k048-0088

3-[(3,5-dibromo-6-oxocyclohexa-2,4-dien-1-ylidene)methylamino]-4-methylbenzoic acid

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_342
Screen concentration 23.3 μM
Source ChemDiv (Drug-like library)
PubChem CID 6820570
SMILES CC1=C(C=C(C=C1)C(=O)O)NC=C2C=C(C=C(C2=O)Br)Br
Standardized SMILES Cc1ccc(cc1N=Cc2cc(Br)cc(Br)c2O)C(=O)O
Molecular weight 413.0607
ALogP 3.12
H-bond donor count 2
H-bond acceptor count 4
Response signature RSC & ERG11

Pool Growth Kinetics
% growth inhibition (Het. pool) 15.97
% growth inhibition (Hom. pool) 6.64


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 6820570
Download HIP data (tab-delimited text)  (excel)
Gene:ARC35(YNR035C)|FD-Score:3.3|P-value:4.80E-4|Clearance:0.03||SGD DESC:Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches; required for cortical localization of calmodulin Gene:ARP9(YMR033W)|FD-Score:3.53|P-value:2.08E-4|Clearance:0.21||SGD DESC:Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation Gene:ATM1(YMR301C)|FD-Score:-3.52|P-value:2.17E-4|Clearance:0||SGD DESC:Mitochondrial inner membrane ATP-binding cassette (ABC) transporter, exports mitochondrially synthesized precursors of iron-sulfur (Fe/S) clusters to the cytosol Gene:DAD2(YKR083C)|FD-Score:3.32|P-value:4.53E-4|Clearance:0.02||SGD DESC:Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis Gene:DML1(YMR211W)|FD-Score:4.51|P-value:3.29E-6|Clearance:0.08||SGD DESC:Essential protein involved in mtDNA inheritance, may also function in the partitioning of the mitochondrial organelle or in the segregation of chromosomes, exhibits regions similar to members of a GTPase family Gene:DRE2(YKR071C)|FD-Score:-4.88|P-value:5.22E-7|Clearance:0||SGD DESC:Component of the cytosolic Fe-S protein assembly (CIA) machinery; contains an Fe-S cluster that receives electrons from NADPH via the action of Tah18pin an early step in the CIA pathway; ortholog of human Ciapin1; protein abundance increases in response to DNA replication stress Gene:ERG11(YHR007C)|FD-Score:4.43|P-value:4.76E-6|Clearance:0.06||SGD DESC:Lanosterol 14-alpha-demethylase; catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 family; associated and coordinately regulated with the P450 reductase Ncp1p Gene:GAB1(YLR459W)|FD-Score:4.26|P-value:1.04E-5|Clearance:0.1||SGD DESC:GPI transamidase subunit, involved in attachment of glycosylphosphatidylinositol (GPI) anchors to proteins; may have a role in recognition of the attachment signal or of the lipid portion of GPI Gene:HSH49(YOR319W)|FD-Score:3.22|P-value:6.35E-4|Clearance:0.13||SGD DESC:U2-snRNP associated splicing factor with similarity to the mammalian splicing factor SAP49; proposed to function as a U2-snRNP assembly factor along with Hsh155p and binding partner Cus1p; contains two RNA recognition motifs (RRM) Gene:PMI40(YER003C)|FD-Score:3.69|P-value:1.13E-4|Clearance:0.16||SGD DESC:Mannose-6-phosphate isomerase, catalyzes the interconversion of fructose-6-P and mannose-6-P; required for early steps in protein mannosylation Gene:PRT1(YOR361C)|FD-Score:3.09|P-value:9.89E-4|Clearance:0.07||SGD DESC:eIF3b subunit of the core complex of translation initiation factor 3 (eIF3), essential for translation; part of a subcomplex (Prt1p-Rpg1p-Nip1p) that stimulates binding of mRNA and tRNA(i)Met to ribosomes Gene:RER2(YBR002C)|FD-Score:4.28|P-value:9.23E-6|Clearance:0.03||SGD DESC:Cis-prenyltransferase involved in dolichol synthesis; participates in endoplasmic reticulum (ER) protein sorting Gene:RFC5(YBR087W)|FD-Score:3.28|P-value:5.27E-4|Clearance:0.02||SGD DESC:Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon Gene:RSC4(YKR008W)|FD-Score:3.77|P-value:8.30E-5|Clearance:0.08||SGD DESC:Component of the RSC chromatin remodeling complex; found in close proximity to nucleosomal DNA; displaced from the surface of nucleosomal DNA after chromatin remodeling; acetylated (K25) by Gcn5p, altering replication stress tolerance; contains tandem bromodomains that recognize histone H3 acetylated on K14 (H3K14ac) by Gcn5p Gene:RSC58(YLR033W)|FD-Score:7.58|P-value:1.69E-14|Clearance:1.89||SGD DESC:Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance Gene:RSC6(YCR052W)|FD-Score:4.58|P-value:2.38E-6|Clearance:0.07||SGD DESC:Component of the RSC chromatin remodeling complex; essential for mitotic growth; homolog of SWI/SNF subunit Swp73p Gene:RSC9(YML127W)|FD-Score:5.07|P-value:1.98E-7|Clearance:0.5||SGD DESC:Component of the RSC chromatin remodeling complex; DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway Gene:SCD5(YOR329C)|FD-Score:-3.45|P-value:2.85E-4|Clearance:0||SGD DESC:Protein required for normal actin organization and endocytosis; targeting subunit for protein phosphatase type 1; undergoes Crm1p-dependent nuclear-cytoplasmic shuttling; multicopy suppressor of clathrin deficiency Gene:SEC13(YLR208W)|FD-Score:4.16|P-value:1.62E-5|Clearance:0.09||SGD DESC:Structural component of 3 distinct complexes; subunit of Nup84 nuclear pore sub-complex (NPC), COPII vesicle coat, and Seh1-associated (SEA) complex; COPII vesicle coat is required for ER to Golgi transport; the Nup84 subcomplex contributes to nucleocytoplasmic transport, NPC biogenesis and processes that may require localization of chromosomes at the nuclear periphery, including transcription; homologous to human SEC13; abundance increases under DNA replication stress Gene:SEC31(YDL195W)|FD-Score:5.69|P-value:6.35E-9|Clearance:0.62||SGD DESC:Component of the Sec13p-Sec31p complex of the COPII vesicle coat, required for vesicle formation in ER to Golgi transport; mutant