Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YOL144W | 6.41 | 7.49E-11 | 1.04 | NOP8 | Nucleolar protein required for 60S ribosomal subunit biogenesis |
YER094C | 5.37 | 4.01E-8 | 0.69 | PUP3 | Beta 3 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit C10 |
YCR052W | 4.68 | 1.46E-6 | 0.05 | RSC6 | Component of the RSC chromatin remodeling complex; essential for mitotic growth; homolog of SWI/SNF subunit Swp73p |
YER003C | 4.62 | 1.88E-6 | 0.08 | PMI40 | Mannose-6-phosphate isomerase, catalyzes the interconversion of fructose-6-P and mannose-6-P; required for early steps in protein mannosylation |
YJL074C | 4.55 | 2.69E-6 | 0.15 | SMC3 | Subunit of the multiprotein cohesin complex required for sister chromatid cohesion in mitotic cells; also required, with Rec8p, for cohesion and recombination during meiosis; phylogenetically conserved SMC chromosomal ATPase family member |
YLR033W | 4.40 | 5.41E-6 | 0.10 | RSC58 | Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance |
YNL161W | 4.30 | 8.64E-6 | 0.09 | CBK1 | Serine/threonine protein kinase of the the RAM signaling network; Ndr/LATS family member; binds regulatory subunit Mob2p; involved in regulation of cellular morphogenesis, polarized growth, and septum destruction; phosphorylation by Cbk1p regulates localization and activity of Ace2p transcription factor and Ssd1p translational repressor; Cbk1p activity is regulated by both phosphorylation and specific localization; relocalizes to cytoplasm upon DNA replication stress |
YER133W | 4.21 | 1.29E-5 | 0.08 | GLC7 | Type 1 serine/threonine protein phosphatase catalytic subunit; involved in various processes including glycogen metabolism, sporulation, mitosis; accumulates at mating projections by interaction with Afr1p; interacts with many regulatory subunits; involved in regulation of the nucleocytoplasmic shuttling of Hxk2p; import into nucleus is inhibited during spindle assembly checkpoint arrest |
YMR208W | 4.12 | 1.86E-5 | 0.31 | ERG12 | Mevalonate kinase, acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate |
YDR145W | 3.81 | 6.90E-5 | 0.01 | TAF12 | Subunit (61/68 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification, similar to histone H2A |
YAL034W-A | 3.80 | 7.16E-5 | 0.04 | MTW1 | Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; critical to kinetochore assembly |
YJL081C | 3.76 | 8.48E-5 | 0.03 | ARP4 | Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes |
YNL189W | 3.73 | 9.40E-5 | 0.00 | SRP1 | Karyopherin alpha homolog, forms a dimer with karyopherin beta Kap95p to mediate import of nuclear proteins, binds the nuclear localization signal of the substrate during import; may also play a role in regulation of protein degradation |
YDR180W | 3.73 | 9.50E-5 | 0.02 | SCC2 | Subunit of cohesin loading factor (Scc2p-Scc4p), a complex required for loading of cohesin complexes onto chromosomes; involved in establishing sister chromatid cohesion during DSB repair via histone H2AX; evolutionarily-conserved adherin |
YJL086C_d | 3.71 | 1.04E-4 | 0.05 | YJL086C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL085W/EXO70 and YJL087C/TRL1 |