Deletion Strain | FD score | P-value | Gene | Gene Description |
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YER090W | 7.57 | 1.91E-14 | TRP2 | Anthranilate synthase, catalyzes the initial step of tryptophan biosynthesis, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp3p |
YDR354W | 6.23 | 2.34E-10 | TRP4 | Anthranilate phosphoribosyl transferase of the tryptophan biosynthetic pathway, catalyzes the phosphoribosylation of anthranilate, subject to the general control system of amino acid biosynthesis |
YDR272W | 6.19 | 3.00E-10 | GLO2 | Cytoplasmic glyoxalase II, catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate |
YPR130C_d | 5.29 | 5.99E-8 | YPR130C_d | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
YPL157W | 5.18 | 1.09E-7 | TGS1 | Trimethyl guanosine synthase, conserved nucleolar methyl transferase that converts the m(7)G cap structure of snRNAs, snoRNAs, and telomerase TLC1 RNA to m(2,2,7)G; also required for nucleolar assembly and splicing of meiotic pre-mRNAs |
YHR157W | 4.82 | 7.04E-7 | REC104 | Protein involved in early stages of meiotic recombination; required for meiotic crossing over; forms a complex with Rec102p and Spo11p necessary during the initiation of recombination |
YMR256C | 4.62 | 1.95E-6 | COX7 | Subunit VII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain |
YBL090W | 4.43 | 4.61E-6 | MRP21 | Mitochondrial ribosomal protein of the small subunit; MRP21 exhibits genetic interactions with mutations in the COX2 and COX3 mRNA 5'-untranslated leader sequences |
YGL200C | 4.20 | 1.34E-5 | EMP24 | Component of the p24 complex; binds to GPI anchor proteins and mediates their efficient transport from the ER to the Golgi; integral membrane protein that associates with endoplasmic reticulum-derived COPII-coated vesicles |
YDR032C | 4.17 | 1.51E-5 | PST2 | Protein with similarity to a family of flavodoxin-like proteins; induced by oxidative stress in a Yap1p dependent manner; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; PST2 has a paralog, RFS1, that arose from the whole genome duplication |
YDR520C_p | 3.91 | 4.54E-5 | URC2_p | Putative Zn(II)2Cys6 motif containing transcription factor; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; similar to S. kluyveri Urc2p involved in uracil catabolism |
YDR476C_p | 3.88 | 5.17E-5 | YDR476C_p | Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDR476C is not an essential gene |
YDR414C | 3.88 | 5.30E-5 | ERD1 | Predicted membrane protein required for the retention of lumenal endoplasmic reticulum proteins; mutants secrete the endogenous ER protein, BiP (Kar2p) |
YER060W | 3.86 | 5.79E-5 | FCY21 | Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function |
YMR119W-A_d | 3.84 | 6.24E-5 | YMR119W-A_d | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |