Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YGR195W | 3.43 | 3.00E-4 | 0.38 | SKI6 | Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp41p (EXOSC4) |
YKL125W | 3.05 | 0.00114 | 0.12 | RRN3 | Protein required for transcription of rDNA by RNA polymerase I; transcription factor independent of DNA template; involved in recruitment of RNA polymerase I to rDNA; structure reveals unique HEAT repeat fold and a surface serine patch; phosphorylation of serine patch impairs cell growth and reduces RNA polymerase I binding in vitro and RNA polymerase I recruitment to the rDNA gene in vivo |
YLR355C | 2.93 | 0.00171 | 0.07 | ILV5 | Bifunctional acetohydroxyacid reductoisomerase and mtDNA binding protein; involved in branched-chain amino acid biosynthesis and maintenance of wild-type mitochondrial DNA; found in mitochondrial nucleoids |
YNL150W_d | 2.86 | 0.00215 | 0.06 | YNL150W_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; extensive overlap with PGA2/YNL149C, an uncharacterized gene with a proposed role in protein trafficking |
YBL084C | 2.80 | 0.00259 | 0.04 | CDC27 | Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition |
YFR005C | 2.76 | 0.00289 | 0.04 | SAD1 | Conserved zinc-finger domain protein involved in pre-mRNA splicing, required for assembly of U4 snRNA into the U4/U6 particle |
YOR048C | 2.72 | 0.00330 | 0.12 | RAT1 | Nuclear 5' to 3' single-stranded RNA exonuclease, involved in RNA metabolism, including rRNA and snRNA processing as well as poly (A+) dependent and independent mRNA transcription termination |
YJL034W | 2.60 | 0.00472 | 0.00 | KAR2 | ATPase involved in protein import into the ER, also acts as a chaperone to mediate protein folding in the ER and may play a role in ER export of soluble proteins; regulates the unfolded protein response via interaction with Ire1p |
YGR048W | 2.59 | 0.00475 | 0.01 | UFD1 | Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase; polyubiquitin binding protein that assists in the dislocation of misfolded, ERAD substrates that are subsequently delivered to the proteasome for degradation; involved in regulated destruction of ER membrane proteins such as HMG-CoA reductase (Hmg1/2p) and cytoplasmic proteins (Fbp1p); involved in mobilizing membrane bound transaction factors by regulated Ub/proteasome-dependent processing (RUP) |
YGL128C | 2.58 | 0.00488 | 0.10 | CWC23 | Component of a complex containing Cef1p, putatively involved in pre-mRNA splicing; has similarity to E. coli DnaJ and other DnaJ-like proteins and to S. pombe Cwf23p |
YBR060C | 2.49 | 0.00643 | 0.03 | ORC2 | Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; interacts with Spp1p and with trimethylated histone H3; phosphorylated by Cdc28p |
YDR489W | 2.46 | 0.00694 | 0.02 | SLD5 | Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery |
YOR362C | 2.44 | 0.00732 | 0.06 | PRE10 | Alpha 7 subunit of the 20S proteasome; protein abundance increases in response to DNA replication stress |
YDR045C | 2.38 | 0.00869 | 0.03 | RPC11 | RNA polymerase III subunit C11; mediates pol III RNA cleavage activity and is important for termination of transcription; homologous to TFIIS |
YDR164C | 2.35 | 0.00940 | 0.01 | SEC1 | Sm-like protein involved in docking and fusion of exocytic vesicles; binds to assembled SNARE complexes at the membrane and stimulates membrane fusion; localization to sites of secretion (bud neck and bud tip) is dependent on SNARE function |