3',4'-dichloroisocoumarin

3,4-dichloroisochromen-1-one

A potent and irreversible inhibitor of serine proteases.

[PubChem] [DrugBank] [Wikipedia] [WikiGenes] [ChEMBL] [ChemSpider] 

PubChem MeSH terms: Serine Proteinase Inhibitors



Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_388
Screen concentration 16.7 μM
Source Miscellaneous
PubChem CID 1609
SMILES C1=CC=C2C(=C1)C(=C(OC2=O)Cl)Cl
Standardized SMILES ClC1=C(Cl)c2ccccc2C(=O)O1
Molecular weight 215.0329
ALogP 2.76
H-bond donor count 0
H-bond acceptor count 2
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 17.45
% growth inhibition (Hom. pool) 14.8


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 1609
Download HIP data (tab-delimited text)  (excel)
Gene:BET2(YPR176C)|FD-Score:3.37|P-value:3.77E-4|Clearance:0.01||SGD DESC:Beta subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p Gene:CDC31(YOR257W)|FD-Score:3.36|P-value:3.87E-4|Clearance:0.23||SGD DESC:Calcium-binding component of the spindle pole body (SPB) half-bridge, required for SPB duplication in mitosis and meiosis II; homolog of mammalian centrin; binds multiubiquitinated proteins and is involved in proteasomal protein degradation Gene:MET30(YIL046W)|FD-Score:-3.37|P-value:3.73E-4|Clearance:0||SGD DESC:F-box protein containing five copies of the WD40 motif, controls cell cycle function, sulfur metabolism, and methionine biosynthesis as part of the ubiquitin ligase complex; interacts with and regulates Met4p, localizes within the nucleus Gene:PRE10(YOR362C)|FD-Score:4.31|P-value:8.10E-6|Clearance:0.13||SGD DESC:Alpha 7 subunit of the 20S proteasome; protein abundance increases in response to DNA replication stress Gene:PRE8(YML092C)|FD-Score:5.84|P-value:2.65E-9|Clearance:0.85||SGD DESC:Alpha 2 subunit of the 20S proteasome Gene:PUP3(YER094C)|FD-Score:3.8|P-value:7.26E-5|Clearance:0.43||SGD DESC:Beta 3 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit C10 Gene:RAM2(YKL019W)|FD-Score:-4.32|P-value:7.94E-6|Clearance:0||SGD DESC:Alpha subunit of both the farnesyltransferase and type I geranylgeranyltransferase that catalyze prenylation of proteins containing a CAAX consensus motif; essential protein required for membrane localization of Ras proteins and a-factor Gene:RHO1(YPR165W)|FD-Score:4.18|P-value:1.45E-5|Clearance:0.15||SGD DESC:GTP-binding protein of the rho subfamily of Ras-like proteins, involved in establishment of cell polarity; regulates protein kinase C (Pkc1p) and the cell wall synthesizing enzyme 1,3-beta-glucan synthase (Fks1p and Gsc2p) Gene:RPB7(YDR404C)|FD-Score:4.03|P-value:2.82E-5|Clearance:0.23||SGD DESC:RNA polymerase II subunit B16; forms two subunit dissociable complex with Rpb4p; involved in recruitment of 3'-end processing factors to transcribing RNA polymerase II complex and in export of mRNA to cytoplasm under stress conditions; also involved in translation initiation Gene:RSE1(YML049C)|FD-Score:3.13|P-value:8.73E-4|Clearance:0.02||SGD DESC:Protein involved in pre-mRNA splicing; component of the pre-spliceosome; associates with U2 snRNA; involved in ER to Golgi transport Gene:SPC105(YGL093W)|FD-Score:8.82|P-value:5.64E-19|Clearance:2.98||SGD DESC:Subunit of a kinetochore-microtubule binding complex with Kre28p that bridges centromeric heterochromatin and kinetochore MAPs and motors; required for sister chromatid bi-orientation and kinetochore binding of SAC components Gene:SSS1(YDR086C)|FD-Score:4.98|P-value:3.10E-7|Clearance:0.48||SGD DESC:Subunit of the Sec61p translocation complex (Sec61p-Sss1p-Sbh1p) that forms a channel for passage of secretory proteins through the endoplasmic reticulum membrane, and of the Ssh1p complex (Ssh1p-Sbh2p-Sss1p); interacts with Ost4p and Wbp1p Gene:STS1(YIR011C)|FD-Score:-3.09|P-value:9.93E-4|Clearance:0||SGD DESC:Protein required for localizing proteasomes to the nucleus; interacts with the karyopherin Srp1p; involved in ubiquitin-mediated protein degradation Gene:TOM40(YMR203W)|FD-Score:4.4|P-value:5.38E-6|Clearance:0.09||SGD DESC:Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; constitutes the core element of the protein conducting pore Gene:YLR379W(YLR379W_d)|FD-Score:3.11|P-value:9.40E-4|Clearance:0.02||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential ORF SEC61/YLR378C Gene:YTH1(YPR107C)|FD-Score:4.5|P-value:3.36E-6|Clearance:0.1||SGD DESC:Essential RNA-binding component of cleavage and polyadenylation factor, contains five zinc fingers; required for pre-mRNA 3'-end processing and polyadenylation Gene:BET2(YPR176C)|FD-Score:3.37|P-value:3.77E-4|Clearance:0.01||SGD DESC:Beta subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p Gene:CDC31(YOR257W)|FD-Score:3.36|P-value:3.87E-4|Clearance:0.23||SGD DESC:Calcium-binding component of the spindle pole body (SPB) half-bridge, required for SPB duplication in mitosis and meiosis II; homolog of mammalian centrin; binds multiubiquitinated proteins and is involved in proteasomal protein degradation Gene:MET30(YIL046W)|FD-Score:-3.37|P-value:3.73E-4|Clearance:0||SGD DESC:F-box protein containing five copies of the WD40 motif, controls cell cycle function, sulfur metabolism, and methionine biosynthesis as part of the ubiquitin ligase complex; interacts with and regulates Met4p, localizes within the nucleus Gene:PRE10(YOR362C)|FD-Score:4.31|P-value:8.10E-6|Clearance:0.13||SGD DESC:Alpha 7 subunit of the 20S proteasome; protein abundance increases in response to DNA replication stress Gene:PRE8(YML092C)|FD-Score:5.84|P-value:2.65E-9|Clearance:0.85||SGD DESC:Alpha 2 subunit of the 20S proteasome Gene:PUP3(YER094C)|FD-Score:3.8|P-value:7.26E-5|Clearance:0.43||SGD DESC:Beta 3 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit C10 Gene:RAM2(YKL019W)|FD-Score:-4.32|P-value:7.94E-6|Clearance:0||SGD DESC:Alpha subunit of both the farnesyltransferase and type I geranylgeranyltransferase that catalyze prenylation of proteins containing a CAAX consensus motif; essential protein required for membrane localization of Ras proteins and a-factor Gene:RHO1(YPR165W)|FD-Score:4.18|P-value:1.45E-5|Clearance:0.15||SGD DESC:GTP-binding protein of the rho subfamily of Ras-like proteins, involved in establishment of cell polarity; regulates protein kinase C (Pkc1p) and the cell wall synthesizing enzyme 1,3-beta-glucan synthase (Fks1p and Gsc2p) Gene:RPB7(YDR404C)|FD-Score:4.03|P-value:2.82E-5|Clearance:0.23||SGD DESC:RNA polymerase II subunit B16; forms two subunit dissociable complex with Rpb4p; involved in recruitment of 3'-end processing factors to transcribing RNA polymerase II complex and in export of mRNA to cytoplasm under stress conditions; also involved in translation initiation Gene:RSE1(YML049C)|FD-Score:3.13|P-value:8.73E-4|Clearance:0.02||SGD DESC:Protein involved in pre-mRNA splicing; component of the pre-spliceosome; associates with U2 snRNA; involved in ER to Golgi transport Gene:SPC105(YGL093W)|FD-Score:8.82|P-value:5.64E-19|Clearance:2.98||SGD DESC:Subunit of a kinetochore-microtubule binding complex with Kre28p that bridges centromeric heterochromatin and kinetochore MAPs and motors; required for sister chromatid bi-orientation and kinetochore binding of SAC components Gene:SSS1(YDR086C)|FD-Score:4.98|P-value:3.10E-7|Clearance:0.48||SGD DESC:Subunit of the Sec61p translocation complex (Sec61p-Sss1p-Sbh1p) that forms a channel for passage of secretory proteins through the endoplasmic reticulum membrane, and of the Ssh1p complex (Ssh1p-Sbh2p-Sss1p); interacts with Ost4p and Wbp1p Gene:STS1(YIR011C)|FD-Score:-3.09|P-value:9.93E-4|Clearance:0||SGD DESC:Protein required for localizing proteasomes to the nucleus; interacts with the karyopherin Srp1p; involved in ubiquitin-mediated protein degradation Gene:TOM40(YMR203W)|FD-Score:4.4|P-value:5.38E-6|Clearance:0.09||SGD DESC:Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; constitutes the core element of the protein conducting pore Gene:YLR379W(YLR379W_d)|FD-Score:3.11|P-value:9.40E-4|Clearance:0.02||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential ORF SEC61/YLR378C Gene:YTH1(YPR107C)|FD-Score:4.5|P-value:3.36E-6|Clearance:0.1||SGD DESC:Essential RNA-binding component of cleavage and polyadenylation factor, contains five zinc fingers; required for pre-mRNA 3'-end processing and polyadenylation

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 1609
Download HOP data (tab-delimited text)  (excel)
Gene:APN1(YKL114C)|FD-Score:4.42|P-value:5.04E-6||SGD DESC:Major apurinic/apyrimidinic endonuclease, 3'-repair diesterase involved in repair of DNA damage by oxidation and alkylating agents; also functions as a 3'-5' exonuclease to repair 7,8-dihydro-8-oxodeoxyguanosine Gene:AQR1(YNL065W)|FD-Score:3.94|P-value:4.10E-5||SGD DESC:Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; confers resistance to short-chain monocarboxylic acids and quinidine; involved in the excretion of excess amino acids; AQR1 has a paralog, QDR1, that arose from the whole genome duplication; relocalizes from plasma membrane to cytoplasm upon DNA replication stress Gene:BUD31(YCR063W)|FD-Score:3.19|P-value:7.02E-4||SGD DESC:Component of the SF3b subcomplex of the U2 snRNP; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern; facilitates passage through G1/S Start, but is not required for G2/M transition or exit from mitosis Gene:CTP1(YBR291C)|FD-Score:3.78|P-value:7.73E-5||SGD DESC:Mitochondrial inner membrane citrate transporter, member of the mitochondrial carrier family Gene:CWC21(YDR482C)|FD-Score:-3.46|P-value:2.65E-4||SGD DESC:Protein involved in RNA splicing by the spliceosome; component of a complex containing Cef1p; interacts genetically with ISY1 and BUD13; may bind RNA; has similarity to S. pombe Cwf21p Gene:FUI1(YBL042C)|FD-Score:9.29|P-value:7.94E-21||SGD DESC:High affinity uridine permease, localizes to the plasma membrane; also mediates low but significant transport of the cytotoxic nucleoside analog 5-fluorouridine; not involved in uracil transport; relative distribution to the vacuole increases upon DNA replication stress Gene:GID8(YMR135C)|FD-Score:3.54|P-value:2.00E-4||SGD DESC:Subunit of GID Complex, binds strongly to central component Vid30p; GID Complex is involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; recruits Rmd5p, Fyv10 and Vid28p to GID Complex; contains LisH, CTLH, and CRA domains that mediate binding to Vid30p (LisH) and Rmd5p and Vid28p (CTLH and CRA); dosage-dependent regulator of START Gene:HAL1(YPR005C)|FD-Score:3.18|P-value:7.49E-4||SGD DESC:Cytoplasmic protein involved in halotolerance; decreases intracellular Na+ (via Ena1p) and increases intracellular K+ by decreasing efflux; expression repressed by Ssn6p-Tup1p and Sko1p and induced by NaCl, KCl, and sorbitol through Gcn4p Gene:IRC21(YMR073C)|FD-Score:4.38|P-value:5.98E-6||SGD DESC:Putative protein of unknown function; may be involved in resistance to carboplatin and cisplatin; null mutant displays increase in spontaneous Rad52p foci; contains a lipid-binding domain and binds cardiolipin in a large-scale study Gene:LDB19(YOR322C)|FD-Score:6.29|P-value:1.60E-10||SGD DESC:Protein involved in regulating the endocytosis of plasma membrane proteins by recruiting the ubiquitin ligase Rsp5p to its target; inhibited by Npr1p-mediated phosphorylation, which affects translocation between the cytosol and the plasma membrane; null mutant has reduced affinity for alcian blue dye Gene:LSB5(YCL034W)|FD-Score:3.12|P-value:9.05E-4||SGD DESC:Protein of unknown function; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; may mediate disassembly of the Pan1 complex from the endocytic coat Gene:MET31(YPL038W)|FD-Score:3.72|P-value:9.85E-5||SGD DESC:Zinc-finger DNA-binding transcription factor; involved in transcriptional regulation of the methionine biosynthetic genes; MET31 has a paralog, MET32, that arose from the whole genome duplication Gene:MGA1(YGR249W)|FD-Score:4.67|P-value:1.49E-6||SGD DESC:Protein similar to heat shock transcription factor; multicopy suppressor of pseudohyphal growth defects of ammonium permease mutants Gene:MLH2(YLR035C)|FD-Score:-3.21|P-value:6.59E-4||SGD DESC:Protein involved in the mismatch repair of certain frameshift intermediates and involved in meiotic recombination; forms a complex with Mlh1p Gene:MRPL27(YBR282W)|FD-Score:3.53|P-value:2.11E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit; homolog of human Bcl-2 interacting protein BMRP Gene:NDJ1(YOL104C)|FD-Score:3.83|P-value:6.45E-5||SGD DESC:Meiosis-specific telomere protein, required for bouquet formation, effective homolog pairing, ordered cross-over distribution, sister chromatid cohesion at meiotic telomeres, chromosomal segregation and telomere-led rapid prophase movement Gene:OM14(YBR230C)|FD-Score:-5.03|P-value:2.43E-7||SGD DESC:Integral mitochondrial outer membrane protein; abundance is decreased in cells grown in glucose relative to other carbon sources; appears to contain 3 alpha-helical transmembrane segments; ORF encodes a 97-basepair intron Gene:PAU24(YBR301W)|FD-Score:3.51|P-value:2.21E-4||SGD DESC:Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; member of the seripauperin multigene family encoded mainly in subtelomeric regions; expressed under anaerobic conditions, completely repressed during aerobic growth Gene:PCS60(YBR222C)|FD-Score:4.29|P-value:8.85E-6||SGD DESC:Peroxisomal protein that binds AMP and mRNA, localizes to both the peroxisomal peripheral membrane and matrix, expression is highly inducible by oleic acid, similar to E. coli long chain acyl-CoA synthetase Gene:PDH1(YPR002W)|FD-Score:4.03|P-value:2.79E-5||SGD DESC:Mitochondrial protein that participates in respiration, induced by diauxic shift; homologous to E. coli PrpD, may take part in the conversion of 2-methylcitrate to 2-methylisocitrate Gene:PHO80(YOL001W)|FD-Score:-3.3|P-value:4.86E-4||SGD DESC:Cyclin, interacts with cyclin-dependent kinase Pho85p; regulates the response to nutrient levels and environmental conditions, including the response to phosphate limitation and stress-dependent calcium signaling Gene:PIH1(YHR034C)|FD-Score:3.55|P-value:1.91E-4||SGD DESC:Component of the conserved R2TP complex (Rvb1-Rvb2-Tah1-Pih1); R2TP complex interacts with Hsp90 (Hsp82p and Hsc82p) to mediate assembly large protein complexes such as box C/D snoRNPs and RNA polymerase II Gene:POC4(YPL144W)|FD-Score:3.91|P-value:4.57E-5||SGD DESC:Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions Gene:RAD6(YGL058W)|FD-Score:-3.35|P-value:4.11E-4||SGD DESC:Ubiquitin-conjugating enzyme (E2), involved in postreplication repair (as a heterodimer with Rad18p), DSBR and checkpoint control (as a heterodimer with Bre1p), ubiquitin-mediated N-end rule protein degradation (as a heterodimer with Ubr1p Gene:REG1(YDR028C)|FD-Score:-3.26|P-value:5.63E-4||SGD DESC:Regulatory subunit of type 1 protein phosphatase Glc7p; involved in negative regulation of glucose-repressible genes; involved in regulation of the nucleocytoplasmic shuttling of Hxk2p Gene:ROM2(YLR371W)|FD-Score:4.16|P-value:1.57E-5||SGD DESC:GDP/GTP exchange factor (GEF) for Rho1p and Rho2p; mutations are synthetically lethal with mutations in rom1, which also encodes a GEF; Rom2p localization to the bud surface is dependent on Ack1p Gene:RPN4(YDL020C)|FD-Score:3.34|P-value:4.12E-4||SGD DESC:Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses; relative distribution to the nucleus increases upon DNA replication stress Gene:RTC3(YHR087W)|FD-Score:5.61|P-value:1.00E-8||SGD DESC:Protein of unknown function involved in RNA metabolism; has structural similarity to SBDS, the human protein mutated in Shwachman-Diamond Syndrome (the yeast SBDS ortholog = SDO1); null mutation suppresses cdc13-1 temperature sensitivity; protein abundance increases in response to DNA replication stress Gene:RUP1(YOR138C)|FD-Score:3.62|P-value:1.45E-4||SGD DESC:Protein that regulates Rsp5p, which is a HECT ubiquitin ligase; has a WW domain consensus motif of PPPSY (residues 131-135) that mediates binding of Rsp5p to Ubp2p; contains an UBA domain; relative distribution to the nucleus increases upon DNA replication stress Gene:SAP4(YGL229C)|FD-Score:-3.21|P-value:6.66E-4||SGD DESC:Protein required for function of the Sit4p protein phosphatase, member of a family of similar proteins that form complexes with Sit4p, including Sap155p, Sap185p, and Sap190p Gene:SAT4(YCR008W)|FD-Score:3.2|P-value:6.98E-4||SGD DESC:Ser/Thr protein kinase involved in salt tolerance; funtions in regulation of Trk1p-Trk2p potassium transporter; partially redundant with Hal5p; has similarity to Npr1p Gene:SGF29(YCL010C)|FD-Score:6.47|P-value:4.92E-11||SGD DESC:Component of the HAT/Core module of the SAGA, SLIK, and ADA complexes; HAT/Core module also contains Gcn5p, Ngg1p, and Ada2p; binds methylated histone H3K4; involved in transcriptional regulation through SAGA and TBP recruitment to target promoters and H3 acetylation Gene:SHM1(YBR263W)|FD-Score:3.22|P-value:6.50E-4||SGD DESC:Mitochondrial serine hydroxymethyltransferase, converts serine to glycine plus 5,10 methylenetetrahydrofolate; involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis; reverse reaction generates serine Gene:SPO23(YBR250W)|FD-Score:-5.1|P-value:1.67E-7||SGD DESC:Protein of unknown function; associates with meiosis-specific protein Spo1p Gene:TPS2(YDR074W)|FD-Score:3.81|P-value:7.01E-5||SGD DESC:Phosphatase subunit of the trehalose-6-P synthase/phosphatase complex; involved in synthesis of the storage carbohydrate trehalose; expression is induced by stress conditions and repressed by the Ras-cAMP pathway; protein abundance increases in response to DNA replication stress Gene:TRP1(YDR007W)|FD-Score:-3.33|P-value:4.27E-4||SGD DESC:Phosphoribosylanthranilate isomerase that catalyzes the third step in tryptophan biosynthesis; in 2004, the sequence of TRP1 from strain S228C was updated by changing the previously annotated internal STOP (TAA) to serine (TCA) Gene:TRP3(YKL211C)|FD-Score:-3.6|P-value:1.56E-4||SGD DESC:Indole-3-glycerol-phosphate synthase; forms bifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p Gene:TSR2(YLR435W)|FD-Score:-3.37|P-value:3.76E-4||SGD DESC:Protein with a potential role in pre-rRNA processing Gene:TVP15(YDR100W)|FD-Score:-3.12|P-value:9.03E-4||SGD DESC:Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p Gene:YBL095W(YBL095W_p)|FD-Score:-3.54|P-value:2.03E-4||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:YCK2(YNL154C)|FD-Score:-3.7|P-value:1.06E-4||SGD DESC:Palmitoylated plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck1p in morphogenesis, proper septin assembly, endocytic trafficking; YCK2 has a paralog, YCK1, that arose from the whole genome duplication Gene:YDR274C(YDR274C_d)|FD-Score:4.09|P-value:2.20E-5||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YET3(YDL072C)|FD-Score:3.47|P-value:2.64E-4||SGD DESC:Protein of unknown function; YET3 null mutant decreases the level of secreted invertase; homolog of human BAP31 protein; protein abundance increases in response to DNA replication stress Gene:YGR111W(YGR111W_p)|FD-Score:3.14|P-value:8.35E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus Gene:YHR049C-A(YHR049C-A_d)|FD-Score:4.86|P-value:5.80E-7||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YIL046W-A(YIL046W-A_p)|FD-Score:3.35|P-value:4.00E-4||SGD DESC:Putative protein of unknown function; identified by expression profiling and mass spectrometry Gene:YIR035C(YIR035C_p)|FD-Score:3.19|P-value:7.22E-4||SGD DESC:Putative cytoplasmic short-chain dehydrogenase/reductase Gene:YIR043C(YIR043C)|FD-Score:3.23|P-value:6.26E-4||SGD DESC:Possible pseudogene in strain S288C; YIR043C and the adjacent ORF, YIR044C, together may encode a non-functional member of the conserved, often subtelomerically-encoded Cos protein family Gene:YJL193W(YJL193W_p)|FD-Score:4.08|P-value:2.25E-5||SGD DESC:Putative protein of unknown function, predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect Gene:YLR366W(YLR366W_d)|FD-Score:-3.4|P-value:3.32E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR364C-A Gene:YME2(YMR302C)|FD-Score:3.53|P-value:2.05E-4||SGD DESC:Integral inner mitochondrial membrane protein with a role in maintaining mitochondrial nucleoid structure and number; mutants exhibit an increased rate of mitochondrial DNA escape; shows some sequence similarity to exonucleases Gene:YML034C-A(YML034C-A_d)|FD-Score:3.14|P-value:8.43E-4||SGD DESC:Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YML131W(YML131W_p)|FD-Score:3.71|P-value:1.05E-4||SGD DESC:Protein of unknown function; similar to medium chain dehydrogenase/reductases; expression induced by stresses including osmotic shock, DNA damaging agents, and other chemicals; GFP-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress Gene:YPL038W-A(YPL038W-A_p)|FD-Score:3.26|P-value:5.48E-4||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR Gene:YPL257W(YPL257W_p)|FD-Score:3.28|P-value:5.20E-4||SGD DESC:Putative protein of unknown function; homozygous diploid deletion strain exhibits low budding index; physically interacts with Hsp82p; YPL257W is not an essential gene Gene:APN1(YKL114C)|FD-Score:4.42|P-value:5.04E-6||SGD DESC:Major apurinic/apyrimidinic endonuclease, 3'-repair diesterase involved in repair of DNA damage by oxidation and alkylating agents; also functions as a 3'-5' exonuclease to repair 7,8-dihydro-8-oxodeoxyguanosine Gene:AQR1(YNL065W)|FD-Score:3.94|P-value:4.10E-5||SGD DESC:Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; confers resistance to short-chain monocarboxylic acids and quinidine; involved in the excretion of excess amino acids; AQR1 has a paralog, QDR1, that arose from the whole genome duplication; relocalizes from plasma membrane to cytoplasm upon DNA replication stress Gene:BUD31(YCR063W)|FD-Score:3.19|P-value:7.02E-4||SGD DESC:Component of the SF3b subcomplex of the U2 snRNP; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern; facilitates passage through G1/S Start, but is not required for G2/M transition or exit from mitosis Gene:CTP1(YBR291C)|FD-Score:3.78|P-value:7.73E-5||SGD DESC:Mitochondrial inner membrane citrate transporter, member of the mitochondrial carrier family Gene:CWC21(YDR482C)|FD-Score:-3.46|P-value:2.65E-4||SGD DESC:Protein involved in RNA splicing by the spliceosome; component of a complex containing Cef1p; interacts genetically with ISY1 and BUD13; may bind RNA; has similarity to S. pombe Cwf21p Gene:FUI1(YBL042C)|FD-Score:9.29|P-value:7.94E-21||SGD DESC:High affinity uridine permease, localizes to the plasma membrane; also mediates low but significant transport of the cytotoxic nucleoside analog 5-fluorouridine; not involved in uracil transport; relative distribution to the vacuole increases upon DNA replication stress Gene:GID8(YMR135C)|FD-Score:3.54|P-value:2.00E-4||SGD DESC:Subunit of GID Complex, binds strongly to central component Vid30p; GID Complex is involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; recruits Rmd5p, Fyv10 and Vid28p to GID Complex; contains LisH, CTLH, and CRA domains that mediate binding to Vid30p (LisH) and Rmd5p and Vid28p (CTLH and CRA); dosage-dependent regulator of START Gene:HAL1(YPR005C)|FD-Score:3.18|P-value:7.49E-4||SGD DESC:Cytoplasmic protein involved in halotolerance; decreases intracellular Na+ (via Ena1p) and increases intracellular K+ by decreasing efflux; expression repressed by Ssn6p-Tup1p and Sko1p and induced by NaCl, KCl, and sorbitol through Gcn4p Gene:IRC21(YMR073C)|FD-Score:4.38|P-value:5.98E-6||SGD DESC:Putative protein of unknown function; may be involved in resistance to carboplatin and cisplatin; null mutant displays increase in spontaneous Rad52p foci; contains a lipid-binding domain and binds cardiolipin in a large-scale study Gene:LDB19(YOR322C)|FD-Score:6.29|P-value:1.60E-10||SGD DESC:Protein involved in regulating the endocytosis of plasma membrane proteins by recruiting the ubiquitin ligase Rsp5p to its target; inhibited by Npr1p-mediated phosphorylation, which affects translocation between the cytosol and the plasma membrane; null mutant has reduced affinity for alcian blue dye Gene:LSB5(YCL034W)|FD-Score:3.12|P-value:9.05E-4||SGD DESC:Protein of unknown function; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; may mediate disassembly of the Pan1 complex from the endocytic coat Gene:MET31(YPL038W)|FD-Score:3.72|P-value:9.85E-5||SGD DESC:Zinc-finger DNA-binding transcription factor; involved in transcriptional regulation of the methionine biosynthetic genes; MET31 has a paralog, MET32, that arose from the whole genome duplication Gene:MGA1(YGR249W)|FD-Score:4.67|P-value:1.49E-6||SGD DESC:Protein similar to heat shock transcription factor; multicopy suppressor of pseudohyphal growth defects of ammonium permease mutants Gene:MLH2(YLR035C)|FD-Score:-3.21|P-value:6.59E-4||SGD DESC:Protein involved in the mismatch repair of certain frameshift intermediates and involved in meiotic recombination; forms a complex with Mlh1p Gene:MRPL27(YBR282W)|FD-Score:3.53|P-value:2.11E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit; homolog of human Bcl-2 interacting protein BMRP Gene:NDJ1(YOL104C)|FD-Score:3.83|P-value:6.45E-5||SGD DESC:Meiosis-specific telomere protein, required for bouquet formation, effective homolog pairing, ordered cross-over distribution, sister chromatid cohesion at meiotic telomeres, chromosomal segregation and telomere-led rapid prophase movement Gene:OM14(YBR230C)|FD-Score:-5.03|P-value:2.43E-7||SGD DESC:Integral mitochondrial outer membrane protein; abundance is decreased in cells grown in glucose relative to other carbon sources; appears to contain 3 alpha-helical transmembrane segments; ORF encodes a 97-basepair intron Gene:PAU24(YBR301W)|FD-Score:3.51|P-value:2.21E-4||SGD DESC:Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; member of the seripauperin multigene family encoded mainly in subtelomeric regions; expressed under anaerobic conditions, completely repressed during aerobic growth Gene:PCS60(YBR222C)|FD-Score:4.29|P-value:8.85E-6||SGD DESC:Peroxisomal protein that binds AMP and mRNA, localizes to both the peroxisomal peripheral membrane and matrix, expression is highly inducible by oleic acid, similar to E. coli long chain acyl-CoA synthetase Gene:PDH1(YPR002W)|FD-Score:4.03|P-value:2.79E-5||SGD DESC:Mitochondrial protein that participates in respiration, induced by diauxic shift; homologous to E. coli PrpD, may take part in the conversion of 2-methylcitrate to 2-methylisocitrate Gene:PHO80(YOL001W)|FD-Score:-3.3|P-value:4.86E-4||SGD DESC:Cyclin, interacts with cyclin-dependent kinase Pho85p; regulates the response to nutrient levels and environmental conditions, including the response to phosphate limitation and stress-dependent calcium signaling Gene:PIH1(YHR034C)|FD-Score:3.55|P-value:1.91E-4||SGD DESC:Component of the