:5.90E-4||SGD DESC:Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm Gene:YLR202C(YLR202C_d)|FD-Score:-3.91|P-value:4.67E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YLR201C; ORF contains a putative intron Gene:YMR013W-A(YMR013W-A_d)|FD-Score:3.1|P-value:9.76E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the characterized snoRNA gene snR73 Gene:YMR135W-A(YMR135W-A_d)|FD-Score:-3.57|P-value:1.77E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YMR279C(YMR279C)|FD-Score:3.4|P-value:3.41E-4||SGD DESC:Putative boron transporter involved in boron efflux and resistance; overexpression mutant but not null mutant displays boron tolerance phenotype; identified as a heat-induced gene in a high-throughout screen; YMR279C is not an essential gene; YMR279C has a paralog, ATR1, that arose from the whole genome duplication Gene:YNL035C(YNL035C_p)|FD-Score:5.35|P-value:4.50E-8||SGD DESC:Protein of unknown function; contains WD-40 domains; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YNL035C is not an essential gene; protein abundance increases in response to DNA replication stress Gene:YNL203C(YNL203C_d)|FD-Score:3.21|P-value:6.59E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YNR040W(YNR040W_p)|FD-Score:-3.19|P-value:7.06E-4||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:YOR131C(YOR131C_p)|FD-Score:3.45|P-value:2.81E-4||SGD DESC:Putative haloacid dehalogenase-like hydrolase; non-essential gene; overexpression causes a cell cycle delay or arrest; protein abundance increases in response to DNA replication stress Gene:YPT11(YNL304W)|FD-Score:3.21|P-value:6.65E-4||SGD DESC:Rab family GTPase that interacts with the C-terminal tail domain of Myo2p; mediates distribution of mitochondria and endoplasmic reticuli to daughter cells

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Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YER038C5.151.28E-70.36KRE29Subunit of the SMC5-SMC6 complex; this complex is involved in removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance
YNR053C4.865.94E-70.36NOG2Putative GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation
YNL247W4.621.91E-60.36YNL247WCysteinyl-tRNA synthetase; may interact with ribosomes, based on co-purification experiments
YOL069W4.289.33E-60.36NUF2Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering
YBR079C4.181.47E-50.36RPG1eIF3a subunit of the core complex of translation initiation factor 3 (eIF3), essential for translation; part of a Prt1p-Rpg1p-Nip1p subcomplex that stimulates binding of mRNA and tRNA(i)Met to ribosomes; involved in translation reinitiation
YDL102W3.934.27E-50.36POL3Catalytic subunit of DNA polymerase delta; required for chromosomal DNA replication during mitosis and meiosis, intragenic recombination, repair of double strand DNA breaks, and DNA replication during nucleotide excision repair (NER)
YPL012W3.571.77E-40.16RRP12Protein required for export of the ribosomal subunits; associates with the RNA components of the pre-ribosomes; has a role in nuclear import in association with Pse1p; contains HEAT-repeats
YBR234C3.413.24E-40.04ARC40Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches
YIL144W3.373.72E-40.01TID3Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); conserved coiled-coil protein involved in chromosome segregation, spindle checkpoint activity, kinetochore assembly and clustering
YOR095C3.373.80E-40.05RKI1Ribose-5-phosphate ketol-isomerase, catalyzes the interconversion of ribose 5-phosphate and ribulose 5-phosphate in the pentose phosphate pathway; participates in pyridoxine biosynthesis
YDR166C3.324.48E-40.23SEC5Essential 107kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; involved in assembly of the exocyst complex; required with Sec3p for ER inheritance where it promotes anchoring of the cortical ER at the bud tip
YLR175W3.099.96E-40.01CBF5Pseudouridine synthase catalytic subunit of box H/ACA small nucleolar ribonucleoprotein particles (snoRNPs), acts on both large and small rRNAs and on snRNA U2; mutations in human ortholog dyskerin cause the disorder dyskeratosis congenita
YDR238C3.080.001040.03SEC26Essential beta-coat protein of the COPI coatomer, involved in ER-to-Golgi protein trafficking and maintenance of normal ER morphology; shares 43% sequence identity with mammalian beta-coat protein (beta-COP)
YBR080C3.050.001140.02SEC18ATPase required for vesicular transport between ER and Golgi, the 'priming' step in homotypic vacuole fusion, autophagy, and protein secretion; releases Sec17p from SNAP complexes; has similarity to mammalian NSF
YBR160W3.030.001240.11CDC28Catalytic subunit of the main cell cycle cyclin-dependent kinase (CDK); alternately associates with G1 cyclins (CLNs) and G2/M cyclins (CLBs) which direct the CDK to specific substrates; involved in modulating membrane trafficking dynamics; protein abundance increases in response to DNA replication stress

