Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YPL043W | 4.83 | 6.69E-7 | 0.71 | NOP4 | Nucleolar protein, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; contains four RNA recognition motifs (RRMs) |
YFR050C | 4.13 | 1.85E-5 | 0.40 | PRE4 | Beta 7 subunit of the 20S proteasome |
YBL004W | 3.73 | 9.55E-5 | 0.13 | UTP20 | Component of the small-subunit (SSU) processome, which is involved in the biogenesis of the 18S rRNA |
YMR290W-A_d | 3.60 | 1.59E-4 | 0.10 | YMR290W-A_d | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential HAS1 gene which encodes an ATP-dependent RNA helicase |
YGR186W | 3.50 | 2.31E-4 | 0.01 | TFG1 | TFIIF (Transcription Factor II) largest subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP74 |
YNL118C | 3.49 | 2.40E-4 | 0.10 | DCP2 | Catalytic subunit of the Dcp1p-Dcp2p decapping enzyme complex; removes the 5' cap structure from mRNAs prior to their degradation; nudix hydrolase family member; forms cytoplasmic foci upon DNA replication stress |
YDR091C | 3.39 | 3.46E-4 | 0.41 | RLI1 | Essential iron-sulfur protein required for ribosome biogenesis and translation initiation and termination; facilitates binding of a multifactor complex (MFC) of initiation factors to the small ribosomal subunit; predicted ABC family ATPase; forms a complex with Lto1p and Yae1p that may be involved in protection of the ribosome from damage due to reactive oxygen species |
YGR091W | 2.98 | 0.00143 | 0.12 | PRP31 | Splicing factor, component of the U4/U6-U5 snRNP complex |
YJR022W | 2.86 | 0.00211 | 0.01 | LSM8 | Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) that is part of spliceosomal U6 snRNP and is also implicated in processing of pre-tRNA, pre-snoRNA, and pre-rRNA |
YML077W | 2.85 | 0.00221 | 0.03 | BET5 | Component of the TRAPP (transport protein particle) complex, which plays an essential role in the vesicular transport from endoplasmic reticulum to Golgi |
YFL039C | 2.82 | 0.00240 | 0.12 | ACT1 | Actin, structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions |
YLR029C | 2.70 | 0.00342 | 0.09 | RPL15A | Ribosomal 60S subunit protein L15A; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15, no bacterial homolog; RPL15A has a paralog, RPL15B, that arose from the whole genome duplication |
YJL002C | 2.62 | 0.00446 | 0.04 | OST1 | Alpha subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins |
YKL154W | 2.58 | 0.00495 | 0.03 | SRP102 | Signal recognition particle (SRP) receptor beta subunit; involved in SRP-dependent protein targeting; anchors the alpha subunit, Srp101p to the ER membrane |
YNL158W | 2.55 | 0.00537 | 0.01 | PGA1 | Essential component of GPI-mannosyltransferase II, responsible for second mannose addition to GPI precursors as a partner of Gpi18p; required for maturation of Gas1p and Pho8p; has synthetic genetic interations with secretory pathway genes |