nsc-638432

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_419
Screen concentration 893.0 μM
Source Miscellaneous
PubChem CID 368090
SMILES CN(C)CCCN1C2=C(C=CC3=CC=CC=C32)C4=C1C5=CC=CC=C5C(=O)O4.Cl
Standardized SMILES CN(C)CCCn1c2c(OC(=O)c3ccccc23)c4ccc5ccccc5c14
Molecular weight 406.9046
ALogP 5.23
H-bond donor count 1
H-bond acceptor count 3
Response signature DNA damage response

Pool Growth Kinetics
% growth inhibition (Het. pool) 3.76
% growth inhibition (Hom. pool) 1.25


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 368090
Download HIP data (tab-delimited text)  (excel)
Gene:ARC40(YBR234C)|FD-Score:3.32|P-value:4.58E-4|Clearance:0.07||SGD DESC:Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches Gene:CAK1(YFL029C)|FD-Score:3.55|P-value:1.95E-4|Clearance:0.23||SGD DESC:Cyclin-dependent kinase-activating kinase required for passage through the cell cycle, phosphorylates and activates Cdc28p; nucleotide-binding pocket differs significantly from those of most other protein kinases Gene:CCT8(YJL008C)|FD-Score:5.54|P-value:1.49E-8|Clearance:1.2||SGD DESC:Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo Gene:PRP4(YPR178W)|FD-Score:3.23|P-value:6.13E-4|Clearance:0||SGD DESC:Splicing factor, component of the U4/U6-U5 snRNP complex Gene:RHO1(YPR165W)|FD-Score:4.05|P-value:2.57E-5|Clearance:0.16||SGD DESC:GTP-binding protein of the rho subfamily of Ras-like proteins, involved in establishment of cell polarity; regulates protein kinase C (Pkc1p) and the cell wall synthesizing enzyme 1,3-beta-glucan synthase (Fks1p and Gsc2p) Gene:RPB8(YOR224C)|FD-Score:4.15|P-value:1.63E-5|Clearance:0.11||SGD DESC:RNA polymerase subunit ABC14.5, common to RNA polymerases I, II, and III Gene:SKI6(YGR195W)|FD-Score:-3.49|P-value:2.45E-4|Clearance:0||SGD DESC:Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp41p (EXOSC4) Gene:SNU56(YDR240C)|FD-Score:3.57|P-value:1.78E-4|Clearance:0.02||SGD DESC:Component of U1 snRNP required for mRNA splicing via spliceosome; yeast specific, no metazoan counterpart; interacts with mRNA in commitment complex Gene:SOF1(YLL011W)|FD-Score:4.35|P-value:6.92E-6|Clearance:0.19||SGD DESC:Essential protein required for biogenesis of 40S (small) ribosomal subunit; has similarity to the beta subunit of trimeric G-proteins and the splicing factor Prp4p Gene:SWC4(YGR002C)|FD-Score:-3.53|P-value:2.08E-4|Clearance:0||SGD DESC:Component of the Swr1p complex that incorporates Htz1p into chromatin; component of the NuA4 histone acetyltransferase complex Gene:TIM54(YJL054W)|FD-Score:3.24|P-value:5.89E-4|Clearance:0.01||SGD DESC:Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane Gene:YDR053W(YDR053W_d)|FD-Score:-3.67|P-value:1.23E-4|Clearance:0||SGD DESC:Putative protein of unknown function; open reading frame overlaps 5' end of essential DBF4 gene encoding the regulatory subunit of the Cdc7p-Dbf4p kinase complex Gene:YDR355C(YDR355C_d)|FD-Score:3.89|P-value:5.03E-5|Clearance:0.32||SGD DESC:Dubious: Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified essential ORF SPC110/YDR356W Gene:YOL134C(YOL134C_d)|FD-Score:3.23|P-value:6.16E-4|Clearance:0.15||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps HRT1, a verified gene that encodes an SCF ubiquitin ligase subunit Gene:YTH1(YPR107C)|FD-Score:-6.54|P-value:2.98E-11|Clearance:0||SGD DESC:Essential RNA-binding component of cleavage and polyadenylation factor, contains five zinc fingers; required for pre-mRNA 3'-end processing and polyadenylation Gene:ARC40(YBR234C)|FD-Score:3.32|P-value:4.58E-4|Clearance:0.07||SGD DESC:Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches Gene:CAK1(YFL029C)|FD-Score:3.55|P-value:1.95E-4|Clearance:0.23||SGD DESC:Cyclin-dependent kinase-activating kinase required for passage through the cell cycle, phosphorylates and activates Cdc28p; nucleotide-binding pocket differs significantly from those of most other protein kinases Gene:CCT8(YJL008C)|FD-Score:5.54|P-value:1.49E-8|Clearance:1.2||SGD DESC:Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo Gene:PRP4(YPR178W)|FD-Score:3.23|P-value:6.13E-4|Clearance:0||SGD DESC:Splicing factor, component of the U4/U6-U5 snRNP complex Gene:RHO1(YPR165W)|FD-Score:4.05|P-value:2.57E-5|Clearance:0.16||SGD DESC:GTP-binding protein of the rho subfamily of Ras-like proteins, involved in establishment of cell polarity; regulates protein kinase C (Pkc1p) and the cell wall synthesizing enzyme 1,3-beta-glucan synthase (Fks1p and Gsc2p) Gene:RPB8(YOR224C)|FD-Score:4.15|P-value:1.63E-5|Clearance:0.11||SGD DESC:RNA polymerase subunit ABC14.5, common to RNA polymerases I, II, and III Gene:SKI6(YGR195W)|FD-Score:-3.49|P-value:2.45E-4|Clearance:0||SGD DESC:Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp41p (EXOSC4) Gene:SNU56(YDR240C)|FD-Score:3.57|P-value:1.78E-4|Clearance:0.02||SGD DESC:Component of U1 snRNP required for mRNA splicing via spliceosome; yeast specific, no metazoan counterpart; interacts with mRNA in commitment complex Gene:SOF1(YLL011W)|FD-Score:4.35|P-value:6.92E-6|Clearance:0.19||SGD DESC:Essential protein required for biogenesis of 40S (small) ribosomal subunit; has similarity to the beta subunit of trimeric G-proteins and the splicing factor Prp4p Gene:SWC4(YGR002C)|FD-Score:-3.53|P-value:2.08E-4|Clearance:0||SGD DESC:Component of the Swr1p complex that incorporates Htz1p into chromatin; component of the NuA4 histone acetyltransferase complex Gene:TIM54(YJL054W)|FD-Score:3.24|P-value:5.89E-4|Clearance:0.01||SGD DESC:Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane Gene:YDR053W(YDR053W_d)|FD-Score:-3.67|P-value:1.23E-4|Clearance:0||SGD DESC:Putative protein of unknown function; open reading frame overlaps 5' end of essential DBF4 gene encoding the regulatory subunit of the Cdc7p-Dbf4p kinase complex Gene:YDR355C(YDR355C_d)|FD-Score:3.89|P-value:5.03E-5|Clearance:0.32||SGD DESC:Dubious: Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified essential ORF SPC110/YDR356W Gene:YOL134C(YOL134C_d)|FD-Score:3.23|P-value:6.16E-4|Clearance:0.15||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps HRT1, a verified gene that encodes an SCF ubiquitin ligase subunit Gene:YTH1(YPR107C)|FD-Score:-6.54|P-value:2.98E-11|Clearance:0||SGD DESC:Essential RNA-binding component of cleavage and polyadenylation factor, contains five zinc fingers; required for pre-mRNA 3'-end processing and polyadenylation

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 368090
Download HOP data (tab-delimited text)  (excel)
Gene:AIP1(YMR092C)|FD-Score:3.79|P-value:7.44E-5||SGD DESC:Actin cortical patch component; interacts with the actin depolymerizing factor cofilin; required to restrict cofilin localization to cortical patches; contains WD repeats; protein increases in abundance and relocalizes from cytoplasm to plasma membrane upon DNA replication stress Gene:ALT1(YLR089C)|FD-Score:3.94|P-value:4.14E-5||SGD DESC:Alanine transaminase (glutamic pyruvic transaminase); involved in alanine biosynthetic and catabolic processes; expression is induced in the presence of alanine; repression is mediated by Nrg1p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; paralogous gene ALT2 is catalytically inactive Gene:APJ1(YNL077W)|FD-Score:3.66|P-value:1.27E-4||SGD DESC:Chaperone with a role in SUMO-mediated protein degradation; member of the DnaJ-like family; conserved across eukaryotes; overexpression interferes with propagation of the [Psi+] prion; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; forms nuclear foci upon DNA replication stress Gene:APM1(YPL259C)|FD-Score:4.53|P-value:2.94E-6||SGD DESC:Mu1-like medium subunit of the clathrin-associated protein complex (AP-1); binds clathrin; involved in clathrin-dependent Golgi protein sorting Gene:APN1(YKL114C)|FD-Score:3.21|P-value:6.72E-4||SGD DESC:Major apurinic/apyrimidinic endonuclease, 3'-repair diesterase involved in repair of DNA damage by oxidation and alkylating agents; also functions as a 3'-5' exonuclease to repair 7,8-dihydro-8-oxodeoxyguanosine Gene:ATG15(YCR068W)|FD-Score:-3.65|P-value:1.34E-4||SGD DESC:Lipase required for intravacuolar lysis of autophagic bodies and Cvt bodies; targeted to intravacuolar vesicles during autophagy via the multivesicular body (MVB) pathway Gene:BAR1(YIL015W)|FD-Score:3.67|P-value:1.20E-4||SGD DESC:Aspartyl protease secreted into the periplasmic space of mating type a cells, helps cells find mating partners, cleaves and inactivates alpha factor allowing cells to recover from alpha-factor-induced cell cycle arrest Gene:BMH1(YER177W)|FD-Score:3.15|P-value:8.12E-4||SGD DESC:14-3-3 protein, major isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress Gene:CIT1(YNR001C)|FD-Score:3.17|P-value:7.52E-4||SGD DESC:Citrate synthase; catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate; the rate-limiting enzyme of the TCA cycle; nuclear encoded mitochondrial protein; CIT1 has a paralog, CIT2, that arose from the whole genome duplication Gene:COG7(YGL005C)|FD-Score:3.34|P-value:4.14E-4||SGD DESC:Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:CTR1(YPR124W)|FD-Score:4.12|P-value:1.87E-5||SGD DESC:High-affinity copper transporter of the plasma membrane; mediates nearly all copper uptake under low copper conditions; transcriptionally induced at low copper levels and degraded at high copper levels; protein increases in abundance and relocalizes from nucleus to plasma membrane upon DNA replication stress Gene:CUE2(YKL090W)|FD-Score:-3.64|P-value:1.36E-4||SGD DESC:Protein of unknown function; has two CUE domains that bind ubiquitin, which may facilitate intramolecular monoubiquitination Gene:ELM1(YKL048C)|FD-Score:-3.14|P-value:8.38E-4||SGD DESC:Serine/threonine protein kinase that regulates cellular morphogenesis, septin behavior, and cytokinesis; required for the regulation of other kinases, such as Kin4p; forms part of the bud neck ring Gene:EMC2(YJR088C)|FD-Score:-3.83|P-value:6.50E-5||SGD DESC:Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm Y57G7A.10/EMC-2, fly CG17556, human TTC35 Gene:ERP2(YAL007C)|FD-Score:3.33|P-value:4.35E-4||SGD DESC:Protein that forms a heterotrimeric complex with Erp1p, Emp24p, and Erv25p; member, along with Emp24p and Erv25p, of the p24 family involved in ER to Golgi transport and localized to COPII-coated vesicles Gene:FCY1(YPR062W)|FD-Score:3.53|P-value:2.10E-4||SGD DESC:Cytosine deaminase, zinc metalloenzyme that catalyzes the hydrolytic deamination of cytosine to uracil; of biomedical interest because it also catalyzes the deamination of 5-fluorocytosine (5FC) to form anticancer drug 5-fluorouracil (5FU) Gene:FMP23(YBR047W_p)|FD-Score:3.33|P-value:4.36E-4||SGD DESC:Putative protein of unknown function; proposed to be involved in iron or copper homeostasis; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:HIS5(YIL116W)|FD-Score:9.13|P-value:3.42E-20||SGD DESC:Histidinol-phosphate aminotransferase, catalyzes the seventh step in histidine biosynthesis; responsive to general control of amino acid biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts Gene:HSP31(YDR533C)|FD-Score:-5.38|P-value:3.72E-8||SGD DESC:Possible chaperone and cysteine protease; has similarity to E. coli Hsp31; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease; exists as a dimer and contains a putative metal-binding site; protein abundance increases in response to DNA replication stress Gene:ICS3(YJL077C)|FD-Score:3.43|P-value:2.97E-4||SGD DESC:Protein of unknown function; may play a role in vacuolar sorting, null mutants are hypersensitive to sortin2 Gene:IRC2(YDR112W_d)|FD-Score:3.58|P-value:1.69E-4||SGD DESC:Dubious open reading frame, unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR111C; null mutant displays increased levels of spontaneous Rad52p foci Gene:IZH4(YOL101C)|FD-Score:3.42|P-value:3.14E-4||SGD DESC:Membrane protein involved in zinc ion homeostasis; member of the four-protein IZH family; expression induced by fatty acids and altered zinc levels; deletion reduces sensitivity to excess zinc; possible role in sterol metabolism; protein increases in abundance and relocalizes from nucleus to ER upon DNA replication stress Gene:MRPL20(YKR085C)|FD-Score:-3.34|P-value:4.25E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:MSR1(YHR091C)|FD-Score:-3.33|P-value:4.42E-4||SGD DESC:Mitochondrial arginyl-tRNA synthetase; mutations in human ortholog are associated with pontocerebellar hypoplasia type 6 Gene:NIT1(YIL164C)|FD-Score:3.69|P-value:1.10E-4||SGD DESC:Nitrilase, member of the nitrilase branch of the nitrilase superfamily; in closely related species and other S. cerevisiae strain backgrounds YIL164C and adjacent ORF, YIL165C, likely constitute a single ORF encoding a nitrilase gene Gene:PHO87(YCR037C)|FD-Score:-3.12|P-value:9.18E-4||SGD DESC:Low-affinity inorganic phosphate (Pi) transporter; involved in activation of PHO pathway; expression is independent of Pi concentration and Pho4p activity; contains 12 membrane-spanning segments; PHO87 has a paralog, PHO90, that arose from the whole genome duplication Gene:PIN3(YPR154W)|FD-Score:4.54|P-value:2.81E-6||SGD DESC:Protein that induces appearance of [PIN+] prion when overproduced Gene:RAD5(YLR032W)|FD-Score:-4.36|P-value:6.39E-6||SGD DESC:DNA helicase; proposed to promote replication fork regression during postreplication repair by template switching; RING finger containing ubiquitin ligase; stimulates the synthesis of free and PCNA-bound polyubiquitin chains by Ubc13p-Mms2p; required for error-prone translesion synthesis; forms nuclear foci upon DNA replication stress Gene:RAD55(YDR076W)|FD-Score:5.14|P-value:1.39E-7||SGD DESC:Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad57p Gene:RAD59(YDL059C)|FD-Score:3.52|P-value:2.18E-4||SGD DESC:Protein involved DNA double-strand break repair; repairs breaks in DNA during vegetative growth via recombination and single-strand annealing; anneals complementary single-stranded DNA; forms nuclear foci upon DNA replication stress; required for loading of Rad52p to DSBs; paralog of Rad52p Gene:RGM1(YMR182C)|FD-Score:3.36|P-value:3.97E-4||SGD DESC:Putative zinc finger DNA binding transcription factor; contains two N-terminal C2H2 zinc fingers and C-terminal proline rich domain; overproduction impairs cell growth and induces expression of genes involved in monosaccharide catabolism and aldehyde metabolism; regulates expression of of Y-prime telomeric elements and subtelomeric COS genes; RGM1 has a paralog, USV1, that arose from the whole genome duplication Gene:ROG1(YGL144C)|FD-Score:-3.6|P-value:1.57E-4||SGD DESC:Protein with putative serine active lipase domain; ROG1 has a paralog, YDL109C, that arose from the whole genome duplication Gene:RPL43A(YPR043W)|FD-Score:-3.34|P-value:4.21E-4||SGD