has increased aneuploidy tolerance Gene:SEC9(YGR009C)|FD-Score:-3.42|P-value:3.08E-4|Clearance:0||SGD DESC:t-SNARE protein important for fusion of secretory vesicles with the plasma membrane; similar to but not functionally redundant with Spo20p; SNAP-25 homolog Gene:SFH1(YLR321C)|FD-Score:3.89|P-value:5.00E-5|Clearance:0.13||SGD DESC:Component of the RSC chromatin remodeling complex; essential gene required for cell cycle progression and maintenance of proper ploidy; phosphorylated in the G1 phase of the cell cycle; Snf5p paralog Gene:STH1(YIL126W)|FD-Score:3.25|P-value:5.87E-4|Clearance:0.02||SGD DESC:ATPase component of the RSC chromatin remodeling complex; required for expression of early meiotic genes; essential helicase-related protein homologous to Snf2p Gene:TEN1(YLR010C)|FD-Score:4.37|P-value:6.16E-6|Clearance:0.09||SGD DESC:Protein that regulates telomeric length; protects telomeric ends in a complex with Cdc13p and Stn1p Gene:TIF6(YPR016C)|FD-Score:-4.17|P-value:1.55E-5|Clearance:0||SGD DESC:Constituent of 66S pre-ribosomal particles, has similarity to human translation initiation factor 6 (eIF6); may be involved in the biogenesis and or stability of 60S ribosomal subunits Gene:UTR5(YEL035C_p)|FD-Score:3.26|P-value:5.58E-4|Clearance:0.01||SGD DESC:Protein of unknown function; transcription may be regulated by Gcr1p; essential for growth under standard (aerobic) conditions but not under anaerobic conditions Gene:YGR265W(YGR265W_d)|FD-Score:4.06|P-value:2.45E-5|Clearance:0.17||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MES1/YGR264C, which encodes methionyl-tRNA synthetase Gene:ARC35(YNR035C)|FD-Score:3.3|P-value:4.80E-4|Clearance:0.03||SGD DESC:Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches; required for cortical localization of calmodulin Gene:ARP9(YMR033W)|FD-Score:3.53|P-value:2.08E-4|Clearance:0.21||SGD DESC:Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation Gene:ATM1(YMR301C)|FD-Score:-3.52|P-value:2.17E-4|Clearance:0||SGD DESC:Mitochondrial inner membrane ATP-binding cassette (ABC) transporter, exports mitochondrially synthesized precursors of iron-sulfur (Fe/S) clusters to the cytosol Gene:DAD2(YKR083C)|FD-Score:3.32|P-value:4.53E-4|Clearance:0.02||SGD DESC:Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis Gene:DML1(YMR211W)|FD-Score:4.51|P-value:3.29E-6|Clearance:0.08||SGD DESC:Essential protein involved in mtDNA inheritance, may also function in the partitioning of the mitochondrial organelle or in the segregation of chromosomes, exhibits regions similar to members of a GTPase family Gene:DRE2(YKR071C)|FD-Score:-4.88|P-value:5.22E-7|Clearance:0||SGD DESC:Component of the cytosolic Fe-S protein assembly (CIA) machinery; contains an Fe-S cluster that receives electrons from NADPH via the action of Tah18pin an early step in the CIA pathway; ortholog of human Ciapin1; protein abundance increases in response to DNA replication stress Gene:ERG11(YHR007C)|FD-Score:4.43|P-value:4.76E-6|Clearance:0.06||SGD DESC:Lanosterol 14-alpha-demethylase; catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 family; associated and coordinately regulated with the P450 reductase Ncp1p Gene:GAB1(YLR459W)|FD-Score:4.26|P-value:1.04E-5|Clearance:0.1||SGD DESC:GPI transamidase subunit, involved in attachment of glycosylphosphatidylinositol (GPI) anchors to proteins; may have a role in recognition of the attachment signal or of the lipid portion of GPI Gene:HSH49(YOR319W)|FD-Score:3.22|P-value:6.35E-4|Clearance:0.13||SGD DESC:U2-snRNP associated splicing factor with similarity to the mammalian splicing factor SAP49; proposed to function as a U2-snRNP assembly factor along with Hsh155p and binding partner Cus1p; contains two RNA recognition motifs (RRM) Gene:PMI40(YER003C)|FD-Score:3.69|P-value:1.13E-4|Clearance:0.16||SGD DESC:Mannose-6-phosphate isomerase, catalyzes the interconversion of fructose-6-P and mannose-6-P; required for early steps in protein mannosylation Gene:PRT1(YOR361C)|FD-Score:3.09|P-value:9.89E-4|Clearance:0.07||SGD DESC:eIF3b subunit of the core complex of translation initiation factor 3 (eIF3), essential for translation; part of a subcomplex (Prt1p-Rpg1p-Nip1p) that stimulates binding of mRNA and tRNA(i)Met to ribosomes Gene:RER2(YBR002C)|FD-Score:4.28|P-value:9.23E-6|Clearance:0.03||SGD DESC:Cis-prenyltransferase involved in dolichol synthesis; participates in endoplasmic reticulum (ER) protein sorting Gene:RFC5(YBR087W)|FD-Score:3.28|P-value:5.27E-4|Clearance:0.02||SGD DESC:Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon Gene:RSC4(YKR008W)|FD-Score:3.77|P-value:8.30E-5|Clearance:0.08||SGD DESC:Component of the RSC chromatin remodeling complex; found in close proximity to nucleosomal DNA; displaced from the surface of nucleosomal DNA after chromatin remodeling; acetylated (K25) by Gcn5p, altering replication stress tolerance; contains tandem bromodomains that recognize histone H3 acetylated on K14 (H3K14ac) by Gcn5p Gene:RSC58(YLR033W)|FD-Score:7.58|P-value:1.69E-14|Clearance:1.89||SGD DESC:Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance Gene:RSC6(YCR052W)|FD-Score:4.58|P-value:2.38E-6|Clearance:0.07||SGD DESC:Component of the RSC chromatin remodeling complex; essential for mitotic growth; homolog of SWI/SNF subunit Swp73p Gene:RSC9(YML127W)|FD-Score:5.07|P-value:1.98E-7|Clearance:0.5||SGD DESC:Component of the RSC chromatin remodeling complex; DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway Gene:SCD5(YOR329C)|FD-Score:-3.45|P-value:2.85E-4|Clearance:0||SGD DESC:Protein required