0960-0234

N-[3-[(3,5-diiodo-6-oxocyclohexa-2,4-dien-1-ylidene)methylamino]phenyl]furan-2-carboxamide

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_4
Screen concentration 25.7 μM
Source ChemDiv (Drug-like library)
PubChem CID 6821112
SMILES C1=CC(=CC(=C1)NC(=O)C2=CC=CO2)NC=C3C=C(C=C(C3=O)I)I
Standardized SMILES Oc1c(I)cc(I)cc1C=Nc2cccc(NC(=O)c3occc3)c2
Molecular weight 558.1084
ALogP 2.84
H-bond donor count 2
H-bond acceptor count 4
Response signature Golgi

Pool Growth Kinetics
% growth inhibition (Het. pool) 17.16
% growth inhibition (Hom. pool) 10.01


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 6821112
Download HIP data (tab-delimited text)  (excel)
Gene:CAB1(YDR531W)|FD-Score:4.33|P-value:7.38E-6|Clearance:0.1||SGD DESC:Pantothenate kinase (ATP:D-pantothenate 4'-phosphotransferase, EC 2.7.1.33); catalyzes the first committed step in the universal biosynthetic pathway for synthesis of coenzyme A (CoA); transcriptionally regulated by Upc2p via a sterol response element Gene:CDC34(YDR054C)|FD-Score:4.23|P-value:1.14E-5|Clearance:0.21||SGD DESC:Ubiquitin-conjugating enzyme (E2); catalytic subunit of SCF ubiquitin-protein ligase complex (together with Skp1p, Rbx1p, Cdc53p, and an F-box protein) that regulates cell cycle progression by targeting key substrates for degradation; protein abundance increases in response to DNA replication stress Gene:CWC24(YLR323C)|FD-Score:3.61|P-value:1.51E-4|Clearance:0.32||SGD DESC:Spliceosome assembly factor, essential for the first step of splicing; component of the pre-catalytic spliceosome complex containing Cef1p; has similarity to S. pombe Cwf24p Gene:DRS1(YLL008W)|FD-Score:3.13|P-value:8.72E-4|Clearance:0.09||SGD DESC:Nucleolar DEAD-box protein required for ribosome assembly and function, including synthesis of 60S ribosomal subunits; constituent of 66S pre-ribosomal particles Gene:ERB1(YMR049C)|FD-Score:-3.51|P-value:2.28E-4|Clearance:0||SGD DESC:Constituent of 66S pre-ribosomal particles, forms a complex with Nop7p and Ytm1p that is required for maturation of the large ribosomal subunit; required for maturation of the 25S and 5.8S ribosomal RNAs; homologous to mammalian Bop1 Gene:ERG11(YHR007C)|FD-Score:7.67|P-value:8.36E-15|Clearance:1.37||SGD DESC:Lanosterol 14-alpha-demethylase; catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 family; associated and coordinately regulated with the P450 reductase Ncp1p Gene:GCD6(YDR211W)|FD-Score:6.79|P-value:5.66E-12|Clearance:1.37||SGD DESC:Catalytic epsilon subunit of the translation initiation factor eIF2B; eIF2B is the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression; forms cytoplasmic foci upon DNA replication stress Gene:HSP10(YOR020C)|FD-Score:3.8|P-value:7.22E-5|Clearance:0.13||SGD DESC:Mitochondrial matrix co-chaperonin that inhibits the ATPase activity of Hsp60p, a mitochondrial chaperonin; involved in protein folding and sorting in the mitochondria; 10 kD heat shock protein with similarity to E. coli groES Gene:IDI1(YPL117C)|FD-Score:3.15|P-value:8.27E-4|Clearance:0.02||SGD DESC:Isopentenyl diphosphate:dimethylallyl diphosphate isomerase (IPP isomerase), catalyzes an essential activation step in the isoprenoid biosynthetic pathway; required for viability Gene:NUP116(YMR047C)|FD-Score:4.85|P-value:6.09E-7|Clearance:0.26||SGD DESC:FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; forms a stable association with Nup82p, Gle2p and two other FG-nucleoporins (Nsp1p and Nup159p) Gene:PGS1(YCL004W)|FD-Score:4.51|P-value:3.31E-6|Clearance:0.17||SGD DESC:Phosphatidylglycerolphosphate synthase, catalyzes the synthesis of phosphatidylglycerolphosphate from CDP-diacylglycerol and sn-glycerol 3-phosphate in the first committed and rate-limiting step of cardiolipin biosynthesis Gene:PMI40(YER003C)|FD-Score:3.3|P-value:4.85E-4|Clearance:0.15||SGD DESC:Mannose-6-phosphate isomerase, catalyzes the interconversion of fructose-6-P and mannose-6-P; required for early steps in protein mannosylation Gene:RRN7(YJL025W)|FD-Score:3.67|P-value:1.22E-4|Clearance:0.05||SGD DESC:Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p Gene:RSC58(YLR033W)|FD-Score:4.02|P-value:2.90E-5|Clearance:0.22||SGD DESC:Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance Gene:RSC8(YFR037C)|FD-Score:4.59|P-value:2.22E-6|Clearance:0.08||SGD DESC:Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters Gene:RSP5(YER125W)|FD-Score:5.1|P-value:1.71E-7|Clearance:0.02||SGD DESC:E3 ubiquitin ligase of the NEDD4 family; involved in regulating many cellular processes including MVB sorting, heat shock response, transcription, endocytosis, and ribosome stability; human homolog is involved in Liddle syndrome; mutant tolerates aneuploidy; ubiquitylates Sec23p Gene:SEC12(YNR026C)|FD-Score:-4.93|P-value:4.17E-7|Clearance:0||SGD DESC:Guanine nucleotide exchange factor (GEF), activates Sar1p by catalyzing the exchange of GDP for GTP; required for the initiation of COPII vesicle formation in ER to Golgi transport; glycosylated integral membrane protein of the ER Gene:STH1(YIL126W)|FD-Score:5.08|P-value:1.87E-7|Clearance:0.23||SGD DESC:ATPase component of the RSC chromatin remodeling complex; required for expression of early meiotic genes; essential helicase-related protein homologous to Snf2p Gene:TID3(YIL144W)|FD-Score:7.07|P-value:7.49E-13|Clearance:1.37||SGD DESC:Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); conserved coiled-coil protein involved in chromosome segregation, spindle checkpoint activity, kinetochore assembly and clustering Gene:YPL251W(YPL251W_d)|FD-Score:5.41|P-value:3.08E-8|Clearance:0.32||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified, essential gene YAH1/YPL252C Gene:CAB1(YDR531W)|FD-Score:4.33|P-value:7.38E-6|Clearance:0.1||SGD DESC:Pantothenate kinase (ATP:D-pantothenate 4'-phosphotransferase, EC 2.7.1.33); catalyzes the first committed step in the universal biosynthetic pathway for synthesis of coenzyme A (CoA); transcriptionally regulated by Upc2p via a sterol response element Gene:CDC34(YDR054C)|FD-Score:4.23|P-value:1.14E-5|Clearance:0.21||SGD DESC:Ubiquitin-conjugating enzyme (E2); catalytic subunit of SCF ubiquitin-protein ligase complex (together with Skp1p, Rbx1p, Cdc53p, and an F-box protein) that regulates cell cycle progression by targeting key substrates for degradation; protein abundance increases in response to DNA replication stress Gene:CWC24(YLR323C)|FD-Score:3.61|P-value:1.51E-4|Clearance:0.32||SGD DESC:Spliceosome assembly factor, essential for the first step of splicing; component of the pre-catalytic spliceosome complex containing Cef1p; has similarity to S. pombe Cwf24p Gene:DRS1(YLL008W)|FD-Score:3.13|P-value:8.72E-4|Clearance:0.09||SGD DESC:Nucleolar DEAD-box protein required for ribosome assembly and function, including synthesis of 60S ribosomal subunits; constituent of 66S pre-ribosomal particles Gene:ERB1(YMR049C)|FD-Score:-3.51|P-value:2.28E-4|Clearance:0||SGD DESC:Constituent of 66S pre-ribosomal particles, forms a complex with Nop7p and Ytm1p that is required for maturation of the large ribosomal subunit; required for maturation of the 25S and 5.8S ribosomal RNAs; homologous to mammalian Bop1 Gene:ERG11(YHR007C)|FD-Score:7.67|P-value:8.36E-15|Clearance:1.37||SGD DESC:Lanosterol 14-alpha-demethylase; catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 family; associated and coordinately regulated with the P450 reductase Ncp1p Gene:GCD6(YDR211W)|FD-Score:6.79|P-value:5.66E-12|Clearance:1.37||SGD DESC:Catalytic epsilon subunit of the translation initiation factor eIF2B; eIF2B is the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression; forms cytoplasmic foci upon DNA replication stress Gene:HSP10(YOR020C)|FD-Score:3.8|P-value:7.22E-5|Clearance:0.13||SGD DESC:Mitochondrial matrix co-chaperonin that inhibits the ATPase activity of Hsp60p, a mitochondrial chaperonin; involved in protein folding and sorting in the mitochondria; 10 kD heat shock protein with similarity to E. coli groES Gene:IDI1(YPL117C)|FD-Score:3.15|P-value:8.27E-4|Clearance:0.02||SGD DESC:Isopentenyl diphosphate:dimethylallyl diphosphate isomerase (IPP isomerase), catalyzes an essential activation step in the isoprenoid biosynthetic pathway; required for viability Gene:NUP116(YMR047C)|FD-Score:4.85|P-value:6.09E-7|Clearance:0.26||SGD DESC:FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; forms a stable association with Nup82p, Gle2p and two other FG-nucleoporins (Nsp1p and Nup159p) Gene:PGS1(YCL004W)|FD-Score:4.51|P-value:3.31E-6|Clearance:0.17||SGD DESC:Phosphatidylglycerolphosphate synthase, catalyzes the synthesis of phosphatidylglycerolphosphate from CDP-diacylglycerol and sn-glycerol 3-phosphate in the first committed and rate-limiting step of cardiolipin biosynthesis Gene:PMI40(YER003C)|FD-Score:3.3|P-value:4.85E-4|Clearance:0.15||SGD DESC:Mannose-6-phosphate isomerase, catalyzes the interconversion of fructose-6-P and mannose-6-P; required for early steps in protein mannosylation Gene:RRN7(YJL025W)|FD-Score:3.67|P-value:1.22E-4|Clearance:0.05||SGD DESC:Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p Gene:RSC58(YLR033W)|FD-Score:4.02|P-value:2.90E-5|Clearance:0.22||SGD DESC:Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance Gene:RSC8(YFR037C)|FD-Score:4.59|P-value:2.22E-6|Clearance:0.08||SGD DESC:Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters Gene:RSP5(YER125W)|FD-Score:5.1|P-value:1.71E-7|Clearance:0.02||SGD DESC:E3 ubiquitin ligase of the NEDD4 family; involved in regulating many cellular processes including MVB sorting, heat shock response, transcription, endocytosis, and ribosome stability; human homolog is involved in Liddle syndrome; mutant tolerates aneuploidy; ubiquitylates Sec23p Gene:SEC12(YNR026C)|FD-Score:-4.93|P-value:4.17E-7|Clearance:0||SGD DESC:Guanine nucleotide exchange factor (GEF), activates Sar1p by catalyzing the exchange of GDP for GTP; required for the initiation of COPII vesicle formation in ER to Golgi transport; glycosylated integral membrane protein of the ER Gene:STH1(YIL126W)|FD-Score:5.08|P-value:1.87E-7|Clearance:0.23||SGD DESC:ATPase component of the RSC chromatin remodeling complex; required for expression of early meiotic genes; essential helicase-related protein homologous to Snf2p Gene:TID3(YIL144W)|FD-Score:7.07|P-value:7.49E-13|Clearance:1.37||SGD DESC:Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); conserved coiled-coil protein involved in chromosome segregation, spindle checkpoint activity, kinetochore assembly and clustering Gene:YPL251W(YPL251W_d)|FD-Score:5.41|P-value:3.08E-8|Clearance:0.32||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified, essential gene YAH1/YPL252C

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 6821112
Download HOP data (tab-delimited text)  (excel)
Gene:ATG11(YPR049C)|FD-Score:3.15|P-value:8.05E-4||SGD DESC:Adapter protein for pexophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; directs receptor-bound cargo to the phagophore assembly site (PAS) for packaging into vesicles; required for recruiting other proteins to the (PAS) Gene:BIO2(YGR286C)|FD-Score:3.59|P-value:1.65E-4||SGD DESC:Biotin synthase, catalyzes the conversion of dethiobiotin to biotin, which is the last step of the biotin biosynthesis pathway; complements E. coli bioB mutant Gene:BIO5(YNR056C)|FD-Score:3.95|P-value:3.91E-5||SGD DESC:Putative transmembrane protein involved in the biotin biosynthesis pathway; responsible for uptake of 7-keto 8-aminopelargonic acid; BIO5 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis Gene:CAP2(YIL034C)|FD-Score:3.29|P-value:5.07E-4||SGD DESC:Beta subunit of the capping protein heterodimer (Cap1p and Cap2p); capping protein (CP) binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to cortical actin patches; protein increases in abundance and relocalizes from bud neck to plasma membrane upon DNA replication stress Gene:COG1(YGL223C)|FD-Score:4.9|P-value:4.89E-7||SGD DESC:Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:COG6(YNL041C)|FD-Score:7.13|P-value:5.15E-13||SGD DESC:Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:COG7(YGL005C)|FD-Score:8.55|P-value:6.14E-18||SGD DESC:Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:COG8(YML071C)|FD-Score:6.31|P-value:1.36E-10||SGD DESC:Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:DGR2(YKL121W_p)|FD-Score:3.42|P-value:3.08E-4||SGD DESC:Protein of unknown function; null mutant is resistant to 2-deoxy-D-glucose and displays abnormally elongated buds Gene:EFT1(YOR133W)|FD-Score:3.57|P-value:1.78E-4||SGD DESC:Elongation factor 2 (EF-2), also encoded by EFT2; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin; EFT1 has a paralog, EFT2, that arose from the whole genome duplication Gene:FAA3(YIL009W)|FD-Score:3.36|P-value:3.93E-4||SGD DESC:Long chain fatty acyl-CoA synthetase, activates imported fatty acids; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery Gene:GET2(YER083C)|FD-Score:4.2|P-value:1.36E-5||SGD DESC:Subunit of the GET complex; involved in insertion of proteins into the ER membrane; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for meiotic nuclear division Gene:GYP1(YOR070C)|FD-Score:3.1|P-value:9.76E-4||SGD DESC:Cis-golgi GTPase-activating protein (GAP) for the Rab family members Ypt1p (in vivo) and for Ypt1p, Sec4p, Ypt7p, and Ypt51p (in vitro); involved in vesicle docking and fusion Gene:HOM2(YDR158W)|FD-Score:3.48|P-value:2.47E-4||SGD DESC:Aspartic beta semi-aldehyde dehydrogenase, catalyzes the second step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis Gene:IRS4(YKR019C)|FD-Score:3.34|P-value:4.12E-4||SGD DESC:EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; IRS4 has a paralog, TAX4, that arose from the whole genome duplication Gene:MRS2(YOR334W)|FD-Score:-3.18|P-value:7.45E-4||SGD DESC:Mitochondrial inner membrane Mg(2+) channel, required for maintenance of intramitochondrial Mg(2+) concentrations at the correct level to support splicing of group II introns Gene:NTH2(YBR001C)|FD-Score:4.52|P-value:3.16E-6||SGD DESC:Putative neutral trehalase, required for thermotolerance; may mediate resistance to other cellular stresses; NTH2 has a paralog, NTH1, that arose from the whole genome duplication Gene:PDR17(YNL264C)|FD-Score:5|P-value:2.81E-7||SGD DESC:Phosphatidylinositol transfer protein (PITP), downregulates Plb1p-mediated turnover of phosphatidylcholine, found in the cytosol and microsomes, homologous to Pdr16p, deletion affects phospholipid composition Gene:RCY1(YJL204C)|FD-Score:3.32|P-value:4.45E-4||SGD DESC:F-box protein involved in recycling plasma membrane proteins internalized by endocytosis; localized to sites of polarized growth Gene:RIF1(YBR275C)|FD-Score:3.58|P-value:1.74E-4||SGD DESC:Protein that binds to the Rap1p C-terminus and acts synergistically with Rif2p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation Gene:RKM2(YDR198C)|FD-Score:-3.76|P-value:8.50E-5||SGD DESC:Ribosomal protein lysine methyltransferase, responsible for trimethylation of the lysine residue at position 3 of Rpl12Ap and Rpl12Bp Gene:RPL20B(YOR312C)|FD-Score:-3.32|P-value:4.55E-4||SGD DESC:Ribosomal 60S subunit protein L20B; homologous to mammalian ribosomal protein L18A, no bacterial homolog; RPL20B has a paralog, RPL20A, that arose from the whole genome duplication Gene:RRG9(YNL213C)|FD-Score:-3.51|P-value:2.27E-4||SGD DESC:Protein of unknown function; null mutant lacks mitochondrial DNA and cannot grow on glycerol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:RSR1(YGR152C)|FD-Score:3.13|P-value:8.64E-4||SGD DESC:GTP-binding protein of the ras superfamily required for bud site selection, morphological changes in response to mating pheromone, and efficient cell fusion; localized to the plasma membrane; significantly similar to mammalian Rap GTPases Gene:SKG6(YHR149C)|FD-Score:3.88|P-value:5.26E-5||SGD DESC:Integral membrane protein that localizes primarily to growing sites such as the bud tip or the cell periphery; potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p Gene:SLZ1(YNL196C_p)|FD-Score:3.96|P-value:3.69E-5||SGD DESC:Sporulation-specific protein with a leucine zipper motif Gene:SUC2(YIL162W)|FD-Score:3.41|P-value:3.20E-4||SGD DESC:Invertase, sucrose hydrolyzing enzyme; a secreted, glycosylated form is regulated by glucose repression, and an intracellular, nonglycosylated enzyme is produced constitutively Gene:SYS1(YJL004C)|FD-Score:4.15|P-value:1.65E-5||SGD DESC:Integral membrane protein of the Golgi required for targeting of the Arf-like GTPase Arl3p to the Golgi; multicopy suppressor of ypt6 null mutation Gene:VMR1(YHL035C)|FD-Score:4.31|P-value:8.25E-6||SGD DESC:Vacuolar membrane protein involved in multiple drug resistance and metal sensitivity; ATP-binding cassette (ABC) family member involved in drug transport; potential Cdc28p substrate; induced under respiratory conditions Gene:VPS63(YLR261C_d)|FD-Score:4.44|P-value:4.51E-6||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene YPT6; deletion causes a vacuolar protein sorting defect Gene:YCR100C(YCR100C_p)|FD-Score:-3.46|P-value:2.69E-4||SGD DESC:Putative protein of unknown function Gene:YHR095W(YHR095W_d)|FD-Score:3.27|P-value:5.29E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YIL032C(YIL032C_d)|FD-Score:3.24|P-value:5.95E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YIL059C(YIL059C_d)|FD-Score:3.32|P-value:4.53E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YIL060W Gene:YMR103C(YMR103C_d)|FD-Score:3.09|P-value:9.99E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YNL146C-A(YNL146C-A_p)|FD-Score:3.31|P-value:4.70E-4||SGD DESC:Putative protein of unknown function Gene:YNL179C(YNL179C_d)|FD-Score:3.37|P-value:3.76E-4||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; deletion in cyr1 mutant results in loss of stress resistance Gene:YOL097W-A(YOL097W-A_p)|FD-Score:3.48|P-value:2.51E-4||SGD DESC:Putative protein of unknown function; identified by expression profiling and mass spectrometry Gene:YOL163W(YOL163W_p)|FD-Score:4.18|P-value:1.43E-5||SGD DESC:Putative protein of unknown function; member of the Dal5p subfamily of the major facilitator family Gene:YOR059C(YOR059C_p)|FD-Score:3.8|P-value:7.31E-5||SGD DESC:Lipid particle protein of unknown function; contains a putative lipase serine active site; induced by transcription factor Rpn4p; protein abundance increases in response to DNA replication stress Gene:YOR105W(YOR105W_p)|FD-Score:3.11|P-value:9.47E-4||SGD DESC:Protein of unknown function; expressed at both mRNA and protein levels Gene:YRR1(YOR162C)|FD-Score:4.33|P-value:7.62E-6||SGD DESC:Zn2-Cys6 zinc-finger transcription factor; activates genes involved in multidrug resistance; paralog of Yrm1p, acting on an overlapping set of target genes; YRR1 has a paralog, PDR8, that arose from the whole genome duplication Gene:ATG11(YPR049C)|FD-Score:3.15|P-value:8.05E-4||SGD DESC:Adapter protein for pexophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; directs receptor-bound cargo to the phagophore assembly site (PAS) for packaging into vesicles; required for recruiting other proteins to the (PAS) Gene:BIO2(YGR286C)|FD-Score:3.59|P-value:1.65E-4||SGD DESC:Biotin synthase, catalyzes the conversion of dethiobiotin to biotin, which is the last step of the biotin biosynthesis pathway; complements E. coli bioB mutant Gene:BIO5(YNR056C)|FD-Score:3.95|P-value:3.91E-5||SGD DESC:Putative transmembrane protein involved in the biotin biosynthesis pathway; responsible for uptake of 7-keto 8-aminopelargonic acid; BIO5 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis Gene:CAP2(YIL034C)|FD-Score:3.29|P-value:5.07E-4||SGD DESC:Beta subunit of the capping protein heterodimer (Cap1p and Cap2p); capping protein (CP) binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to cortical actin patches; protein increases in abundance and relocalizes from bud neck to plasma membrane upon DNA replication stress Gene:COG1(YGL223C)|FD-Score:4.9|P-value:4.89E-7||SGD DESC:Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:COG6(YNL041C)|FD-Score:7.13|P-value:5.15E-13||SGD DESC:Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:COG7(YGL005C)|FD-Score:8.55|P-value:6.14E-18||SGD DESC:Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:COG8(YML071C)|FD-Score:6.31|P-value:1.36E-10||SGD DESC:Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:DGR2(YKL121W_p)|FD-Score:3.42|P-value:3.08E-4||SGD DESC:Protein of unknown function; null mutant is resistant to 2-deoxy-D-glucose and displays abnormally elongated buds Gene:EFT1(YOR133W)|FD-Score:3.57|P-value:1.78E-4||SGD DESC:Elongation factor 2 (EF-2), also encoded by EFT2; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin; EFT1 has a paralog, EFT2, that arose from the whole genome duplication Gene:FAA3(YIL009W)|FD-Score:3.36|P-value:3.93E-4||SGD DESC:Long chain fatty acyl-CoA synthetase, activates imported fatty acids; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery Gene:GET2(YER083C)|FD-Score:4.2|P-value:1.36E-5||SGD DESC:Subunit of the GET complex; involved in insertion of proteins into the ER membrane; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for meiotic nuclear division Gene:GYP1(YOR070C)|FD-Score:3.1|P-value:9.76E-4||SGD DESC:Cis-golgi GTPase-activating protein (GAP) for the Rab family members Ypt1p (in vivo) and for Ypt1p, Sec4p, Ypt7p, and Ypt51p (in vitro); involved in vesicle docking and fusion Gene:HOM2(YDR158W)|FD-Score:3.48|P-value:2.47E-4||SGD DESC:Aspartic beta semi-aldehyde dehydrogenase, catalyzes the second step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis Gene:IRS4(YKR019C)|FD-Score:3.34|P-value:4.12E-4||SGD DESC:EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; IRS4 has a paralog, TAX4, that arose from the whole genome duplication Gene:MRS2(YOR334W)|FD-Score:-3.18|P-value:7.45E-4||SGD DESC:Mitochondrial inner membrane Mg(2+) channel, required for maintenance of intramitochondrial Mg(2+) concentrations at the correct level to support splicing of group II introns Gene:NTH2(YBR001C)|FD-Score:4.52|P-value:3.16E-6||SGD DESC:Putative neutral trehalase, required for thermotolerance; may mediate resistance to other cellular stresses; NTH2 has a paralog, NTH1, that arose from the whole genome duplication Gene:PDR17(YNL264C)|FD-Score:5|P-value:2.81E-7||SGD DESC:Phosphatidylinositol transfer protein (PITP), downregulates Plb1p-mediated turnover of phosphatidylcholine, found in the cytosol and microsomes, homologous to Pdr16p, deletion affects phospholipid composition Gene:RCY1(YJL204C)|FD-Score:3.32|P-value:4.45E-4||SGD DESC:F-box protein involved in recycling plasma membrane proteins internalized by endocytosis; localized to sites of polarized growth Gene:RIF1(YBR275C)|FD-Score:3.58|P-value:1.74E-4||SGD DESC:Protein that binds to the Rap1p C-terminus and acts synergistically with Rif2p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation Gene:RKM2(YDR198C)|FD-Score:-3.76|P-value:8.50E-5||SGD DESC:Ribosomal protein lysine methyltransferase, responsible for trimethylation of the lysine residue at position 3 of Rpl12Ap and Rpl12Bp Gene:RPL20B(YOR312C)|FD-Score:-3.32|P-value:4.55E-4||SGD DESC:Ribosomal 60S subunit protein L20B; homologous to mammalian ribosomal protein L18A, no bacterial homolog; RPL20B has a paralog, RPL20A, that arose from the whole genome duplication Gene:RRG9(YNL213C)|FD-Score:-3.51|P-value:2.27E-4||SGD DESC:Protein of unknown function; null mutant lacks mitochondrial DNA and cannot grow on glycerol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:RSR1(YGR152C)|FD-Score:3.13|P-value:8.64E-4||SGD DESC:GTP-binding protein of the ras superfamily required for bud site selection, morphological changes in response to mating pheromone, and efficient cell fusion; localized to the plasma membrane; significantly similar to mammalian Rap GTPases Gene:SKG6(YHR149C)|FD-Score:3.88|P-value:5.26E-5||SGD DESC:Integral membrane protein that localizes primarily to growing sites such as the bud tip or the cell periphery; potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p Gene:SLZ1(YNL196C_p)|FD-Score:3.96|P-value:3.69E-5||SGD DESC:Sporulation-specific protein with a leucine zipper motif Gene:SUC2(YIL162W)|FD-Score:3.41|P-value:3.20E-4||SGD DESC:Invertase, sucrose hydrolyzing enzyme; a secreted, glycosylated form is regulated by glucose repression, and an intracellular, nonglycosylated enzyme is produced constitutively Gene:SYS1(YJL004C)|FD-Score:4.15|P-value:1.65E-5||SGD DESC:Integral membrane protein of the Golgi required for targeting of the Arf-like GTPase Arl3p to the Golgi; multicopy suppressor of ypt6 null mutation Gene:VMR1(YHL035C)|FD-Score:4.31|P-value:8.25E-6||SGD DESC:Vacuolar membrane protein involved in multiple drug resistance and metal sensitivity; ATP-binding cassette (ABC) family member involved in drug transport; potential Cdc28p substrate; induced under respiratory conditions Gene:VPS63(YLR261C_d)|FD-Score:4.44|P-value:4.51E-6||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene YPT6; deletion causes a vacuolar protein sorting defect Gene:YCR100C(YCR100C_p)|FD-Score:-3.46|P-value:2.69E-4||SGD DESC:Putative protein of unknown function Gene:YHR095W(YHR095W_d)|FD-Score:3.27|P-value:5.29E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YIL032C(YIL032C_d)|FD-Score:3.24|P-value:5.95E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YIL059C(YIL059C_d)|FD-Score:3.32|P-value:4.53E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YIL060W Gene:YMR103C(YMR103C_d)|FD-Score:3.09|P-value:9.99E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YNL146C-A(YNL146C-A_p)|FD-Score:3.31|P-value:4.70E-4||SGD DESC:Putative protein of unknown function Gene:YNL179C(YNL179C_d)|FD-Score:3.37|P-value:3.76E-4||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; deletion in cyr1 mutant results in loss of stress resistance Gene:YOL097W-A(YOL097W-A_p)|FD-Score:3.48|P-value:2.51E-4||SGD DESC:Putative protein of unknown function; identified by expression profiling and mass spectrometry Gene:YOL163W(YOL163W_p)|FD-Score:4.18|P-value:1.43E-5||SGD