Deletion Strain | FD score | P-value | Gene | Gene Description |
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YHR025W | 32.00 | 4.16E-225 | THR1 | Homoserine kinase, conserved protein required for threonine biosynthesis; expression is regulated by the GCN4-mediated general amino acid control pathway |
YJR139C | 8.76 | 1.01E-18 | HOM6 | Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase), dimeric enzyme that catalyzes the third step in the common pathway for methionine and threonine biosynthesis; enzyme has nucleotide-binding, dimerization and catalytic regions |
YPL148C | 8.74 | 1.19E-18 | PPT2 | Phosphopantetheine:protein transferase (PPTase), activates mitochondrial acyl carrier protein (Acp1p) by phosphopantetheinylation |
YKR028W | 7.66 | 9.65E-15 | SAP190 | Protein that forms a complex with the Sit4p protein phosphatase; required for Sit4p function; member of a family of similar proteins including Sap4p, Sap155p, and Sap185p; SAP190 has a paralog, SAP185, that arose from the whole genome duplication |
YCR050C_p | 5.90 | 1.85E-9 | YCR050C_p | Non-essential protein of unknown function; deletion mutant is synthetically sick or lethal with alpha-synuclein |
YKL002W | 5.89 | 1.90E-9 | DID4 | Class E Vps protein of the ESCRT-III complex, required for sorting of integral membrane proteins into lumenal vesicles of multivesicular bodies, and for delivery of newly synthesized vacuolar enzymes to the vacuole, involved in endocytosis |
YCL029C | 5.79 | 3.62E-9 | BIK1 | Microtubule-associated protein, component of the interface between microtubules and kinetochore, involved in sister chromatid separation; essential in polyploid cells but not in haploid or diploid cells; ortholog of mammalian CLIP-170 |
YGL151W | 5.54 | 1.49E-8 | NUT1 | Component of the RNA polymerase II mediator complex, which is required for transcriptional activation and also has a role in basal transcription |
YLR357W | 5.34 | 4.63E-8 | RSC2 | Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; involved in telomere maintenance |
YJL121C | 5.12 | 1.49E-7 | RPE1 | D-ribulose-5-phosphate 3-epimerase, catalyzes a reaction in the non-oxidative part of the pentose-phosphate pathway; mutants are sensitive to oxidative stress |
YER107C | 5.00 | 2.84E-7 | GLE2 | RNA export factor associated with the nuclear pore complex (NPC); associates with NUP116p; required for polyadenylated RNA export but not for protein import; homologous to S. pombe Rae1p and human RAE1 |
YPL086C | 4.96 | 3.61E-7 | ELP3 | Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; exhibits histone acetyltransferase activity that is directed to histones H3 and H4; disruption confers resistance to K. lactis zymotoxin |
YNR006W | 4.89 | 5.09E-7 | VPS27 | Endosomal protein that forms a complex with Hse1p; required for recycling Golgi proteins, forming lumenal membranes and sorting ubiquitinated proteins destined for degradation; has Ubiquitin Interaction Motifs which bind ubiquitin (Ubi4p) |
YPR173C | 4.84 | 6.53E-7 | VPS4 | AAA-ATPase involved in multivesicular body (MVB) protein sorting, ATP-bound Vps4p localizes to endosomes and catalyzes ESCRT-III disassembly and membrane release; ATPase activity is activated by Vta1p; regulates cellular sterol metabolism |
YGR200C | 4.72 | 1.17E-6 | ELP2 | Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; target of Kluyveromyces lactis zymocin |