for normal actin organization and endocytosis; targeting subunit for protein phosphatase type 1; undergoes Crm1p-dependent nuclear-cytoplasmic shuttling; multicopy suppressor of clathrin deficiency Gene:SEC13(YLR208W)|FD-Score:4.16|P-value:1.62E-5|Clearance:0.09||SGD DESC:Structural component of 3 distinct complexes; subunit of Nup84 nuclear pore sub-complex (NPC), COPII vesicle coat, and Seh1-associated (SEA) complex; COPII vesicle coat is required for ER to Golgi transport; the Nup84 subcomplex contributes to nucleocytoplasmic transport, NPC biogenesis and processes that may require localization of chromosomes at the nuclear periphery, including transcription; homologous to human SEC13; abundance increases under DNA replication stress Gene:SEC31(YDL195W)|FD-Score:5.69|P-value:6.35E-9|Clearance:0.62||SGD DESC:Component of the Sec13p-Sec31p complex of the COPII vesicle coat, required for vesicle formation in ER to Golgi transport; mutant has increased aneuploidy tolerance Gene:SEC9(YGR009C)|FD-Score:-3.42|P-value:3.08E-4|Clearance:0||SGD DESC:t-SNARE protein important for fusion of secretory vesicles with the plasma membrane; similar to but not functionally redundant with Spo20p; SNAP-25 homolog Gene:SFH1(YLR321C)|FD-Score:3.89|P-value:5.00E-5|Clearance:0.13||SGD DESC:Component of the RSC chromatin remodeling complex; essential gene required for cell cycle progression and maintenance of proper ploidy; phosphorylated in the G1 phase of the cell cycle; Snf5p paralog Gene:STH1(YIL126W)|FD-Score:3.25|P-value:5.87E-4|Clearance:0.02||SGD DESC:ATPase component of the RSC chromatin remodeling complex; required for expression of early meiotic genes; essential helicase-related protein homologous to Snf2p Gene:TEN1(YLR010C)|FD-Score:4.37|P-value:6.16E-6|Clearance:0.09||SGD DESC:Protein that regulates telomeric length; protects telomeric ends in a complex with Cdc13p and Stn1p Gene:TIF6(YPR016C)|FD-Score:-4.17|P-value:1.55E-5|Clearance:0||SGD DESC:Constituent of 66S pre-ribosomal particles, has similarity to human translation initiation factor 6 (eIF6); may be involved in the biogenesis and or stability of 60S ribosomal subunits Gene:UTR5(YEL035C_p)|FD-Score:3.26|P-value:5.58E-4|Clearance:0.01||SGD DESC:Protein of unknown function; transcription may be regulated by Gcr1p; essential for growth under standard (aerobic) conditions but not under anaerobic conditions Gene:YGR265W(YGR265W_d)|FD-Score:4.06|P-value:2.45E-5|Clearance:0.17||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MES1/YGR264C, which encodes methionyl-tRNA synthetase

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 6820570
Download HOP data (tab-delimited text)  (excel)
Gene:AIM41(YOR215C)|FD-Score:3.15|P-value:8.23E-4||SGD DESC:Putative protein of unknown function; the authentic protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays reduced frequency of mitochondrial genome loss Gene:AMD1(YML035C)|FD-Score:-3.17|P-value:7.75E-4||SGD DESC:AMP deaminase; tetrameric enzyme that catalyzes the deamination of AMP to form IMP and ammonia; thought to be involved in regulation of intracellular purine (adenine, guanine, and inosine) nucleotide pools Gene:ANR2(YKL047W_p)|FD-Score:-3.19|P-value:7.03E-4||SGD DESC:Putative protein of unknown function, predicted to be palmitoylated; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm Gene:API2(YDR525W_d)|FD-Score:4.67|P-value:1.48E-6||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 26% of ORF overlaps the dubious ORF YDR524C-A; insertion mutation in a cdc34-2 mutant background causes altered bud morphology Gene:BSC4(YNL269W)|FD-Score:3.68|P-value:1.18E-4||SGD DESC:Protein of unknown function, ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; readthrough is increased upon depletion of Sup35p Gene:BUL2(YML111W)|FD-Score:3.78|P-value:7.69E-5||SGD DESC:Component of the Rsp5p E3-ubiquitin ligase complex; involved in intracellular amino acid permease sorting, functions in heat shock element mediated gene expression, essential for growth in stress conditions; BUL2 has a paralog, BUL1, that arose from the whole genome duplication Gene:BXI1(YNL305C)|FD-Score:3.65|P-value:1.29E-4||SGD DESC:Protein involved in apoptosis; variously described as containing a BCL-2 homology (BH3) domain or as a member of the BAX inhibitor family; reported to promote apoptosis under some conditions and to inhibit it in others; localizes to ER and vacuole; may link the unfolded protein response to apoptosis via regulation of calcium-mediated signaling; translocates to mitochondria under apoptosis-inducing conditions in a process involving Mir1p and Cor1p Gene:CHO2(YGR157W)|FD-Score:4.24|P-value:1.11E-5||SGD DESC:Phosphatidylethanolamine methyltransferase (PEMT), catalyzes the first step in the conversion of phosphatidylethanolamine to phosphatidylcholine during the methylation pathway of phosphatidylcholine biosynthesis Gene:COG6(YNL041C)|FD-Score:6.5|P-value:4.10E-11||SGD DESC:Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:COG7(YGL005C)|FD-Score:4.01|P-value:3.01E-5||SGD DESC:Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:COG8(YML071C)|FD-Score:4.49|P-value:3.50E-6||SGD DESC:Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:CPR4(YCR069W)|FD-Score:3.6|P-value:1.59E-4||SGD DESC:Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; has a potential role in the secretory pathway Gene:DAL7(YIR031C)|FD-Score:4.22|P-value:1.24E-5||SGD DESC:Malate synthase, role in allantoin degradation unknown; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation Gene:FYV4(YHR059W)|FD-Score:-3.17|P-value:7.59E-4||SGD DESC:Protein of unknown function, required for survival upon exposure to K1 killer toxin Gene:GUT1(YHL032C)|FD-Score:3.11|P-value:9.45E-4||SGD DESC:Glycerol kinase, converts glycerol to glycerol-3-phosphate; glucose repression of expression is mediated by Adr1p and Ino2p-Ino4p; derepression of expression on non-fermentable carbon sources is mediated by Opi1p and Rsf1p Gene:IRS4(YKR019C)|FD-Score:3.85|P-value:6.00E-5||SGD DESC:EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; IRS4 has a paralog, TAX4, that arose from the whole genome duplication Gene:JEM1(YJL073W)|FD-Score:3.55|P-value:1.91E-4||SGD DESC:DnaJ-like chaperone required for nuclear membrane fusion during mating, localizes to the ER membrane; exhibits genetic interactions with KAR2 Gene:LIF1(YGL090W)|FD-Score:3.25|P-value:5.81E-4||SGD DESC:Component of the DNA ligase IV complex that mediates nonhomologous end joining in DNA double-strand break repair; physically interacts with Dnl4p and Nej1p; homologous to mammalian XRCC4 protein Gene:LYS12(YIL094C)|FD-Score:4.47|P-value:3.94E-6||SGD DESC:Homo-isocitrate dehydrogenase, an NAD-linked mitochondrial enzyme required for the fourth step in the biosynthesis of lysine, in which homo-isocitrate is oxidatively decarboxylated to alpha-ketoadipate Gene:MDS3(YGL197W)|FD-Score:4.85|P-value:6.14E-7||SGD DESC:Putative component of the TOR regulatory pathway; negative regulator of early meiotic gene expression; required, with Pmd1p, for growth under alkaline conditions; has an N-terminal kelch-like domain Gene:MDY2(YOL111C)|FD-Score:3.51|P-value:2.26E-4||SGD DESC:Protein with a role in insertion of tail-anchored proteins into the ER membrane; forms a complex with Get4p; required for efficient mating; involved in shmoo formation and nuclear migration in the pre-zygote; associates with ribosomes Gene:MLH3(YPL164C)|FD-Score:3.48|P-value:2.50E-4||SGD DESC:Protein involved in DNA mismatch repair and crossing-over during meiotic recombination; forms a complex with Mlh1p; mammalian homolog is implicated mammalian microsatellite instability Gene:MRPL40(YPL173W)|FD-Score:3.26|P-value:5.61E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:NPC2(YDL046W)|FD-Score:3.9|P-value:4.84E-5||SGD DESC:Functional homolog of human NPC2/He1, which is a cholesterol-binding protein whose deficiency causes Niemann-Pick type C2 disease involving retention of cholesterol in lysosomes Gene:ODC1(YPL134C)|FD-Score:6.39|P-value:8.47E-11||SGD DESC:Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for lysine and glutamate biosynthesis and lysine catabolism; suppresses, in multicopy, an fmc1 null mutation Gene:PCL1(YNL289W)|FD-Score:4.46|P-value:4.14E-6||SGD DESC:Cyclin, interacts with cyclin-dependent kinase Pho85p; member of the Pcl1,2-like subfamily, involved in the regulation of polarized growth and morphogenesis and progression through the cell cycle; is ubiquitinated by Dma1p; phosphorylation by Pho85p targets it for degradation; localizes to sites of polarized cell growth Gene:PET10(YKR046C)|FD-Score:-4.1|P-value:2.04E-5||SGD DESC:Protein of unknown function that co-purifies with lipid particles; expression pattern suggests a role in respiratory growth; computational analysis of large-scale protein-protein interaction data suggests a role in ATP/ADP exchange Gene:PEX17(YNL214W)|FD-Score:3.23|P-value:6.21E-4||SGD DESC:Peroxisomal membrane peroxin and subunit of the docking complex that facilitates the import of peroxisomal matrix proteins; required for peroxisome biogenesis Gene:PGM1(YKL127W)|FD-Score:3.64|P-value:1.37E-4||SGD DESC:Phosphoglucomutase, minor isoform; catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism Gene:RHO5(YNL180C)|FD-Score:3.4|P-value:3.41E-4||SGD DESC:Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely involved in protein kinase C (Pkc1p)-dependent signal transduction pathway that controls cell integrity Gene:RLM1(YPL089C)|FD-Score:3.87|P-value:5.52E-5||SGD DESC:MADS-box transcription factor; component of the protein kinase C-mediated MAP kinase pathway involved in the maintenance of cell integrity; phosphorylated and activated by the MAP-kinase Slt2p; RLM1 has a paralog, SMP1, that arose from the whole genome duplication Gene:RPL8A(YHL033C)|FD-Score:3.27|P-value:5.31E-4||SGD DESC:Ribosomal 60S subunit protein L8A; mutation results in decreased amounts of free 60S subunits; homologous to mammalian ribosomal protein L7A, no bacterial homolog; RPL8A has a paralog, RPL8B, that arose from the whole genome duplication Gene:SIP18(YMR175W)|FD-Score:3.2|P-value:6.79E-4||SGD DESC:Phospholipid-binding hydrophilin; essential to overcome desiccation-rehydration process; expression is induced by osmotic stress Gene:SNF11(YDR073W)|FD-Score:3.1|P-value:9.82E-4||SGD DESC:Subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; interacts with a highly conserved 40-residue sequence of Snf2p; relocates to the cytosol under hypoxic conditions Gene:SWA2(YDR320C)|FD-Score:5.54|P-value:1.49E-8||SGD DESC:Auxilin-like protein involved in vesicular transport; clathrin-binding protein required for uncoating of clathrin-coated vesicles Gene:TLG2(YOL018C)|FD-Score:3.34|P-value:4.13E-4||SGD DESC:Syntaxin-like t-SNARE that forms a complex with Tlg1p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; binds Vps45p, which prevents Tlg2p degradation and also facilitates t-SNARE complex formation; homologous to mammalian SNARE protein syntaxin 16 (Sx16) Gene:VAM6(YDL077C)|FD-Score:-3.79|P-value:7.53E-5||SGD DESC:Vacuolar