DESC:Ribosomal 60S subunit protein L43A; null mutation confers a dominant lethal phenotype; homologous to mammalian ribosomal protein L37A, no bacterial homolog; RPL43A has a paralog, RPL43B, that arose from the whole genome duplication Gene:RTG2(YGL252C)|FD-Score:4.74|P-value:1.05E-6||SGD DESC:Sensor of mitochondrial dysfunction; regulates the subcellular location of Rtg1p and Rtg3p, transcriptional activators of the retrograde (RTG) and TOR pathways; Rtg2p is inhibited by the phosphorylated form of Mks1p Gene:SBE22(YHR103W)|FD-Score:3.38|P-value:3.56E-4||SGD DESC:Protein involved in the transport of cell wall components from the Golgi to the cell surface; similar in structure and functionally redundant with Sbe2p; involved in bud growth Gene:SCP160(YJL080C)|FD-Score:3.21|P-value:6.60E-4||SGD DESC:Essential RNA-binding G protein effector of mating response pathway, mainly associated with nuclear envelope and ER, interacts in mRNA-dependent manner with translating ribosomes via multiple KH domains, similar to vertebrate vigilins Gene:SGF73(YGL066W)|FD-Score:3.22|P-value:6.50E-4||SGD DESC:SAGA complex subunit; has a role in anchoring the deubiquitination module into SAGA and SLIK complexes; involved in preinitiation complex assembly at promoters; human ortholog ataxin-7 is associated with spinocerebellar ataxia diseases; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay Gene:SOL3(YHR163W)|FD-Score:-4.13|P-value:1.85E-5||SGD DESC:6-phosphogluconolactonase; catalyzes the second step of the pentose phosphate pathway; weak multicopy suppressor of los1-1 mutation; homologous to Sol2p and Sol1p; SOL3 has a paralog, SOL4, that arose from the whole genome duplication Gene:TUS1(YLR425W)|FD-Score:3.39|P-value:3.47E-4||SGD DESC:Guanine nucleotide exchange factor (GEF) that modulate Rho1p activity; involved in the cell integrity signaling pathway; interacts with Rgl1p; localization of Tus1p to the bed neck is regulated by Rgl1p; multicopy suppressor of tor2 mutation and ypk1 ypk2 double mutation; potential Cdc28p substrate Gene:UBP1(YDL122W)|FD-Score:-5.2|P-value:9.97E-8||SGD DESC:Ubiquitin-specific protease that removes ubiquitin from ubiquitinated proteins; cleaves at the C terminus of ubiquitin fusions irrespective of their size; capable of cleaving polyubiquitin chains Gene:YBL071C(YBL071C_d)|FD-Score:4.74|P-value:1.07E-6||SGD DESC:Dubious open reading frame, predicted protein contains a peroxisomal targeting signal Gene:YCL002C(YCL002C_p)|FD-Score:4.11|P-value:1.97E-5||SGD DESC:Putative protein of unknown function; YCL002C is not an essential gene Gene:YCR050C(YCR050C_p)|FD-Score:4.07|P-value:2.39E-5||SGD DESC:Non-essential protein of unknown function; deletion mutant is synthetically sick or lethal with alpha-synuclein Gene:YGR137W(YGR137W_d)|FD-Score:4.23|P-value:1.15E-5||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YHR138C(YHR138C_p)|FD-Score:3.47|P-value:2.60E-4||SGD DESC:Protein of unknown function; similar to Pbi2p; double null mutant lacking Pbi2p and Yhr138cp exhibits highly fragmented vacuoles; protein abundance increases in response to DNA replication stress Gene:YKE4(YIL023C)|FD-Score:3.4|P-value:3.31E-4||SGD DESC:Zinc transporter; localizes to the ER; null mutant is sensitive to calcofluor white, leads to zinc accumulation in cytosol; ortholog of the mouse KE4 and member of the ZIP (ZRT, IRT-like Protein) family Gene:YMR253C(YMR253C_p)|FD-Score:4.53|P-value:3.02E-6||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; YMR253C is not an essential gene Gene:YNL205C(YNL205C_d)|FD-Score:3.6|P-value:1.61E-4||SGD DESC:Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YOL024W(YOL024W_p)|FD-Score:3.33|P-value:4.39E-4||SGD DESC:Putative protein of unknown function; predicted to have thiol-disulfide oxidoreductase active site; YOL024W has a paralog, IGD1, that arose from the whole genome duplication Gene:YOR097C(YOR097C_p)|FD-Score:3.32|P-value:4.45E-4||SGD DESC:Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen; YOR097C is not an essential gene Gene:YPL197C(YPL197C_d)|FD-Score:-3.11|P-value:9.21E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the ribosomal gene RPB7B Gene:YPS5(YGL259W_p)|FD-Score:3.65|P-value:1.29E-4||SGD DESC:Protein with similarity to GPI-anchored aspartic proteases such as Yap1p and Yap3p Gene:AIP1(YMR092C)|FD-Score:3.79|P-value:7.44E-5||SGD DESC:Actin cortical patch component; interacts with the actin depolymerizing factor cofilin; required to restrict cofilin localization to cortical patches; contains WD repeats; protein increases in abundance and relocalizes from cytoplasm to plasma membrane upon DNA replication stress Gene:ALT1(YLR089C)|FD-Score:3.94|P-value:4.14E-5||SGD DESC:Alanine transaminase (glutamic pyruvic transaminase); involved in alanine biosynthetic and catabolic processes; expression is induced in the presence of alanine; repression is mediated