Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
---|
YDL097C | 5.98 | 1.13E-9 | 2.12 | RPN6 | Essential, non-ATPase regulatory subunit of the 26S proteasome lid; required for the assembly and activity of the 26S proteasome; the human homolog (S9 protein) partially rescues Rpn6p depletion; protein abundance increases in response to DNA replication stress |
YOL120C | 3.86 | 5.61E-5 | 0.38 | RPL18A | Ribosomal 60S subunit protein L18A; intron of RPL18A pre-mRNA forms stem-loop structures that are a target for Rnt1p cleavage leading to degradation; homologous to mammalian ribosomal protein L18, no bacterial homolog; RPL18A has a paralog, RPL18B, that arose from the whole genome duplication |
YGL047W | 3.48 | 2.49E-4 | 0.01 | ALG13 | Catalytic component of UDP-GlcNAc transferase; required for the second step of dolichyl-linked oligosaccharide synthesis; anchored to the ER membrane via interaction with Alg14p; similar to bacterial and human glycosyltransferases; protein abundance increases in response to DNA replication stress |
YOL040C | 3.47 | 2.60E-4 | 0.16 | RPS15 | Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15 and bacterial S19 |
YGR116W | 3.31 | 4.66E-4 | 0.02 | SPT6 | Nucleosome remodeling protein; functions in various aspects of transcription, chromatin maintenance, and RNA processing; required for the maintenance of chromatin structure during transcription in order to inhibit transcription from promoters within the coding region |
YGR115C_d | 3.29 | 4.97E-4 | 0.02 | YGR115C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified and essential ORF SPT6/YGR115C |
YFR052W | 3.28 | 5.28E-4 | 0.07 | RPN12 | Subunit of the 19S regulatory particle of the 26S proteasome lid; synthetically lethal with RPT1, which is an ATPase component of the 19S regulatory particle; physically interacts with Nob1p and Rpn3p; protein abundance increases in response to DNA replication stress |
YDL195W | 3.21 | 6.66E-4 | 0.01 | SEC31 | Component of the Sec13p-Sec31p complex of the COPII vesicle coat, required for vesicle formation in ER to Golgi transport; mutant has increased aneuploidy tolerance |
YHR062C | 3.20 | 6.92E-4 | 0.05 | RPP1 | Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs |
YFL029C | 3.15 | 8.24E-4 | 0.03 | CAK1 | Cyclin-dependent kinase-activating kinase required for passage through the cell cycle, phosphorylates and activates Cdc28p; nucleotide-binding pocket differs significantly from those of most other protein kinases |
YOL144W | 3.12 | 9.07E-4 | 0.06 | NOP8 | Nucleolar protein required for 60S ribosomal subunit biogenesis |
YKL042W | 3.06 | 0.00110 | 0.02 | SPC42 | Central plaque component of spindle pole body (SPB); involved in SPB duplication, may facilitate attachment of the SPB to the nuclear membrane |
YLR198C_d | 3.04 | 0.00117 | 0.02 | YLR198C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene SIK1/YLR197W |
YGL247W | 3.02 | 0.00127 | 0.06 | BRR6 | Essential nuclear envelope integral membrane protein required for nuclear envelope morphology, nuclear pore complex localization, nuclear export; exhibits synthetic lethal genetic interactions with genes involved in lipid metabolism |
YML010W | 2.96 | 0.00155 | 0.05 | SPT5 | Component of the universally conserved Spt4/5 complex (DSIF complex); the complex has multiple roles in concert with RNA polymerases I and II, including regulation of transcription elongation, RNA processing, quality control, and transcription-coupled DNA repair |