9151644

N-(5,6-dimethyl-3-phenylpyrazolo[1,5-a]pyrimidin-7-yl)-N',N'-dimethylethane-1,2-diamine

[PubChem] [DrugBank] [Wikipedia] [WikiGenes] [ChEMBL] [ChemSpider] 



Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_3353
Screen concentration 39.3 μM
Source Chembridge (Drug-like library)
PubChem CID 4909158
SMILES CC1=C(N2C(=C(C=N2)C3=CC=CC=C3)N=C1C)NCCN(C)C
Standardized SMILES CN(C)CCNc1c(C)c(C)nc2c(cnn12)c3ccccc3
Molecular weight 309.4087
ALogP 2.88
H-bond donor count 1
H-bond acceptor count 4
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 18.9
% growth inhibition (Hom. pool) 11.76


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 4909158
Download HIP data (tab-delimited text)  (excel)
Gene:BRN1(YBL097W)|FD-Score:3.11|P-value:9.36E-4|Clearance:0.13||SGD DESC:Subunit of the condensin complex; required for chromosome condensation and for clustering of tRNA genes at the nucleolus; may influence multiple aspects of chromosome transmission Gene:CAB2(YIL083C)|FD-Score:3.14|P-value:8.53E-4|Clearance:0.03||SGD DESC:Probable phosphopantothenoylcysteine synthetase (PPCS), which catalyzes the second step of coenzyme A biosynthesis from pantothenate; null mutant lethality is complemented by E. coli coaBC (encoding a bifunctional enzyme with PPCS activity) Gene:GPI13(YLL031C)|FD-Score:-3.4|P-value:3.33E-4|Clearance:0||SGD DESC:ER membrane localized phosphoryltransferase that adds phosphoethanolamine onto the third mannose residue of the glycosylphosphatidylinositol (GPI) anchor precursor; similar to human PIG-O protein Gene:ISD11(YER048W-A)|FD-Score:3.37|P-value:3.76E-4|Clearance:0.04||SGD DESC:Cysteine desulfurase (Nfs1p) activator; essential for the formation of the persulfide intermediate at the desulfurase active site during pyridoxal phosphate-dependent desulfuration of cysteine; required for mitochondrial iron-sulfur cluster biosynthesis Gene:LSM3(YLR438C-A)|FD-Score:3.39|P-value:3.49E-4|Clearance:0.02||SGD DESC:Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; protein increases in abundance and relocalizes from nucleus to cytoplasmic foci upon DNA replication stress Gene:PRE1(YER012W)|FD-Score:-3.72|P-value:1.01E-4|Clearance:0||SGD DESC:Beta 4 subunit of the 20S proteasome; localizes to the nucleus throughout the cell cycle Gene:RPL25(YOL127W)|FD-Score:-3.23|P-value:6.14E-4|Clearance:0||SGD DESC:Ribosomal 60S subunit protein L25; primary rRNA-binding ribosomal protein component of large ribosomal subunit; binds to 25S rRNA via a conserved C-terminal motif; homologous to mammalian ribosomal protein L23A and bacterial L23 Gene:RPO31(YOR116C)|FD-Score:5.65|P-value:8.18E-9|Clearance:1.59||SGD DESC:RNA polymerase III largest subunit C160, part of core enzyme; similar to bacterial beta-prime subunit and to RPA190 and RPO21 Gene:SRP101(YDR292C)|FD-Score:4.06|P-value:2.47E-5|Clearance:0.43||SGD DESC:Signal recognition particle (SRP) receptor alpha subunit; contain GTPase domains; involved in SRP-dependent protein targeting; interacts with the beta subunit, Srp102p Gene:SRP54(YPR088C)|FD-Score:3.51|P-value:2.26E-4|Clearance:0.12||SGD DESC:Signal recognition particle (SRP) subunit (homolog of mammalian SRP54); contains the signal sequence-binding activity of SRP, interacts with the SRP RNA, and mediates binding of SRP to signal receptor; contains GTPase domain Gene:SSC1(YJR045C)|FD-Score:3.62|P-value:1.45E-4|Clearance:0.12||SGD DESC:Hsp70 family ATPase; constituent of the import motor component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); involved in protein translocation and folding; subunit of SceI endonuclease; SSC1 has a paralog, ECM10, that arose from the whole genome duplication Gene:SWD2(YKL018W)|FD-Score:-3.21|P-value:6.69E-4|Clearance:0||SGD DESC:Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lys 4 and is involved in telomeric silencing; subunit of CPF (cleavage and polyadenylation factor), a complex involved in RNAP II transcription termination Gene:TIM23(YNR017W)|FD-Score:3.33|P-value:4.39E-4|Clearance:0.19||SGD DESC:Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); involved in protein import into mitochondrial matrix and inner membrane; with Tim17p, contributes to architecture and function of the import channel Gene:UTP15(YMR093W)|FD-Score:-3.45|P-value:2.84E-4|Clearance:0||SGD DESC:Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA Gene:BRN1(YBL097W)|FD-Score:3.11|P-value:9.36E-4|Clearance:0.13||SGD DESC:Subunit of the condensin complex; required for chromosome condensation and for clustering of tRNA genes at the nucleolus; may influence multiple aspects of chromosome transmission Gene:CAB2(YIL083C)|FD-Score:3.14|P-value:8.53E-4|Clearance:0.03||SGD DESC:Probable phosphopantothenoylcysteine synthetase (PPCS), which catalyzes the second step of coenzyme A biosynthesis from pantothenate; null mutant lethality is complemented by E. coli coaBC (encoding a bifunctional enzyme with PPCS activity) Gene:GPI13(YLL031C)|FD-Score:-3.4|P-value:3.33E-4|Clearance:0||SGD DESC:ER membrane localized phosphoryltransferase that adds phosphoethanolamine onto the third mannose residue of the glycosylphosphatidylinositol (GPI) anchor precursor; similar to human PIG-O protein Gene:ISD11(YER048W-A)|FD-Score:3.37|P-value:3.76E-4|Clearance:0.04||SGD DESC:Cysteine desulfurase (Nfs1p) activator; essential for the formation of the persulfide intermediate at the desulfurase active site during pyridoxal phosphate-dependent desulfuration of cysteine; required for mitochondrial iron-sulfur cluster biosynthesis Gene:LSM3(YLR438C-A)|FD-Score:3.39|P-value:3.49E-4|Clearance:0.02||SGD DESC:Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; protein increases in abundance and relocalizes from nucleus to cytoplasmic foci upon DNA replication stress Gene:PRE1(YER012W)|FD-Score:-3.72|P-value:1.01E-4|Clearance:0||SGD DESC:Beta 4 subunit of the 20S proteasome; localizes to the nucleus throughout the cell cycle Gene:RPL25(YOL127W)|FD-Score:-3.23|P-value:6.14E-4|Clearance:0||SGD DESC:Ribosomal 60S subunit protein L25; primary rRNA-binding ribosomal protein component of large ribosomal subunit; binds to 25S rRNA via a conserved C-terminal motif; homologous to mammalian ribosomal protein L23A and bacterial L23 Gene:RPO31(YOR116C)|FD-Score:5.65|P-value:8.18E-9|Clearance:1.59||SGD DESC:RNA polymerase III largest subunit C160, part of core enzyme; similar to bacterial beta-prime subunit and to RPA190 and RPO21 Gene:SRP101(YDR292C)|FD-Score:4.06|P-value:2.47E-5|Clearance:0.43||SGD DESC:Signal recognition particle (SRP) receptor alpha subunit; contain GTPase domains; involved in SRP-dependent protein targeting; interacts with the beta subunit, Srp102p Gene:SRP54(YPR088C)|FD-Score:3.51|P-value:2.26E-4|Clearance:0.12||SGD DESC:Signal recognition particle (SRP) subunit (homolog of mammalian SRP54); contains the signal sequence-binding activity of SRP, interacts with the SRP RNA, and mediates binding of SRP to signal receptor; contains GTPase domain Gene:SSC1(YJR045C)|FD-Score:3.62|P-value:1.45E-4|Clearance:0.12||SGD DESC:Hsp70 family ATPase; constituent of the import motor component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); involved in protein translocation and folding; subunit of SceI endonuclease; SSC1 has a paralog, ECM10, that arose from the whole genome duplication Gene:SWD2(YKL018W)|FD-Score:-3.21|P-value:6.69E-4|Clearance:0||SGD DESC:Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lys 4 and is involved in telomeric silencing; subunit of CPF (cleavage and polyadenylation factor), a complex involved in RNAP II transcription termination Gene:TIM23(YNR017W)|FD-Score:3.33|P-value:4.39E-4|Clearance:0.19||SGD DESC:Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); involved in protein import into mitochondrial matrix and inner membrane; with Tim17p, contributes to architecture and function of the import channel Gene:UTP15(YMR093W)|FD-Score:-3.45|P-value:2.84E-4|Clearance:0||SGD DESC:Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 4909158
Download HOP data (tab-delimited text)  (excel)
Gene:ASI2(YNL159C)|FD-Score:-3.35|P-value:4.08E-4||SGD DESC:Integral inner nuclear membrane protein that acts with Asi1p and Asi3p to ensure the fidelity of SPS-sensor signalling by maintaining the dormant repressed state of gene expression in the absence of inducing signals Gene:ATG22(YCL038C)|FD-Score:3.84|P-value:6.11E-5||SGD DESC:Vacuolar integral membrane protein required for efflux of amino acids during autophagic body breakdown in the vacuole; null mutation causes a gradual loss of viability during starvation Gene:CDC50(YCR094W)|FD-Score:5.05|P-value:2.19E-7||SGD DESC:Endosomal protein that interacts with phospholipid flippase Drs2p; interaction with Cdc50p is essential for Drs2p catalytic activity; mutations affect cell polarity and polarized growth; similar to Lem3p; CDC50 has a paralog, YNR048W, that arose from the whole genome duplication Gene:COG1(YGL223C)|FD-Score:-4.28|P-value:9.46E-6||SGD DESC:Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:COQ5(YML110C)|FD-Score:3.27|P-value:5.47E-4||SGD DESC:2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase, involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes Gene:CRF1(YDR223W)|FD-Score:3.41|P-value:3.25E-4||SGD DESC:Transcriptional corepressor involved in repression of ribosomal protein (RP) gene transcription via the TOR signaling pathway which promotes accumulation of Crf1p in the nucleus; role in repression of RP genes varies by strain Gene:DAL1(YIR027C)|FD-Score:3.74|P-value:9.33E-5||SGD DESC:Allantoinase, converts allantoin to allantoate in the first step of allantoin degradation; expression sensitive to nitrogen catabolite repression Gene:DMC1(YER179W)|FD-Score:4.69|P-value:1.35E-6||SGD DESC:Meiosis-specific protein required for repair of double-strand breaks and pairing between homologous chromosomes; homolog of Rad51p and the bacterial RecA protein; binds ssDNA and dsDNA, forms helical filaments; stimulated by Rdh54p Gene:ECM14(YHR132C)|FD-Score:3.67|P-value:1.24E-4||SGD DESC:Putative metalloprotease with similarity to the zinc carboxypeptidase family, required for normal cell wall assembly Gene:ECM19(YLR390W)|FD-Score:-4.28|P-value:9.18E-6||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:ECM31(YBR176W)|FD-Score:3.09|P-value:9.86E-4||SGD DESC:Ketopantoate hydroxymethyltransferase, required for pantothenic acid biosynthesis, converts 2-oxoisovalerate into 2-dehydropantoate Gene:EOS1(YNL080C)|FD-Score:3.95|P-value:3.86E-5||SGD DESC:Protein involved in N-glycosylation; deletion mutation confers sensitivity to exidative stress and shows synthetic lethality with mutations in the spindle checkpoint genes BUB3 and MAD1; YNL080C is not an essential gene Gene:ERP1(YAR002C-A)|FD-Score:3.18|P-value:7.31E-4||SGD DESC:Member of the p24 family involved in ER to Golgi transport; forms heterotrimeric complex with Erp2p, Emp24p, and Erv25p; localized to COPII-coated vesicles; ERP1 has a paralog, ERP6, that arose from the whole genome duplication Gene:FCJ1(YKR016W)|FD-Score:3.12|P-value:8.98E-4||SGD DESC:Mitochondrial inner membrane protein, ortholog of mammalian mitofilin; involved in import of intermembrane space (IMS) proteins, probably by positioning Mia40p relative to the TOM complex to receive incoming proteins; also has an essential role in the maintenance of crista junctions and inner membrane architecture, as a component of the mitochondrial inner membrane organizing system (MICOS, MitOS or MINOS), a scaffold-like structure on the IMS side of the inner membrane Gene:GET3(YDL100C)|FD-Score:-3.88|P-value:5.32E-5||SGD DESC:Guanine nucleotide exchange factor for Gpa1p; amplifies G protein signaling; subunit of the GET complex, which is involved in Golgi to ER trafficking and insertion of proteins into the ER membrane; has low-level ATPase activity; protein abundance increases in response to DNA replication stress Gene:GIT1(YCR098C)|FD-Score:3.76|P-value:8.61E-5||SGD DESC:Plasma membrane permease, mediates uptake of glycerophosphoinositol and glycerophosphocholine as sources of the nutrients inositol and phosphate; expression and transport rate are regulated by phosphate and inositol availability Gene:GRE1(YPL223C)|FD-Score:4|P-value:3.18E-5||SGD DESC:Hydrophilin essential in dessication-rehydration process; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway Gene:GUP1(YGL084C)|FD-Score:3.59|P-value:1.68E-4||SGD DESC:Plasma membrane protein involved in remodeling GPI anchors; member of the MBOAT family of putative membrane-bound O-acyltransferases; proposed to be involved in glycerol transport Gene:HOM6(YJR139C)|FD-Score:5.07|P-value:2.02E-7||SGD DESC:Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase), dimeric enzyme that catalyzes the third step in the common pathway for methionine and threonine biosynthesis; enzyme has nucleotide-binding, dimerization and catalytic regions Gene:IFM1(YOL023W)|FD-Score:3.55|P-value:1.90E-4||SGD DESC:Mitochondrial translation initiation factor 2 Gene:IKI3(YLR384C)|FD-Score:3.42|P-value:3.15E-4||SGD DESC:Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; maintains structural integrity of Elongator; homolog of human IKAP, mutations in which cause familial dysautonomia (FD) Gene:IRC11(YOR013W_d)|FD-Score:3.36|P-value:3.87E-4||SGD DESC:Dubious opening reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YOR012C; null mutant displays increased levels of spontaneous Rad52 foci Gene:LDB18(YLL049W)|FD-Score:3.21|P-value:6.71E-4||SGD DESC:Component of the dynactin complex, which is required for dynein activity; null mutant exhibits defects in nuclear migration and spindle orientation and has reduced affinity for alcian blue dye; has homology to mammalian dynactin subunit p24 Gene:MSN2(YMR037C)|FD-Score:3.5|P-value:2.34E-4||SGD DESC:Transcriptional activator; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of responsive genes, inducing gene expression; MSN2 has a paralog, MSN4, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress Gene:MSS18(YPR134W)|FD-Score:4.12|P-value:1.88E-5||SGD DESC:Nuclear encoded protein needed for efficient splicing of mitochondrial COX1 aI5beta intron; mss18 mutations block cleavage of 5' exon - intron junction; phenotype of intronless strain suggests additional functions Gene:MTQ1(YNL063W)|FD-Score:3.67|P-value:1.23E-4||SGD DESC:S-adenosylmethionine-dependent methyltransferase; methylates translational release factor Mrf1p; similar to E.coli PrmC; is not an essential gene Gene:MUK1(YPL070W)|FD-Score:-4.1|P-value:2.08E-5||SGD DESC:Cytoplasmic protein of unknown function containing a Vps9 domain; computational analysis of large-scale protein-protein interaction data suggests a possible role in transcriptional regulation Gene:NMA111(YNL123W)|FD-Score:5.72|P-value:5.46E-9||SGD DESC:Serine protease and general molecular chaperone; involved in response to heat stress and promotion of apoptosis; may contribute to lipid homeostasis; sequence similarity to the mammalian Omi/HtrA2 family of serine proteases Gene:PRM10(YJL108C)|FD-Score:3.24|P-value:5.99E-4||SGD DESC:Pheromone-regulated protein, proposed to be involved in mating; predicted to have 5 transmembrane segments; induced by treatment with 8-methoxypsoralen and UVA irradiation Gene:PXL1(YKR090W)|FD-Score:4.1|P-value:2.10E-5||SGD DESC:Protein that localizes to sites of polarized growth; required for selection and/or maintenance of polarized growth sites, may modulate signaling by the GTPases Cdc42p and Rho1p; contains LIM domains and has similarity to metazoan paxillin; relocalizes from bud neck to cytoplasm upon DNA replication stress Gene:RCN1(YKL159C)|FD-Score:3.16|P-value:7.90E-4||SGD DESC:Protein involved in calcineurin regulation during calcium signaling; has similarity to H. sapiens DSCR1 which is found in the Down Syndrome candidate region Gene:RCY1(YJL204C)|FD-Score:5.98|P-value:1.12E-9||SGD DESC:F-box protein involved in recycling plasma membrane proteins internalized by endocytosis; localized to sites of polarized growth Gene:RPL22A(YLR061W)|FD-Score:3.5|P-value:2.30E-4||SGD DESC:Ribosomal 60S subunit protein L22A; required for the oxidative stress response in yeast; homologous to mammalian ribosomal protein L22, no bacterial homolog; RPL22A has a paralog, RPL22B, that arose from the whole genome duplication Gene:RPN4(YDL020C)|FD-Score:-4.57|P-value:2.43E-6||SGD DESC:Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses; relative distribution to the nucleus increases upon DNA replication stress Gene:RPS29A(YLR388W)|FD-Score:3.26|P-value:5.52E-4||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S29 and bacterial S14; RPS29A has a paralog, RPS29B, that arose from the whole genome duplication Gene:RTR1(YER139C)|FD-Score:-4.24|P-value:1.11E-5||SGD DESC:CTD phosphatase; dephosphorylates S5-P in the C-terminal domain of Rpo21p; has a cysteine-rich motif required for function and conserved in eukaryotes; shuttles between the nucleus and cytoplasm; RTR1 has a paralog, RTR2, that arose from the whole genome duplication Gene:SED1(YDR077W)|FD-Score:3.41|P-value:3.22E-4||SGD DESC:Major stress-induced structural GPI-cell wall glycoprotein in stationary-phase cells, associates with translating ribosomes, possible role in mitochondrial genome maintenance; ORF contains two distinct variable minisatellites Gene:SLZ1(YNL196C_p)|FD-Score:-3.71|P-value:1.03E-4||SGD DESC:Sporulation-specific protein with a leucine zipper motif Gene:SNU66(YOR308C)|FD-Score:3.37|P-value:3.80E-4||SGD DESC:Component of the U4/U6.U5 snRNP complex involved in pre-mRNA splicing via spliceosome; also required for pre-5S rRNA processing and may act in concert with Rnh70p; has homology to human SART-1 Gene:TRM2(YKR056W)|FD-Score:3.45|P-value:2.85E-4||SGD DESC:tRNA methyltransferase, 5-methylates the uridine residue at position 54 of tRNAs and may also have a role in tRNA stabilization or maturation; endo-exonuclease with a role in DNA repair Gene:YAR029W(YAR029W_p)|FD-Score:3.23|P-value:6.19E-4||SGD DESC:Member of DUP240 gene family but contains no transmembrane domains; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern Gene:YBR072C-A(YBR072C-A_p)|FD-Score:3.09|P-value:9.90E-4||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR Gene:YBR138C(YBR138C_p)|FD-Score:3.59|P-value:1.64E-4||SGD DESC:Cytoplasmic protein of unknown function, potentially phosphorylated by Cdc28p; YBR138C is not an essential gene Gene:YGL015C(YGL015C_p)|FD-Score:3.21|P-value:6.72E-4||SGD DESC:Putative protein of unknown function; null mutants accumulate cargo in the Golgi Gene:YGR151C(YGR151C_d)|FD-Score:-3.36|P-value:3.96E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF RSR1/BUD1/YGR152C; relative distribution to the nucleus increases upon DNA replication stress Gene:YHP1(YDR451C)|FD-Score:4.47|P-value:3.87E-6||SGD DESC:Homeobox transcriptional repressor; binds Mcm1p and early cell cycle box (ECB) elements of cell cycle regulated genes, thereby restricting ECB-mediated transcription to the M/G1 interval; YHP1 has a paralog, YOX1, that arose from the whole genome duplication Gene:YHR182W(YHR182W_p)|FD-Score:4.57|P-value:2.38E-6||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and cytoplasm; relocalizes from bud neck to cytoplasm upon DNA replication stress Gene:YJR111C(YJR111C_p)|FD-Score:-3.25|P-value:5.76E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondria Gene:YLL044W(YLL044W_d)|FD-Score:3.74|P-value:9.09E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcription of both YLL044W and the overlapping gene RPL8B is reduced in the gcr1 null mutant Gene:YMR141C(YMR141C_d)|FD-Score:3.3|P-value:4.79E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YMR158W-B(YMR158W-B_d)|FD-Score:-3.87|P-value:5.52E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene ATG16/YMR159C Gene:YMR31(YFR049W)|FD-Score:-3.9|P-value:4.83E-5||SGD DESC:Mitochondrial ribosomal protein of the small subunit, has similarity to human mitochondrial ribosomal protein MRP-S36 Gene:YNR062C(YNR062C_p)|FD-Score:-3.59|P-value:1.63E-4||SGD DESC:Putative membrane protein of unknown function Gene:YNR073C(YNR073C_p)|FD-Score:6.36|P-value:9.77E-11||SGD DESC:Putative mannitol dehydrogenase; identical in amino acid sequence to Dsf1p Gene:YOR338W(YOR338W_p)|FD-Score:-4.33|P-value:7.34E-6||SGD DESC:Putative protein of unknown function; YOR338W transcription is regulated by Azf1p and its transcript is a specific target of the G protein effector Scp160p; identified as being required for sporulation in a high-throughput mutant screen; YOR338W has a paralog, FUN19, that arose from the whole genome duplication Gene:YPR098C(YPR098C)|FD-Score:3.27|P-value:5.44E-4||SGD DESC:Protein of unknown function, localized to the mitochondrial outer membrane Gene:YPR108W-A(YPR108W-A_p)|FD-Score:3.44|P-value:2.92E-4||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR Gene:YPS1(YLR120C)|FD-Score:3.9|P-value:4.71E-5||SGD DESC:Aspartic protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor Gene:YPT31(YER031C)|FD-Score:3.55|P-value:1.92E-4||SGD DESC:Rab family GTPase; involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi; YPT31 has a paralog, YPT32, that arose from the whole genome duplication Gene:YPT6(YLR262C)|FD-Score:-3.88|P-value:5.17E-5||SGD DESC:Rab family GTPase, Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi, maturation of the vacuolar carboxypeptidase Y; has similarity to the human GTPase, Rab6 Gene:YTP1(YNL237W)|FD-Score:-3.39|P-value:3.48E-4||SGD DESC:Probable type-III integral membrane protein of unknown function, has regions of similarity to mitochondrial electron transport proteins Gene:ASI2(YNL159C)|FD-Score:-3.35|P-value:4.08E-4||SGD DESC:Integral inner nuclear membrane protein that acts with Asi1p and Asi3p to ensure the fidelity of SPS-sensor signalling by maintaining the dormant repressed state of gene expression in the absence of inducing signals Gene:ATG22(YCL038C)|FD-Score:3.84|P-value:6.11E-5||SGD DESC:Vacuolar integral membrane protein required for efflux of amino acids during autophagic body breakdown in the vacuole; null mutation causes a gradual loss of viability during starvation Gene:CDC50(YCR094W)|FD-Score:5.05|P-value:2.19E-7||SGD DESC:Endosomal protein that interacts with phospholipid flippase Drs2p; interaction with Cdc50p is essential for Drs2p catalytic activity; mutations affect cell polarity and polarized growth; similar to Lem3p; CDC50 has a paralog, YNR048W, that arose from the whole genome duplication Gene:COG1(YGL223C)|FD-Score:-4.28|P-value:9.46E-6||SGD DESC:Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:COQ5(YML110C)|FD-Score:3.27|P-value:5.47E-4||SGD DESC:2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase, involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes Gene:CRF1(YDR223W)|FD-Score:3.41|P-value:3.25E-4||SGD DESC:Transcriptional corepressor involved in repression of ribosomal protein (RP) gene transcription via the TOR signaling pathway which promotes accumulation of Crf1p in the nucleus; role in repression of RP genes varies by strain Gene:DAL1(YIR027C)|FD-Score:3.74|P-value:9.33E-5||SGD DESC:Allantoinase, converts allantoin to allantoate in the first step of allantoin degradation; expression sensitive to nitrogen catabolite repression Gene:DMC1(YER179W)|FD-Score:4.69|P-value:1.35E-6||SGD DESC:Meiosis-specific protein required for repair of double-strand breaks and pairing between homologous chromosomes; homolog of Rad51p and the bacterial RecA protein; binds ssDNA and dsDNA, forms helical filaments; stimulated by Rdh54p Gene:ECM14(YHR132C)|FD-Score:3.67|P-value:1.24E-4||SGD DESC:Putative metalloprotease with similarity to the zinc carboxypeptidase family, required for normal cell wall assembly Gene:ECM19(YLR390W)|FD-Score:-4.28|P-value:9.18E-6||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:ECM31(YBR176W)|FD-Score:3.09|P-value:9.86E-4||SGD DESC:Ketopantoate hydroxymethyltransferase, required for pantothenic acid biosynthesis, converts 2-oxoisovalerate into 2-dehydropantoate Gene:EOS1(YNL080C)|FD-Score:3.95|P-value:3.86E-5||SGD DESC:Protein involved in N-glycosylation; deletion mutation confers sensitivity to exidative stress and shows synthetic lethality with mutations in the spindle checkpoint genes BUB3 and MAD1; YNL080C is not an essential gene Gene:ERP1(YAR002C-A)|FD-Score:3.18|P-value:7.31E-4||SGD DESC:Member of the p24 family involved in ER to Golgi transport; forms heterotrimeric complex with Erp2p, Emp24p, and Erv25p; localized to COPII-coated vesicles; ERP1 has a paralog, ERP6, that arose from the whole genome duplication Gene:FCJ1(YKR016W)|FD-Score:3.12|P-value:8.98E-4||SGD DESC:Mitochondrial inner membrane protein, ortholog of mammalian mitofilin; involved in import of intermembrane space (IMS) proteins, probably by positioning Mia40p relative to the TOM complex to receive incoming proteins; also has an essential role in the maintenance of crista junctions and inner membrane architecture, as a component of the mitochondrial inner membrane organizing system (MICOS, MitOS or MINOS), a scaffold-like structure on the IMS side of the inner membrane Gene:GET3(YDL100C)|FD-Score:-3.88|P-value:5.32E-5||SGD DESC:Guanine nucleotide exchange factor for Gpa1p; amplifies G protein signaling; subunit of the GET complex, which is involved in Golgi to ER trafficking and insertion of proteins into the ER membrane; has low-level ATPase activity; protein abundance increases in response to DNA replication stress Gene:GIT1(YCR098C)|FD-Score:3.76|P-value:8.61E-5||SGD DESC:Plasma membrane permease, mediates uptake of glycerophosphoinositol and glycerophosphocholine as sources of the nutrients inositol and phosphate; expression and transport rate are regulated by phosphate and inositol availability Gene:GRE1(YPL223C)|FD-Score:4|P-value:3.18E-5||SGD DESC:Hydrophilin essential in dessication-rehydration process; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway Gene:GUP1(YGL084C)|FD-Score:3.59|P-value:1.68E-4||SGD DESC:Plasma membrane protein involved in remodeling GPI anchors; member of the MBOAT family of putative membrane-bound O-acyltransferases; proposed to be involved in glycerol transport Gene:HOM6(YJR139C)|FD-Score:5.07|P-value:2.02E-7||SGD DESC:Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase), dimeric enzyme that catalyzes the third step in the common pathway for methionine and threonine biosynthesis; enzyme has nucleotide-binding, dimerization and catalytic regions Gene:IFM1(YOL023W)|FD-Score:3.55|P-value:1.90E-4||SGD DESC:Mitochondrial translation initiation factor 2 Gene:IKI3(YLR384C)|FD-Score:3.42|P-value:3.15E-4||SGD DESC:Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; maintains structural integrity of Elongator; homolog of human IKAP, mutations in which cause familial dysautonomia (FD) Gene:IRC11(YOR013W_d)|FD-Score:3.36|P-value:3.87E-4||SGD DESC:Dubious opening reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YOR012C; null mutant displays increased levels of spontaneous Rad52 foci Gene:LDB18(YLL049W)|FD-Score:3.21|P-value:6.71E-4||SGD DESC:Component of the dynactin complex, which is required for dynein activity; null mutant exhibits defects in nuclear migration and spindle orientation and has reduced affinity for alcian blue dye; has homology to mammalian dynactin subunit p24 Gene:MSN2(YMR037C)|FD-Score:3.5|P-value:2.34E-4||SGD DESC:Transcriptional activator; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of responsive genes, inducing gene expression; MSN2 has a paralog, MSN4, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress Gene:MSS18(YPR134W)|FD-Score:4.12|P-value:1.88E-5||SGD DESC:Nuclear encoded protein needed for efficient splicing of mitochondrial COX1 aI5beta intron; mss18 mutations block cleavage of 5' exon - intron junction; phenotype of intronless strain suggests additional functions Gene:MTQ1(YNL063W)|FD-Score:3.67|P-value:1.23E-4||SGD