by Nrg1p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; paralogous gene ALT2 is catalytically inactive Gene:APJ1(YNL077W)|FD-Score:3.66|P-value:1.27E-4||SGD DESC:Chaperone with a role in SUMO-mediated protein degradation; member of the DnaJ-like family; conserved across eukaryotes; overexpression interferes with propagation of the [Psi+] prion; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; forms nuclear foci upon DNA replication stress Gene:APM1(YPL259C)|FD-Score:4.53|P-value:2.94E-6||SGD DESC:Mu1-like medium subunit of the clathrin-associated protein complex (AP-1); binds clathrin; involved in clathrin-dependent Golgi protein sorting Gene:APN1(YKL114C)|FD-Score:3.21|P-value:6.72E-4||SGD DESC:Major apurinic/apyrimidinic endonuclease, 3'-repair diesterase involved in repair of DNA damage by oxidation and alkylating agents; also functions as a 3'-5' exonuclease to repair 7,8-dihydro-8-oxodeoxyguanosine Gene:ATG15(YCR068W)|FD-Score:-3.65|P-value:1.34E-4||SGD DESC:Lipase required for intravacuolar lysis of autophagic bodies and Cvt bodies; targeted to intravacuolar vesicles during autophagy via the multivesicular body (MVB) pathway Gene:BAR1(YIL015W)|FD-Score:3.67|P-value:1.20E-4||SGD DESC:Aspartyl protease secreted into the periplasmic space of mating type a cells, helps cells find mating partners, cleaves and inactivates alpha factor allowing cells to recover from alpha-factor-induced cell cycle arrest Gene:BMH1(YER177W)|FD-Score:3.15|P-value:8.12E-4||SGD DESC:14-3-3 protein, major isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress Gene:CIT1(YNR001C)|FD-Score:3.17|P-value:7.52E-4||SGD DESC:Citrate synthase; catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate; the rate-limiting enzyme of the TCA cycle; nuclear encoded mitochondrial protein; CIT1 has a paralog, CIT2, that arose from the whole genome duplication Gene:COG7(YGL005C)|FD-Score:3.34|P-value:4.14E-4||SGD DESC:Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:CTR1(YPR124W)|FD-Score:4.12|P-value:1.87E-5||SGD DESC:High-affinity copper transporter of the plasma membrane; mediates nearly all copper uptake under low copper conditions; transcriptionally induced at low copper levels and degraded at high copper levels; protein increases in abundance and relocalizes from nucleus to plasma membrane upon DNA replication stress Gene:CUE2(YKL090W)|FD-Score:-3.64|P-value:1.36E-4||SGD DESC:Protein of unknown function; has two CUE domains that bind ubiquitin, which may facilitate intramolecular monoubiquitination Gene:ELM1(YKL048C)|FD-Score:-3.14|P-value:8.38E-4||SGD DESC:Serine/threonine protein kinase that regulates cellular morphogenesis, septin behavior, and cytokinesis; required for the regulation of other kinases, such as Kin4p; forms part of the bud neck ring Gene:EMC2(YJR088C)|FD-Score:-3.83|P-value:6.50E-5||SGD DESC:Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm Y57G7A.10/EMC-2, fly CG17556, human TTC35 Gene:ERP2(YAL007C)|FD-Score:3.33|P-value:4.35E-4||SGD DESC:Protein that forms a heterotrimeric complex with Erp1p, Emp24p, and Erv25p; member, along with Emp24p and Erv25p, of the p24 family involved in ER to Golgi transport and localized to COPII-coated vesicles Gene:FCY1(YPR062W)|FD-Score:3.53|P-value:2.10E-4||SGD DESC:Cytosine deaminase, zinc metalloenzyme that catalyzes the hydrolytic deamination of cytosine to uracil; of biomedical interest because it also catalyzes the deamination of 5-fluorocytosine (5FC) to form anticancer drug 5-fluorouracil (5FU) Gene:FMP23(YBR047W_p)|FD-Score:3.33|P-value:4.36E-4||SGD DESC:Putative protein of unknown function; proposed to be involved in iron or copper homeostasis; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:HIS5(YIL116W)|FD-Score:9.13|P-value:3.42E-20||SGD DESC:Histidinol-phosphate aminotransferase, catalyzes the seventh step in histidine biosynthesis; responsive to general control of amino acid biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts Gene:HSP31(YDR533C)|FD-Score:-5.38|P-value:3.72E-8||SGD DESC:Possible chaperone and cysteine protease; has similarity to E. coli Hsp31; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease; exists as a dimer and contains a putative metal-binding site; protein abundance increases in response to DNA replication stress Gene:ICS3(YJL077C)|FD-Score:3.43|P-value:2.97E-4||SGD DESC:Protein of unknown function; may play a role in vacuolar sorting, null mutants are hypersensitive to sortin2 Gene:IRC2(YDR112W_d)|FD-Score:3.58|P-value:1.69E-4||SGD DESC:Dubious open reading frame, unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR111C; null mutant displays increased levels of spontaneous Rad52p foci Gene:IZH4(YOL101C)|FD-Score:3.42|P-value:3.14E-4||SGD DESC:Membrane protein involved in zinc ion homeostasis; member of the four-protein IZH family; expression induced by fatty acids and altered zinc levels; deletion reduces sensitivity