DESC:Putative protein of unknown function; member of the Dal5p subfamily of the major facilitator family Gene:YOR059C(YOR059C_p)|FD-Score:3.8|P-value:7.31E-5||SGD DESC:Lipid particle protein of unknown function; contains a putative lipase serine active site; induced by transcription factor Rpn4p; protein abundance increases in response to DNA replication stress Gene:YOR105W(YOR105W_p)|FD-Score:3.11|P-value:9.47E-4||SGD DESC:Protein of unknown function; expressed at both mRNA and protein levels Gene:YRR1(YOR162C)|FD-Score:4.33|P-value:7.62E-6||SGD DESC:Zn2-Cys6 zinc-finger transcription factor; activates genes involved in multidrug resistance; paralog of Yrm1p, acting on an overlapping set of target genes; YRR1 has a paralog, PDR8, that arose from the whole genome duplication

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YHR007C7.678.36E-151.37ERG11Lanosterol 14-alpha-demethylase; catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 family; associated and coordinately regulated with the P450 reductase Ncp1p
YIL144W7.077.49E-131.37TID3Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); conserved coiled-coil protein involved in chromosome segregation, spindle checkpoint activity, kinetochore assembly and clustering
YDR211W6.795.66E-121.37GCD6Catalytic epsilon subunit of the translation initiation factor eIF2B; eIF2B is the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression; forms cytoplasmic foci upon DNA replication stress
YPL251W_d5.413.08E-80.32YPL251W_dDubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified, essential gene YAH1/YPL252C
YER125W5.101.71E-70.02RSP5E3 ubiquitin ligase of the NEDD4 family; involved in regulating many cellular processes including MVB sorting, heat shock response, transcription, endocytosis, and ribosome stability; human homolog is involved in Liddle syndrome; mutant tolerates aneuploidy; ubiquitylates Sec23p
YIL126W5.081.87E-70.23STH1ATPase component of the RSC chromatin remodeling complex; required for expression of early meiotic genes; essential helicase-related protein homologous to Snf2p
YMR047C4.856.09E-70.26NUP116FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; forms a stable association with Nup82p, Gle2p and two other FG-nucleoporins (Nsp1p and Nup159p)
YFR037C4.592.22E-60.08RSC8Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters
YCL004W4.513.31E-60.17PGS1Phosphatidylglycerolphosphate synthase, catalyzes the synthesis of phosphatidylglycerolphosphate from CDP-diacylglycerol and sn-glycerol 3-phosphate in the first committed and rate-limiting step of cardiolipin biosynthesis
YDR531W4.337.38E-60.10CAB1Pantothenate kinase (ATP:D-pantothenate 4'-phosphotransferase, EC 2.7.1.33); catalyzes the first committed step in the universal biosynthetic pathway for synthesis of coenzyme A (CoA); transcriptionally regulated by Upc2p via a sterol response element
YDR054C4.231.14E-50.21CDC34Ubiquitin-conjugating enzyme (E2); catalytic subunit of SCF ubiquitin-protein ligase complex (together with Skp1p, Rbx1p, Cdc53p, and an F-box protein) that regulates cell cycle progression by targeting key substrates for degradation; protein abundance increases in response to DNA replication stress
YLR033W4.022.90E-50.22RSC58Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance
YOR020C3.807.22E-50.13HSP10Mitochondrial matrix co-chaperonin that inhibits the ATPase activity of Hsp60p, a mitochondrial chaperonin; involved in protein folding and sorting in the mitochondria; 10 kD heat shock protein with similarity to E. coli groES
YJL025W3.671.22E-40.05RRN7Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p
YLR323C3.611.51E-40.32CWC24Spliceosome assembly factor, essential for the first step of splicing; component of the pre-catalytic spliceosome complex containing Cef1p; has similarity to S. pombe Cwf24p

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YGL005C8.556.14E-18COG7Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
YNL041C7.135.15E-13COG6Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
YML071C6.311.36E-10COG8Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
YNL264C5.002.81E-7PDR17Phosphatidylinositol transfer protein (PITP), downregulates Plb1p-mediated turnover of phosphatidylcholine, found in the cytosol and microsomes, homologous to Pdr16p, deletion affects phospholipid composition