DESC:S-adenosylmethionine-dependent methyltransferase; methylates translational release factor Mrf1p; similar to E.coli PrmC; is not an essential gene Gene:MUK1(YPL070W)|FD-Score:-4.1|P-value:2.08E-5||SGD DESC:Cytoplasmic protein of unknown function containing a Vps9 domain; computational analysis of large-scale protein-protein interaction data suggests a possible role in transcriptional regulation Gene:NMA111(YNL123W)|FD-Score:5.72|P-value:5.46E-9||SGD DESC:Serine protease and general molecular chaperone; involved in response to heat stress and promotion of apoptosis; may contribute to lipid homeostasis; sequence similarity to the mammalian Omi/HtrA2 family of serine proteases Gene:PRM10(YJL108C)|FD-Score:3.24|P-value:5.99E-4||SGD DESC:Pheromone-regulated protein, proposed to be involved in mating; predicted to have 5 transmembrane segments; induced by treatment with 8-methoxypsoralen and UVA irradiation Gene:PXL1(YKR090W)|FD-Score:4.1|P-value:2.10E-5||SGD DESC:Protein that localizes to sites of polarized growth; required for selection and/or maintenance of polarized growth sites, may modulate signaling by the GTPases Cdc42p and Rho1p; contains LIM domains and has similarity to metazoan paxillin; relocalizes from bud neck to cytoplasm upon DNA replication stress Gene:RCN1(YKL159C)|FD-Score:3.16|P-value:7.90E-4||SGD DESC:Protein involved in calcineurin regulation during calcium signaling; has similarity to H. sapiens DSCR1 which is found in the Down Syndrome candidate region Gene:RCY1(YJL204C)|FD-Score:5.98|P-value:1.12E-9||SGD DESC:F-box protein involved in recycling plasma membrane proteins internalized by endocytosis; localized to sites of polarized growth Gene:RPL22A(YLR061W)|FD-Score:3.5|P-value:2.30E-4||SGD DESC:Ribosomal 60S subunit protein L22A; required for the oxidative stress response in yeast; homologous to mammalian ribosomal protein L22, no bacterial homolog; RPL22A has a paralog, RPL22B, that arose from the whole genome duplication Gene:RPN4(YDL020C)|FD-Score:-4.57|P-value:2.43E-6||SGD DESC:Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses; relative distribution to the nucleus increases upon DNA replication stress Gene:RPS29A(YLR388W)|FD-Score:3.26|P-value:5.52E-4||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S29 and bacterial S14; RPS29A has a paralog, RPS29B, that arose from the whole genome duplication Gene:RTR1(YER139C)|FD-Score:-4.24|P-value:1.11E-5||SGD DESC:CTD phosphatase; dephosphorylates S5-P in the C-terminal domain of Rpo21p; has a cysteine-rich motif required for function and conserved in eukaryotes; shuttles between the nucleus and cytoplasm; RTR1 has a paralog, RTR2, that arose from the whole genome duplication Gene:SED1(YDR077W)|FD-Score:3.41|P-value:3.22E-4||SGD DESC:Major stress-induced structural GPI-cell wall glycoprotein in stationary-phase cells, associates with translating ribosomes, possible role in mitochondrial genome maintenance; ORF contains two distinct variable minisatellites Gene:SLZ1(YNL196C_p)|FD-Score:-3.71|P-value:1.03E-4||SGD DESC:Sporulation-specific protein with a leucine zipper motif Gene:SNU66(YOR308C)|FD-Score:3.37|P-value:3.80E-4||SGD DESC:Component of the U4/U6.U5 snRNP complex involved in pre-mRNA splicing via spliceosome; also required for pre-5S rRNA processing and may act in concert with Rnh70p; has homology to human SART-1 Gene:TRM2(YKR056W)|FD-Score:3.45|P-value:2.85E-4||SGD DESC:tRNA methyltransferase, 5-methylates the uridine residue at position 54 of tRNAs and may also have a role in tRNA stabilization or maturation; endo-exonuclease with a role in DNA repair Gene:YAR029W(YAR029W_p)|FD-Score:3.23|P-value:6.19E-4||SGD DESC:Member of DUP240 gene family but contains no transmembrane domains; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern Gene:YBR072C-A(YBR072C-A_p)|FD-Score:3.09|P-value:9.90E-4||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR Gene:YBR138C(YBR138C_p)|FD-Score:3.59|P-value:1.64E-4||SGD DESC:Cytoplasmic protein of unknown function, potentially phosphorylated by Cdc28p; YBR138C is not an essential gene Gene:YGL015C(YGL015C_p)|FD-Score:3.21|P-value:6.72E-4||SGD DESC:Putative protein of unknown function; null mutants accumulate cargo in the Golgi Gene:YGR151C(YGR151C_d)|FD-Score:-3.36|P-value:3.96E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF RSR1/BUD1/YGR152C; relative distribution to the nucleus increases upon DNA replication stress Gene:YHP1(YDR451C)|FD-Score:4.47|P-value:3.87E-6||SGD DESC:Homeobox transcriptional repressor; binds Mcm1p and early cell cycle box (ECB) elements of cell cycle regulated genes, thereby restricting ECB-mediated transcription to the M/G1 interval; YHP1 has a paralog, YOX1, that arose from the whole genome duplication Gene:YHR182W(YHR182W_p)|FD-Score:4.57|P-value:2.38E-6||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and cytoplasm; relocalizes from bud neck to cytoplasm upon DNA replication stress Gene:YJR111C(YJR111C_p)|FD-Score:-3.25|P-value:5.76E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondria Gene:YLL044W(YLL044W_d)|FD-Score:3.74|P-value:9.09E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcription of both YLL044W and the overlapping gene RPL8B is reduced in the gcr1 null mutant Gene:YMR141C(YMR141C_d)|FD-Score:3.3|P-value:4.79E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YMR158W-B(YMR158W-B_d)|FD-Score:-3.87|P-value:5.52E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene ATG16/YMR159C Gene:YMR31(YFR049W)|FD-Score:-3.9|P-value:4.83E-5||SGD DESC:Mitochondrial ribosomal protein of the small subunit, has similarity to human mitochondrial ribosomal protein MRP-S36 Gene:YNR062C(YNR062C_p)|FD-Score:-3.59|P-value:1.63E-4||SGD DESC:Putative membrane protein of unknown function Gene:YNR073C(YNR073C_p)|FD-Score:6.36|P-value:9.77E-11||SGD DESC:Putative mannitol dehydrogenase; identical in amino acid sequence to Dsf1p Gene:YOR338W(YOR338W_p)|FD-Score:-4.33|P-value:7.34E-6||SGD DESC:Putative protein of unknown function; YOR338W transcription is regulated by Azf1p and its transcript is a specific target of the G protein effector Scp160p; identified as being required for sporulation in a high-throughput mutant screen; YOR338W has a paralog, FUN19, that arose from the whole genome duplication Gene:YPR098C(YPR098C)|FD-Score:3.27|P-value:5.44E-4||SGD DESC:Protein of unknown function, localized to the mitochondrial outer membrane Gene:YPR108W-A(YPR108W-A_p)|FD-Score:3.44|P-value:2.92E-4||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR Gene:YPS1(YLR120C)|FD-Score:3.9|P-value:4.71E-5||SGD DESC:Aspartic protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor Gene:YPT31(YER031C)|FD-Score:3.55|P-value:1.92E-4||SGD DESC:Rab family GTPase; involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi; YPT31 has a paralog, YPT32, that arose from the whole genome duplication Gene:YPT6(YLR262C)|FD-Score:-3.88|P-value:5.17E-5||SGD DESC:Rab family GTPase, Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi, maturation of the vacuolar carboxypeptidase Y; has similarity to the human GTPase, Rab6 Gene:YTP1(YNL237W)|FD-Score:-3.39|P-value:3.48E-4||SGD DESC:Probable type-III integral membrane protein of unknown function, has regions of similarity to mitochondrial electron transport proteins

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YOR116C5.658.18E-91.59RPO31RNA polymerase III largest subunit C160, part of core enzyme; similar to bacterial beta-prime subunit and to RPA190 and RPO21
YDR292C4.062.47E-50.43SRP101Signal recognition particle (SRP) receptor alpha subunit; contain GTPase domains; involved in SRP-dependent protein targeting; interacts with the beta subunit, Srp102p
YJR045C3.621.45E-40.12SSC1Hsp70 family ATPase; constituent of the import motor component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); involved in protein translocation and folding; subunit of SceI endonuclease; SSC1 has a paralog, ECM10, that arose from the whole genome duplication
YPR088C3.512.26E-40.12SRP54Signal recognition particle (SRP) subunit (homolog of mammalian SRP54); contains the signal sequence-binding activity of SRP, interacts with the SRP RNA, and mediates binding of SRP to signal receptor; contains GTPase domain
YLR438C-A3.393.49E-40.02LSM3Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; protein increases in abundance and relocalizes from nucleus to cytoplasmic foci upon DNA replication stress
YER048W-A3.373.76E-40.04ISD11Cysteine desulfurase (Nfs1p) activator; essential for the formation of the persulfide intermediate at the desulfurase active site during pyridoxal phosphate-dependent desulfuration of cysteine; required for mitochondrial iron-sulfur cluster biosynthesis
YNR017W3.334.39E-40.19TIM23Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); involved in protein import into mitochondrial matrix and inner membrane; with Tim17p, contributes to architecture and function of the import channel
YIL083C3.148.53E-40.03CAB2Probable phosphopantothenoylcysteine synthetase (PPCS), which catalyzes the second step of coenzyme A biosynthesis from pantothenate; null mutant lethality is complemented by E. coli coaBC (encoding a bifunctional enzyme with PPCS activity)
YBL097W3.119.36E-40.13BRN1Subunit of the condensin complex; required for chromosome condensation and for clustering of tRNA genes at the nucleolus; may influence multiple aspects of chromosome transmission
YBL084C2.980.001450.14CDC27Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition
YPL255W2.840.002280.04BBP1Protein required for the spindle pole body (SPB) duplication, localized at the central plaque periphery; forms a complex with a nuclear envelope protein Mps2p and SPB components Spc29p and Kar1p; required for mitotic functions of Cdc5p
YFR003C2.790.002610.07YPI1Regulatory subunit of the type I protein phosphatase (PP1) Glc7p; Glc7p participates in the regulation of a variety of metabolic processes including mitosis and glycogen metabolism; in vitro evidence suggests Ypi1p is an inhibitor of Glc7p while in vivo evidence suggests it is an activator; overproduction causes decreased cellular content of glycogen; partial depletion causes lithium sensitivity, while overproduction confers lithium-tolerance
YGL207W2.720.003240.06SPT16Subunit of the heterodimeric FACT complex (Spt16p-Pob3p), which associates with chromatin via interaction with Nhp6Ap and Nhp6Bp, and reorganizes nucleosomes to facilitate access to DNA by RNA and DNA polymerases; some mutations cause reduced nucleosome occupancy over highly transcribed regions of the yeast genome
YDL145C2.660.003850.05COP1Alpha subunit of COPI vesicle coatomer complex, which surrounds transport vesicles in the early secretory pathway
YJR065C2.610.004480.07ARP3Essential component of the Arp2/3 complex, which is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YNR073C_p6.369.77E-11YNR073C_pPutative mannitol dehydrogenase; identical in amino acid sequence to Dsf1p
YJL204C5.981.12E-9RCY1F-box protein involved in recycling plasma membrane proteins internalized by endocytosis; localized to sites of polarized growth
