Deletion Strain | FD score | P-value | Gene | Gene Description |
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YLR387C | 7.66 | 9.03E-15 | REH1 | Cytoplasmic 60S subunit biogenesis factor, associates with pre-60S particles; similar to Rei1p and shares partially redundant function in cytoplasmic 60S subunit maturation; contains dispersed C2H2 zinc finger domains |
YER161C | 5.63 | 8.81E-9 | SPT2 | Protein involved in negative regulation of transcription; required for RNA polyadenylation; exhibits regulated interactions with both histones and SWI-SNF components, has similarity to mammalian HMG1 proteins |
YAR002C-A | 5.38 | 3.67E-8 | ERP1 | Member of the p24 family involved in ER to Golgi transport; forms heterotrimeric complex with Erp2p, Emp24p, and Erv25p; localized to COPII-coated vesicles; ERP1 has a paralog, ERP6, that arose from the whole genome duplication |
YKL098W | 5.18 | 1.11E-7 | MTC2 | Protein of unknown function; mtc2 is synthetically sick with cdc13-1 |
YOR243C | 5.02 | 2.54E-7 | PUS7 | Pseudouridine synthase, catalyzes pseudouridylation at positions 35 and 56 in U2 snRNA, position 50 in 5S rRNA, position 13 in cytoplasmic tRNAs, and position 35 in pre-tRNA(Tyr); conserved in archaea, vertebrates, and some bacteria |
YLR453C | 4.66 | 1.57E-6 | RIF2 | Protein that binds to the Rap1p C-terminus and acts synergistically with Rif1p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation |
YKR058W | 4.50 | 3.43E-6 | GLG1 | Glycogenin glucosyltransferase; self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; similar to mammalian glycogenin; GLG1 has a paralog, GLG2, that arose from the whole genome duplication |
YOL002C | 4.48 | 3.69E-6 | IZH2 | Plasma membrane protein involved in zinc homeostasis and osmotin-induced apoptosis; transcription regulated by Zap1p, zinc and fatty acid levels; similar to mammalian adiponectins; deletion increases sensitivity to elevated zinc |
YCR085W_d | 4.26 | 1.04E-5 | YCR085W_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
YLR172C | 4.24 | 1.12E-5 | DPH5 | Methyltransferase required for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); not essential for viability; GFP-Dph5p fusion protein localizes to the cytoplasm |
YDL001W | 4.04 | 2.70E-5 | RMD1 | Cytoplasmic protein required for sporulation |
YAL042C-A_d | 4.02 | 2.94E-5 | YAL042C-A_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF ERV46/YAL042W; YAL042C-A is a non-essential gene |
YER177W | 4.01 | 3.06E-5 | BMH1 | 14-3-3 protein, major isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress |
YDR011W | 3.88 | 5.24E-5 | SNQ2 | Plasma membrane ATP-binding cassette (ABC) transporter, multidrug transporter involved in multidrug resistance and resistance to singlet oxygen species |
YPR147C_p | 3.83 | 6.28E-5 | YPR147C_p | Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS |