Deletion Strain | FD score | P-value | Gene | Gene Description |
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YPL125W | 10.50 | 3.20E-26 | KAP120 | Karyopherin responsible for the nuclear import of ribosome maturation factor Rfp1p |
YBR281C | 7.60 | 1.46E-14 | DUG2 | Component of glutamine amidotransferase (GATase II); forms a complex with Dug3p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p) |
YDL081C | 7.57 | 1.81E-14 | RPP1A | Ribosomal stalk protein P1 alpha, involved in the interaction between translational elongation factors and the ribosome; accumulation of P1 in the cytoplasm is regulated by phosphorylation and interaction with the P2 stalk component |
YPL223C | 6.98 | 1.46E-12 | GRE1 | Hydrophilin essential in dessication-rehydration process; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway |
YPR119W | 6.07 | 6.54E-10 | CLB2 | B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome |
YLR284C | 5.89 | 1.99E-9 | ECI1 | Peroxisomal delta3,delta2-enoyl-CoA isomerase, hexameric protein that converts 3-hexenoyl-CoA to trans-2-hexenoyl-CoA, essential for the beta-oxidation of unsaturated fatty acids, oleate-induced |
YDR447C | 5.84 | 2.64E-9 | RPS17B | Ribosomal protein 51 (rp51) of the small (40s) subunit; homologous to mammalian ribosomal protein S17, no bacterial homolog; RPS17B has a paralog, RPS17A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress |
YJL105W | 5.60 | 1.08E-8 | SET4 | Protein of unknown function, contains a SET domain; SET4 has a paralog, SET3, that arose from the whole genome duplication |
YMR233W | 5.44 | 2.73E-8 | TRI1 | Non-essential sumoylated protein of unknown function; similar to components of human SWI/SNF complex including SMRD3; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm, nucleus and nucleolus; TRI1 has a paralog, UAF30, that arose from the whole genome duplication |
YCL037C | 5.39 | 3.57E-8 | SRO9 | Cytoplasmic RNA-binding protein; associates with translating ribosomes; involved in heme regulation of Hap1p as a component of the HMC complex, also involved in the organization of actin filaments; contains a La motif; SRO9 has a paralog, SLF1, that arose from the whole genome duplication |
YPL102C_d | 4.93 | 4.13E-7 | YPL102C_d | Dubious open reading frame, not conserved in closely related Saccharomyces species; deletion mutation enhances replication of Brome mosaic virus in S. cerevisiae, but this is likely due to effects on the overlapping gene ELP4 |
YCR050C_p | 4.89 | 5.07E-7 | YCR050C_p | Non-essential protein of unknown function; deletion mutant is synthetically sick or lethal with alpha-synuclein |
YLR122C_d | 4.87 | 5.47E-7 | YLR122C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR123C |
YOL083W | 4.65 | 1.70E-6 | ATG34 | Receptor protein involved in selective autophagy during starvation; specifically involved in the transport of cargo protein alpha-mannosidase (Ams1p); Atg19p paralog |
YGR081C | 4.64 | 1.77E-6 | SLX9 | Protein required for pre-rRNA processing; associated with the 90S pre-ribosome and 43S small ribosomal subunit precursor; interacts with U3 snoRNA; deletion mutant has synthetic fitness defect with an sgs1 deletion mutant |