to excess zinc; possible role in sterol metabolism; protein increases in abundance and relocalizes from nucleus to ER upon DNA replication stress Gene:MRPL20(YKR085C)|FD-Score:-3.34|P-value:4.25E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:MSR1(YHR091C)|FD-Score:-3.33|P-value:4.42E-4||SGD DESC:Mitochondrial arginyl-tRNA synthetase; mutations in human ortholog are associated with pontocerebellar hypoplasia type 6 Gene:NIT1(YIL164C)|FD-Score:3.69|P-value:1.10E-4||SGD DESC:Nitrilase, member of the nitrilase branch of the nitrilase superfamily; in closely related species and other S. cerevisiae strain backgrounds YIL164C and adjacent ORF, YIL165C, likely constitute a single ORF encoding a nitrilase gene Gene:PHO87(YCR037C)|FD-Score:-3.12|P-value:9.18E-4||SGD DESC:Low-affinity inorganic phosphate (Pi) transporter; involved in activation of PHO pathway; expression is independent of Pi concentration and Pho4p activity; contains 12 membrane-spanning segments; PHO87 has a paralog, PHO90, that arose from the whole genome duplication Gene:PIN3(YPR154W)|FD-Score:4.54|P-value:2.81E-6||SGD DESC:Protein that induces appearance of [PIN+] prion when overproduced Gene:RAD5(YLR032W)|FD-Score:-4.36|P-value:6.39E-6||SGD DESC:DNA helicase; proposed to promote replication fork regression during postreplication repair by template switching; RING finger containing ubiquitin ligase; stimulates the synthesis of free and PCNA-bound polyubiquitin chains by Ubc13p-Mms2p; required for error-prone translesion synthesis; forms nuclear foci upon DNA replication stress Gene:RAD55(YDR076W)|FD-Score:5.14|P-value:1.39E-7||SGD DESC:Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad57p Gene:RAD59(YDL059C)|FD-Score:3.52|P-value:2.18E-4||SGD DESC:Protein involved DNA double-strand break repair; repairs breaks in DNA during vegetative growth via recombination and single-strand annealing; anneals complementary single-stranded DNA; forms nuclear foci upon DNA replication stress; required for loading of Rad52p to DSBs; paralog of Rad52p Gene:RGM1(YMR182C)|FD-Score:3.36|P-value:3.97E-4||SGD DESC:Putative zinc finger DNA binding transcription factor; contains two N-terminal C2H2 zinc fingers and C-terminal proline rich domain; overproduction impairs cell growth and induces expression of genes involved in monosaccharide catabolism and aldehyde metabolism; regulates expression of of Y-prime telomeric elements and subtelomeric COS genes; RGM1 has a paralog, USV1, that arose from the whole genome duplication Gene:ROG1(YGL144C)|FD-Score:-3.6|P-value:1.57E-4||SGD DESC:Protein with putative serine active lipase domain; ROG1 has a paralog, YDL109C, that arose from the whole genome duplication Gene:RPL43A(YPR043W)|FD-Score:-3.34|P-value:4.21E-4||SGD DESC:Ribosomal 60S subunit protein L43A; null mutation confers a dominant lethal phenotype; homologous to mammalian ribosomal protein L37A, no bacterial homolog; RPL43A has a paralog, RPL43B, that arose from the whole genome duplication Gene:RTG2(YGL252C)|FD-Score:4.74|P-value:1.05E-6||SGD DESC:Sensor of mitochondrial dysfunction; regulates the subcellular location of Rtg1p and Rtg3p, transcriptional activators of the retrograde (RTG) and TOR pathways; Rtg2p is inhibited by the phosphorylated form of Mks1p Gene:SBE22(YHR103W)|FD-Score:3.38|P-value:3.56E-4||SGD DESC:Protein involved in the transport of cell wall components from the Golgi to the cell surface; similar in structure and functionally redundant with Sbe2p; involved in bud growth Gene:SCP160(YJL080C)|FD-Score:3.21|P-value:6.60E-4||SGD DESC:Essential RNA-binding G protein effector of mating response pathway, mainly associated with nuclear envelope and ER, interacts in mRNA-dependent manner with translating ribosomes via multiple KH domains, similar to vertebrate vigilins Gene:SGF73(YGL066W)|FD-Score:3.22|P-value:6.50E-4||SGD DESC:SAGA complex subunit; has a role in anchoring the deubiquitination module into SAGA and SLIK complexes; involved in preinitiation complex assembly at promoters; human ortholog ataxin-7 is associated with spinocerebellar ataxia diseases; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay Gene:SOL3(YHR163W)|FD-Score:-4.13|P-value:1.85E-5||SGD DESC:6-phosphogluconolactonase; catalyzes the second step of the pentose phosphate pathway; weak multicopy suppressor of los1-1 mutation; homologous to Sol2p and Sol1p; SOL3 has a paralog, SOL4, that arose from the whole genome duplication Gene:TUS1(YLR425W)|FD-Score:3.39|P-value:3.47E-4||SGD DESC:Guanine nucleotide exchange factor (GEF) that modulate Rho1p activity; involved in the cell integrity signaling pathway; interacts with Rgl1p; localization of Tus1p to the bed neck is regulated by Rgl1p; multicopy suppressor of tor2 mutation and ypk1 ypk2 double mutation; potential Cdc28p substrate Gene:UBP1(YDL122W)|FD-Score:-5.2|P-value:9.97E-8||SGD DESC:Ubiquitin-specific protease that