9151559

N-[[5-(3-chloro-4-fluorophenyl)furan-2-yl]methyl]-1-azabicyclo[2.2.2]octan-3-amine dihydrochloride

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_3352
Screen concentration 45.6 μM
Source Chembridge (Drug-like library)
PubChem CID 17159339
SMILES C1CN2CCC1C(C2)NCC3=CC=C(O3)C4=CC(=C(C=C4)F)Cl.Cl.Cl
Standardized SMILES Fc1ccc(cc1Cl)c2oc(CNC3CN4CCC3CC4)cc2
Molecular weight 407.7375
ALogP 4.53
H-bond donor count 3
H-bond acceptor count 4
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 9.35
% growth inhibition (Hom. pool) 4.69


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 17159339
Download HIP data (tab-delimited text)  (excel)
Gene:DNA2(YHR164C)|FD-Score:-3.6|P-value:1.60E-4|Clearance:0||SGD DESC:Tripartite DNA replication factor; has single-stranded DNA-dependent ATPase, ATP-dependent nuclease, and helicase activities; required for Okazaki fragment processing; involved in DNA repair; cell-cycle dependent localization; forms nuclear foci upon DNA replication stress Gene:MED4(YOR174W)|FD-Score:3.45|P-value:2.85E-4|Clearance:0.01||SGD DESC:Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation Gene:MTR3(YGR158C)|FD-Score:3.29|P-value:5.10E-4|Clearance:0.17||SGD DESC:Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hMtr3p (EXOSC6) Gene:RAT1(YOR048C)|FD-Score:3.44|P-value:2.92E-4|Clearance:0.15||SGD DESC:Nuclear 5' to 3' single-stranded RNA exonuclease, involved in RNA metabolism, including rRNA and snRNA processing as well as poly (A+) dependent and independent mRNA transcription termination Gene:RFC1(YOR217W)|FD-Score:3.11|P-value:9.20E-4|Clearance:0.09||SGD DESC:Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon Gene:RPN3(YER021W)|FD-Score:3.65|P-value:1.31E-4|Clearance:0.21||SGD DESC:Essential, non-ATPase regulatory subunit of the 26S proteasome lid, similar to the p58 subunit of the human 26S proteasome; temperature-sensitive alleles cause metaphase arrest, suggesting a role for the proteasome in cell cycle control Gene:SEC39(YLR440C)|FD-Score:-3.25|P-value:5.71E-4|Clearance:0||SGD DESC:Component of the Dsl1p tethering complex that interacts with ER SNAREs Sec20p and Use1p; proposed to be involved in protein secretion; localizes to the ER and nuclear envelope Gene:SPC110(YDR356W)|FD-Score:4.15|P-value:1.65E-5|Clearance:0.48||SGD DESC:Inner plaque spindle pole body (SPB) component, ortholog of human kendrin; involved in connecting nuclear microtubules to SPB; interacts with Tub4p-complex and calmodulin; phosphorylated by Mps1p in cell cycle-dependent manner Gene:SPT5(YML010W)|FD-Score:-3.17|P-value:7.71E-4|Clearance:0||SGD DESC:Component of the universally conserved Spt4/5 complex (DSIF complex); the complex has multiple roles in concert with RNA polymerases I and II, including regulation of transcription elongation, RNA processing, quality control, and transcription-coupled DNA repair Gene:UTP4(YDR324C)|FD-Score:3.67|P-value:1.21E-4|Clearance:0.02||SGD DESC:Subunit of U3-containing 90S preribosome and Small Subunit (SSU) processome complexes involved in production of 18S rRNA and assembly of small ribosomal subunit; member of t-Utp subcomplex involved with transcription of 35S rRNA transcript Gene:DNA2(YHR164C)|FD-Score:-3.6|P-value:1.60E-4|Clearance:0||SGD DESC:Tripartite DNA replication factor; has single-stranded DNA-dependent ATPase, ATP-dependent nuclease, and helicase activities; required for Okazaki fragment processing; involved in DNA repair; cell-cycle dependent localization; forms nuclear foci upon DNA replication stress Gene:MED4(YOR174W)|FD-Score:3.45|P-value:2.85E-4|Clearance:0.01||SGD DESC:Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation Gene:MTR3(YGR158C)|FD-Score:3.29|P-value:5.10E-4|Clearance:0.17||SGD DESC:Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hMtr3p (EXOSC6) Gene:RAT1(YOR048C)|FD-Score:3.44|P-value:2.92E-4|Clearance:0.15||SGD DESC:Nuclear 5' to 3' single-stranded RNA exonuclease, involved in RNA metabolism, including rRNA and snRNA processing as well as poly (A+) dependent and independent mRNA transcription termination Gene:RFC1(YOR217W)|FD-Score:3.11|P-value:9.20E-4|Clearance:0.09||SGD DESC:Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon Gene:RPN3(YER021W)|FD-Score:3.65|P-value:1.31E-4|Clearance:0.21||SGD DESC:Essential, non-ATPase regulatory subunit of the 26S proteasome lid, similar to the p58 subunit of the human 26S proteasome; temperature-sensitive alleles cause metaphase arrest, suggesting a role for the proteasome in cell cycle control Gene:SEC39(YLR440C)|FD-Score:-3.25|P-value:5.71E-4|Clearance:0||SGD DESC:Component of the Dsl1p tethering complex that interacts with ER SNAREs Sec20p and Use1p; proposed to be involved in protein secretion; localizes to the ER and nuclear envelope Gene:SPC110(YDR356W)|FD-Score:4.15|P-value:1.65E-5|Clearance:0.48||SGD DESC:Inner plaque spindle pole body (SPB) component, ortholog of human kendrin; involved in connecting nuclear microtubules to SPB; interacts with Tub4p-complex and calmodulin; phosphorylated by Mps1p in cell cycle-dependent manner Gene:SPT5(YML010W)|FD-Score:-3.17|P-value:7.71E-4|Clearance:0||SGD DESC:Component of the universally conserved Spt4/5 complex (DSIF complex); the complex has multiple roles in concert with RNA polymerases I and II, including regulation of transcription elongation, RNA processing, quality control, and transcription-coupled DNA repair Gene:UTP4(YDR324C)|FD-Score:3.67|P-value:1.21E-4|Clearance:0.02||SGD DESC:Subunit of U3-containing 90S preribosome and Small Subunit (SSU) processome complexes involved in production of 18S rRNA and assembly of small ribosomal subunit; member of t-Utp subcomplex involved with transcription of 35S rRNA transcript

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 17159339
Download HOP data (tab-delimited text)  (excel)
Gene:AIM43(YPL099C)|FD-Score:3.88|P-value:5.26E-5||SGD DESC:Protein of unknown function; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss Gene:ALG8(YOR067C)|FD-Score:4.16|P-value:1.62E-5||SGD DESC:Glucosyl transferase, involved in N-linked glycosylation; adds glucose to the dolichol-linked oligosaccharide precursor prior to transfer to protein during lipid-linked oligosaccharide biosynthesis; similar to Alg6p Gene:APE1(YKL103C)|FD-Score:-3.19|P-value:7.21E-4||SGD DESC:Vacuolar aminopeptidase yscI; zinc metalloproteinase that belongs to the peptidase family M18; often used as a marker protein in studies of autophagy and cytosol to vacuole targeting (CVT) pathway; protein increases in abundance and relative distribution to cytoplasmic foci increases upon DNA replication stress Gene:ATG34(YOL083W)|FD-Score:3.87|P-value:5.48E-5||SGD DESC:Receptor protein involved in selective autophagy during starvation; specifically involved in the transport of cargo protein alpha-mannosidase (Ams1p); Atg19p paralog Gene:COQ5(YML110C)|FD-Score:3.44|P-value:2.95E-4||SGD DESC:2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase, involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes Gene:COS10(YNR075W)|FD-Score:3.2|P-value:6.88E-4||SGD DESC:Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins Gene:CWC21(YDR482C)|FD-Score:3.2|P-value:6.98E-4||SGD DESC:Protein involved in RNA splicing by the spliceosome; component of a complex containing Cef1p; interacts genetically with ISY1 and BUD13; may bind RNA; has similarity to S. pombe Cwf21p Gene:DAL1(YIR027C)|FD-Score:3.61|P-value:1.56E-4||SGD DESC:Allantoinase, converts allantoin to allantoate in the first step of allantoin degradation; expression sensitive to nitrogen catabolite repression Gene:DAP2(YHR028C)|FD-Score:3.65|P-value:1.33E-4||SGD DESC:Dipeptidyl aminopeptidase, synthesized as a glycosylated precursor; localizes to the vacuolar membrane; similar to Ste13p Gene:FIG1(YBR040W)|FD-Score:3.17|P-value:7.75E-4||SGD DESC:Integral membrane protein required for efficient mating; may participate in or regulate the low affinity Ca2+ influx system, which affects intracellular signaling and cell-cell fusion during mating Gene:GPH1(YPR160W)|FD-Score:3.41|P-value:3.27E-4||SGD DESC:Non-essential glycogen phosphorylase required for the mobilization of glycogen, activity is regulated by cyclic AMP-mediated phosphorylation, expression is regulated by stress-response elements and by the HOG MAP kinase pathway Gene:HAL5(YJL165C)|FD-Score:-3.27|P-value:5.44E-4||SGD DESC:Putative protein kinase; overexpression increases sodium and lithium tolerance, whereas gene disruption increases cation and low pH sensitivity and impairs potassium uptake, suggesting a role in regulation of Trk1p and/or Trk2p transporters; HAL5 has a paralog, KKQ8, that arose from the whole genome duplication Gene:IOC2(YLR095C)|FD-Score:-4.55|P-value:2.74E-6||SGD DESC:Member of a complex (Isw1b) with Isw1p and Ioc4p that exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing, contains a PHD finger motif Gene:IZH2(YOL002C)|FD-Score:-5.51|P-value:1.78E-8||SGD DESC:Plasma membrane protein involved in zinc homeostasis and osmotin-induced apoptosis; transcription regulated by Zap1p, zinc and fatty acid levels; similar to mammalian adiponectins; deletion increases sensitivity to elevated zinc Gene:LIF1(YGL090W)|FD-Score:4.44|P-value:4.54E-6||SGD DESC:Component of the DNA ligase IV complex that mediates nonhomologous end joining in DNA double-strand break repair; physically interacts with Dnl4p and Nej1p; homologous to mammalian XRCC4 protein Gene:LOH1(YJL038C)|FD-Score:3.45|P-value:2.80E-4||SGD DESC:Protein of unknown function with proposed roles in maintenance of genome integrity and also in spore wall assembly; induced during sporulation; repressed during vegetative growth by Sum1p and Hst1p; sequence similar to IRC1 Gene:MAK31(YCR020C-A)|FD-Score:-3.48|P-value:2.52E-4||SGD DESC:Non-catalytic subunit of N-terminal acetyltransferase of the NatC type; required for replication of dsRNA virus; member of the Sm protein family Gene:MCK1(YNL307C)|FD-Score:-3.34|P-value:4.26E-4||SGD DESC:Protein serine/threonine/tyrosine (dual-specificity) kinase; involved in control of chromosome segregation and in regulating entry into meiosis; interacts with Clb2p and Mih1p; inhibits Clb2p-Cdk1 activity; related to mammalian glycogen synthase kinases of the GSK-3 family Gene:MGA1(YGR249W)|FD-Score:3.25|P-value:5.86E-4||SGD DESC:Protein similar to heat shock transcription factor; multicopy suppressor of pseudohyphal growth defects of ammonium permease mutants Gene:MPM1(YJL066C)|FD-Score:3.12|P-value:9.13E-4||SGD DESC:Mitochondrial intermembrane space protein of unknown function Gene:MRM1(YOR201C)|FD-Score:3.1|P-value:9.54E-4||SGD DESC:Ribose methyltransferase that modifies a functionally critical, conserved nucleotide in mitochondrial 21S rRNA Gene:MRPS5(YBR251W)|FD-Score:3.31|P-value:4.68E-4||SGD DESC:Mitochondrial ribosomal protein of the small subunit Gene:MUK1(YPL070W)|FD-Score:3.5|P-value:2.29E-4||SGD DESC:Cytoplasmic protein of unknown function containing a Vps9 domain; computational analysis of large-scale protein-protein interaction data suggests a possible role in transcriptional regulation Gene:PHO5(YBR093C)|FD-Score:3.73|P-value:9.61E-5||SGD DESC:Repressible acid phosphatase (1 of 3) that also mediates extracellular nucleotide-derived phosphate hydrolysis; secretory pathway derived cell surface glycoprotein; induced by phosphate starvation and coordinately regulated by PHO4 and PHO2 Gene:PIP2(YOR363C)|FD-Score:-3.11|P-value:9.51E-4||SGD DESC:Autoregulatory oleate-specific transcriptional activator of peroxisome proliferation, contains Zn(2)-Cys(6) cluster domain, forms heterodimer with Oaf1p, binds oleate response elements (OREs), activates beta-oxidation genes; PIP2 has a paralog, OAF1, that arose from the whole genome duplication Gene:RAD57(YDR004W)|FD-Score:3.65|P-value:1.32E-4||SGD DESC:Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad55p Gene:RCN2(YOR220W_p)|FD-Score:3.13|P-value:8.66E-4||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; phosphorylated in response to alpha factor; protein abundance increases in response to DNA replication stress Gene:RCO1(YMR075W)|FD-Score:3.11|P-value:9.48E-4||SGD DESC:Essential subunit of the histone deacetylase Rpd3S complex; interacts with Eaf3p Gene:REH1(YLR387C)|FD-Score:-3.98|P-value:3.39E-5||SGD DESC:Cytoplasmic 60S subunit biogenesis factor, associates with pre-60S particles; similar to Rei1p and shares partially redundant function in cytoplasmic 60S subunit maturation; contains dispersed C2H2 zinc finger domains Gene:RIM8(YGL045W)|FD-Score:3.47|P-value:2.56E-4||SGD DESC:Protein involved in proteolytic activation of Rim101p in response to alkaline pH; interacts with ESCRT-1 subunits Stp22p and Vps28p; essential for anaerobic growth; member of the arrestin-related trafficking adaptor family Gene:RLF2(YPR018W)|FD-Score:-3.32|P-value:4.50E-4||SGD DESC:Largest subunit (p90) of the Chromatin Assembly Complex (CAF-1); chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure; deactivation of the DNA damage checkpoint after DNA repair; and chromatin dynamics during transcription Gene:RPS7A(YOR096W)|FD-Score:4.19|P-value:1.40E-5||SGD DESC:Protein component of the small (40S) ribosomal subunit; interacts with Kti11p; deletion causes hypersensitivity to zymocin; homologous to mammalian ribosomal protein S7, no bacterial homolog; RPS7A has a paralog, RPS7B, that arose from the whole genome duplication Gene:RSF2(YJR127C)|FD-Score:-4.28|P-value:9.29E-6||SGD DESC:Zinc-finger protein; involved in transcriptional control of both nuclear and mitochondrial genes, many of which specify products required for glycerol-based growth, respiration, and other functions; RSF2 has a paralog, TDA9, that arose from the whole genome duplication; relocalizes from nucleus to cytoplasm upon DNA replication stress Gene:RTG1(YOL067C)|FD-Score:4.2|P-value:1.34E-5||SGD DESC:Transcription factor (bHLH) involved in interorganelle communication between mitochondria, peroxisomes, and nucleus Gene:SDH1(YKL148C)|FD-Score:-3.97|P-value:3.62E-5||SGD DESC:Flavoprotein subunit of succinate dehydrogenase; couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain; FAD binding to Sdh1p is required for the assembly of the succinate dehydrogenase subunits Gene:SGE1(YPR198W)|FD-Score:-3.61|P-value:1.55E-4||SGD DESC:Plasma membrane multidrug transporter of the major facilitator superfamily, acts as an extrusion permease; partial multicopy suppressor of gal11 mutations Gene:SPI1(YER150W)|FD-Score:4.15|P-value:1.64E-5||SGD DESC:GPI-anchored cell wall protein involved in weak acid resistance; basal expression requires Msn2p/Msn4p; expression is induced under conditions of stress and during the diauxic shift; similar to Sed1p Gene:SPR1(YOR190W)|FD-Score:3.63|P-value:1.41E-4||SGD DESC:Sporulation-specific exo-1,3-beta-glucanase; contributes to ascospore thermoresistance Gene:SPS18(YNL204C)|FD-Score:3.29|P-value:5.01E-4||SGD DESC:Protein of unknown function, contains a putative zinc-binding domain; expressed during sporulation Gene:SSU1(YPL092W)|FD-Score:3.33|P-value:4.41E-4||SGD DESC:Plasma membrane sulfite pump involved in sulfite metabolism and required for efficient sulfite efflux; major facilitator superfamily protein Gene:SXM1(YDR395W)|FD-Score:3.16|P-value:7.77E-4||SGD DESC:Nuclear transport factor (karyopherin) involved in protein transport between the cytoplasm and nucleoplasm; similar to Nmd5p, Cse1p, Lph2p, and the human cellular apoptosis susceptibility protein, CAS1 Gene:TOF2(YKR010C)|FD-Score:-3.58|P-value:1.74E-4||SGD DESC:Protein required for rDNA silencing and mitotic rDNA condensation; stimulates Cdc14p phosphatase activity and biphasic release to promote rDNA repeat segregation; required for condensin recruitment to the replication fork barrier site; TOF2 has a paralog, NET1, that arose from the whole genome duplication Gene:TPM2(YIL138C)|FD-Score:-3.89|P-value:4.92E-5||SGD DESC:Minor isoform of tropomyosin; binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; appears to have distinct and also overlapping functions with Tpm1p; TPM2 has a paralog, TPM1, that arose from the whole genome duplication Gene:TPN1(YGL186C)|FD-Score:5.57|P-value:1.31E-8||SGD DESC:Plasma membrane pyridoxine (vitamin B6) transporter; member of the purine-cytosine permease subfamily within the major facilitator superfamily; proton symporter with similarity to Fcy21p, Fcy2p, and Fcy22p Gene:TRI1(YMR233W)|FD-Score:4.01|P-value:3.04E-5||SGD DESC:Non-essential sumoylated protein of unknown function; similar to components of human SWI/SNF complex including SMRD3; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm, nucleus and nucleolus; TRI1 has a paralog, UAF30, that arose from the whole genome duplication Gene:TRP4(YDR354W)|FD-Score:-5.76|P-value:4.11E-9||SGD DESC:Anthranilate phosphoribosyl transferase of the tryptophan biosynthetic pathway, catalyzes the phosphoribosylation of anthranilate, subject to the general control system of amino acid biosynthesis Gene:YBR178W(YBR178W_d)|FD-Score:-3.72|P-value:9.93E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR177C Gene:YCR087W(YCR087W_d)|FD-Score:4.81|P-value:7.55E-7||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized gene YCR087C-A; YCR087W is not an essential gene Gene:YER130C(YER130C_p)|FD-Score:-3.37|P-value:3.77E-4||SGD DESC:Protein of unknown function; transcription is regulated by Haa1p, Sok2p and Zap1p transcriptional activators; computational analysis suggests a role as a transcription factor; C. albicans homolog (MNL1) plays a role in adaptation to stress Gene:YER152C(YER152C)|FD-Score:4.1|P-value:2.09E-5||SGD DESC:Protein with 2-aminoadipate transaminase activity; shares amino acid similarity with the aminotransferases Aro8p and Aro9p; YER152C is not an essential gene Gene:YFL034W(YFL034W_p)|FD-Score:3.11|P-value:9.24E-4||SGD DESC:Putative integral membrane protein that interacts with Rpp0p, which is a component of the ribosomal stalk Gene:YFR056C(YFR056C_d)|FD-Score:7.1|P-value:6.42E-13||SGD DESC:Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W Gene:YGR137W(YGR137W_d)|FD-Score:5.37|P-value:3.93E-8||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YGR273C(YGR273C_p)|FD-Score:-3.71|P-value:1.04E-4||SGD DESC:Putative protein of unknown function; expression downregulated by treatment with 8-methoxypsoralen plus UVA irradiation; YGR273C is not an essential gene Gene:YJL007C(YJL007C_d)|FD-Score:4.61|P-value:2.00E-6||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YML054C-A(YML054C-A_p)|FD-Score:-3.66|P-value:1.28E-4||SGD DESC:Putative protein of unknown function Gene:YMR027W(YMR027W_p)|FD-Score:-3.68|P-value:1.15E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; YMR027W is not an essential gene Gene:YMR141C(YMR141C_d)|FD-Score:3.2|P-value:6.82E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YOL036W(YOL036W_p)|FD-Score:3.15|P-value:8.24E-4||SGD DESC:Protein of unknown function; potential Cdc28p substrate; YOL036W has a paralog, YIR016W, that arose from the whole genome duplication Gene:YOR170W(YOR170W_d)|FD-Score:3.79|P-value:7.67E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene LCB4 Gene:YOR283W(YOR283W)|FD-Score:-3.44|P-value:2.88E-4||SGD DESC:Phosphatase with a broad substrate specificity and some similarity to GPM1/YKL152C, a phosphoglycerate mutase; YOR283W is not an essential gene Gene:YPL229W(YPL229W_p)|FD-Score:3.21|P-value:6.60E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; not an essential gene; YPL229W has a paralog, YMR181C, that arose from the whole genome duplication Gene:AIM43(YPL099C)|FD-Score:3.88|P-value:5.26E-5||SGD DESC:Protein of unknown function; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss Gene:ALG8(YOR067C)|FD-Score:4.16|P-value:1.62E-5||SGD DESC:Glucosyl transferase, involved in N-linked glycosylation; adds glucose to the dolichol-linked oligosaccharide precursor prior to transfer to protein during lipid-linked oligosaccharide biosynthesis; similar to Alg6p Gene:APE1(YKL103C)|FD-Score:-3.19|P-value:7.21E-4||SGD DESC:Vacuolar aminopeptidase yscI; zinc metalloproteinase that belongs to the peptidase family M18; often used as a marker protein in studies of autophagy and cytosol to vacuole targeting (CVT) pathway; protein increases in abundance and relative distribution to cytoplasmic foci increases upon DNA replication stress Gene:ATG34(YOL083W)|FD-Score:3.87|P-value:5.48E-5||SGD DESC:Receptor protein involved in selective autophagy during starvation; specifically involved in the transport of cargo protein alpha-mannosidase (Ams1p); Atg19p paralog Gene:COQ5(YML110C)|FD-Score:3.44|P-value:2.95E-4||SGD DESC:2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase, involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes Gene:COS10(YNR075W)|FD-Score:3.2|P-value:6.88E-4||SGD DESC:Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins Gene:CWC21(YDR482C)|FD-Score:3.2|P-value:6.98E-4||SGD DESC:Protein involved in RNA splicing by the spliceosome; component of a complex containing Cef1p; interacts genetically with ISY1 and BUD13; may bind RNA; has similarity to S. pombe Cwf21p Gene:DAL1(YIR027C)|FD-Score:3.61|P-value:1.56E-4||SGD DESC:Allantoinase, converts allantoin to allantoate in the first step of allantoin degradation; expression sensitive to nitrogen catabolite repression Gene:DAP2(YHR028C)|FD-Score:3.65|P-value:1.33E-4||SGD DESC:Dipeptidyl aminopeptidase, synthesized as a glycosylated precursor; localizes to the vacuolar membrane; similar to Ste13p Gene:FIG1(YBR040W)|FD-Score:3.17|P-value:7.75E-4||SGD DESC:Integral membrane protein required for efficient mating; may participate in or regulate the low affinity Ca2+ influx system, which affects intracellular signaling and cell-cell fusion during mating Gene:GPH1(YPR160W)|FD-Score:3.41|P-value:3.27E-4||SGD DESC:Non-essential glycogen phosphorylase required for the mobilization of glycogen, activity is regulated by cyclic AMP-mediated phosphorylation, expression is regulated by stress-response elements and by the HOG MAP kinase pathway Gene:HAL5(YJL165C)|FD-Score:-3.27|P-value:5.44E-4||SGD DESC:Putative protein kinase; overexpression increases sodium and lithium tolerance, whereas gene disruption increases cation and low pH sensitivity and impairs potassium uptake, suggesting a role in regulation of Trk1p and/or Trk2p transporters; HAL5 has a paralog, KKQ8, that arose from the whole genome duplication Gene:IOC2(YLR095C)|FD-Score:-4.55|P-value:2.74E-6||SGD DESC:Member of a complex (Isw1b) with Isw1p and Ioc4p that exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing, contains a PHD finger motif Gene:IZH2(YOL002C)|FD-Score:-5.51|P-value:1.78E-8||SGD DESC:Plasma membrane protein involved in zinc homeostasis and osmotin-induced apoptosis; transcription regulated by Zap1p, zinc and fatty acid levels; similar to mammalian adiponectins; deletion increases sensitivity to elevated zinc Gene:LIF1(YGL090W)|FD-Score:4.44|P-value:4.54E-6||SGD DESC:Component of the DNA ligase IV complex that mediates nonhomologous end joining in DNA double-strand break repair; physically interacts with Dnl4p and Nej1p; homologous to mammalian XRCC4 protein Gene:LOH1(YJL038C)|FD-Score:3.45|P-value:2.80E-4||SGD DESC:Protein of unknown function with proposed roles in maintenance of genome integrity and also in spore wall assembly; induced during sporulation; repressed during vegetative growth by Sum1p and Hst1p; sequence similar to IRC1 Gene:MAK31(YCR020C-A)|FD-Score:-3.48|P-value:2.52E-4||SGD DESC:Non-catalytic subunit of N-terminal acetyltransferase of the NatC type; required for replication of dsRNA virus; member of the Sm protein family Gene:MCK1(YNL307C)|FD-Score:-3.34|P-value:4.26E-4||SGD DESC:Protein serine/threonine/tyrosine (dual-specificity) kinase; involved in control of chromosome segregation and in regulating entry into meiosis; interacts with Clb2p and Mih1p; inhibits Clb2p-Cdk1 activity; related to mammalian glycogen synthase kinases of the GSK-3 family Gene:MGA1(YGR249W)|FD-Score:3.25|P-value:5.86E-4||SGD DESC:Protein similar to heat shock transcription factor; multicopy suppressor of pseudohyphal growth defects of ammonium permease mutants Gene:MPM1(YJL066C)|FD-Score:3.12|P-value:9.13E-4||SGD DESC:Mitochondrial intermembrane space protein of unknown function Gene:MRM1(YOR201C)|FD-Score:3.1|P-value:9.54E-4||SGD DESC:Ribose methyltransferase that modifies a functionally critical, conserved nucleotide in mitochondrial 21S rRNA Gene:MRPS5(YBR251W)|FD-Score:3.31|P-value:4.68E-4||SGD DESC:Mitochondrial ribosomal protein of the small subunit Gene:MUK1(YPL070W)|FD-Score:3.5|P-value:2.29E-4||SGD DESC:Cytoplasmic protein of unknown function containing a Vps9 domain; computational analysis of large-scale protein-protein interaction data suggests a possible role in transcriptional regulation Gene:PHO5(YBR093C)|FD-Score:3.73|P-value:9.61E-5||SGD DESC:Repressible acid phosphatase (1 of 3) that also mediates extracellular nucleotide-derived phosphate hydrolysis; secretory pathway derived cell surface glycoprotein; induced by phosphate starvation and coordinately regulated by PHO4 and PHO2 Gene:PIP2(YOR363C)|FD-Score:-3.11|P-value:9.51E-4||SGD DESC:Autoregulatory oleate-specific transcriptional activator of peroxisome proliferation, contains Zn(2)-Cys(6) cluster domain, forms heterodimer with Oaf1p, binds oleate response elements (OREs), activates beta-oxidation genes; PIP2 has a paralog, OAF1, that arose from the whole genome duplication Gene:RAD57(YDR004W)|FD-Score:3.65|P-value:1.32E-4||SGD DESC:Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad55p Gene:RCN2(YOR220W_p)|FD-Score:3.13|P-value:8.66E-4||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; phosphorylated in response to alpha factor; protein abundance increases in response to DNA replication stress Gene:RCO1(YMR075W)|FD-Score:3.11|P-value:9.48E-4||SGD DESC:Essential subunit of the histone deacetylase Rpd3S complex; interacts with Eaf3p Gene:REH1(YLR387C)|FD-Score:-3.98|P-value:3.39E-5||SGD DESC:Cytoplasmic 60S subunit biogenesis factor, associates with pre-60S particles; similar to Rei1p and shares partially redundant function in cytoplasmic 60S subunit maturation; contains dispersed C2H2 zinc finger domains Gene:RIM8(YGL045W)|FD-Score:3.47|P-value:2.56E-4||SGD DESC:Protein involved in proteolytic activation of Rim101p in response to alkaline pH; interacts with ESCRT-1 subunits Stp22p and Vps28p; essential for anaerobic growth; member of the arrestin-related trafficking adaptor family Gene:RLF2(YPR018W)|FD-Score:-3.32|P-value:4.50E-4||SGD DESC:Largest subunit (p90) of the Chromatin Assembly Complex (CAF-1); chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure; deactivation of the DNA damage checkpoint after DNA repair; and chromatin dynamics during transcription Gene:RPS7A(YOR096W)|FD-Score:4.19|P-value:1.40E-5||SGD DESC:Protein component of the small (40S) ribosomal subunit; interacts with Kti11p; deletion causes hypersensitivity to zymocin; homologous to mammalian ribosomal protein S7, no bacterial homolog; RPS7A has a paralog, RPS7B, that arose from the whole genome duplication Gene:RSF2(YJR127C)|FD-Score:-4.28|P-value:9.29E-6||SGD DESC:Zinc-finger protein; involved in transcriptional control of both nuclear and mitochondrial genes, many of which specify products required for glycerol-based growth, respiration, and other functions; RSF2 has a paralog, TDA9, that arose from the whole genome duplication; relocalizes from nucleus to cytoplasm upon DNA replication stress Gene:RTG1(YOL067C)|FD-Score:4.2|P-value:1.34E-5||SGD DESC:Transcription factor (bHLH) involved in interorganelle communication between mitochondria, peroxisomes, and nucleus Gene:SDH1(YKL148C)|FD-Score:-3.97|P-value:3.62E-5||SGD DESC:Flavoprotein subunit of succinate dehydrogenase; couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain; FAD binding to Sdh1p is required for the assembly of the succinate dehydrogenase subunits Gene:SGE1(YPR198W)|FD-Score:-3.61|P-value:1.55E-4||SGD DESC:Plasma membrane multidrug transporter of the major facilitator superfamily, acts as an extrusion permease; partial multicopy suppressor of gal11 mutations Gene:SPI1(YER150W)|FD-Score:4.15|P-value:1.64E-5||SGD DESC:GPI-anchored cell wall protein involved in weak acid resistance; basal expression requires Msn2p/Msn4p; expression is induced under conditions of stress and during the diauxic shift; similar to Sed1p Gene:SPR1(YOR190W)|FD-Score:3.63|P-value:1.41E-4||SGD DESC:Sporulation-specific exo-1,3-beta-glucanase; contributes to ascospore thermoresistance Gene:SPS18(YNL204C)|FD-Score:3.29|P-value:5.01E-4||SGD DESC:Protein of unknown function, contains a putative zinc-binding domain; expressed during sporulation Gene:SSU1(YPL092W)|FD-Score:3.33|P-value:4.41E-4||SGD DESC:Plasma membrane sulfite pump involved in sulfite metabolism and required for efficient sulfite efflux; major facilitator superfamily protein Gene:SXM1(YDR395W)|FD-Score:3.16|P-value:7.77E-4||SGD DESC:Nuclear transport factor (karyopherin) involved in protein transport between the cytoplasm and nucleoplasm; similar to Nmd5p, Cse1p, Lph2p, and the human cellular apoptosis susceptibility protein, CAS1 Gene:TOF2(YKR010C)|FD-Score:-3.58|P-value:1.74E-4||SGD DESC:Protein required for rDNA silencing and mitotic rDNA condensation; stimulates Cdc14p phosphatase activity and biphasic release to promote rDNA repeat segregation; required for condensin recruitment to the replication fork barrier site; TOF2 has a paralog, NET1, that arose from the whole genome duplication Gene:TPM2(YIL138C)|FD-Score:-3.89|P-value:4.92E-5||SGD DESC:Minor isoform of tropomyosin; binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; appears to have distinct and also overlapping functions with Tpm1p; TPM2 has a paralog, TPM1, that arose from the whole genome duplication Gene:TPN1(YGL186C)|FD-Score:5.57|P-value:1.31E-8||SGD DESC:Plasma membrane pyridoxine (vitamin B6) transporter; member of the purine-cytosine permease subfamily within the major facilitator superfamily; proton symporter with similarity to Fcy21p, Fcy2p, and Fcy22p Gene:TRI1(YMR233W)|FD-Score:4.01|P-value:3.04E-5||SGD DESC:Non-essential sumoylated protein of unknown function; similar to components of human SWI/SNF complex including SMRD3; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm, nucleus and nucleolus; TRI1 has a paralog, UAF30, that arose from the whole genome duplication Gene:TRP4(YDR354W)|FD-Score:-5.76|P-value:4.11E-9||SGD DESC:Anthranilate phosphoribosyl transferase of the tryptophan biosynthetic pathway, catalyzes the phosphoribosylation