YGL223C4.904.89E-7COG1Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
YBR001C4.523.16E-6NTH2Putative neutral trehalase, required for thermotolerance; may mediate resistance to other cellular stresses; NTH2 has a paralog, NTH1, that arose from the whole genome duplication
YLR261C_d4.444.51E-6VPS63_dDubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene YPT6; deletion causes a vacuolar protein sorting defect
YOR162C4.337.62E-6YRR1Zn2-Cys6 zinc-finger transcription factor; activates genes involved in multidrug resistance; paralog of Yrm1p, acting on an overlapping set of target genes; YRR1 has a paralog, PDR8, that arose from the whole genome duplication
YHL035C4.318.25E-6VMR1Vacuolar membrane protein involved in multiple drug resistance and metal sensitivity; ATP-binding cassette (ABC) family member involved in drug transport; potential Cdc28p substrate; induced under respiratory conditions
YER083C4.201.36E-5GET2Subunit of the GET complex; involved in insertion of proteins into the ER membrane; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for meiotic nuclear division
YOL163W_p4.181.43E-5YOL163W_pPutative protein of unknown function; member of the Dal5p subfamily of the major facilitator family
YJL004C4.151.65E-5SYS1Integral membrane protein of the Golgi required for targeting of the Arf-like GTPase Arl3p to the Golgi; multicopy suppressor of ypt6 null mutation
YNL196C_p3.963.69E-5SLZ1_pSporulation-specific protein with a leucine zipper motif
YNR056C3.953.91E-5BIO5Putative transmembrane protein involved in the biotin biosynthesis pathway; responsible for uptake of 7-keto 8-aminopelargonic acid; BIO5 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis
YHR149C3.885.26E-5SKG6Integral membrane protein that localizes primarily to growing sites such as the bud tip or the cell periphery; potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p

GO enrichment analysis for SGTC_4
biological processes

protein complexes

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.2807.30E-105SGTC_6320781-2353 4.7 μMChemDiv (Drug-like library)68115150.209877Golgi
0.2793.30E-104SGTC_1453737-0113 38.4 μMChemDiv (Drug-like library)68493510.343284DNA intercalators
0.2749.56E-101SGTC_203k066-0004 30.9 μMChemDiv (Drug-like library)67954120.246575RSC & ERG11
0.2572.38E-88SGTC_643k048-0106 28.4 μMChemDiv (Drug-like library)67639200.232877RSC & ERG11
0.2561.12E-87SGTC_1162k048-0130 20.1 μMChemDiv (Drug-like library)67974060.253731Golgi
0.2527.73E-85SGTC_7830848-0141 92.7 μMChemDiv (Drug-like library)67550760.166667RSC & ERG11
0.2405.84E-77SGTC_329k048-0121 21.3 μMChemDiv (Drug-like library)68329020.272727RSC & ERG11
0.2344.70E-73SGTC_13061185-0270 9.0 μMChemDiv (Drug-like library)15480760.0512821Golgi
0.2331.16E-72SGTC_8550428-0020 25.0 μMChemDiv (Drug-like library)68124140.2Golgi
0.2275.72E-69SGTC_590k048-0076 22.4 μMChemDiv (Drug-like library)68328140.242857RSC & ERG11
0.2263.91E-68SGTC_7461095-0025 46.6 μMChemDiv (Drug-like library)67492860.178082RSC & ERG11
0.2138.28E-61SGTC_624k048-0052 28.0 μMChemDiv (Drug-like library)68355310.277778Golgi
0.2092.13E-58SGTC_185k048-0037 25.5 μMChemDiv (Drug-like library)68275890.22973RSC & ERG11
0.2084.48E-58SGTC_10603448-7350 82.0 μMChemDiv (Drug-like library)5701780.176471Golgi
0.2036.65E-55SGTC_220964-0034 14.5 μMChemDiv (Drug-like library)1384020.0142857unfolded protein response

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_9701315-008919.5 μM0.6666676811083ChemDiv (Drug-like library)582.172883.93523RSC & ERG11
SGTC_8940960-023855.9 μM0.656741907ChemDiv (Drug-like library)340.760422.64724
SGTC_5720960-008717.7 μM0.5652176796365ChemDiv (Drug-like library)444.869784.8426
SGTC_5660958-006816.5 μM0.4558826815365ChemDiv (Drug-like library)492.1358233.99424RSC & ERG11
SGTC_4300958-011516.4 μM0.4492756833180ChemDiv (Drug-like library)508.590424.45323
SGTC_20255147754141 μM0.448276315777Chembridge (Fragment library)229.231341.74913
SGTC_2860902572538.96 μM0.38235340546248Chembridge (Drug-like library)313.327843.39515RPP1 & pyrimidine depletion
SGTC_2881315-001935.1 μM0.3756811474ChemDiv (Drug-like library)541.120963.9423RSC & ERG11
SGTC_7571066-0008322 μM0.3684216842497ChemDiv (Drug-like library)596.15644.09815Golgi
SGTC_5571315-011016.2 μM0.3484856833801ChemDiv (Drug-like library)509.077562.63114Golgi