removes ubiquitin from ubiquitinated proteins; cleaves at the C terminus of ubiquitin fusions irrespective of their size; capable of cleaving polyubiquitin chains Gene:YBL071C(YBL071C_d)|FD-Score:4.74|P-value:1.07E-6||SGD DESC:Dubious open reading frame, predicted protein contains a peroxisomal targeting signal Gene:YCL002C(YCL002C_p)|FD-Score:4.11|P-value:1.97E-5||SGD DESC:Putative protein of unknown function; YCL002C is not an essential gene Gene:YCR050C(YCR050C_p)|FD-Score:4.07|P-value:2.39E-5||SGD DESC:Non-essential protein of unknown function; deletion mutant is synthetically sick or lethal with alpha-synuclein Gene:YGR137W(YGR137W_d)|FD-Score:4.23|P-value:1.15E-5||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YHR138C(YHR138C_p)|FD-Score:3.47|P-value:2.60E-4||SGD DESC:Protein of unknown function; similar to Pbi2p; double null mutant lacking Pbi2p and Yhr138cp exhibits highly fragmented vacuoles; protein abundance increases in response to DNA replication stress Gene:YKE4(YIL023C)|FD-Score:3.4|P-value:3.31E-4||SGD DESC:Zinc transporter; localizes to the ER; null mutant is sensitive to calcofluor white, leads to zinc accumulation in cytosol; ortholog of the mouse KE4 and member of the ZIP (ZRT, IRT-like Protein) family Gene:YMR253C(YMR253C_p)|FD-Score:4.53|P-value:3.02E-6||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; YMR253C is not an essential gene Gene:YNL205C(YNL205C_d)|FD-Score:3.6|P-value:1.61E-4||SGD DESC:Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YOL024W(YOL024W_p)|FD-Score:3.33|P-value:4.39E-4||SGD DESC:Putative protein of unknown function; predicted to have thiol-disulfide oxidoreductase active site; YOL024W has a paralog, IGD1, that arose from the whole genome duplication Gene:YOR097C(YOR097C_p)|FD-Score:3.32|P-value:4.45E-4||SGD DESC:Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen; YOR097C is not an essential gene Gene:YPL197C(YPL197C_d)|FD-Score:-3.11|P-value:9.21E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the ribosomal gene RPB7B Gene:YPS5(YGL259W_p)|FD-Score:3.65|P-value:1.29E-4||SGD DESC:Protein with similarity to GPI-anchored aspartic proteases such as Yap1p and Yap3p

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YJL008C5.541.49E-81.20CCT8Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
YLL011W4.356.92E-60.19SOF1Essential protein required for biogenesis of 40S (small) ribosomal subunit; has similarity to the beta subunit of trimeric G-proteins and the splicing factor Prp4p
YOR224C4.151.63E-50.11RPB8RNA polymerase subunit ABC14.5, common to RNA polymerases I, II, and III
YPR165W4.052.57E-50.16RHO1GTP-binding protein of the rho subfamily of Ras-like proteins, involved in establishment of cell polarity; regulates protein kinase C (Pkc1p) and the cell wall synthesizing enzyme 1,3-beta-glucan synthase (Fks1p and Gsc2p)
YDR355C_d3.895.03E-50.32YDR355C_dDubious: Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified essential ORF SPC110/YDR356W
YDR240C3.571.78E-40.02SNU56Component of U1 snRNP required for mRNA splicing via spliceosome; yeast specific, no metazoan counterpart; interacts with mRNA in commitment complex
YFL029C3.551.95E-40.23CAK1Cyclin-dependent kinase-activating kinase required for passage through the cell cycle, phosphorylates and activates Cdc28p; nucleotide-binding pocket differs significantly from those of most other protein kinases
YBR234C3.324.58E-40.07ARC40Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches
YJL054W3.245.89E-40.01TIM54Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane
YPR178W3.236.13E-40.00PRP4Splicing factor, component of the U4/U6-U5 snRNP complex
YOL134C_d3.236.16E-40.15YOL134C_dDubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps HRT1, a verified gene that encodes an SCF ubiquitin ligase subunit
YLR163C3.080.001020.14MAS1Smaller subunit of the mitochondrial processing protease (MPP), essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins
YDR397C2.950.001600.03NCB2Subunit of a heterodimeric NC2 transcription regulator complex with Bur6p; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2beta
YHR170W2.910.001790.06NMD3Protein involved in nuclear export of the large ribosomal subunit; acts as a Crm1p-dependent adapter protein for export of nascent ribosomal subunits through the nuclear pore complex
YPR016C2.860.002140.00TIF6Constituent of 66S pre-ribosomal particles, has similarity to human translation initiation factor 6 (eIF6); may be involved in the biogenesis and or stability of 60S ribosomal subunits

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YIL116W9.133.42E-20HIS5Histidinol-phosphate aminotransferase, catalyzes the seventh step in histidine biosynthesis; responsive to general control of amino acid biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts
YDR076W5.141.39E-7RAD55Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad57p
