Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YDL195W | 6.79 | 5.49E-12 | 1.52 | SEC31 | Component of the Sec13p-Sec31p complex of the COPII vesicle coat, required for vesicle formation in ER to Golgi transport; mutant has increased aneuploidy tolerance |
YHR062C | 5.27 | 6.65E-8 | 0.63 | RPP1 | Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs |
YPR107C | 4.64 | 1.73E-6 | 0.57 | YTH1 | Essential RNA-binding component of cleavage and polyadenylation factor, contains five zinc fingers; required for pre-mRNA 3'-end processing and polyadenylation |
YNL272C | 4.07 | 2.37E-5 | 0.03 | SEC2 | Guanyl-nucleotide exchange factor for the small G-protein Sec4p; essential for post-Golgi vesicle transport and for autophagy; associates with the exocyst, via exocyst subunit Sec15p, on secretory vesicles |
YDR353W | 4.03 | 2.75E-5 | 0.12 | TRR1 | Cytoplasmic thioredoxin reductase; key regulatory enzyme that determines the redox state of the thioredoxin system, which acts as a disulfide reductase system and protects cells against both oxidative and reductive stress; protein abundance increases in response to DNA replication stress; TRR1 has a paralog, TRR2, that arose from the whole genome duplication |
YNL260C_p | 3.91 | 4.55E-5 | 0.16 | LTO1_p | Essential protein that forms a complex with Rli1p and Yae1p; ortholog of human ORAOV1, which is overexpressed in solid tumors; inviability of null mutant under standard conditions is complemented by overexpression of ORAOV1; essential for growth under standard (aerobic) conditions but not under anaerobic conditions; may have a role in protection of ribosomal assembly and function from damage due to reactive oxygen species |
YOR203W_d | 3.75 | 8.73E-5 | 0.02 | YOR203W_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps 5' end of essential DED1 gene required for translation initiation |
YOL077C | 3.73 | 9.46E-5 | 0.26 | BRX1 | Nucleolar protein, constituent of 66S pre-ribosomal particles; depletion leads to defects in rRNA processing and a block in the assembly of large ribosomal subunits; possesses a sigma(70)-like RNA-binding motif |
YMR059W | 3.48 | 2.55E-4 | 0.01 | SEN15 | Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p |
YJL025W | 3.47 | 2.60E-4 | 0.09 | RRN7 | Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p |
YNL287W | 3.38 | 3.59E-4 | 0.02 | SEC21 | Gamma subunit of coatomer, a heptameric protein complex that together with Arf1p forms the COPI coat; involved in ER to Golgi transport of selective cargo |
YKR038C | 3.36 | 3.85E-4 | 0.16 | KAE1 | Highly conserved ATPase of HSP70/DnaK family; component of the EKC/KEOPS complex with Bud32p, Cgi121p, Pcc1p, and Gon7p; EKC/KEOPS complex is required for t6A tRNA modification and may have roles in telomere maintenance and transcription |
YML098W | 3.20 | 6.85E-4 | 0.14 | TAF13 | TFIID subunit (19 kDa), involved in RNA polymerase II transcription initiation, similar to histone H4 with atypical histone fold motif of Spt3-like transcription factors |
YGR267C | 3.07 | 0.00108 | 0.03 | FOL2 | GTP-cyclohydrolase I, catalyzes the first step in the folic acid biosynthetic pathway |
YLR145W | 3.03 | 0.00121 | 0.00 | RMP1 | Subunit of RNase MRP, which processes pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; unlike most subunits, not shared between RNase MRP and nuclear RNase P |