YNL123W5.725.46E-9NMA111Serine protease and general molecular chaperone; involved in response to heat stress and promotion of apoptosis; may contribute to lipid homeostasis; sequence similarity to the mammalian Omi/HtrA2 family of serine proteases
YJR139C5.072.02E-7HOM6Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase), dimeric enzyme that catalyzes the third step in the common pathway for methionine and threonine biosynthesis; enzyme has nucleotide-binding, dimerization and catalytic regions
YCR094W5.052.19E-7CDC50Endosomal protein that interacts with phospholipid flippase Drs2p; interaction with Cdc50p is essential for Drs2p catalytic activity; mutations affect cell polarity and polarized growth; similar to Lem3p; CDC50 has a paralog, YNR048W, that arose from the whole genome duplication
YER179W4.691.35E-6DMC1Meiosis-specific protein required for repair of double-strand breaks and pairing between homologous chromosomes; homolog of Rad51p and the bacterial RecA protein; binds ssDNA and dsDNA, forms helical filaments; stimulated by Rdh54p
YHR182W_p4.572.38E-6YHR182W_pProtein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and cytoplasm; relocalizes from bud neck to cytoplasm upon DNA replication stress
YDR451C4.473.87E-6YHP1Homeobox transcriptional repressor; binds Mcm1p and early cell cycle box (ECB) elements of cell cycle regulated genes, thereby restricting ECB-mediated transcription to the M/G1 interval; YHP1 has a paralog, YOX1, that arose from the whole genome duplication
YPR134W4.121.88E-5MSS18Nuclear encoded protein needed for efficient splicing of mitochondrial COX1 aI5beta intron; mss18 mutations block cleavage of 5' exon - intron junction; phenotype of intronless strain suggests additional functions
YKR090W4.102.10E-5PXL1Protein that localizes to sites of polarized growth; required for selection and/or maintenance of polarized growth sites, may modulate signaling by the GTPases Cdc42p and Rho1p; contains LIM domains and has similarity to metazoan paxillin; relocalizes from bud neck to cytoplasm upon DNA replication stress
YPL223C4.003.18E-5GRE1Hydrophilin essential in dessication-rehydration process; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway
YNL080C3.953.86E-5EOS1Protein involved in N-glycosylation; deletion mutation confers sensitivity to exidative stress and shows synthetic lethality with mutations in the spindle checkpoint genes BUB3 and MAD1; YNL080C is not an essential gene
YLR120C3.904.71E-5YPS1Aspartic protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor
YCL038C3.846.11E-5ATG22Vacuolar integral membrane protein required for efflux of amino acids during autophagic body breakdown in the vacuole; null mutation causes a gradual loss of viability during starvation
YCR098C3.768.61E-5GIT1Plasma membrane permease, mediates uptake of glycerophosphoinositol and glycerophosphocholine as sources of the nutrients inositol and phosphate; expression and transport rate are regulated by phosphate and inositol availability

GO enrichment analysis for SGTC_3353
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.1271.49E-22SGTC_1811447-1644 8.1 μMChemDiv (Drug-like library)5346000.0574713endomembrane recycling
0.1263.06E-22SGTC_2738aclarubicin 5.5 μMMiscellaneous4514150.072RNA pol III & RNase P/MRP
0.1201.65E-20SGTC_7881182-0090 188.0 μMChemDiv (Drug-like library)57151850.0757576endomembrane recycling
0.1202.94E-20SGTC_2694st077685 81.9 μMTimTec (Natural product derivative library)28380960.103896endomembrane recycling
0.1186.92E-20SGTC_13943474-0001 65.7 μMChemDiv (Drug-like library)50176660.0789474endomembrane recycling
0.1095.23E-17SGTC_8870885-0007 9.6 μMChemDiv (Drug-like library)57194580.103896endomembrane recycling
0.1072.34E-16SGTC_9541189-0853 2.9 μMChemDiv (Drug-like library)28281940.0869565endomembrane recycling
0.1041.10E-15SGTC_29939054257 71.4 μMChembridge (Drug-like library)64702170.111111fatty acid desaturase (OLE1)
0.1019.83E-15SGTC_33479188721 44.7 μMChembridge (Drug-like library)441184110.0882353
0.0976.27E-14SGTC_28879044784 58.4 μMChembridge (Drug-like library)64655460.142857fatty acid desaturase (OLE1)
0.0976.38E-14SGTC_30819117243 49.5 μMChembridge (Drug-like library)455955890.08fatty acid desaturase (OLE1)
0.0979.08E-14SGTC_1930st074634 34.3 μMTimTec (Natural product derivative library)6842530.151515RNA pol III & RNase P/MRP
0.0971.04E-13SGTC_2544sphondin 68.5 μMMicrosource (Natural product library)1081040.0540541RNA pol III & RNase P/MRP
0.0952.95E-13SGTC_30719117417 49.5 μMChembridge (Drug-like library)455955900.0985916fatty acid desaturase (OLE1)
0.0953.12E-13SGTC_2784092-0821 23.9 μMChemDiv (Drug-like library)8779000.0793651plasma membrane duress

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_3351915031221.6 μM0.6181824904905Chembridge (Drug-like library)329.398363.17114cell wall
SGTC_3320913700535.14 μM0.4745764908713Chembridge (Drug-like library)335.4463.39704endomembrane recycling
SGTC_335091504993.57 μM0.4545454910996Chembridge (Drug-like library)355.435643.69214cell wall
SGTC_3316913663910.55 μM0.3939394903665Chembridge (Drug-like library)347.45673.5704
SGTC_3266913686049.47 μM0.3787884871271Chembridge (Drug-like library)343.424944.02214cell wall
SGTC_331191311462.88 μM0.3787884900406Chembridge (Drug-like library)343.424944.02914cell wall
SGTC_332291390582.11 μM0.3676474908926Chembridge (Drug-like library)343.424943.80714cell wall
SGTC_23995884133200 μM0.333333722445Miscellaneous319.403543.75814cell wall signaling
SGTC_6631486-073313.9 μM0.333333722445ChemDiv (Drug-like library)319.403543.75814cell wall signaling
SGTC_3342914779114.51 μM0.3333331838168Chembridge (Drug-like library)349.816843.34914