of anthranilate, subject to the general control system of amino acid biosynthesis Gene:YBR178W(YBR178W_d)|FD-Score:-3.72|P-value:9.93E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR177C Gene:YCR087W(YCR087W_d)|FD-Score:4.81|P-value:7.55E-7||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized gene YCR087C-A; YCR087W is not an essential gene Gene:YER130C(YER130C_p)|FD-Score:-3.37|P-value:3.77E-4||SGD DESC:Protein of unknown function; transcription is regulated by Haa1p, Sok2p and Zap1p transcriptional activators; computational analysis suggests a role as a transcription factor; C. albicans homolog (MNL1) plays a role in adaptation to stress Gene:YER152C(YER152C)|FD-Score:4.1|P-value:2.09E-5||SGD DESC:Protein with 2-aminoadipate transaminase activity; shares amino acid similarity with the aminotransferases Aro8p and Aro9p; YER152C is not an essential gene Gene:YFL034W(YFL034W_p)|FD-Score:3.11|P-value:9.24E-4||SGD DESC:Putative integral membrane protein that interacts with Rpp0p, which is a component of the ribosomal stalk Gene:YFR056C(YFR056C_d)|FD-Score:7.1|P-value:6.42E-13||SGD DESC:Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W Gene:YGR137W(YGR137W_d)|FD-Score:5.37|P-value:3.93E-8||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YGR273C(YGR273C_p)|FD-Score:-3.71|P-value:1.04E-4||SGD DESC:Putative protein of unknown function; expression downregulated by treatment with 8-methoxypsoralen plus UVA irradiation; YGR273C is not an essential gene Gene:YJL007C(YJL007C_d)|FD-Score:4.61|P-value:2.00E-6||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YML054C-A(YML054C-A_p)|FD-Score:-3.66|P-value:1.28E-4||SGD DESC:Putative protein of unknown function Gene:YMR027W(YMR027W_p)|FD-Score:-3.68|P-value:1.15E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; YMR027W is not an essential gene Gene:YMR141C(YMR141C_d)|FD-Score:3.2|P-value:6.82E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YOL036W(YOL036W_p)|FD-Score:3.15|P-value:8.24E-4||SGD DESC:Protein of unknown function; potential Cdc28p substrate; YOL036W has a paralog, YIR016W, that arose from the whole genome duplication Gene:YOR170W(YOR170W_d)|FD-Score:3.79|P-value:7.67E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene LCB4 Gene:YOR283W(YOR283W)|FD-Score:-3.44|P-value:2.88E-4||SGD DESC:Phosphatase with a broad substrate specificity and some similarity to GPM1/YKL152C, a phosphoglycerate mutase; YOR283W is not an essential gene Gene:YPL229W(YPL229W_p)|FD-Score:3.21|P-value:6.60E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; not an essential gene; YPL229W has a paralog, YMR181C, that arose from the whole genome duplication

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YDR356W4.151.65E-50.48SPC110Inner plaque spindle pole body (SPB) component, ortholog of human kendrin; involved in connecting nuclear microtubules to SPB; interacts with Tub4p-complex and calmodulin; phosphorylated by Mps1p in cell cycle-dependent manner
YDR324C3.671.21E-40.02UTP4Subunit of U3-containing 90S preribosome and Small Subunit (SSU) processome complexes involved in production of 18S rRNA and assembly of small ribosomal subunit; member of t-Utp subcomplex involved with transcription of 35S rRNA transcript
YER021W3.651.31E-40.20RPN3Essential, non-ATPase regulatory subunit of the 26S proteasome lid, similar to the p58 subunit of the human 26S proteasome; temperature-sensitive alleles cause metaphase arrest, suggesting a role for the proteasome in cell cycle control
YOR174W3.452.85E-40.01MED4Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
YOR048C3.442.92E-40.15RAT1Nuclear 5' to 3' single-stranded RNA exonuclease, involved in RNA metabolism, including rRNA and snRNA processing as well as poly (A+) dependent and independent mRNA transcription termination
YGR158C3.295.10E-40.17MTR3Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hMtr3p (EXOSC6)
YOR217W3.119.20E-40.09RFC1Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon
YIL126W3.030.001220.12STH1ATPase component of the RSC chromatin remodeling complex; required for expression of early meiotic genes; essential helicase-related protein homologous to Snf2p
YGL091C2.910.001780.07NBP35Essential iron-sulfur cluster binding protein localized in the cytoplasm; forms a complex with Cfd1p that is involved in iron-sulfur protein assembly in the cytosol; similar to P-loop NTPases
YNL113W2.840.002230.04RPC19RNA polymerase subunit AC19, common to RNA polymerases I and III
YLR198C_d2.810.002500.02YLR198C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene SIK1/YLR197W
YLR076C_d2.780.002690.04YLR076C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential gene RPL10 which encodes the ribosomal protein L10
YOR210W2.740.003060.06RPB10RNA polymerase subunit ABC10-beta, common to RNA polymerases I, II, and III
YJL069C2.680.003640.01UTP18Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data
YFR042W2.680.003730.02KEG1Integral membrane protein of the ER; physically interacts with Kre6p; has a role in the synthesis of beta-1,6-glucan in the cell wall; required for cell viability