protein that plays a critical role in the tethering steps of vacuolar membrane fusion by facilitating guanine nucleotide exchange on small guanosine triphosphatase Ypt7p Gene:YAP1802(YGR241C)|FD-Score:3.19|P-value:7.14E-4||SGD DESC:Protein of the AP180 family, involved in clathrin cage assembly; binds Pan1p and clathrin; YAP1802 has a paralog, YAP1801, that arose from the whole genome duplication Gene:YBR182C-A(YBR182C-A_p)|FD-Score:-3.23|P-value:6.17E-4||SGD DESC:Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching Gene:YDL085C-A(YDL085C-A_p)|FD-Score:3.12|P-value:9.14E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus Gene:YER137C(YER137C_p)|FD-Score:3.37|P-value:3.77E-4||SGD DESC:Putative protein of unknown function Gene:YIR042C(YIR042C_p)|FD-Score:3.68|P-value:1.15E-4||SGD DESC:Putative protein of unknown function; YIR042C is a non-essential gene Gene:YKL044W(YKL044W_p)|FD-Score:4.36|P-value:6.55E-6||SGD DESC:Protein of unknown function; mRNA identified as translated by ribosome profiling data Gene:YLR030W(YLR030W_p)|FD-Score:3.22|P-value:6.32E-4||SGD DESC:Putative protein of unknown function Gene:YLR184W(YLR184W_d)|FD-Score:3.99|P-value:3.34E-5||SGD DESC:Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YMR158W-B(YMR158W-B_d)|FD-Score:4.61|P-value:2.04E-6||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene ATG16/YMR159C Gene:YMR253C(YMR253C_p)|FD-Score:3.43|P-value:3.00E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; YMR253C is not an essential gene Gene:YOL097W-A(YOL097W-A_p)|FD-Score:-3.53|P-value:2.09E-4||SGD DESC:Putative protein of unknown function; identified by expression profiling and mass spectrometry Gene:YOR325W(YOR325W_d)|FD-Score:3.84|P-value:6.08E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF FRT1 Gene:YPK9(YOR291W)|FD-Score:3.72|P-value:9.99E-5||SGD DESC:Vacuolar protein with a possible role in sequestering heavy metals; has similarity to the type V P-type ATPase Spf1p; homolog of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome Gene:YPR196W(YPR196W_p)|FD-Score:6.08|P-value:5.88E-10||SGD DESC:Putative maltose-responsive transcription factor Gene:YRM1(YOR172W)|FD-Score:3.86|P-value:5.67E-5||SGD DESC:Zn2-Cys6 zinc-finger transcription factor that activates genes involved in multidrug resistance; paralog of Yrr1p, acting on an overlapping set of target genes Gene:YRR1(YOR162C)|FD-Score:5.16|P-value:1.23E-7||SGD DESC:Zn2-Cys6 zinc-finger transcription factor; activates genes involved in multidrug resistance; paralog of Yrm1p, acting on an overlapping set of target genes; YRR1 has a paralog, PDR8, that arose from the whole genome duplication Gene:YVH1(YIR026C)|FD-Score:3.98|P-value:3.51E-5||SGD DESC:Protein phosphatase involved in vegetative growth at low temperatures, sporulation, and glycogen accumulation; mutants are defective in 60S ribosome assembly; member of the dual-specificity family of protein phosphatases Gene:AIM41(YOR215C)|FD-Score:3.15|P-value:8.23E-4||SGD DESC:Putative protein of unknown function; the authentic protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays reduced frequency of mitochondrial genome loss Gene:AMD1(YML035C)|FD-Score:-3.17|P-value:7.75E-4||SGD DESC:AMP deaminase; tetrameric enzyme that catalyzes the deamination of AMP to form IMP and ammonia; thought to be involved in regulation of intracellular purine (adenine, guanine, and inosine) nucleotide pools Gene:ANR2(YKL047W_p)|FD-Score:-3.19|P-value:7.03E-4||SGD DESC:Putative protein of unknown function, predicted to be palmitoylated; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm Gene:API2(YDR525W_d)|FD-Score:4.67|P-value:1.48E-6||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 26% of ORF overlaps the dubious ORF YDR524C-A; insertion mutation in a cdc34-2 mutant background causes altered bud morphology Gene:BSC4(YNL269W)|FD-Score:3.68|P-value:1.18E-4||SGD DESC:Protein of unknown function, ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; readthrough is increased upon depletion of Sup35p Gene:BUL2(YML111W)|FD-Score:3.78|P-value:7.69E-5||SGD DESC:Component of the Rsp5p E3-ubiquitin ligase complex; involved in intracellular amino acid permease sorting, functions in heat shock element mediated gene expression, essential for growth in stress conditions; BUL2 has a paralog, BUL1, that arose from the whole genome duplication Gene:BXI1(YNL305C)|FD-Score:3.65|P-value:1.29E-4||SGD DESC:Protein involved in apoptosis; variously described as containing a BCL-2 homology (BH3) domain or as a member of the BAX inhibitor family; reported to promote apoptosis under some conditions and to inhibit it in others; localizes to ER and vacuole; may link the unfolded protein response to apoptosis via regulation of calcium-mediated signaling; translocates to mitochondria under apoptosis-inducing conditions in a process involving Mir1p and Cor1p Gene:CHO2(YGR157W)|FD-Score:4.24|P-value:1.11E-5||SGD DESC:Phosphatidylethanolamine methyltransferase (PEMT), catalyzes the first step in the conversion of phosphatidylethanolamine to phosphatidylcholine during the methylation pathway of phosphatidylcholine biosynthesis Gene:COG6(YNL041C)|FD-Score:6.5|P-value:4.10E-11||SGD DESC:Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:COG7(YGL005C)|FD-Score:4.01|P-value:3.01E-5||SGD DESC:Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:COG8(YML071C)|FD-Score:4.49|P-value:3.50E-6||SGD DESC:Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:CPR4(YCR069W)|FD-Score:3.6|P-value:1.59E-4||SGD DESC:Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; has a potential role in the secretory pathway Gene:DAL7(YIR031C)|FD-Score:4.22|P-value:1.24E-5||SGD DESC:Malate synthase, role in allantoin degradation unknown; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation Gene:FYV4(YHR059W)|FD-Score:-3.17|P-value:7.59E-4||SGD DESC:Protein of unknown function, required for survival upon exposure to K1 killer toxin Gene:GUT1(YHL032C)|FD-Score:3.11|P-value:9.45E-4||SGD DESC:Glycerol kinase, converts glycerol to glycerol-3-phosphate; glucose repression of expression is mediated by Adr1p and Ino2p-Ino4p; derepression of expression on non-fermentable carbon sources is mediated by Opi1p and Rsf1p Gene:IRS4(YKR019C)|FD-Score:3.85|P-value:6.00E-5||SGD DESC:EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; IRS4 has a paralog, TAX4, that arose from the whole genome duplication Gene:JEM1(YJL073W)|FD-Score:3.55|P-value:1.91E-4||SGD DESC:DnaJ-like chaperone required for nuclear membrane fusion during mating, localizes to the ER membrane; exhibits genetic interactions with KAR2 Gene:LIF1(YGL090W)|FD-Score:3.25|P-value:5.81E-4||SGD DESC:Component of the DNA ligase IV complex that mediates nonhomologous end joining in DNA double-strand break repair; physically interacts with Dnl4p and Nej1p; homologous to mammalian XRCC4 protein Gene:LYS12(YIL094C)|FD-Score:4.47|P-value:3.94E-6||SGD DESC:Homo-isocitrate dehydrogenase, an NAD-linked mitochondrial enzyme required for the fourth step in the biosynthesis of lysine, in which homo-isocitrate is oxidatively decarboxylated to alpha-ketoadipate Gene:MDS3(YGL197W)|FD-Score:4.85|P-value:6.14E-7||SGD DESC:Putative component of the TOR regulatory pathway; negative regulator of early meiotic gene expression; required, with Pmd1p, for growth under alkaline conditions; has an N-terminal kelch-like domain Gene:MDY2(YOL111C)|FD-Score:3.51|P-value:2.26E-4||SGD DESC:Protein with a role in insertion of tail-anchored proteins into the ER membrane; forms a complex with Get4p; required for efficient mating; involved in shmoo formation and nuclear migration in the pre-zygote; associates with ribosomes Gene:MLH3(YPL164C)|FD-Score:3.48|P-value:2.50E-4||SGD DESC:Protein involved in DNA mismatch repair and crossing-over during meiotic recombination; forms a complex with Mlh1p; mammalian homolog is implicated mammalian microsatellite instability Gene:MRPL40(YPL173W)|FD-Score:3.26|P-value:5.61E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:NPC2(YDL046W)|FD-Score:3.9|P-value:4.84E-5||SGD DESC:Functional homolog of human NPC2/He1, which is a cholesterol-binding protein whose deficiency causes Niemann-Pick type C2 disease involving retention of cholesterol in lysosomes Gene:ODC1(YPL134C)|FD-Score:6.39|P-value:8.47E-11||SGD DESC:Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for lysine and glutamate biosynthesis and lysine catabolism; suppresses, in multicopy, an fmc1 null mutation Gene:PCL1(YNL289W)|FD-Score:4.46|P-value:4.14E-6||SGD DESC:Cyclin, interacts with cyclin-dependent kinase Pho85p; member of the Pcl1,2-like subfamily, involved in the regulation of polarized growth and morphogenesis and progression through the cell cycle; is ubiquitinated by Dma1p; phosphorylation by Pho85p targets it for degradation; localizes to sites of polarized cell growth Gene:PET10(YKR046C)|FD-Score:-4.1|P-value:2.04E-5||SGD DESC:Protein of unknown function that co-purifies with lipid particles; expression pattern suggests a role in respiratory growth; computational analysis of large-scale protein-protein interaction data suggests a role in ATP/ADP exchange Gene:PEX17(YNL214W)|FD-Score:3.23|P-value:6.21E-4||SGD DESC:Peroxisomal membrane peroxin and subunit of the docking complex that facilitates the import of peroxisomal matrix proteins; required for peroxisome biogenesis Gene:PGM1(YKL127W)|FD-Score:3.64|P-value:1.37E-4||SGD DESC:Phosphoglucomutase, minor isoform; catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism Gene:RHO5(YNL180C)|FD-Score:3.4|P-value:3.41E-4||SGD DESC:Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely involved in protein kinase C (Pkc1p)-dependent signal transduction pathway that controls cell integrity Gene:RLM1(YPL089C)|FD-Score:3.87|P-value:5.52E-5||SGD DESC:MADS-box transcription factor; component of the protein kinase C-mediated MAP kinase pathway involved in the maintenance of cell integrity; phosphorylated and activated by the MAP-kinase Slt2p; RLM1 has a paralog, SMP1, that arose from the whole genome duplication Gene:RPL8A(YHL033C)|FD-Score:3.27|P-value:5.31E-4||SGD DESC:Ribosomal 60S subunit protein L8A; mutation results in decreased amounts of free 60S subunits; homologous to mammalian ribosomal protein L7A, no bacterial homolog; RPL8A has a paralog, RPL8B, that arose from the whole genome duplication Gene:SIP18(YMR175W)|FD-Score:3.2|P-value:6.79E-4||SGD DESC:Phospholipid-binding hydrophilin; essential to overcome desiccation-rehydration process; expression is induced by osmotic stress Gene:SNF11(YDR073W)|FD-Score:3.1|P-value:9.82E-4||SGD DESC:Subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; interacts with a highly conserved 40-residue sequence of Snf2p; relocates to the cytosol under hypoxic conditions Gene:SWA2(YDR320C)|FD-Score:5.54|P-value:1.49E-8||SGD DESC:Auxilin-like protein involved in vesicular transport; clathrin-binding protein required for uncoating of clathrin-coated vesicles Gene:TLG2(YOL018C)|FD-Score:3.34|P-value:4.13E-4||SGD DESC:Syntaxin-like t-SNARE that forms a complex with Tlg1p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; binds Vps45p, which prevents Tlg2p degradation and also facilitates t-SNARE complex formation; homologous to mammalian SNARE protein syntaxin 16 (Sx16) Gene:VAM6(YDL077C)|FD-Score:-3.79|P-value:7.53E-5||SGD DESC:Vacuolar protein that plays a critical role in the tethering steps of vacuolar membrane fusion by facilitating guanine nucleotide exchange on small guanosine triphosphatase Ypt7p Gene:YAP1802(YGR241C)|FD-Score:3.19|P-value:7.14E-4||SGD DESC:Protein of the AP180 family, involved in clathrin cage assembly; binds Pan1p and clathrin; YAP1802 has a paralog, YAP1801, that arose from the whole genome duplication Gene:YBR182C-A(YBR182C-A_p)|FD-Score:-3.23|P-value:6.17E-4||SGD DESC:Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching Gene:YDL085C-A(YDL085C-A_p)|FD-Score:3.12|P-value:9.14E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus Gene:YER137C(YER137C_p)|FD-Score:3.37|P-value:3.77E-4||SGD DESC:Putative protein of unknown function Gene:YIR042C(YIR042C_p)|FD-Score:3.68|P-value:1.15E-4||SGD DESC:Putative protein of unknown function; YIR042C is a non-essential gene Gene:YKL044W(YKL044W_p)|FD-Score:4.36|P-value:6.55E-6||SGD DESC:Protein of unknown function; mRNA identified as translated by ribosome profiling data Gene:YLR030W(YLR030W_p)|FD-Score:3.22|P-value:6.32E-4||SGD DESC:Putative protein of unknown function Gene:YLR184W(YLR184W_d)|FD-Score:3.99|P-value:3.34E-5||SGD DESC:Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YMR158W-B(YMR158W-B_d)|FD-Score:4.61|P-value:2.04E-6||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene ATG16/YMR159C Gene:YMR253C(YMR253C_p)|FD-Score:3.43|P-value:3.00E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; YMR253C is not an essential gene Gene:YOL097W-A(YOL097W-A_p)|FD-Score:-3.53|P-value:2.09E-4||SGD DESC:Putative protein of unknown function; identified by expression profiling and mass spectrometry Gene:YOR325W(YOR325W_d)|FD-Score:3.84|P-value:6.08E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF FRT1 Gene:YPK9(YOR291W)|FD-Score:3.72|P-value:9.99E-5||SGD DESC:Vacuolar protein with a possible role in sequestering heavy metals; has similarity to the type V P-type ATPase Spf1p; homolog of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome Gene:YPR196W(YPR196W_p)|FD-Score:6.08|P-value:5.88E-10||SGD DESC:Putative maltose-responsive transcription factor Gene:YRM1(YOR172W)|FD-Score:3.86|P-value:5.67E-5||SGD DESC:Zn2-Cys6 zinc-finger transcription factor that activates genes involved in multidrug resistance; paralog of Yrr1p, acting on an overlapping set of target genes Gene:YRR1(YOR162C)|FD-Score:5.16|P-value:1.23E-7||SGD DESC:Zn2-Cys6 zinc-finger transcription factor; activates genes involved in multidrug resistance; paralog of Yrm1p, acting on an overlapping set of target genes; YRR1 has a paralog, PDR8, that arose from the whole genome duplication Gene:YVH1(YIR026C)|FD-Score:3.98|P-value:3.51E-5||SGD DESC:Protein phosphatase involved in vegetative growth at low temperatures, sporulation, and glycogen accumulation; mutants are defective in 60S ribosome assembly; member of the dual-specificity family of protein phosphatases

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YLR033W7.581.69E-141.89RSC58Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance
YDL195W5.696.35E-90.62SEC31Component of the Sec13p-Sec31p complex of the COPII vesicle coat, required for vesicle formation in ER to Golgi transport; mutant has increased aneuploidy tolerance
YML127W5.071.98E-70.50RSC9Component of the RSC chromatin remodeling complex; DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway
YCR052W4.582.38E-60.07RSC6Component of the RSC chromatin remodeling complex; essential for mitotic growth; homolog of SWI/SNF subunit Swp73p
YMR211W4.513.29E-60.08DML1Essential protein involved in mtDNA inheritance, may also function in the partitioning of the mitochondrial organelle or in the segregation of chromosomes, exhibits regions similar to members of a GTPase family
YHR007C4.434.76E-60.06ERG11Lanosterol 14-alpha-demethylase; catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 family; associated and coordinately regulated with the P450 reductase Ncp1p
YLR010C4.376.16E-60.09TEN1Protein that regulates telomeric length; protects telomeric ends in a complex with Cdc13p and Stn1p
YBR002C4.289.23E-60.03RER2Cis-prenyltransferase involved in dolichol synthesis; participates in endoplasmic reticulum (ER) protein sorting
YLR459W4.261.04E-50.10GAB1GPI transamidase subunit, involved in attachment of glycosylphosphatidylinositol (GPI) anchors to proteins; may have a role in recognition of the attachment signal or of the lipid portion of GPI
YLR208W4.161.62E-50.09SEC13Structural component of 3 distinct complexes; subunit of Nup84 nuclear pore sub-complex (NPC), COPII vesicle coat, and Seh1-associated (SEA) complex; COPII vesicle coat is required for ER to Golgi transport; the Nup84 subcomplex contributes to nucleocytoplasmic transport, NPC biogenesis and processes that may require localization of chromosomes at the nuclear periphery, including transcription; homologous to human SEC13; abundance increases under DNA replication stress
YGR265W_d4.062.45E-50.17YGR265W_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MES1/YGR264C, which encodes methionyl-tRNA synthetase
YLR321C3.895.00E-50.12SFH1Component of the RSC chromatin remodeling complex; essential gene required for cell cycle progression and maintenance of proper ploidy; phosphorylated in the G1 phase of the cell cycle; Snf5p paralog
YKR008W3.778.30E-50.08RSC4Component of the RSC chromatin remodeling complex; found in close proximity to nucleosomal DNA; displaced from the surface of nucleosomal DNA after chromatin remodeling; acetylated (K25) by Gcn5p, altering replication stress tolerance; contains tandem bromodomains that recognize histone H3 acetylated on K14 (H3K14ac) by Gcn5p
YER003C3.691.13E-40.16PMI40Mannose-6-phosphate isomerase, catalyzes the interconversion of fructose-6-P and mannose-6-P; required for early steps in protein mannosylation
YMR033W3.532.08E-40.21ARP9Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YNL041C6.504.10E-11COG6Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
YPL134C6.398.47E-11ODC1Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for lysine and glutamate biosynthesis and lysine catabolism; suppresses, in multicopy, an fmc1 null mutation
YPR196W_p6.085.88E-10YPR196W_pPutative maltose-responsive transcription factor
YDR320C5.541.49E-8SWA2Auxilin-like protein involved in vesicular transport; clathrin-binding protein required for uncoating of clathrin-coated vesicles
YOR162C5.161.23E-7YRR1Zn2-Cys6 zinc-finger transcription factor; activates genes involved in multidrug resistance; paralog of Yrm1p, acting on an overlapping set of target genes; YRR1 has a paralog, PDR8, that arose from the whole genome duplication
YGL197W4.856.14E-7MDS3Putative component of the TOR regulatory pathway; negative regulator of early meiotic gene expression; required, with Pmd1p, for growth under alkaline conditions; has an N-terminal kelch-like domain
YDR525W_d4.671.48E-6API2_dDubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 26% of ORF overlaps the dubious ORF YDR524C-A; insertion mutation in a cdc34-2 mutant background causes altered bud morphology
YMR158W-B_d4.612.04E-6YMR158W-B_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene ATG16/YMR159C
YML071C4.493.50E-6COG8Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
YIL094C4.473.94E-6LYS12Homo-isocitrate dehydrogenase, an NAD-linked mitochondrial enzyme required for the fourth step in the biosynthesis of lysine, in which homo-isocitrate is oxidatively decarboxylated to alpha-ketoadipate
YNL289W4.464.14E-6PCL1Cyclin, interacts with cyclin-dependent kinase Pho85p; member of the Pcl1,2-like subfamily, involved in the regulation of polarized growth and morphogenesis and progression through the cell cycle; is ubiquitinated by Dma1p; phosphorylation by Pho85p targets it for degradation; localizes to sites of polarized cell growth
YKL044W_p4.366.55E-6YKL044W_pProtein of unknown function; mRNA identified as translated by ribosome profiling data
YGR157W4.241.11E-5CHO2Phosphatidylethanolamine methyltransferase (PEMT), catalyzes the first step in the conversion of phosphatidylethanolamine to phosphatidylcholine during the methylation pathway of phosphatidylcholine biosynthesis
YIR031C4.221.24E-5DAL7Malate synthase, role in allantoin degradation unknown; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation
YGL005C4.013.01E-5COG7Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments

GO enrichment analysis for SGTC_342
biological processes

protein complexes

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.2961.64E-119SGTC_329k048-0121 21.3 μMChemDiv (Drug-like library)68329020.5RSC & ERG11
0.2807.86E-107SGTC_643k048-0106 28.4 μMChemDiv (Drug-like library)67639200.421053RSC & ERG11
0.2564.01E-89SGTC_9701315-0089 19.5 μMChemDiv (Drug-like library)68110830.28169RSC & ERG11
0.2522.88E-86SGTC_7830848-0141 92.7 μMChemDiv (Drug-like library)67550760.413793RSC & ERG11
0.2501.29E-84SGTC_590k048-0076 22.4 μMChemDiv (Drug-like library)68328140.418182RSC & ERG11
0.2419.70E-79SGTC_203k066-0004 30.9 μMChemDiv (Drug-like library)67954120.38983RSC & ERG11
0.2281.31E-70SGTC_3241315-0088 19.6 μMChemDiv (Drug-like library)67874210.423729RSC & ERG11
0.2246.15E-68SGTC_331k048-0133 24.5 μMChemDiv (Drug-like library)68135820.425926RSC & ERG11
0.2182.23E-64SGTC_5660958-0068 16.5 μMChemDiv (Drug-like library)68153650.451613RSC & ERG11
0.2183.08E-64SGTC_322k048-0136 19.3 μMChemDiv (Drug-like library)68232820.457627RSC & ERG11
0.2171.23E-63SGTC_1162k048-0130 20.1 μMChemDiv (Drug-like library)67974060.442308Golgi
0.2155.74E-63SGTC_7461095-0025 46.6 μMChemDiv (Drug-like library)67492860.45283RSC & ERG11
0.2126.55E-61SGTC_2881315-0019 35.1 μMChemDiv (Drug-like library)68114740.253968RSC & ERG11
0.2074.19E-58SGTC_8550428-0020 25.0 μMChemDiv (Drug-like library)68124140.169492Golgi
0.2041.05E-56SGTC_185k048-0037 25.5 μMChemDiv (Drug-like library)68275890.464286RSC & ERG11

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_624k048-005228 μM0.5370376835531ChemDiv (Drug-like library)414.04882.30735Golgi
SGTC_13531498-12068.11 μM0.5208336756808ChemDiv (Drug-like library)371.024062.76223mitochondrial response to ROS
SGTC_329k048-012121.3 μM0.56832902ChemDiv (Drug-like library)480.921193.58212RSC & ERG11
SGTC_185k048-003725.49 μM0.4642866827589ChemDiv (Drug-like library)414.04882.30735RSC & ERG11
SGTC_322k048-013619.3 μM0.4576276823282ChemDiv (Drug-like library)430.04822.88215RSC & ERG11
SGTC_7461095-002546.6 μM0.452836749286ChemDiv (Drug-like library)377.055081.73915RSC & ERG11
SGTC_5660958-006816.5 μM0.4516136815365ChemDiv (Drug-like library)492.1358233.99424RSC & ERG11
SGTC_1162k048-013020.1 μM0.4423086797406ChemDiv (Drug-like library)431.120624.52312Golgi
SGTC_331k048-013324.5 μM0.4259266813582ChemDiv (Drug-like library)356.012721.85413RSC & ERG11
SGTC_3241315-008819.6 μM0.4237296787421ChemDiv (Drug-like library)440.152284.60214RSC & ERG11