conserved R2TP complex (Rvb1-Rvb2-Tah1-Pih1); R2TP complex interacts with Hsp90 (Hsp82p and Hsc82p) to mediate assembly large protein complexes such as box C/D snoRNPs and RNA polymerase II Gene:POC4(YPL144W)|FD-Score:3.91|P-value:4.57E-5||SGD DESC:Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions Gene:RAD6(YGL058W)|FD-Score:-3.35|P-value:4.11E-4||SGD DESC:Ubiquitin-conjugating enzyme (E2), involved in postreplication repair (as a heterodimer with Rad18p), DSBR and checkpoint control (as a heterodimer with Bre1p), ubiquitin-mediated N-end rule protein degradation (as a heterodimer with Ubr1p Gene:REG1(YDR028C)|FD-Score:-3.26|P-value:5.63E-4||SGD DESC:Regulatory subunit of type 1 protein phosphatase Glc7p; involved in negative regulation of glucose-repressible genes; involved in regulation of the nucleocytoplasmic shuttling of Hxk2p Gene:ROM2(YLR371W)|FD-Score:4.16|P-value:1.57E-5||SGD DESC:GDP/GTP exchange factor (GEF) for Rho1p and Rho2p; mutations are synthetically lethal with mutations in rom1, which also encodes a GEF; Rom2p localization to the bud surface is dependent on Ack1p Gene:RPN4(YDL020C)|FD-Score:3.34|P-value:4.12E-4||SGD DESC:Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses; relative distribution to the nucleus increases upon DNA replication stress Gene:RTC3(YHR087W)|FD-Score:5.61|P-value:1.00E-8||SGD DESC:Protein of unknown function involved in RNA metabolism; has structural similarity to SBDS, the human protein mutated in Shwachman-Diamond Syndrome (the yeast SBDS ortholog = SDO1); null mutation suppresses cdc13-1 temperature sensitivity; protein abundance increases in response to DNA replication stress Gene:RUP1(YOR138C)|FD-Score:3.62|P-value:1.45E-4||SGD DESC:Protein that regulates Rsp5p, which is a HECT ubiquitin ligase; has a WW domain consensus motif of PPPSY (residues 131-135) that mediates binding of Rsp5p to Ubp2p; contains an UBA domain; relative distribution to the nucleus increases upon DNA replication stress Gene:SAP4(YGL229C)|FD-Score:-3.21|P-value:6.66E-4||SGD DESC:Protein required for function of the Sit4p protein phosphatase, member of a family of similar proteins that form complexes with Sit4p, including Sap155p, Sap185p, and Sap190p Gene:SAT4(YCR008W)|FD-Score:3.2|P-value:6.98E-4||SGD DESC:Ser/Thr protein kinase involved in salt tolerance; funtions in regulation of Trk1p-Trk2p potassium transporter; partially redundant with Hal5p; has similarity to Npr1p Gene:SGF29(YCL010C)|FD-Score:6.47|P-value:4.92E-11||SGD DESC:Component of the HAT/Core module of the SAGA, SLIK, and ADA complexes; HAT/Core module also contains Gcn5p, Ngg1p, and Ada2p; binds methylated histone H3K4; involved in transcriptional regulation through SAGA and TBP recruitment to target promoters and H3 acetylation Gene:SHM1(YBR263W)|FD-Score:3.22|P-value:6.50E-4||SGD DESC:Mitochondrial serine hydroxymethyltransferase, converts serine to glycine plus 5,10 methylenetetrahydrofolate; involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis; reverse reaction generates serine Gene:SPO23(YBR250W)|FD-Score:-5.1|P-value:1.67E-7||SGD DESC:Protein of unknown function; associates with meiosis-specific protein Spo1p Gene:TPS2(YDR074W)|FD-Score:3.81|P-value:7.01E-5||SGD DESC:Phosphatase subunit of the trehalose-6-P synthase/phosphatase complex; involved in synthesis of the storage carbohydrate trehalose; expression is induced by stress conditions and repressed by the Ras-cAMP pathway; protein abundance increases in response to DNA replication stress Gene:TRP1(YDR007W)|FD-Score:-3.33|P-value:4.27E-4||SGD DESC:Phosphoribosylanthranilate isomerase that catalyzes the third step in tryptophan biosynthesis; in 2004, the sequence of TRP1 from strain S228C was updated by changing the previously annotated internal STOP (TAA) to serine (TCA) Gene:TRP3(YKL211C)|FD-Score:-3.6|P-value:1.56E-4||SGD DESC:Indole-3-glycerol-phosphate synthase; forms bifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p Gene:TSR2(YLR435W)|FD-Score:-3.37|P-value:3.76E-4||SGD DESC:Protein with a potential role in pre-rRNA processing Gene:TVP15(YDR100W)|FD-Score:-3.12|P-value:9.03E-4||SGD DESC:Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p Gene:YBL095W(YBL095W_p)|FD-Score:-3.54|P-value:2.03E-4||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:YCK2(YNL154C)|FD-Score:-3.7|P-value:1.06E-4||SGD DESC:Palmitoylated plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck1p in morphogenesis, proper septin assembly, endocytic trafficking; YCK2 has a paralog, YCK1, that arose from the whole genome duplication Gene:YDR274C(YDR274C_d)|FD-Score:4.09|P-value:2.20E-5||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YET3(YDL072C)|FD-Score:3.47|P-value:2.64E-4||SGD DESC:Protein of unknown function; YET3 null mutant decreases the level of secreted invertase; homolog of human BAP31 protein; protein abundance increases in response to DNA replication stress Gene:YGR111W(YGR111W_p)|FD-Score:3.14|P-value:8.35E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus Gene:YHR049C-A(YHR049C-A_d)|FD-Score:4.86|P-value:5.80E-7||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YIL046W-A(YIL046W-A_p)|FD-Score:3.35|P-value:4.00E-4||SGD DESC:Putative protein of unknown function; identified by expression profiling and mass spectrometry Gene:YIR035C(YIR035C_p)|FD-Score:3.19|P-value:7.22E-4||SGD DESC:Putative cytoplasmic short-chain dehydrogenase/reductase Gene:YIR043C(YIR043C)|FD-Score:3.23|P-value:6.26E-4||SGD DESC:Possible pseudogene in strain S288C; YIR043C and the adjacent ORF, YIR044C, together may encode a non-functional member of the conserved, often subtelomerically-encoded Cos protein family Gene:YJL193W(YJL193W_p)|FD-Score:4.08|P-value:2.25E-5||SGD DESC:Putative protein of unknown function, predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect Gene:YLR366W(YLR366W_d)|FD-Score:-3.4|P-value:3.32E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR364C-A Gene:YME2(YMR302C)|FD-Score:3.53|P-value:2.05E-4||SGD DESC:Integral inner mitochondrial membrane protein with a role in maintaining mitochondrial nucleoid structure and number; mutants exhibit an increased rate of mitochondrial DNA escape; shows some sequence similarity to exonucleases Gene:YML034C-A(YML034C-A_d)|FD-Score:3.14|P-value:8.43E-4||SGD DESC:Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YML131W(YML131W_p)|FD-Score:3.71|P-value:1.05E-4||SGD DESC:Protein of unknown function; similar to medium chain dehydrogenase/reductases; expression induced by stresses including osmotic shock, DNA damaging agents, and other chemicals; GFP-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress Gene:YPL038W-A(YPL038W-A_p)|FD-Score:3.26|P-value:5.48E-4||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR Gene:YPL257W(YPL257W_p)|FD-Score:3.28|P-value:5.20E-4||SGD DESC:Putative protein of unknown function; homozygous diploid deletion strain exhibits low budding index; physically interacts with Hsp82p; YPL257W is not an essential gene

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YGL093W8.825.64E-192.98SPC105Subunit of a kinetochore-microtubule binding complex with Kre28p that bridges centromeric heterochromatin and kinetochore MAPs and motors; required for sister chromatid bi-orientation and kinetochore binding of SAC components
YML092C5.842.65E-90.85PRE8Alpha 2 subunit of the 20S proteasome
YDR086C4.983.10E-70.48SSS1Subunit of the Sec61p translocation complex (Sec61p-Sss1p-Sbh1p) that forms a channel for passage of secretory proteins through the endoplasmic reticulum membrane, and of the Ssh1p complex (Ssh1p-Sbh2p-Sss1p); interacts with Ost4p and Wbp1p
YPR107C4.503.36E-60.10YTH1Essential RNA-binding component of cleavage and polyadenylation factor, contains five zinc fingers; required for pre-mRNA 3'-end processing and polyadenylation
YMR203W4.405.38E-60.09TOM40Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; constitutes the core element of the protein conducting pore
YOR362C4.318.10E-60.13PRE10Alpha 7 subunit of the 20S proteasome; protein abundance increases in response to DNA replication stress
YPR165W4.181.45E-50.15RHO1GTP-binding protein of the rho subfamily of Ras-like proteins, involved in establishment of cell polarity; regulates protein kinase C (Pkc1p) and the cell wall synthesizing enzyme 1,3-beta-glucan synthase (Fks1p and Gsc2p)
YDR404C4.032.82E-50.23RPB7RNA polymerase II subunit B16; forms two subunit dissociable complex with Rpb4p; involved in recruitment of 3'-end processing factors to transcribing RNA polymerase II complex and in export of mRNA to cytoplasm under stress conditions; also involved in translation initiation
YER094C3.807.26E-50.43PUP3Beta 3 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit C10
YPR176C3.373.77E-40.01BET2Beta subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p
YOR257W3.363.87E-40.23CDC31Calcium-binding component of the spindle pole body (SPB) half-bridge, required for SPB duplication in mitosis and meiosis II; homolog of mammalian centrin; binds multiubiquitinated proteins and is involved in proteasomal protein degradation
YML049C3.138.73E-40.02RSE1Protein involved in pre-mRNA splicing; component of the pre-spliceosome; associates with U2 snRNA; involved in ER to Golgi transport
YLR379W_d3.119.40E-40.02YLR379W_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential ORF SEC61/YLR378C
YDR087C3.080.001020.11RRP1Essential evolutionarily conserved nucleolar protein necessary for biogenesis of 60S ribosomal subunits and processing of pre-rRNAs to mature rRNAs, associated with several distinct 66S pre-ribosomal particles
YMR076C2.980.001450.05PDS5Protein required for establishment and maintenance of sister chromatid condensation and cohesion, colocalizes with cohesin on chromosomes, may function as a protein-protein interaction scaffold; also required during meiosis

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YBL042C9.297.94E-21FUI1High affinity uridine permease, localizes to the plasma membrane; also mediates low but significant transport of the cytotoxic nucleoside analog 5-fluorouridine; not involved in uracil transport; relative distribution to the vacuole increases upon DNA replication stress
YCL010C6.474.92E-11SGF29Component of the HAT/Core module of the SAGA, SLIK, and ADA complexes; HAT/Core module also contains Gcn5p, Ngg1p, and Ada2p; binds methylated histone H3K4; involved in transcriptional regulation through SAGA and TBP recruitment to target promoters and H3 acetylation
YOR322C6.291.60E-10LDB19Protein involved in regulating the endocytosis of plasma membrane proteins by recruiting the ubiquitin ligase Rsp5p to its target; inhibited by Npr1p-mediated phosphorylation, which affects translocation between the cytosol and the plasma membrane; null mutant has reduced affinity for alcian blue dye
YHR087W5.611.00E-8RTC3Protein of unknown function involved in RNA metabolism; has structural similarity to SBDS, the human protein mutated in Shwachman-Diamond Syndrome (the yeast SBDS ortholog = SDO1); null mutation suppresses cdc13-1 temperature sensitivity; protein abundance increases in response to DNA replication stress
YHR049C-A_d4.865.80E-7YHR049C-A_dDubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGR249W4.671.49E-6MGA1Protein similar to heat shock transcription factor; multicopy suppressor of pseudohyphal growth defects of ammonium permease mutants
YKL114C4.425.04E-6APN1Major apurinic/apyrimidinic endonuclease, 3'-repair diesterase involved in repair of DNA damage by oxidation and alkylating agents; also functions as a 3'-5' exonuclease to repair 7,8-dihydro-8-oxodeoxyguanosine
YMR073C4.385.98E-6IRC21Putative protein of unknown function; may be involved in resistance to carboplatin and cisplatin; null mutant displays increase in spontaneous Rad52p foci; contains a lipid-binding domain and binds cardiolipin in a large-scale study
YBR222C4.298.85E-6PCS60Peroxisomal protein that binds AMP and mRNA, localizes to both the peroxisomal peripheral membrane and matrix, expression is highly inducible by oleic acid, similar to E. coli long chain acyl-CoA synthetase
YLR371W4.161.57E-5ROM2GDP/GTP exchange factor (GEF) for Rho1p and Rho2p; mutations are synthetically lethal with mutations in rom1, which also encodes a GEF; Rom2p localization to the bud surface is dependent on Ack1p
YDR274C_d4.092.20E-5YDR274C_dDubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YJL193W_p4.082.25E-5YJL193W_pPutative protein of unknown function, predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect
YPR002W4.032.79E-5PDH1Mitochondrial protein that participates in respiration, induced by diauxic shift; homologous to E. coli PrpD, may take part in the conversion of 2-methylcitrate to 2-methylisocitrate
YNL065W3.944.10E-5AQR1Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; confers resistance to short-chain monocarboxylic acids and quinidine; involved in the excretion of excess amino acids; AQR1 has a paralog, QDR1, that arose from the whole genome duplication; relocalizes from plasma membrane to cytoplasm upon DNA replication stress
YPL144W3.914.57E-5POC4Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions

GO enrichment analysis for SGTC_388
No biological processes are significantly enriched (FDR < 0.1).

protein complexes

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.1681.25E-38SGTC_24295902844 64.4 μMMiscellaneous19277900.142857
0.1681.30E-38SGTC_635k038-0028 24.7 μMChemDiv (Drug-like library)40351020.0967742ubiquinone biosynthesis & proteasome
0.1673.83E-38SGTC_294k038-0071 157.0 μMChemDiv (Drug-like library)241528260.0526316ubiquinone biosynthesis & proteasome
0.1586.80E-34SGTC_30641327-0027 10.0 μMChemDiv (Drug-like library)160004550.12069
0.1553.63E-33SGTC_1420335-0849 62.7 μMChemDiv (Drug-like library)38890430.0833333ubiquinone biosynthesis & proteasome
0.1524.67E-32SGTC_30591327-0034 3.0 μMChemDiv (Drug-like library)159985800.0833333
0.1491.24E-30SGTC_1370438-0332 85.4 μMChemDiv (Drug-like library)20633930.0714286ubiquinone biosynthesis & proteasome
0.1455.73E-29SGTC_1880MG-132 525.0 μMMiscellaneous4623820.101695
0.1381.71E-26SGTC_216k038-0035 28.4 μMChemDiv (Drug-like library)44442310.0566038ubiquinone biosynthesis & proteasome
0.1382.17E-26SGTC_200k038-0079 37.5 μMChemDiv (Drug-like library)34366830.0714286ubiquinone biosynthesis & proteasome
0.1348.20E-25SGTC_5860957-0265 8.2 μMChemDiv (Drug-like library)67523090.0821918cell wall
0.1331.94E-24SGTC_30631327-0034 4.0 μMChemDiv (Drug-like library)159985800.0833333
0.1284.52E-23SGTC_165k038-0023 64.4 μMChemDiv (Drug-like library)463685430.0677966ubiquinone biosynthesis & proteasome
0.1286.85E-23SGTC_30601327-0027 12.5 μMChemDiv (Drug-like library)160004550.12069
0.1249.78E-22SGTC_64000l-0018 272.1 μMChemDiv (Drug-like library)68111190.0441176ubiquinone biosynthesis & proteasome

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_1693xanthone101.9 μM0.379317020TimTec (Natural product derivative library)196.201422.96402DNA damage response
SGTC_2532xanthone78.9 μM0.379317020Microsource (Natural product library)196.201422.96402
SGTC_200481-00134.94 μM0.363636182045ChemDiv (Drug-like library)241.070142.68602
SGTC_2080521252412.4 μM0.352941260183Chembridge (Fragment library)221.639721.36113copper-dependent oxidative stress
SGTC_2130NSC 72.45 μM0.35294121448Chembridge (Fragment library)235.66631.89703copper-dependent oxidative stress
SGTC_1678st01926580.2 μM0.3255367020TimTec (Natural product derivative library)249.264043.6080360S ribosome export
SGTC_1722st0343043.65 μM0.3243244036148TimTec (Natural product derivative library)263.50453.1502mitochondrial processes
SGTC_1850st05623817 μM0.3181825393177TimTec (Natural product derivative library)272.683163.813RPP1 & pyrimidine depletion
SGTC_230775389266.34 μM0.31428696582Chembridge (Fragment library)228.031621.77303
SGTC_1849st05623919.2 μM0.3111115393181TimTec (Natural product derivative library)286.709744.24713RPP1 & pyrimidine depletion
SGTC_15983(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin19.1 μM0.3043486312947TimTec (Pure natural product library)348.779125.27913