YGL252C4.741.05E-6RTG2Sensor of mitochondrial dysfunction; regulates the subcellular location of Rtg1p and Rtg3p, transcriptional activators of the retrograde (RTG) and TOR pathways; Rtg2p is inhibited by the phosphorylated form of Mks1p
YBL071C_d4.741.07E-6YBL071C_dDubious open reading frame, predicted protein contains a peroxisomal targeting signal
YPR154W4.542.81E-6PIN3Protein that induces appearance of [PIN+] prion when overproduced
YPL259C4.532.94E-6APM1Mu1-like medium subunit of the clathrin-associated protein complex (AP-1); binds clathrin; involved in clathrin-dependent Golgi protein sorting
YMR253C_p4.533.02E-6YMR253C_pPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; YMR253C is not an essential gene
YGR137W_d4.231.15E-5YGR137W_dDubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YPR124W4.121.87E-5CTR1High-affinity copper transporter of the plasma membrane; mediates nearly all copper uptake under low copper conditions; transcriptionally induced at low copper levels and degraded at high copper levels; protein increases in abundance and relocalizes from nucleus to plasma membrane upon DNA replication stress
YCL002C_p4.111.97E-5YCL002C_pPutative protein of unknown function; YCL002C is not an essential gene
YCR050C_p4.072.39E-5YCR050C_pNon-essential protein of unknown function; deletion mutant is synthetically sick or lethal with alpha-synuclein
YLR089C3.944.14E-5ALT1Alanine transaminase (glutamic pyruvic transaminase); involved in alanine biosynthetic and catabolic processes; expression is induced in the presence of alanine; repression is mediated by Nrg1p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; paralogous gene ALT2 is catalytically inactive
YMR092C3.797.44E-5AIP1Actin cortical patch component; interacts with the actin depolymerizing factor cofilin; required to restrict cofilin localization to cortical patches; contains WD repeats; protein increases in abundance and relocalizes from cytoplasm to plasma membrane upon DNA replication stress
YIL164C3.691.10E-4NIT1Nitrilase, member of the nitrilase branch of the nitrilase superfamily; in closely related species and other S. cerevisiae strain backgrounds YIL164C and adjacent ORF, YIL165C, likely constitute a single ORF encoding a nitrilase gene
YIL015W3.671.20E-4BAR1Aspartyl protease secreted into the periplasmic space of mating type a cells, helps cells find mating partners, cleaves and inactivates alpha factor allowing cells to recover from alpha-factor-induced cell cycle arrest

GO enrichment analysis for SGTC_419
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.0985.03E-14SGTC_698k064-0052 127.0 μMChemDiv (Drug-like library)50887510.151899DNA damage response
0.0872.13E-11SGTC_2671danthron 100.0 μMMicrosource (Natural product library)29500.137931DNA damage response
0.0782.30E-9SGTC_558k064-0027 21.3 μMChemDiv (Drug-like library)50885260.108108DNA damage response
0.0715.52E-8SGTC_32859112818 20.9 μMChembridge (Drug-like library)170179470.0795455cell wall
0.0707.87E-8SGTC_1079idarubicin 2.4 μMNIH Clinical Collection6363620.114583DNA damage response
0.0663.28E-7SGTC_1082camptothecin 424.9 nMTimTec (Natural product library)25380.134831DNA damage response
0.0663.92E-7SGTC_23559061122 103.1 μMChembridge (Fragment library)53029570.151515
0.0641.02E-6SGTC_411enrofloxacin 100.0 μMMiscellaneous711880.0795455DNA damage response
0.0622.02E-6SGTC_1707st032323 6.3 μMTimTec (Natural product derivative library)31320570.120482DNA damage response
0.0612.38E-6SGTC_33319141060 2.0 μMChembridge (Drug-like library)49065670.117647cell wall
0.0603.71E-6SGTC_1902st060212 70.5 μMTimTec (Natural product derivative library)6889440.144928
0.0603.82E-6SGTC_6320781-2353 4.7 μMChemDiv (Drug-like library)68115150.0561798Golgi
0.0604.17E-6SGTC_21495554786 194.8 μMChembridge (Fragment library)7450630.126761cell wall signaling
0.0595.89E-6SGTC_8630466-0191 129.0 μMChemDiv (Drug-like library)7651600.140845cell wall
0.0571.21E-5SGTC_33509150499 3.6 μMChembridge (Drug-like library)49109960.1cell wall

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_2385hr heat shock (37°C) + nsc-6384328.93 μM1368090Miscellaneous406.904625.23213heat shock/prefoldin
SGTC_468gf-109203x121 μM0.301372396ICCB bioactive library412.483663.55723amide catabolism
SGTC_3883',4'-dichloroisocoumarin16.7 μM0.2592591609Miscellaneous215.032862.75802
SGTC_1982st07246771.9 μM0.2575763163533TimTec (Natural product derivative library)278.32513.99803
SGTC_6470140-023681 μM0.254545990837ChemDiv (Drug-like library)406.606724.07104
SGTC_2435hr heat shock (37°C) + splitomicin1 μM0.2542375269Miscellaneous198.21732.83102heat shock/prefoldin
SGTC_424splitomicin100 mM0.2542375269Miscellaneous198.21732.83102
SGTC_12033992-3522103 μM0.2345685322312ChemDiv (Drug-like library)429.388534.56418
SGTC_20225136654200 μM0.2333331713771Chembridge (Fragment library)204.225180.99703
SGTC_7510833-0568350 μM0.229736954252ChemDiv (Drug-like library)311.358322.70924