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YFR035C_p11.601.37E-31YFR035C_pPutative protein of unknown function, deletion mutant exhibits synthetic phenotype with alpha-synuclein
YBR268W8.751.07E-18MRPL37Mitochondrial ribosomal protein of the large subunit
YPR121W6.981.48E-12THI22Protein with similarity to hydroxymethylpyrimidine phosphate kinases; member of a gene family with THI20 and THI21; not required for thiamine biosynthesis
YPL200W6.484.60E-11CSM4Protein required for accurate chromosome segregation during meiosis; involved in meiotic telomere clustering (bouquet formation) and telomere-led rapid prophase movements
YPR159W6.417.47E-11KRE6Type II integral membrane protein required for beta-1,6 glucan biosynthesis; putative beta-glucan synthase; localizes to the ER, plasma membrane, sites of polarized growth and secretory vesicles; functionally redundant with Skn1p
YPL049C6.222.54E-10DIG1MAP kinase-responsive inhibitor of the Ste12p transcription factor, involved in the regulation of mating-specific genes and the invasive growth pathway; related regulators Dig1p and Dig2p bind to Ste12p
YGR052W_p6.163.52E-10FMP48_pPutative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; induced by treatment with 8-methoxypsoralen and UVA irradiation
YNL035C_p5.354.50E-8YNL035C_pProtein of unknown function; contains WD-40 domains; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YNL035C is not an essential gene; protein abundance increases in response to DNA replication stress
YGL222C5.267.38E-8EDC1RNA-binding protein that activates mRNA decapping directly; binds to the mRNA substrate and enhances the activity of the decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress
YHR181W5.131.47E-7SVP26Integral membrane protein of the early Golgi apparatus and endoplasmic reticulum, involved in COP II vesicle transport; may also function to promote retention of proteins in the early Golgi compartment
YMR238W5.101.72E-7DFG5Putative mannosidase, essential glycosylphosphatidylinositol (GPI)-anchored membrane protein required for cell wall biogenesis in bud formation, involved in filamentous growth, homologous to Dcw1p
YAL064C-A_p4.701.33E-6TDA8_pPutative protein of unknown function; null mutant is sensitive to expression of the top1-T722A allele; not an essential gene
YFR021W4.572.39E-6ATG18Phosphoinositide binding protein; required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; binds both phosphatidylinositol (3,5)-bisphosphate and phosphatidylinositol 3-phosphate; WD-40 repeat protein; relocalizes from vacuole to cytoplasm upon DNA replication stress; has 4 mammalian homologs WIPI1, WIPI2, WIPI3 and WIPI4/WDR45; mutations in human WDR45 cause static encephalopathy of childhood with neurodegeneration in adulthood
YER083C4.424.83E-6GET2Subunit of the GET complex; involved in insertion of proteins into the ER membrane; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for meiotic nuclear division
YCR095W-A_p4.337.37E-6YCR095W-A_pPutative protein of unknown function

GO enrichment analysis for SGTC_3326
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.0631.15E-6SGTC_12951013-0063 9.8 μMChemDiv (Drug-like library)68260380.0740741
0.0631.39E-6SGTC_13893405-0187 19.0 μMChemDiv (Drug-like library)7998900.12987
0.0534.23E-5SGTC_1833st055984 71.0 μMTimTec (Natural product derivative library)6762880.0853659
0.0526.02E-5SGTC_31699102970 49.5 μMChembridge (Drug-like library)170278390.173333RPP1 & pyrimidine depletion
0.0527.49E-5SGTC_1691st019933 84.6 μMTimTec (Natural product derivative library)61760820.121622
0.0517.74E-5SGTC_32609137109 49.5 μMChembridge (Drug-like library)174783460.11842160S ribosome export
0.0501.04E-4SGTC_28037707263 71.4 μMChembridge (Drug-like library)21992290.1125
0.0501.08E-4SGTC_30149081533 49.5 μMChembridge (Drug-like library)213672650.0909091
0.0482.11E-4SGTC_31789107506 49.5 μMChembridge (Drug-like library)88971940.156627
0.0454.84E-4SGTC_15153460-0031 42.1 μMChemDiv (Drug-like library)28765960.119565DNA intercalators
0.0455.58E-4SGTC_15141189-1591 158.0 μMChemDiv (Drug-like library)7676980.0864198
0.0430.00108SGTC_720r052-1644 49.9 μMChemDiv (Drug-like library)14228630.0697674TSC3-RPN4
0.0420.00123SGTC_29829019404 26.0 μMChembridge (Drug-like library)223332320.0941176
0.0420.00141SGTC_28639028737 58.4 μMChembridge (Drug-like library)64609170.102273
0.0410.00170SGTC_480am 92016 50.0 μMICCB bioactive library21290.0842105

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_3343914837918.98 μM0.7678571955036Chembridge (Drug-like library)349.472583.96804
SGTC_334591484103.56 μM0.7543864903596Chembridge (Drug-like library)413.514783.9715
SGTC_3339914588314.94 μM0.7166672030670Chembridge (Drug-like library)379.498563.43515
SGTC_3340914663411.1 μM0.6885254907387Chembridge (Drug-like library)365.471983.14615
SGTC_3329914123327.56 μM0.64909101Chembridge (Drug-like library)405.416793.39418
SGTC_3333914182012.09 μM0.5156251939433Chembridge (Drug-like library)349.472583.97404
SGTC_334891494643.54 μM0.4782611951442Chembridge (Drug-like library)379.498563.56915
SGTC_335691518114.48 μM0.4647891859254Chembridge (Drug-like library)357.451524.0914cell wall
SGTC_3328914062429.04 μM0.4531254904392Chembridge (Drug-like library)335.4463.33104
SGTC_3349914970323 μM0.4347834910494Chembridge (Drug-like library)351.44542.50915