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YFR056C_d7.106.42E-13YFR056C_dDubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W
YGL186C5.571.31E-8TPN1Plasma membrane pyridoxine (vitamin B6) transporter; member of the purine-cytosine permease subfamily within the major facilitator superfamily; proton symporter with similarity to Fcy21p, Fcy2p, and Fcy22p
YGR137W_d5.373.93E-8YGR137W_dDubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YCR087W_d4.817.55E-7YCR087W_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized gene YCR087C-A; YCR087W is not an essential gene
YJL007C_d4.612.00E-6YJL007C_dDubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGL090W4.444.54E-6LIF1Component of the DNA ligase IV complex that mediates nonhomologous end joining in DNA double-strand break repair; physically interacts with Dnl4p and Nej1p; homologous to mammalian XRCC4 protein
YOL067C4.201.34E-5RTG1Transcription factor (bHLH) involved in interorganelle communication between mitochondria, peroxisomes, and nucleus
YOR096W4.191.40E-5RPS7AProtein component of the small (40S) ribosomal subunit; interacts with Kti11p; deletion causes hypersensitivity to zymocin; homologous to mammalian ribosomal protein S7, no bacterial homolog; RPS7A has a paralog, RPS7B, that arose from the whole genome duplication
YOR067C4.161.62E-5ALG8Glucosyl transferase, involved in N-linked glycosylation; adds glucose to the dolichol-linked oligosaccharide precursor prior to transfer to protein during lipid-linked oligosaccharide biosynthesis; similar to Alg6p
YER150W4.151.64E-5SPI1GPI-anchored cell wall protein involved in weak acid resistance; basal expression requires Msn2p/Msn4p; expression is induced under conditions of stress and during the diauxic shift; similar to Sed1p
YER152C4.102.09E-5YER152CProtein with 2-aminoadipate transaminase activity; shares amino acid similarity with the aminotransferases Aro8p and Aro9p; YER152C is not an essential gene
YMR233W4.013.04E-5TRI1Non-essential sumoylated protein of unknown function; similar to components of human SWI/SNF complex including SMRD3; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm, nucleus and nucleolus; TRI1 has a paralog, UAF30, that arose from the whole genome duplication
YPL099C3.885.26E-5AIM43Protein of unknown function; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss
YOL083W3.875.48E-5ATG34Receptor protein involved in selective autophagy during starvation; specifically involved in the transport of cargo protein alpha-mannosidase (Ams1p); Atg19p paralog
YOR170W_d3.797.67E-5YOR170W_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene LCB4

GO enrichment analysis for SGTC_3352
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.0831.99E-10SGTC_30199081971 49.5 μMChembridge (Drug-like library)164518030.0952381
0.0691.04E-7SGTC_1740st038286 13.2 μMTimTec (Natural product derivative library)7167860.0779221
0.0672.12E-7SGTC_21535569715 200.0 μMChembridge (Fragment library)20547010.142857iron homeostasis
0.0622.20E-6SGTC_7192810-4230 27.3 μMChemDiv (Drug-like library)7210790.125
0.0612.36E-6SGTC_7181130-0073 349.0 μMChemDiv (Drug-like library)67400200.0625
0.0613.22E-6SGTC_5733702-0553 84.7 μMChemDiv (Drug-like library)12227560.126984
0.0595.64E-6SGTC_1974544-0043 41.6 μMChemDiv (Drug-like library)8965230.1endomembrane recycling
0.0571.02E-5SGTC_1979st071809 45.3 μMTimTec (Natural product derivative library)49763330.10989RPP1 & pyrimidine depletion
0.0542.81E-5SGTC_9373122-0005 46.7 μMChemDiv (Drug-like library)7595350.0512821
0.0527.19E-5SGTC_1977st070720 65.3 μMTimTec (Natural product derivative library)6821880.0731707
0.0518.42E-5SGTC_7881182-0090 188.0 μMChemDiv (Drug-like library)57151850.056338endomembrane recycling
0.0518.91E-5SGTC_33469158254 43.6 μMChembridge (Drug-like library)176395000.105263
0.0519.04E-5SGTC_21555570423 76.0 μMChembridge (Fragment library)7974020.115942ergosterol biosynthesis
0.0519.73E-5SGTC_1040074-0074 591.0 μMChemDiv (Drug-like library)39431240.103896
0.0501.14E-4SGTC_217ketoconazole 989.0 nMMiscellaneous4562010.125ergosterol depletion effects on membrane

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_3309912934025.76 μM0.64285717158987Chembridge (Drug-like library)424.192084.98833
SGTC_3218913128549.47 μM0.52727317156417Chembridge (Drug-like library)304.1873434.33723endomembrane recycling
SGTC_2991907466971.43 μM0.46774217333109Chembridge (Drug-like library)353.2182034.25924azole & statin
SGTC_2990907410571.43 μM0.3382356502001Chembridge (Drug-like library)288.732223.66624
SGTC_3001907604171.43 μM0.33823516004211Chembridge (Drug-like library)289.720283.73425
SGTC_3018908260249.47 μM0.30158717332089Chembridge (Drug-like library)335.227743.83823
SGTC_23599039622200 μM0.2833336463596Chembridge (Fragment library)241.6891232.94623endomembrane recycling
SGTC_294790726397.68 μM0.26315816488146Chembridge (Drug-like library)314.7398432.08415tubulin folding & SWR complex
SGTC_2944906734625.62 μM0.2615386473075Chembridge (Drug-like library)324.20184.1723
SGTC_2950907289521.46 μM0.26153817332245Chembridge (Drug-like library)379.678743.92223